{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:34:21Z","timestamp":1772951661296,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.jsbmb.2013.12.018","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T22:24:04Z","timestamp":1388701444000},"page":"7-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Structural and evolutionary analysis of the co-activator binding domain in vertebrate progesterone receptors"],"prefix":"10.1016","volume":"141","author":[{"given":"Stephanie R.","family":"Kattoula","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2013.12.018_bib0005","first-page":"502","article-title":"Physiological action of progesterone in target tissues","volume":"18","author":"Graham","year":"1997","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0010","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1210\/rp.57.1.339","article-title":"Reproductive functions of progesterone receptors","volume":"57","author":"Conneely","year":"2002","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0015","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/med.20083","article-title":"The evolution of progesterone receptor ligands","volume":"27","author":"Madauss","year":"2007","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0020","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1056\/NEJMra061360","article-title":"Parturition","volume":"356","author":"Smith","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0025","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mce.2011.10.030","article-title":"The biology of progesterone receptor in the normal mammary gland and in breast cancer","volume":"357","author":"Obr","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0030","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.tem.2012.05.002","article-title":"Recent advances in understanding the endocrinology of human birth","volume":"23","author":"Smith","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0035","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.tem.2005.08.007","article-title":"Evolution of neuroendocrine mechanisms that regulate sexual behavior","volume":"16","author":"Crews","year":"2005","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0040","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.yfrne.2006.07.003","article-title":"The many faces of progesterone: a role in adult and developing male brain","volume":"27","author":"Wagner","year":"2006","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0045","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/molbev\/msh200","article-title":"Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems","volume":"21","author":"Bertrand","year":"2004","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0050","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/icb\/45.1.172","article-title":"Xenobiotics and the evolution of multicellular animals: emergence and diversification of ligand-activated transcription factors","volume":"45","author":"Baker","year":"2005","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0055","doi-asserted-by":"crossref","first-page":"11913","DOI":"10.1073\/pnas.0812138106","article-title":"Independent elaboration of steroid hormone signaling pathways in metazoans","volume":"106","author":"Markov","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0060","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-physiol-021909-135917","article-title":"Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics","volume":"72","author":"Huang","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000497","article-title":"Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor","volume":"8","author":"Bridgham","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mce.2010.06.018","article-title":"What are nuclear receptor ligands?","volume":"334","author":"Sladek","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0075","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1126\/science.270.5240.1354","article-title":"Sequence and characterization of a coactivator for the steroid hormone receptor superfamily","volume":"270","author":"Onate","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0080","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/42750","article-title":"A signature motif in transcriptional co-activators mediates binding to nuclear receptors","volume":"387","author":"Heery","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0085","doi-asserted-by":"crossref","first-page":"12101","DOI":"10.1074\/jbc.273.20.12101","article-title":"The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors","volume":"273","author":"Onate","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0090","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/emboj\/17.2.507","article-title":"The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways","volume":"17","author":"Voegel","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0095","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1210\/mend.12.2.0065","article-title":"Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities","volume":"12","author":"Ding","year":"1998","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0100","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1101\/gad.12.21.3357","article-title":"Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation","volume":"12","author":"McInerney","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0105","doi-asserted-by":"crossref","first-page":"36865","DOI":"10.1074\/jbc.R100041200","article-title":"Coregulator codes of transcriptional regulation by nuclear receptors","volume":"276","author":"Rosenfeld","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0110","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1128\/MCB.23.11.3763-3773.2003","article-title":"Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification","volume":"23","author":"Li","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0115","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1210\/me.2005-0247","article-title":"The evolution of mineralocorticoid receptors","volume":"20","author":"Hu","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0120","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0092-8674(02)00817-6","article-title":"Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition","volume":"110","author":"Bledsoe","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0125","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.molcel.2005.06.026","article-title":"Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor","volume":"19","author":"Li","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0130","doi-asserted-by":"crossref","first-page":"8060","DOI":"10.1074\/jbc.M407046200","article-title":"The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor","volume":"280","author":"Estebanez-Perpina","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0135","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0092-8674(00)81717-1","article-title":"The structural basis of estrogen receptor\/coactivator recognition and the antagonism of this interaction by tamoxifen","volume":"95","author":"Shiau","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0140","doi-asserted-by":"crossref","first-page":"21862","DOI":"10.1074\/jbc.M200764200","article-title":"Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha","volume":"277","author":"Warnmark","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0145","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.steroids.2010.10.008","article-title":"3D models of lamprey progesterone receptor complexed with progesterone, 7alpha-hydroxy-progesterone and 15alpha-hydroxy-progesterone","volume":"76","author":"Baker","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0150","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jsbmb.2012.04.007","article-title":"Evolutionary analysis of the segment from helix 3 through helix 5 in vertebrate progesterone receptors","volume":"132","author":"Baker","year":"2012","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0155","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/bies.10252","article-title":"Evolution of adrenal and sex steroid action in vertebrates: a ligand-based mechanism for complexity","volume":"25","author":"Baker","year":"2003","journal-title":"Bioessays"},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0160","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbrc.2008.08.047","article-title":"Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: implications for estrogen receptor evolution","volume":"375","author":"Baker","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0165","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mce.2010.07.013","article-title":"Origin and diversification of steroids: co-evolution of enzymes and nuclear receptors","volume":"334","author":"Baker","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0170","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.steroids.2012.12.011","article-title":"What are the physiological estrogens?","volume":"78","author":"Baker","year":"2013","journal-title":"Steroids"},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0175","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nsmb939","article-title":"Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension","volume":"12","author":"Fagart","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0180","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/30775","article-title":"Atomic structure of progesterone complexed with its receptor","volume":"393","author":"Williams","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0185","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"Sali","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0190","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2148-7-24","article-title":"Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors","volume":"7","author":"Baker","year":"2007","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0195","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0200","doi-asserted-by":"crossref","first-page":"12971","DOI":"10.1074\/jbc.M110.205112","article-title":"Exploration of dimensions of estrogen potency: parsing ligand binding and coactivator binding affinities","volume":"286","author":"Jeyakumar","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0205","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1073\/pnas.091553298","article-title":"Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions","volume":"98","author":"Thornton","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0210","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00239-008-9074-8","article-title":"Genomic evidence for a simpler clotting scheme in jawless vertebrates","volume":"66","author":"Doolittle","year":"2008","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0215","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00427-008-0208-1","article-title":"The lamprey in evolutionary studies","volume":"218","author":"Osorio","year":"2008","journal-title":"Dev. Genes Evol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0220","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2307\/25470671","article-title":"Insights from a sea lamprey into the evolution of neural crest gene regulatory network","volume":"214","author":"Sauka-Spengler","year":"2008","journal-title":"Biol. Bull."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0225","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mce.2010.10.017","article-title":"Origin and evolution of the ligand-binding ability of nuclear receptors","volume":"334","author":"Markov","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0230","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mce.2010.06.017","article-title":"Nuclear hormone receptors in chordates","volume":"334","author":"Bertrand","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0235","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jsbmb.2013.07.009","article-title":"Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors","volume":"137","author":"Baker","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0240","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1021\/jm030640n","article-title":"Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes","volume":"47","author":"Madauss","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0245","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1210\/me.2009-0362","article-title":"Minireview: not picking pockets: nuclear receptor alternate-site modulators (NRAMs)","volume":"24","author":"Moore","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0250","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/cmdc.201000507","article-title":"Discovering small-molecule estrogen receptor alpha\/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency","volume":"6","author":"Sun","year":"2011","journal-title":"ChemMedChem"},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0255","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1016\/j.bmcl.2012.09.007","article-title":"3,3\u2032-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding","volume":"22","author":"Weiser","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jsbmb.2013.12.018_bib0260","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1021\/jm201438f","article-title":"True antiandrogens-selective non-ligand-binding pocket disruptors of androgen receptor-coactivator interactions: novel tools for prostate cancer","volume":"55","author":"Caboni","year":"2012","journal-title":"J. Med. Chem."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076013002914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076013002914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:41:48Z","timestamp":1760744508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076013002914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":52,"alternative-id":["S0960076013002914"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2013.12.018","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural and evolutionary analysis of the co-activator binding domain in vertebrate progesterone receptors","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2013.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}