{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:02:59Z","timestamp":1760781779810,"version":"build-2065373602"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.jsbmb.2014.09.022","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T18:10:28Z","timestamp":1411755028000},"page":"21-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis"],"prefix":"10.1016","volume":"145","author":[{"given":"Grzegorz","family":"Wicher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Norlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2014.09.022_bib0005","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.neuroscience.2005.10.066","article-title":"Neuroactive steroids: old players in a new game","volume":"138","author":"Melcangi","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.mam.2009.02.001","article-title":"Oxysterols and neurodegenerative diseases","volume":"30","author":"Bj\u00f6rkhem","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0015","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000097747","article-title":"Local neurosteroid production in the hippocampus: influence on synaptic plasticity of memory","volume":"84","author":"Mukai","year":"2006","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0020","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.pneurobio.2009.07.001","article-title":"Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance","volume":"89","author":"Zheng","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0025","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1073\/pnas.94.10.4925","article-title":"Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7\u03b1-hydroxy dehydroepiandrosterone and 7\u03b1-hydroxy pregnenolone","volume":"94","author":"Rose","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.yfrne.2008.11.002","article-title":"Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)","volume":"30","author":"Maninger","year":"2009","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0035","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mce.2008.04.016","article-title":"Estradiol regulation of progesterone synthesis in the brain","volume":"290","author":"Micevych","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0040","article-title":"Dehydroepiandrosterone: a neuroactive steroid","author":"Starka","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0045","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1073\/pnas.0700899104","article-title":"Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig","volume":"104","author":"Radhakrishnan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0050","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.mam.2009.02.006","article-title":"Cytotoxic effects of oxysterols associated with human diseases: induction of cell death (apoptosis and\/or oncosis), oxidative and inflammatory activities, and phospholipidosis","volume":"30","author":"Vejux","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0055","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neulet.2012.07.057","article-title":"Effects of oxysterols on staurosporine-induced cell death in neuroblastoma SH-SY5Y cells","volume":"525","author":"Emanuelsson","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0060","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jsbmb.2007.04.004","article-title":"Selective conversion by microglia of dehydroepiandrosterone to 5-androstenediol \u2013 a steroid with inherent estrogenic properties","volume":"107","author":"Jellinck","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0065","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.bbalip.2010.04.009","article-title":"1\u03b1,25-Dihydroxyvitamin D3 affects hormone production and expression of steroidogenic enzymes in human adrenocortical NCI-H295R cells","volume":"1801","author":"Lundqvist","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0070","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.bbalip.2012.03.007","article-title":"Effects of CYP7B1-related steroids on androgen receptor activation in different cell lines","volume":"1821","author":"Lundqvist","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0075","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1210\/endo.140.8.6907","article-title":"Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain","volume":"140","author":"Zwain","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0080","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/j.biocel.2004.02.023","article-title":"Glial cells","volume":"36","author":"Jessen","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0085","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.brainresrev.2004.12.021","article-title":"Peripheral nerves: a target for the action of neuroactive steroids","volume":"48","author":"Melcangi","year":"2005","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0090","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.neuint.2011.01.024","article-title":"Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism","volume":"58","author":"Fex Svenningsen","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0095","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0074-7742(01)46059-4","article-title":"Neurosteroid 7-hydroxylation products in the brain","volume":"46","author":"Morfin","year":"2001","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0100","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/pros.20630","article-title":"Regulation and expression of human CYP7B1 in prostate: overexpression of CYP7B1 during progression of prostatic adenocarcinoma","volume":"67","author":"Olsson","year":"2007","journal-title":"Prostate"},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0105","first-page":"1206","article-title":"CYP7B1-mediated metabolism of 5\u03b1-androstane-3\u03b1,17\u03b2-diol (3\u03b1-a novel): pathway for potential regulation of the cellular levels of androgens and neurosteroidsBiochim","volume":"1791","author":"Pettersson","year":"2009","journal-title":"Biophys. Acta"},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0110","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ajhg.2007.10.001","article-title":"Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration","volume":"82","author":"Tsaousidou","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0115","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1083\/jcb.85.3.890","article-title":"Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue","volume":"85","author":"McCarthy","year":"1980","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nprot.2006.486","article-title":"Human and rat adult Schwann cell cultures: fast and efficient enrichment and highly effective non-viral transfection protocol","volume":"2","author":"Haastert","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0125","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1083\/jcb.112.3.457","article-title":"The effects of cAMP on differentiation of cultured Schwann cells: progression from an early phenotype (04+) to a myelin phenotype (P0+, GFAP-, N-CAM-, NGF-receptor-) depends on growth inhibition","volume":"112","author":"Morgan","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0130","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0006-8993(79)90048-9","article-title":"Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve","volume":"165","author":"Brockes","year":"1979","journal-title":"Brain Res."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0165-0270(97)00146-5","article-title":"Cold jet: a method to obtain pure Schwann cell cultures without the need for cytotoxic apoptosis-inducing drug treatment","volume":"78","author":"Jirsova","year":"1997","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0140","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0005-2760(97)00193-8","article-title":"Biochemical characterization of the 7\u03b1-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes","volume":"1390","author":"Norlin","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0145","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1111\/j.1742-4658.2008.06336.x","article-title":"CYP7B1-mediated metabolism of dehydroepiandrosterone and 5\u03b1-androstane-3\u03b2,17\u03b2-diol \u2013 potential role(s) for estrogen signaling","volume":"275","author":"Pettersson","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0150","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0155","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11010-008-9745-1","article-title":"Regulatory role of cytochrome P450scc and pregnenolone in myelination by rat Schwann cells","volume":"313","author":"Zhu","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0160","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1196\/annals.1366.003","article-title":"Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging","volume":"1088","author":"Charalampopoulos","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0165","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neuroscience.2011.06.076","article-title":"Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence","volume":"191","author":"Marx","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0170","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1083\/jcb.121.1.135","article-title":"Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density","volume":"121","author":"Akwa","year":"1993","journal-title":"J. Cell Biol."},{"issue":"Pt 1","key":"10.1016\/j.jsbmb.2014.09.022_bib0175","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/bj3220175","article-title":"Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons","volume":"322","author":"Zhang","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0180","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.exger.2006.06.032","article-title":"Role of astrocytes in estrogen-mediated neuroprotection","volume":"42","author":"Dhandapani","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0185","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000289568","article-title":"Estrogen actions on neuroendocrine glia","volume":"91","author":"Micevych","year":"2010","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0190","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/j.1471-4159.2010.06770.x","article-title":"17\u03b2-Estradiol protects Schwann cells against H2O2-induced cytotoxicity and increases transplanted Schwann cell survival in a cervical hemicontusion spinal cord injury model","volume":"115","author":"Siriphorn","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0195","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.brainresrev.2004.12.018","article-title":"Glia\u2013neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones","volume":"48","author":"Garcia-Ovejero","year":"2005","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.jsbmb.2014.09.022_bib0200","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0960-0760(01)00108-X","article-title":"7-Hydroxydehydroepiandrosterone epimers in the life span","volume":"78","author":"Hampl","year":"2001","journal-title":"J. Steroid Biochem. Mol. Biol."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076014002210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076014002210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:45:04Z","timestamp":1760744704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076014002210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":40,"alternative-id":["S0960076014002210"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2014.09.022","relation":{},"ISSN":["0960-0760"],"issn-type":[{"type":"print","value":"0960-0760"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2014.09.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}