{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:45:25Z","timestamp":1791978325922,"version":"4.4.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.jsbmb.2014.08.012","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T23:52:45Z","timestamp":1408751565000},"page":"410-416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"PB","title":["Voltage-gated calcium channels in the human adrenal and primary aldosteronism"],"prefix":"10.1016","volume":"144","author":[{"given":"Saulo J.A.","family":"Felizola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitoshi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikiyo","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumi","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuka","family":"Aritomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Tojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2014.08.012_bib0005","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1210\/en.2012-1339","article-title":"Minireview: aldosterone biosynthesis: electrically gated for our protection","volume":"153","author":"Guagliardo","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10741-005-2343-3","article-title":"Aldosterone biosynthesis, regulation, and classical mechanism of action","volume":"10","author":"Williams","year":"2005","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0015","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/01.HYP.0000201443.63240.a7","article-title":"Effects of aldosterone on the vasculature","volume":"47","author":"Schiffrin","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0020","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1198785","article-title":"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension","volume":"331","author":"Choi","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0025","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/hr.2010.191","article-title":"Expression of N-type calcium channels in human adrenocortical cells and their contribution to corticosteroid synthesis","volume":"34","author":"Aritomi","year":"2011","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0030","doi-asserted-by":"crossref","first-page":"568","DOI":"10.5551\/jat.1628","article-title":"Protective effects of efonidipine, a T- and L-type calcium channel blocker, on renal function and arterial stiffness in type 2 diabetic patients with hypertension and nephropathy","volume":"16","author":"Sasaki","year":"2009","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0035","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1291\/hypres.30.691","article-title":"Comparison of the effects of efonidipine and amlodipine on aldosterone in patients with hypertension","volume":"30","author":"Tanaka","year":"2007","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0040","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0022-3565(24)37868-1","article-title":"Inhibitory action of mibefradil on calcium signaling and aldosterone synthesis in bovine adrenal glomerulosa cells","volume":"287","author":"Rossier","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0045","article-title":"Metallothionein-3 (MT-3) in the human adrenal cortex and its disorders","author":"Felizola","year":"2013","journal-title":"Endocr. Pathol."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0050","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1530\/JME-13-0248","article-title":"PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues","volume":"52","author":"Felizola","year":"2014","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0055","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.mce.2013.09.025","article-title":"Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway","volume":"382","author":"Felizola","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0060","first-page":"716","article-title":"Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies","volume":"109","author":"McCarty","year":"1985","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0065","first-page":"5419","article-title":"Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody","volume":"46","author":"Budwit-Novotny","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0070","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ejphar.2008.02.001","article-title":"Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyearsidine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R","volume":"28","author":"Akizuki","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0075","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00380-011-0191-8","article-title":"L\/N-type calcium channel blocker suppresses reflex aldosterone production induced by antihypertensive action","volume":"27","author":"Aritomi","year":"2012","journal-title":"Heart Vessels"},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0080","first-page":"F706","article-title":"Ca2+ channels and aldosterone secretion: modulation by K+ and atrial natriuretic peptide","volume":"261","author":"Barrett","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0085","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1073\/pnas.85.7.2412","article-title":"Ca channels in adrenal glomerulosa cells: K+ and angiotensin II increase T-type Ca channel current","volume":"85","author":"Cohen","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0090","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0303-7207(01)00384-7","article-title":"Role of membrane depolarization and T-type Ca2+2+ channels in angiotensin II and K++ stimulated aldosterone secretion","volume":"175","author":"Lotshaw","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0095","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev.ph.58.030196.001553","article-title":"Low-threshold calcium currents in central nervous system neurons","volume":"58","author":"Huguenard","year":"1996","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0100","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pbiomolbio.2005.05.003","article-title":"Voltage-dependent calcium channels and cardiac pacemaker activity: from ionic currents to genes","volume":"90","author":"Mangoni","year":"2006","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0105","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1172\/JCI61996","article-title":"Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators","volume":"122","author":"Hu","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0110","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1055\/s-2007-978911","article-title":"Neuroendocrine properties of adrenocortical cells","volume":"30","author":"Ehrhart-Bornstein","year":"1998","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0115","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.3748\/wjg.14.4984","article-title":"Calcium signaling and T-type calcium channels in cancer cell cycling","volume":"14","author":"Taylor","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0120","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/HYPERTENSIONAHA.111.186239","article-title":"Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas","volume":"59","author":"Azizan","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0125","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/HYPERTENSIONAHA.114.03419","article-title":"Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma","volume":"64","author":"Fernandes-Rosa","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0130","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1097\/HJH.0000000000000186","article-title":"KCNJ5 gene somatic mutations affect cardiac remodelling but do not preclude cure of high blood pressure and regression of left ventricular hypertrophy in primary aldosteronism","volume":"32","author":"Rossi","year":"2014","journal-title":"J. Hypertens."},{"key":"10.1016\/j.jsbmb.2014.08.012_bib0135","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1210\/jc.2011-2885","article-title":"Expression and mutations of KCNJ5 mRNA in Japanese patients with aldosterone-producing adenomas","volume":"97","author":"Taguchi","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076014001915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076014001915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:45:13Z","timestamp":1760744713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076014001915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":27,"alternative-id":["S0960076014001915"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2014.08.012","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Voltage-gated calcium channels in the human adrenal and primary aldosteronism","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2014.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}