{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:44:05Z","timestamp":1791078245319,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.jsbmb.2014.07.011","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T09:45:17Z","timestamp":1406713517000},"page":"402-409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"PB","title":["The vitamin D system is deregulated in pancreatic diseases"],"prefix":"10.1016","volume":"144","author":[{"given":"Doris","family":"Hummel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Borka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Bajna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u00f6","family":"K\u00e1llay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Csaba","family":"Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2014.07.011_bib0005","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1056\/NEJMra0901557","article-title":"Pancreatic cancer","volume":"362","author":"Hidalgo","year":"2010","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0010","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1210\/er.2012-1000","article-title":"The nonskeletal effects of vitamin D: an endocrine society scientific statement","volume":"33","author":"Rosen","year":"2012","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0015","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/88.2.491S","article-title":"From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health","volume":"88","author":"Norman","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0020","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jsbmb.2005.06.004","article-title":"Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment","volume":"97","author":"Townsend","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.rdc.2012.03.004","article-title":"The vitamin D receptor: new paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D3","volume":"38","author":"Pike","year":"2012","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0030","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbapap.2010.06.022","article-title":"Cytochromes P450 are essential players in the vitamin D signaling system","volume":"1814","author":"Schuster","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2174\/187152013804487434","article-title":"Role of Calcium, vitamin D, and the extrarenal vitamin D hydroxylases during carcinogenesis","volume":"13","author":"H\u00f6baus","year":"2013","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0040","doi-asserted-by":"crossref","first-page":"30337","DOI":"10.1074\/jbc.M201804200","article-title":"Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D","volume":"277","author":"Canaff","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0045","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2337\/diabetes.49.3.409","article-title":"The extracellular calcium-sensing receptor on human beta-cells negatively modulates insulin secretion","volume":"49","author":"Squires","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev-nutr-080508-141248","article-title":"Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer","volume":"29","author":"McCullough","year":"2009","journal-title":"Ann. Rev. Nutr."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0055","doi-asserted-by":"crossref","first-page":"e66768","DOI":"10.1371\/journal.pone.0066768","article-title":"Genetic variants in vitamin d pathway genes and risk of pancreas cancer; results from a population-based case-control study in Ontario, Canada","volume":"8","author":"Anderson","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0060","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/MPA.0b013e3181ce654d","article-title":"Ultraviolet B irradiance and vitamin D status are inversely associated with incidence rates of pancreatic cancer worldwide","volume":"39","author":"Mohr","year":"2010","journal-title":"Pancreas"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0065","doi-asserted-by":"crossref","unstructured":"Skinner HG, Michaud DS, Giovannucci E, Willett WC, Colditz GA, Fuchs CS 2006 Vitamin D. intake and the risk for pancreatic cancer in two cohort studies. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 15:1688\u20131695.","DOI":"10.1158\/1055-9965.EPI-06-0206"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0070","first-page":"91","article-title":"Vitamin D calcium, and retinol intake, and pancreatic cancer in a population-based case-control study in the San Francisco Bay area","volume":"22","author":"Zablotska","year":"2011","journal-title":"Cancer Causes Control:CCC"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0075","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/aje\/kwq120","article-title":"Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: cohort consortium vitamin D pooling project of rarer cancers","volume":"172","author":"Stolzenberg-Solomon","year":"2010","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0080","doi-asserted-by":"crossref","first-page":"10213","DOI":"10.1158\/0008-5472.CAN-06-1876","article-title":"A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers","volume":"66","author":"Stolzenberg-Solomon","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0085","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1158\/0008-5472.CAN-08-2694","article-title":"Serum vitamin D and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian screening trial","volume":"69","author":"Stolzenberg-Solomon","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0090","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.3760\/cma.j.issn.0366-6999.20122850","article-title":"Vitamin D status and the risk of pancreatic cancer: a meta-analysis","volume":"126","author":"Liu","year":"2013","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0095","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1158\/1055-9965.EPI-11-0836","article-title":"Plasma 25-hydroxyvitamin D and risk of pancreatic cancer","volume":"21","author":"Wolpin","year":"2012","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0100","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1038\/sj.bjc.6605658","article-title":"Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies","volume":"102","author":"Bao","year":"2010","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/1479-5876-11-206","article-title":"Vitamin D deficiency and prognostics among patients with pancreatic adenocarcinoma","volume":"11","author":"Cho","year":"2013","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0110","series-title":"Pathology and Genetics of Tumours of the Digestive System","author":"WHO","year":"2000"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0115","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jsbmb.2012.09.003","article-title":"Prevention of preneoplastic lesions by dietary vitamin D in a mouse model of colorectal carcinogenesis","volume":"136","author":"Hummel","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mcp.2004.10.001","article-title":"Housekeeping gene variability in normal and cancerous colorectal, pancreatic, esophageal, gastric and hepatic tissues","volume":"19","author":"Rubie","year":"2005","journal-title":"Mol. Cell Probes"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0125","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1369\/jhc.2009.954339","article-title":"The candidate oncogene CYP24A1: a potential biomarker for colorectal tumorigenesis","volume":"58","author":"Horv\u00e1th","year":"2010","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2013.10.015","article-title":"Regulation of the calcium-sensing receptor expression by 1,25-dihydroxyvitamin D3, interleukin -6, and tumor necrosis factor alpha in colon cancer cells","author":"Fetahu","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0135","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/cyto.a.22258","article-title":"Automated recognition of tissue-associated erythrocytes (ARETE)-a new tool in tissue cytometry","volume":"83","author":"Heindl","year":"2013","journal-title":"Cytometry A"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0140","doi-asserted-by":"crossref","first-page":"e31507","DOI":"10.1371\/journal.pone.0031507","article-title":"DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0145","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/gut.51.5.705","article-title":"Extracellular calcium sensing receptor in human pancreatic cells","volume":"51","author":"R\u00e1cz","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0150","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrc2196","article-title":"Vitamin D signalling pathways in cancer: potential for anticancer therapeutics","volume":"7","author":"Deeb","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0155","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jcb.10423","article-title":"New insights into the mechanisms of vitamin D action","volume":"88","author":"Christakos","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0160","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1998.78.4.1193","article-title":"Current understanding of the molecular actions of vitamin D","volume":"78","author":"Jones","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0165","series-title":"Vitamin D","first-page":"167","article-title":"The vitamin D receptor","author":"Pike","year":"2005"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0170","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1158\/1078-0432.CCR-04-2359","article-title":"Autocrine metabolism of vitamin D in normal and malignant breast tissue","volume":"11","author":"Townsend","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0175","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1517\/14796694.1.3.415","article-title":"Nutritional regulation of extrarenal vitamin D hydroxylase expression - potential application in tumor prevention and therapy","volume":"1","author":"Cross","year":"2005","journal-title":"Future Oncol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0180","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jsbmb.2005.06.005","article-title":"The Vitamin D endocrine system of the gut\u2013its possible role in colorectal cancer prevention","volume":"97","author":"Cross","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0185","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/annonc\/mdh056","article-title":"Clinical significance of the overexpression of the candidate oncogene CYP24 in esophageal cancer","volume":"15","author":"Mimori","year":"2004","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0190","first-page":"1547","article-title":"K-ras mutations in pancreatic ductal proliferative lesions","volume":"145","author":"Klimstra","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0195","first-page":"1731","article-title":"Tumor-suppressive pathways in pancreatic carcinoma","volume":"57","author":"Rozenblum","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0200","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jsbmb.2012.09.022","article-title":"Differential response to 1\u03b1,25-dihydroxyvitamin D3 (1\u03b1,25(OH) 2D3) in non-small cell lung cancer cells with distinct oncogene mutations","volume":"136","author":"Zhang","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0205","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000069149","article-title":"Vitamin D receptor is expressed in pancreatic cancer cells and a vitamin D3 analogue decreases cell number","volume":"3","author":"Albrechtsson","year":"2003","journal-title":"Pancreatology"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0210","first-page":"310872","article-title":"MART-10, a new generation of vitamin D analog, is more potent than 1\u03b1,25-dihydroxyvitamin D(3) in inhibiting cell proliferation and inducing apoptosis in ER+ MCF-7 breast cancer cells","author":"Chiang","year":"2012","journal-title":"Evid Based Complement. Alternat. Med."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0215","doi-asserted-by":"crossref","first-page":"430","DOI":"10.4161\/cbt.7.3.5418","article-title":"19-nor-1 alpha,25-dihydroxyvitamin D2 (paricalcitol) inhibits the proliferation of human pancreatic cancer cells in vitro and in vivo","volume":"7","author":"Schwartz","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0220","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.3892\/ol.2013.1215","article-title":"Association of vitamin D receptor gene polymorphisms with pancreatic cancer: a pilot study in a North China population","volume":"5","author":"Li","year":"2013","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0225","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1096\/fj.02-0424fje","article-title":"Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor","volume":"17","author":"Zeitz","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0230","first-page":"148673","article-title":"The role of vitamin d deficiency in the incidence, progression, and complications of type 1 diabetes mellitus","author":"Chakhtoura","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0235","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0240","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jsbmb.2012.08.012","article-title":"Investigation of the vitamin D receptor gene (VDR) and its interaction with protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) on risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY)","volume":"133","author":"Frederiksen","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0245","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1210\/en.2013-1409","article-title":"Discovery of molecular pathways mediating 1,25-dihydroxyvitamin D3 protection against cytokine-induced inflammation and damage of human and male mouse islets of Langerhans","volume":"155","author":"Wolden-Kirk","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0250","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0960-0760(03)00072-4","article-title":"Transcriptional inhibition of the human insulin receptor gene by aldosterone","volume":"84","author":"Calle","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0255","first-page":"351385","article-title":"Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis","author":"Alvarez","year":"2010","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0260","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1001\/jama.294.22.2872","article-title":"Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers","volume":"294","author":"Stolzenberg-Solomon","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0265","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1007\/s11605-010-1349-x","article-title":"Insulin, leptin, and tumoral adipocytes promote murine pancreatic cancer growth","volume":"14","author":"White","year":"2010","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.jsbmb.2014.07.011_bib0270","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0039-128X(97)00041-X","article-title":"Low extracellular calcium enhances beta cell sensitivity to the stimulatory influence of 1,25-dihydroxyvitamin D3 on insulin release by islets from vitamin D3-deficient rats","volume":"62","author":"Faure-Dussert","year":"1997","journal-title":"Steroids"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076014001356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076014001356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:45:19Z","timestamp":1760744719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076014001356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":54,"alternative-id":["S0960076014001356"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2014.07.011","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The vitamin D system is deregulated in pancreatic diseases","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2014.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}