{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T22:28:11Z","timestamp":1776464891372,"version":"3.51.2"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.jsbmb.2014.01.001","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T11:15:33Z","timestamp":1389611733000},"page":"26-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["DNA damage response (DDR) via NKX3.1 expression in prostate cells"],"prefix":"10.1016","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-6349","authenticated-orcid":false,"given":"Burcu","family":"Erbaykent-Tepedelen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selda","family":"Karamil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceren","family":"Gonen-Korkmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4040-2568","authenticated-orcid":false,"given":"Kemal S.","family":"Korkmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2014.01.001_bib0005","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-1119(00)00453-4","article-title":"Full-length cDNA sequence and genomic organization of human NKX3A \u2013 alternative forms and regulation by both androgens and estrogens","volume":"260","author":"Korkmaz","year":"2000","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.jsbmb.2014.01.001_bib0010","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/(SICI)1097-0045(19980401)35:1<71::AID-PROS10>3.0.CO;2-H","article-title":"Isolation and androgen regulation of the human homeobox cDNA, NKX3.1","volume":"35","author":"Prescott","year":"1998","journal-title":"Prostate"},{"issue":"8","key":"10.1016\/j.jsbmb.2014.01.001_bib0015","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1101\/gad.13.8.966","article-title":"Roles for Nkx3.1 in prostate development and cancer","volume":"13","author":"Bhatia-Gaur","year":"1999","journal-title":"Genes Dev."},{"issue":"21","key":"10.1016\/j.jsbmb.2014.01.001_bib0020","first-page":"6111","article-title":"Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression","volume":"60","author":"Bowen","year":"2000","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.jsbmb.2014.01.001_bib0025","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1158\/0008-5472.CAN-05-1550","article-title":"Germ-line mutation of NKX3.1 cosegregates with hereditary prostate cancer and alters the homeodomain structure and function","volume":"66","author":"Zheng","year":"2006","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.jsbmb.2014.01.001_bib0030","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ccr.2006.03.031","article-title":"NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss","volume":"9","author":"Lei","year":"2006","journal-title":"Cancer Cell"},{"issue":"8","key":"10.1016\/j.jsbmb.2014.01.001_bib0035","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1074\/jbc.M708630200","article-title":"Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1","volume":"283","author":"Guan","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jsbmb.2014.01.001_bib0040","doi-asserted-by":"crossref","first-page":"662","DOI":"10.4161\/cc.9.4.10764","article-title":"gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization","volume":"9","author":"Lobrich","year":"2010","journal-title":"Cell Cycle"},{"issue":"11","key":"10.1016\/j.jsbmb.2014.01.001_bib0045","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1093\/carcin\/bgm157","article-title":"H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase","volume":"28","author":"Hanasoge","year":"2007","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.jsbmb.2014.01.001_bib0050","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2307\/3579232","article-title":"Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to X rays in one normal and two hypersensitive human fibroblast cell lines","volume":"144","author":"Badie","year":"1995","journal-title":"Radiat. Res."},{"issue":"10","key":"10.1016\/j.jsbmb.2014.01.001_bib0055","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrc1977","article-title":"Topoisomerase I inhibitors: camptothecins and beyond","volume":"6","author":"Pommier","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.jsbmb.2014.01.001_bib0060","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/cr.2007.111","article-title":"Regulation of DNA double-strand break repair pathway choice","volume":"18","author":"Shrivastav","year":"2008","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.jsbmb.2014.01.001_bib0065","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ncb1599","article-title":"Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair","volume":"9","author":"Berkovich","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jsbmb.2014.01.001_bib0070","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1101\/sqb.2005.70.002","article-title":"The ATM-dependent DNA damage signaling pathway","volume":"70","author":"Kitagawa","year":"2005","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"issue":"6778","key":"10.1016\/j.jsbmb.2014.01.001_bib0075","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/35007091","article-title":"ATM phosphorylates p95\/nbs1 in an S-phase checkpoint pathway","volume":"404","author":"Lim","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jsbmb.2014.01.001_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-230X(08)60095-0","article-title":"p53 and ATM: cell cycle, cell death, and cancer","volume":"71","author":"Morgan","year":"1997","journal-title":"Adv. Cancer Res."},{"issue":"5","key":"10.1016\/j.jsbmb.2014.01.001_bib0085","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.ijrobp.2006.08.064","article-title":"Relationship between DNA double-strand break rejoining and cell survival after exposure to ionizing radiation in human fibroblast strains with differing ATM\/p53 status: implications for evaluation of clinical radiosensitivity","volume":"66","author":"Mirzayans","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"10","key":"10.1016\/j.jsbmb.2014.01.001_bib0090","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.4161\/cc.7.10.5963","article-title":"Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation","volume":"7","author":"Zhao","year":"2008","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.jsbmb.2014.01.001_bib0095","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/cr.2007.109","article-title":"The DNA damage response pathways: at the crossroad of protein modifications","volume":"18","author":"Huen","year":"2008","journal-title":"Cell Res."},{"issue":"58","key":"10.1016\/j.jsbmb.2014.01.001_bib0100","doi-asserted-by":"crossref","first-page":"8967","DOI":"10.1038\/sj.onc.1206136","article-title":"Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability","volume":"21","author":"Tauchi","year":"2002","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.jsbmb.2014.01.001_bib0105","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.celrep.2013.06.039","article-title":"Functional activation of ATM by the prostate cancer suppressor NKX3.1","volume":"4","author":"Bowen","year":"2013","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.jsbmb.2014.01.001_bib0110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1042\/BJ20130012","article-title":"Structural and functional interactions of the prostate cancer suppressor protein NKX3.1 with topoisomerase I","volume":"453","author":"Song","year":"2013","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.jsbmb.2014.01.001_bib0115","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbrc.2011.09.035","article-title":"NKX3.1 contributes to S phase entry and regulates DNA damage response (DDR) in prostate cancer cell lines","volume":"414","author":"Erbaykent-Tepedelen","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.jsbmb.2014.01.001_bib0120","doi-asserted-by":"crossref","first-page":"10827","DOI":"10.1074\/jbc.M413336200","article-title":"Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells","volume":"280","author":"Mayeur","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.jsbmb.2014.01.001_bib0125","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1158\/0008-5472.CAN-09-3138","article-title":"NKX3.1 activates cellular response to DNA damage","volume":"70","author":"Bowen","year":"2010","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.jsbmb.2014.01.001_bib0130","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/S0002-9440(10)63571-7","article-title":"NKX3.1 expression is lost in testicular germ cell tumors","volume":"163","author":"Skotheim","year":"2003","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.jsbmb.2014.01.001_bib0135","first-page":"31","article-title":"Combined effect of doxorubicin and dehydroepiandrosterone on proliferation and oxidative stress in Saccharomyces cerevisiae cells","volume":"73","author":"Saenko Iu","year":"2010","journal-title":"Eksp. Klin. Farmakol."},{"issue":"3","key":"10.1016\/j.jsbmb.2014.01.001_bib0140","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1083\/jcb.153.3.613","article-title":"Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways","volume":"153","author":"Rappold","year":"2001","journal-title":"J. Cell Biol."},{"issue":"22","key":"10.1016\/j.jsbmb.2014.01.001_bib0145","doi-asserted-by":"crossref","first-page":"20303","DOI":"10.1074\/jbc.M300198200","article-title":"Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes","volume":"278","author":"Furuta","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.jsbmb.2014.01.001_bib0150","doi-asserted-by":"crossref","first-page":"7144","DOI":"10.1158\/0008-5472.CAN-04-1433","article-title":"Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines","volume":"64","author":"Banath","year":"2004","journal-title":"Cancer Res."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096007601400003X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096007601400003X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:41:56Z","timestamp":1760744516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096007601400003X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":30,"alternative-id":["S096007601400003X"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2014.01.001","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA damage response (DDR) via NKX3.1 expression in prostate cells","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2014.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}