{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:52:29Z","timestamp":1761519149219,"version":"build-2065373602"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jsbmb.2015.08.013","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T11:25:21Z","timestamp":1439983521000},"page":"151-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Reprint of \u201cUse of medroxyprogesterone acetate for hormone therapy in postmenopausal women: Is it safe?\u201d"],"prefix":"10.1016","volume":"153","author":[{"given":"Frank Z.","family":"Stanczyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhagu R.","family":"Bhavnani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"volume":"Vol. 2","year":"1983","author":"Campio","key":"10.1016\/j.jsbmb.2015.08.013_bib0005"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0010","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial","volume":"288","author":"Rossouw","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0015","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1001\/jama.291.14.1701","article-title":"Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial","volume":"291","author":"Anderson","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/humupd\/dmi046","article-title":"New progestagens for contraceptive use","volume":"12","author":"Sitruk-Ware","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0025","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1124\/dmd.108.022525","article-title":"Metabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetate","volume":"36","author":"Zhang","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0030","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1210\/jc.2005-0352","article-title":"Effects of oral and transdermal estradiol administration on levels of sex hormone-binding globulin in postmenopausal women with and without a history of intrahepatic cholestasis of pregnancy","volume":"90","author":"Ropponen","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0035","first-page":"373","article-title":"Radioimmunoassay of serum progesterone acetate (Provera\u00ae in women following oral and intravaginal administration","volume":"26","author":"Hiroi","year":"1975","journal-title":"Contraception"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0040","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0378-5122(94)90129-5","article-title":"Plasma concentrations of medroxyprogesterone acetate, estradiol and estrone following oral administration of Klimaxil, Trisequence\/Provera and Divina. A randomized, single-blind, triple cross-over bioavailability study in menopausal women","volume":"18","author":"Svensson","year":"1994","journal-title":"Maturitas"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0045","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0010-7824(76)90099-8","article-title":"Pharmacokinetic observations on medroxyprogesterone acetate administered orally and vaginally","volume":"14","author":"Victor","year":"1976","journal-title":"Contraception"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0050","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.maturitas.2003.01.001","article-title":"Pharmacokinetics of estradiol valerate and medroxyprogesterone acetate in different age groups of postmenopausal women","volume":"47","author":"J\u00e4rvinen","year":"2004","journal-title":"Maturitas"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0055","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1096\/fj.06-7518com","article-title":"Disruption of androgen receptor signaling by synthetic progestins may increase risk of developing breast cancer","volume":"21","author":"Birrell","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0060","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1258\/mi.2008.008015","article-title":"Testosterone and the breast","volume":"14","author":"Shufelt","year":"2008","journal-title":"Menopause Int."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.acthis.2005.01.002","article-title":"Relationship between the expression of various markers and prognostic factors in breast cancer","volume":"107","author":"Anim","year":"2005","journal-title":"Acta Histochem."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0070","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1200\/JCO.1995.13.7.1572","article-title":"Medroxyprogesterone acetate therapy in advanced breast cancer: the predictive value of androgen receptor expression","volume":"13","author":"Birrell","year":"1995","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0075","first-page":"2557","article-title":"Estrogen, androgen, glucocorticoid, and progesterone receptors in progestin-induced regression of human breast cancer","volume":"40","author":"Teulings","year":"1980","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0080","doi-asserted-by":"crossref","first-page":"8487","DOI":"10.1158\/0008-5472.CAN-04-3077","article-title":"Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetate","volume":"65","author":"Buchanan","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0303-7207(99)00109-4","article-title":"Androgen receptor agonist activity of the synthetic progestin, medroxyprogesterone acetate in human breast cancer cells","volume":"154","author":"Bentel","year":"1999","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0090","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1210\/mend.13.3.0255","article-title":"Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone","volume":"13","author":"Kemppainen","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0002-9378(97)80024-5","article-title":"Proliferation of breast epithelial cells in healthy women during the menstrual cycle","volume":"176","author":"S\u00f6derqvist","year":"1997","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0100","doi-asserted-by":"crossref","first-page":"R1036","DOI":"10.1186\/bcr1340","article-title":"The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cells","volume":"7","author":"Ghatge","year":"2005","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0105","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10549-008-0003-8","article-title":"Transcriptional profiles of progestogen effects in the postmenopausal breast","volume":"114","author":"Wood","year":"2009","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10549-006-9276-y","article-title":"Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys","volume":"101","author":"Wood","year":"2007","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0115","first-page":"4559","article-title":"Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breast","volume":"84","author":"Hofseth","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0120","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.fertnstert.2010.09.062","article-title":"Effects of percutaneous estradiol-oral progesterone versus oral conjugated equine estrogens\u2013medroxyprogesterone acetate on breast cell proliferation and bcl-2 protein in healthy women","volume":"95","author":"Murkes","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0125","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/GME.0b013e31828ebfb6","article-title":"Effect of hormone therapy on breast epithelial cell proliferation","volume":"20","author":"Stanczyk","year":"2013","journal-title":"Menopause"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0130","series-title":"Clinical Gynecologic Endocrinology and Infertility","first-page":"736","author":"Speroff","year":"2005"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0135","doi-asserted-by":"crossref","first-page":"262","DOI":"10.7326\/0003-4819-130-4_Part_1-199902160-00003","article-title":"Effects of estrogen and estrogen\u2013progestin on mammographic parenchymal density. Postmenopausal Estrogen\/Progestin Interventions (PEPI) Investigators","volume":"130","author":"Greendale","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0140","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/humupd\/dmi028","article-title":"Breast cancer risk with postmenopausal hormone treatment","volume":"11","author":"Collins","year":"2005","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0145","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0140-6736(03)14596-5","article-title":"Breast cancer and hormone-replacement therapy in the Million Women Study","volume":"362","author":"Beral","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10549-007-9523-x","article-title":"Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study","volume":"107","author":"Fournier","year":"2008","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0155","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1472-6874-6-13","article-title":"Breast cancer risk associated with different HRT formulations: a register-based case\u2013control study","volume":"6","author":"Dinger","year":"2006","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0160","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1001\/jama.289.24.3243","article-title":"Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial","volume":"289","author":"Chlebowski","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0165","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/jama.288.1.49","article-title":"Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen\/progestin Replacement Study follow-up (HERS II)","volume":"288","author":"Grady","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0170","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1001\/jama.297.13.1465","article-title":"Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause","volume":"297","author":"Rossouw","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0175","doi-asserted-by":"crossref","first-page":"211","DOI":"10.7326\/0003-4819-152-4-201002160-00005","article-title":"Coronary heart disease in postmenopausal recipients of estrogen plus progestin therapy: does the increased risk ever disappear? A randomized trial","volume":"152","author":"Toh","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0180","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1001\/archinte.168.20.2245","article-title":"Inflammatory, lipid, thrombotic, and genetic markers of coronary heart disease risk in the women's health initiative trials of hormone therapy","volume":"168","author":"Rossouw","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0185","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/gme.0b013e31826f80e0","article-title":"Coronary heart disease events in the Women's Health Initiative hormone trials: effect modification by metabolic syndrome: a nested case-control study within the Women's Health Initiative randomized clinical trials","volume":"20","author":"Wild","year":"2013","journal-title":"Menopause"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0190","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1001\/jama.1995.03520270033028","article-title":"Effects of estrogen or estrogen\/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen\/Progestin Interventions (PEPI) Trial","volume":"273","author":"The Writing Group for the PEPI Trial","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0195","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S0015-0282(01)01699-5","article-title":"Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: analysis of studies published from 1974\u20132000","volume":"75","author":"Godsland","year":"2001","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0200","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1592\/phco.30.5.442","article-title":"Cardiovascular and metabolic effects of medroxyprogesterone acetate versus conjugated equine estrogen after premenopausal hysterectomy with bilateral ovariectomy","volume":"30","author":"Kalyan","year":"2010","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0205","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0301-2115(97)00182-6","article-title":"The effect of progestagens on the carotid artery pulsatility index in postmenopausal women on oestrogen replacement therapy","volume":"76","author":"Luckas","year":"1998","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0210","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/0735-1097(94)90184-8","article-title":"Effects of hormone replacement therapy on reactivity of atherosclerotic coronary arteries in cynomolgus monkeys","volume":"24","author":"Williams","year":"1994","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0215","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1210\/jc.2004-1557","article-title":"Medroxyprogesterone acetate and dihydrotestosterone induce coronary hyperreactivity in intact male rhesus monkeys","volume":"90","author":"Mishra","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0220","first-page":"H2645","article-title":"Ca2+ release mechanism of primate drug-induced coronary vasospasm","volume":"272","author":"Miyagawa","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0225","first-page":"649","article-title":"Ovarian steroid protection against coronary artery hyperreactivity in rhesus monkeys","volume":"83","author":"Minshall","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0230","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0039-128X(03)00123-5","article-title":"MPA and postmenopausal coronary artery atherosclerosis revisited","volume":"68","author":"Clarkson","year":"2003","journal-title":"Steroids"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0235","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1447-0756.2010.01441.x","article-title":"Effect of conjugated estrogen versus conjugated estrogen associated with medroxyprogesterone acetate in postmenopausal women on internal carotid artery pulsatility index: a randomized pilot study","volume":"37","author":"Wender","year":"2011","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0240","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/13697130902929567","article-title":"The effects of hormone replacement therapy on myocardial performance in early postmenopausal women","volume":"13","author":"Duzenli","year":"2010","journal-title":"Climacteric"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0245","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1136\/bmj.39555.441944.BE","article-title":"Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: systematic review and meta-analysis","volume":"336","author":"Canonico","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0250","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/CIRCULATIONAHA.106.642280","article-title":"Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study","volume":"115","author":"Canonico","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0255","doi-asserted-by":"crossref","DOI":"10.1111\/j.1538-7836.2012.04919.x","article-title":"Venous thromboembolism risk in relation to use of different types of postmenopausal hormone therapy in a large prospective study","author":"Sweetland","year":"2012","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0260","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/bmj.39266.425069.AD","article-title":"Main morbidities recorded in the women's international study of long duration oestrogen after menopause (WISDOM): a randomised controlled trial of hormone replacement therapy in postmenopausal women","volume":"335","author":"Vickers","year":"2007","journal-title":"BMJ"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0265","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.maturitas.2011.10.002","article-title":"Progestogens and venous thromboembolism among postmenopausal women using hormone therapy","volume":"70","author":"Canonico","year":"2011","journal-title":"Maturitas"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0270","series-title":"Treatment of the Postmenopausal Woman, Basic and Clinical Aspects","first-page":"491","article-title":"Risk of pulmonary embolism\/venous thrombosis","author":"Westhoff","year":"2007"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0275","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.annemergmed.2006.07.932","article-title":"ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury","volume":"49","author":"Wright","year":"2007","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0280","doi-asserted-by":"crossref","first-page":"R61","DOI":"10.1186\/cc6887","article-title":"Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial","volume":"12","author":"Xiao","year":"2008","journal-title":"Crit. Care"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0285","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/02699050701867399","article-title":"Effects of medroxyprogesterone acetate on cerebral oedema and spatial learning performance after traumatic brain injury in rats","volume":"22","author":"Wright","year":"2008","journal-title":"Brain Inj."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0290","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1210\/endo.143.1.8582","article-title":"Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate","volume":"143","author":"Nilsen","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0295","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.1073\/pnas.1334098100","article-title":"Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling","volume":"100","author":"Nilsen","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0300","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/09513590600863337","article-title":"Medroxyprogesterone acetate exacerbates glutamate excitotoxicity","volume":"22","author":"Nilsen","year":"2006","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0305","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/neu.20293","article-title":"Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective","volume":"66","author":"Ciriza","year":"2006","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0310","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1159\/000095400","article-title":"medroxyprogesterone acetate effects on central and peripheral allopregnanolone and beta-endorphin levels","volume":"83","author":"Bernardi","year":"2006","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0315","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1210\/en.2008-1247","article-title":"The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression","volume":"150","author":"Jodhka","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0320","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1210\/en.2010-1061","article-title":"Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function","volume":"152","author":"Irwin","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0325","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1210\/en.2007-1227","article-title":"Progesterone and estrogen regulate oxidative metabolism in brain mitochondria","volume":"149","author":"Irwin","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0330","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1001\/jama.289.20.2651","article-title":"Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial","volume":"289","author":"Shumaker","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0335","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1001\/jama.289.20.2663","article-title":"Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial","volume":"289","author":"Rapp","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0340","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1212\/01.wnl.0000339037.76336.cf","article-title":"Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study","volume":"72","author":"Resnick","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.jsbmb.2015.08.013_bib0345","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/humupd\/dmp022","article-title":"Hormone therapy and cognitive function","volume":"15","author":"Maki","year":"2009","journal-title":"Hum. Reprod. Update"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076015001612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076015001612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:48:49Z","timestamp":1760744929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076015001612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":69,"alternative-id":["S0960076015001612"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2015.08.013","relation":{},"ISSN":["0960-0760"],"issn-type":[{"type":"print","value":"0960-0760"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reprint of \u201cUse of medroxyprogesterone acetate for hormone therapy in postmenopausal women: Is it safe?\u201d","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2015.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2013.11.011","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}