{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:05:29Z","timestamp":1789437929950,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.jsbmb.2016.05.023","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T07:59:31Z","timestamp":1465631971000},"page":"222-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Merlin, the product of NF2 gene, is associated with aromatase expression and estrogen formation in human liver tissues and liver cancer cells"],"prefix":"10.1016","volume":"172","author":[{"given":"Letizia","family":"Cocciadiferro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitale","family":"Miceli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orazia M.","family":"Granata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Carruba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jsbmb.2016.05.023_bib0005","first-page":"826","article-title":"A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor","volume":"75","author":"Trofatter","year":"1993","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jsbmb.2016.05.023_bib0010","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tcb.2009.02.006","article-title":"Merlin and the ERM proteins ?regulators of receptor distribution and signaling at the cell cortex","volume":"19","author":"McClatchey","year":"2009","journal-title":"Trends Cell Biol."},{"issue":"9679","key":"10.1016\/j.jsbmb.2016.05.023_bib0015","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/S0140-6736(09)60259-2","article-title":"Neurofibromatosis type 2","volume":"373","author":"Asthagiri","year":"2009","journal-title":"Lancet Lond. Engl."},{"issue":"4","key":"10.1016\/j.jsbmb.2016.05.023_bib0020","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S1097-2765(03)00382-4","article-title":"Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1","volume":"12","author":"Kissil","year":"2003","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.jsbmb.2016.05.023_bib0025","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1534-5807(01)00009-0","article-title":"The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling","volume":"1","author":"Shaw","year":"2001","journal-title":"Dev. Cell"},{"issue":"15","key":"10.1016\/j.jsbmb.2016.05.023_bib0030","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1128\/MCB.01581-08","article-title":"NF2\/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth","volume":"29","author":"James","year":"2009","journal-title":"Mol. Cell. Biol."},{"issue":"5","key":"10.1016\/j.jsbmb.2016.05.023_bib0035","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1083\/jcb.200703010","article-title":"Contact-dependent inhibition of EGFR signaling by Nf2\/Merlin","volume":"177","author":"Curto","year":"2007","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.jsbmb.2016.05.023_bib0040","first-page":"400","article-title":"Merlin: the wizard requires protein stability to function as a tumor suppressor","volume":"1826","author":"Morrow","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"52","key":"10.1016\/j.jsbmb.2016.05.023_bib0045","doi-asserted-by":"crossref","first-page":"8447","DOI":"10.1038\/sj.onc.1207794","article-title":"Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression","volume":"23","author":"Rong","year":"2004","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.jsbmb.2016.05.023_bib0050","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1101\/gad.1909210","article-title":"The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev."},{"issue":"6","key":"10.1016\/j.jsbmb.2016.05.023_bib0055","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.cell.2013.08.025","article-title":"Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin\/NF2","volume":"154","author":"Yin","year":"2013","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jsbmb.2016.05.023_bib0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ncb1339","article-title":"The tumour-suppressor genes NF2\/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis","volume":"8","author":"Hamaratoglu","year":"2006","journal-title":"Nat. Cell Biol."},{"issue":"16","key":"10.1016\/j.jsbmb.2016.05.023_bib0065","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1101\/gad.1938710","article-title":"Nf2\/Merlin controls progenitor homeostasis and tumorigenesis in the liver","volume":"24","author":"Benhamouche","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.jsbmb.2016.05.023_bib0070","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1749-6632.2009.03706.x","article-title":"Aromatase in nontumoral and malignant human liver tissues and cells","volume":"1155","author":"Carruba","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"3","key":"10.1016\/j.jsbmb.2016.05.023_bib0075","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1515\/HMBCI.2011.003","article-title":"Estrogen signalling through amphiregulin may be implicated in human hepatocellular carcinoma","volume":"5","author":"Carruba","year":"2011","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"issue":"5","key":"10.1016\/j.jsbmb.2016.05.023_bib0080","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/omi.2010.0108","article-title":"Expression of wild-type and variant estrogen receptor alpha in liver carcinogenesis and tumor progression","volume":"15","author":"Miceli","year":"2011","journal-title":"Omics J. Integr. Biol."},{"issue":"3\u20135","key":"10.1016\/j.jsbmb.2016.05.023_bib0085","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jsbmb.2009.01.013","article-title":"Androgen metabolism and biotransformation in nontumoral and malignant human liver tissues and cells","volume":"113","author":"Granata","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.jsbmb.2016.05.023_bib0090","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"issue":"Suppl. 1","key":"10.1016\/j.jsbmb.2016.05.023_bib0095","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1053\/j.gastro.2004.09.011","article-title":"Primary liver cancer: worldwide incidence and trends","volume":"127","author":"Bosch","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jsbmb.2016.05.023_bib0100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1479-5876-12-93","article-title":"Role of estrogen in hepatocellular carcinoma: is inflammation the key?","volume":"12","author":"Shi","year":"2014","journal-title":"J. Transl. Med."},{"issue":"5","key":"10.1016\/j.jsbmb.2016.05.023_bib0105","first-page":"579","article-title":"Liver and sex hormones","volume":"3","author":"Laroche","year":"1953","journal-title":"Rev. Int. H\u00e9patol."},{"issue":"1","key":"10.1016\/j.jsbmb.2016.05.023_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/1992\/72761","article-title":"Hepatocellular carcinoma and sex hormones","volume":"6","author":"Nagasue","year":"1992","journal-title":"HPB Surg. World J. Hepatic Pancreat. Biliary Surg."},{"issue":"2","key":"10.1016\/j.jsbmb.2016.05.023_bib0115","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1200\/JCO.1998.16.2.411","article-title":"Evaluation of antiandrogen therapy in unresectable hepatocellular carcinoma: results of a European Organization for Research and Treatment of Cancer multicentric double-blind trial","volume":"16","author":"Grimaldi","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jsbmb.2016.05.023_bib0120","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1196\/annals.1386.007","article-title":"Hormonal treatment of human hepatocellular carcinoma","volume":"1089","author":"Di Maio","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"24","key":"10.1016\/j.jsbmb.2016.05.023_bib0125","doi-asserted-by":"crossref","first-page":"9063","DOI":"10.1073\/pnas.0603339103","article-title":"A variant of estrogen receptor-{alpha}, hER36: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling","volume":"103","author":"Wang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2016.05.023_bib0130","first-page":"1525","article-title":"ER36: a novel biomarker and potential therapeutic target in breast cancer","volume":"7","author":"Su","year":"2014","journal-title":"OncoTargets Ther."},{"issue":"21","key":"10.1016\/j.jsbmb.2016.05.023_bib0135","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1200\/JCO.2008.17.2254","article-title":"Expression of ER36, a novel variant of estrogen receptor, and resistance to tamoxifen treatment in breast cancer","volume":"27","author":"Shi","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jsbmb.2016.05.023_bib0140","article-title":"High ER\u03b136 expression level and membrane location predict poor prognosis in renal cell carcinoma","volume":"048","author":"Wang","year":"2015","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.1016\/j.jsbmb.2016.05.023_bib0145","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.canlet.2007.01.015","article-title":"Amphiregulin: a new growth factor in hepatocarcinogenesis","volume":"254","author":"Berasain","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jsbmb.2016.05.023_bib0150","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.semcdb.2014.01.005","article-title":"Amphiregulin","volume":"28","author":"Berasain","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.jsbmb.2016.05.023_bib0155","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10549-005-9070-2","article-title":"Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth","volume":"96","author":"Britton","year":"2006","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jsbmb.2016.05.023_bib0160","article-title":"ER36-mediated rapid estrogen signaling positively regulates ER-positive breast cancer stem\/progenitor cells","volume":"8034","author":"Deng","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jsbmb.2016.05.023_bib0165","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/bcr1740","article-title":"Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage","volume":"9","author":"LaMarca","year":"2007","journal-title":"Breast Cancer Res. BCR"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076016301534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076016301534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:55:59Z","timestamp":1760745359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076016301534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":33,"alternative-id":["S0960076016301534"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2016.05.023","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Merlin, the product of NF2 gene, is associated with aromatase expression and estrogen formation in human liver tissues and liver cancer cells","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2016.05.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}