{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:39:54Z","timestamp":1781188794291,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.jsbmb.2016.02.010","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T04:33:00Z","timestamp":1455165180000},"page":"31-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Steroidogenic pathways involved in androgen biosynthesis in eumenorrheic women and patients with polycystic ovary syndrome"],"prefix":"10.1016","volume":"158","author":[{"given":"Kazuki","family":"Saito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Iwasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Miyado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonobu","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisuke","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimichi","family":"Miyashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Irahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Fukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 4","key":"10.1016\/j.jsbmb.2016.02.010_bib0005","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0015-0282(02)02985-0","article-title":"Androgen production in women","volume":"77","author":"Burger","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0010","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/er.2010-0013","article-title":"The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders","volume":"32","author":"Miller","year":"2011","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0015","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1210\/jc.2010-2200","article-title":"Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome","volume":"96","author":"Rosencrantz","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0020","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/jog.12524","article-title":"Comparison of steroidogenic pathways among normoandrogenic and hyperandrogenic polycystic ovary syndrome patients and normal cycling women","volume":"41","author":"Medeiros","year":"2015","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0025","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/dvdy.23892","article-title":"Backdoor pathway biosynthesis: implications for normal and abnormal human sex development","volume":"242","author":"Fukami","year":"2013","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0030","first-page":"19","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","author":"The Rotterdam ESHRE\/ASRM-sponsored PCOS consensus workshop group","year":"2004","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"The Rotterdam ESHRE\/ASRM-sponsored PCOS consensus workshop group","year":"2004","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0040","series-title":"Williams Textbook of Endocrinology","first-page":"581","article-title":"Physiology and pathology of the female reproductive axis","author":"Bulun","year":"2011"},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0045","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1056\/NEJM199207163270304","article-title":"Detection of functional ovarian hyperandrogenism in women with androgen excess","volume":"327","author":"Ehrmann","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0050","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1210\/jcem.86.12.8088","article-title":"The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome","volume":"86","author":"Nelson","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0055","doi-asserted-by":"crossref","first-page":"e93805","DOI":"10.1371\/journal.pone.0093805","article-title":"Simultaneous measurement of thirteen steroid hormones in women with polycystic ovary syndrome and control women using liquid chromatography-tandem mass spectrometry","volume":"9","author":"Keefe","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0060","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1365-2265.2005.02256.x","article-title":"Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS)","volume":"62","author":"Kumar","year":"2005","journal-title":"Clin. Endoctinol. (Oxf)"},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0065","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jsbmb.2014.06.003","article-title":"DHEA: DHEAS and PCOS","volume":"145","author":"Goodarzi","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0070","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0015-0282(16)53510-9","article-title":"Dysregulation of cytochrome P450c 17 alpha as the cause of polycystic ovarian syndrome","volume":"53","author":"Rosenfield","year":"1990","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0075","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1210\/jc.2005-2460","article-title":"Urine steroid hormone profile analysis in cytochrome P450 oxidoreductase deficiency: implication for the backdoor pathway to dihydrotestosterone","volume":"91","author":"Homma","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0080","doi-asserted-by":"crossref","first-page":"E367","DOI":"10.1210\/jc.2011-1997","article-title":"Increased activation of the alternative backdoor pathway in patients with 21-hydroxylase deficiency: evidence from urinary steroid hormone analysis","volume":"97","author":"Kamrath","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0085","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1210\/jc.2002-021875","article-title":"Beyond adrenal and ovarian androgen generation: increased peripheral 5\u03b1-reductase activity in women with polycystic ovary syndrome","volume":"88","author":"Fassnacht","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0090","first-page":"1111","article-title":"Evidence for increased androsterone metabolism in some normoandrogenic women with acne","volume":"76","author":"Carmina","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0095","doi-asserted-by":"crossref","first-page":"6154","DOI":"10.1016\/S0021-9258(19)43521-7","article-title":"Steroid structure and androgenic activity","volume":"248","author":"Liao","year":"1973","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0100","doi-asserted-by":"crossref","first-page":"13728","DOI":"10.1073\/pnas.1107898108","article-title":"Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer","volume":"108","author":"Chang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0105","doi-asserted-by":"crossref","first-page":"602","DOI":"10.7150\/ijbs.8844","article-title":"Beyond T and DHT\u2014novel steroid derivatives capable of wild type androgen receptor activation","volume":"10","author":"Mostaghel","year":"2014","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0110","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.fertnstert.2009.06.025","article-title":"The phenotype of hirsute women: a comparison of polycystic ovary syndrome and 21-hydroxylase-deficient nonclassic adrenal hyperplasia","volume":"9","author":"Pall","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0115","first-page":"1318","article-title":"Luteinizing hormone receptor steroidogenesis acute regulatory protein, and steroidogenic enzyme messenger ribonucleic acids are overexpressed in thecal and granulosa cells from polycystic ovaries","volume":"86","author":"Jakimiuk","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0120","first-page":"2414","article-title":"5a-reductase activity in women with polycystic ovary syndrome","volume":"84","author":"Jakimiuk","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0125","doi-asserted-by":"crossref","first-page":"26380","DOI":"10.1074\/jbc.M300688200","article-title":"The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis","volume":"278","author":"Wood","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.jsbmb.2016.02.010_bib0130","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/S0140-6736(15)60331-2","article-title":"Effect of insulin on AKR1C3 expression in female adipose tissue: in-vivo and in-vitro study of adipose androgen generation in polycystic ovary syndrome","volume":"385","author":"O\u2019Reilly","year":"2015","journal-title":"Lancet."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0135","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1093\/humrep\/17.9.2219","article-title":"What is polycystic ovary syndrome? Are national views important?","volume":"17","author":"Balen","year":"2002","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0140","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1210\/jcem-66-1-131","article-title":"The impact of obesity and chronic hyperinsulinemia on gonadotropin release and gonadal steroid secretion in the polycystic ovary syndrome","volume":"66","author":"Dunaif","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2016.02.010_bib0145","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1210\/jc.2014-2569","article-title":"Adrenal androgen excess and body mass index in polycystic ovary syndrome","volume":"100","author":"Moran","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076016300218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076016300218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:50:27Z","timestamp":1760745027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076016300218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":29,"alternative-id":["S0960076016300218"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2016.02.010","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Steroidogenic pathways involved in androgen biosynthesis in eumenorrheic women and patients with polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2016.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}