{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:48:09Z","timestamp":1789451289562,"version":"build-2803163510"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.jsbmb.2016.09.023","type":"journal-article","created":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T04:49:50Z","timestamp":1475297390000},"page":"215-222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Possible influence of vitamin D on male reproduction"],"prefix":"10.1016","volume":"173","author":[{"given":"Ida Marie","family":"Boisen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"B\u00f8llehuus Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Juel","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Lanske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Juul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3800-4253","authenticated-orcid":false,"given":"Martin","family":"Blomberg Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2016.09.023_bib0005","article-title":"Vitamin D and male reproduction","author":"Blomberg Jensen","year":"2014","journal-title":"Nat. Publ. Gr."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0010","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.140.3563.184","article-title":"Spermatogenesis in man: an estimate of its duration","volume":"80\u2013140","author":"Heller","year":"1963","journal-title":"Science"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0015","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/humupd\/dmn055","article-title":"New insights into epididymal biology and function","volume":"15","author":"Cornwall","year":"2009","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0020","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1530\/rep.0.1250769","article-title":"Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood","volume":"125","author":"Sharpe","year":"2003","journal-title":"Reproduction"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0025","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1530\/REP-09-0377","article-title":"Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors","volume":"139","author":"O\u2019shaughnessy","year":"2010","journal-title":"Reproduction"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0030","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1152\/physrev.00017.2015","article-title":"Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility","volume":"96","author":"Skakkebaek","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0035","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2164\/jandrol.04100","article-title":"Bioactivity of androgens within the testes and serum of normal men","volume":"26","author":"Jarow","year":"2005","journal-title":"J. Androl."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0040","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1073\/pnas.0308114100","article-title":"A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis","volume":"101","author":"De Gendt","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0045","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1073\/pnas.0307306101","article-title":"Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells","volume":"101","author":"Chang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0050","doi-asserted-by":"crossref","first-page":"17718","DOI":"10.1073\/pnas.0608556103","article-title":"Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells","volume":"103","author":"Zhang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0055","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/humrep\/16.5.972","article-title":"Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects","volume":"16","author":"Skakkebaek","year":"2001","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0060","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1530\/REP-12-0064","article-title":"Vitamin D metabolism, sex hormones, and male reproductive function","volume":"144","author":"Blomberg Jensen","year":"2012","journal-title":"Reproduction"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0065","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0070","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5694\/j.1326-5377.2001.tb143195.x","article-title":"Vitamin D insufficiency in south-east Queensland","volume":"174","author":"McGrath","year":"2001","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0075","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.tibs.2004.10.005","article-title":"Enzymes involved in the activation and inactivation of vitamin D","volume":"29","author":"Prosser","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0080","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1073\/pnas.0402490101","article-title":"Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase","volume":"101","author":"Cheng","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0085","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1210\/er.2008-0004","article-title":"Vitamin D and human health: lessons from vitamin D receptor null mice","volume":"29","author":"Bouillon","year":"2008","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0090","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.1016\/S0021-9258(19)44557-2","article-title":"25- Hydroxycholecalciferol-1-hydroxylase: subcellular location and properties","volume":"247","author":"Gray","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0095","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/ndt\/gfh587","article-title":"Is vitamin D indispensable for Ca2+ homeostasis: lessons from knockout mouse models?","volume":"20","author":"Hoenderop","year":"2005","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.abb.2011.11.003","article-title":"25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D","volume":"523","author":"Jones","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0105","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1056\/NEJMc1110226","article-title":"CYP24A1 mutations in idiopathic infantile hypercalcemia","volume":"365","author":"Ji","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0110","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.bone.2007.11.002","article-title":"Vitamin D deficiency as a risk factor for osteoporotic fractures","volume":"42","author":"van Schoor","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0115","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.pbiomolbio.2006.02.016","article-title":"Vitamin D physiology","volume":"92","author":"Lips","year":"2006","journal-title":"Prog. Biophys. Mol. Biol"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0120","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/ki.2010.17","article-title":"Vitamin D: a pleiotropic hormone","volume":"78","author":"Verstuyf","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0125","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.abb.2005.02.001","article-title":"Expression patterns of mouse and human CYP orthologs (families 1\u20134) during development and in different adult tissues","volume":"436","author":"Choudhary","year":"2005","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0130","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/humrep\/deq024","article-title":"Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract","volume":"25","author":"Blomberg Jensen","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0135","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7827-7-140","article-title":"Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism","volume":"7","author":"Aquila","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0140","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.urology.2006.09.011","article-title":"Vitamin D receptor found in human sperm","volume":"68","author":"Corbett","year":"2006","journal-title":"Urology"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0145","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0022-4731(90)90274-V","article-title":"Characterisation of receptors for 1,25-dihydroxyvitamin D3, in the human testis","volume":"35","author":"Habib","year":"1990","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0150","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1593\/neo.121164","article-title":"Vitamin D metabolism and effects on pluripotency genes and cell differentiation in testicular germ cell tumors in vitro and in vivo","volume":"14","author":"Blomberg Jensen","year":"2012","journal-title":"Neoplasia"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0155","doi-asserted-by":"crossref","first-page":"E646","DOI":"10.1210\/jc.2010-1628","article-title":"Bone mineral density and testicular failure: evidence for a role of vitamin D 25-hydroxylase in human testis","volume":"96","author":"Foresta","year":"2011","journal-title":"JCEM Online"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0160","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1172\/JCI108389","article-title":"The effect of hepatectomy on the synthesis of 25-hydroxyvitamin D3","volume":"57","author":"Olson","year":"1976","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0165","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(10)61916-2","article-title":"Testiculopathy and vitamin D insufficiency","volume":"376","author":"Foresta","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0170","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-2605.2012.01256.x","article-title":"Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality","volume":"35","author":"Blomberg Jensen","year":"2012","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0175","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1056\/NEJMoa003005","article-title":"Sperm morphology, motility, and concentration in fertile and infertile men","volume":"345","author":"Guzick","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0180","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1469-7580.2008.00975.x","article-title":"Human sperm anatomy: ultrastructural localization of 1\u03b1,25-dihydroxyvitamin D3 receptor and its possible role in the human male gamete","volume":"213","author":"Aquila","year":"2008","journal-title":"J. Anat."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0185","first-page":"1","article-title":"Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa","volume":"0","author":"Blomberg Jensen","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0190","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1172\/JCI65952","article-title":"Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis","volume":"123","author":"Oury","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0195","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.cell.2011.02.004","article-title":"Endocrine regulation of male fertility by the skeleton","volume":"144","author":"Oury","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0200","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng0897-391","article-title":"Mice lacking the vitamin D receptor exhibit imparied bone formation, uterine hypoplasia and growth retardation after weaning","volume":"16","author":"Tatsuya","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0205","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1210\/endo.141.4.7403","article-title":"Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads","volume":"141","author":"Kinuta","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0210","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/jn\/119.5.741","article-title":"Vitamin D is necessary for reproductive functions of the male rat","volume":"119","author":"Kwiecinski","year":"1989","journal-title":"J. Nutr."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0215","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mce.2013.06.036","article-title":"Characterization of the testicular, epididymal and endocrine phenotypes in the Leuven Vdr-deficient mouse model: targeting estrogen signalling","volume":"377","author":"Blomberg Jensen","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0220","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1093\/jn\/122.6.1338","article-title":"Normalization of serum calcium restores fertility in vitamin D-deficient male rats","volume":"122","author":"Uhland","year":"1992","journal-title":"J. Nutr."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0225","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1365-2605.2012.01287.x","article-title":"Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men","volume":"35","author":"Yang","year":"2012","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0230","article-title":"Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men","volume":"1\u20135","author":"Ramlau-hansen","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0235","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12958-015-0126-9","article-title":"Males with low serum levels of vitamin D have lower pregnancy rates when ovulation induction and timed intercourse are used as a treatment for infertile couples: results from a pilot study","volume":"13","author":"Tartagni","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0240","first-page":"1082","article-title":"Efficacy and safety of vitamin D in the treatment of idiopathic oligoasthenozoospermia","volume":"20","author":"Deng","year":"2015","journal-title":"Natl. J. Androl."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0245","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/oxfordjournals.humrep.a137729","article-title":"Seasonality in human reproduction: an update","volume":"7","author":"Rojansky","year":"1992","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0250","article-title":"Vitamin D supplementation and male infertility: the CBG- study a randomized clinical trial","author":"Blomberg Jensen","year":"2016","journal-title":"Clin. Trials"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0255","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/humrep\/dew152","article-title":"Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men","volume":"31","author":"Jensen","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0260","doi-asserted-by":"crossref","DOI":"10.1016\/0303-7207(84)90154-0","article-title":"The effect of calcium on the potentiation of LH-stimulated steroidogenesis and inhibition of LH-stimulated cyclic AMP production by LHRH agonist (ICI 118630) in rat Leydig cells","volume":"34","author":"Sullivan","year":"1984","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0265","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1530\/EJE-11-0743","article-title":"Association of hypogonadism with vitamin d status: the european male ageing study","volume":"166","author":"Lee","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0270","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/j.2047-2927.2014.00247.x","article-title":"Serum vitamin D levels and hypogonadism in men","volume":"2","author":"Lerchbaum","year":"2014","journal-title":"Andrology"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0275","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1210\/jc.2014-1690","article-title":"Testicular synthesis and vitamin D action","volume":"99","author":"Hofer","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0280","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1055\/s-0033-1345139","article-title":"Supplementation with vitamin D does not increase serum testosterone levels in healthy males","volume":"45","author":"Jorde","year":"2013","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0285","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1055\/s-0030-1269854","article-title":"Effect of vitamin D supplementation on testosterone levels in men","volume":"43","author":"Pilz","year":"2011","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0290","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrcardio.2016.73","article-title":"Vitamin D and cardiovascular disease prevention","volume":"13","author":"Pilz","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0295","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1111\/jsm.12661","article-title":"Vitamin D and erectile dysfunction","volume":"11","author":"Barassi","year":"2014","journal-title":"J. Sex Med."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0300","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1210\/en.2009-0855","article-title":"Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy","volume":"151","author":"Krishnan","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PPO.0b013e3181c51ee6","article-title":"Vitamin D: considerations in the continued development as an agent for cancer prevention and therapy","volume":"16","author":"Trump","year":"2010","journal-title":"Cancer J."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0310","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc3691","article-title":"The role of vitamin D in reducing cancer risk and progression","volume":"14","author":"Feldman","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0315","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/jnci\/djj101","article-title":"Prospective study of predictors of vitamin D status and cancer incidence and mortality in men","volume":"98","author":"Giovannucci","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0320","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrc2196","article-title":"Vitamin D signalling pathways in cancer: potential for anticancer therapeutics","volume":"7","author":"Deeb","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0325","first-page":"695","article-title":"1 Alpha,25-dihydroxyvitamin D3 and platinum drugs act synergistically to inhibit the growth of prostate cancer cell lines","volume":"5","author":"Moffatt","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0330","first-page":"2848","article-title":"Combined effects of 1,25-dihydroxyvitamin D3 and platinum drugs on the growth of MCF-7 cells","volume":"51","author":"Cho","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0335","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/nar\/gkj460","article-title":"Regulation of the human p21(waf1\/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor","volume":"34","author":"Saram\u00e4ki","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0340","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1172\/JCI41939","article-title":"Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer","volume":"120","author":"Koster","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0345","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jsbmb.2012.10.008","article-title":"Influence of vitamin D on cisplatin sensitivity in testicular germ cell cancer-derived cell lines and in a NTera2 xenograft model","volume":"136","author":"J\u00f8rgensen","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0350","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1073\/pnas.94.18.9831","article-title":"Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia","volume":"94","author":"Li","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0355","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1210\/mend.16.7.0866","article-title":"Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D","volume":"16","author":"Erben","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0360","doi-asserted-by":"crossref","first-page":"7498","DOI":"10.1073\/pnas.131029498","article-title":"Targeted ablation of the 25-hydroxyvitamin D 1alpha \u2212hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction","volume":"98","author":"Panda","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0365","doi-asserted-by":"crossref","first-page":"E51","DOI":"10.1152\/ajpendo.00076.2014","article-title":"Active vitamin D deficiency mediated by extracellular calcium and phosphorus results in male infertility in young mice","volume":"308","author":"Sun","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0370","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/aja.2012.77","article-title":"Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters","volume":"14","author":"Hammoud","year":"2012","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0375","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1016\/j.fertnstert.2014.12.075","article-title":"Role of vitamin D deficiency in male fertility","volume":"103","author":"Waud","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0380","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1210\/jc.2003-032187","article-title":"Serum estradiol, testosterone, and sex hormone-binding globulin as regulators of peak bone mass and bone turnover rate in young Finnish men","volume":"89","author":"V\u00e4lim\u00e4ki","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0385","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1469-1809.1999.6350429.x","article-title":"Statistical genetic analysis of plasma levels of vitamin D: familial study","volume":"63","author":"Livshits","year":"1999","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0390","article-title":"Association of serum inorganic phosphate with sex steroid hormones and vitamin D in a nationally representative sample of men","volume":"1\u201310","author":"Wulaningsih","year":"2014","journal-title":"Andrology"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0395","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1365-2265.2010.03926.x","article-title":"Serum 25-hydroxyvitamin D concentration and physical function in adult men","volume":"74","author":"Ceglia","year":"2011","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0400","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12958-015-0068-2","article-title":"Vitamin D is associated with testosterone and hypogonadism in Chinese men: results from a cross-sectional SPECT-China study","volume":"13","author":"Wang","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0405","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4103\/1008-682X.142137","article-title":"Serum 25-hydroxyvitamin D levels and testosterone deficiency in middle-aged Korean men: a cross-sectional study","volume":"17","author":"Tak","year":"2015","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0410","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/j.1365-2265.2008.03272.x","article-title":"Relationship between calcium absorption and plasma dehydroepiandrosterone sulphate (DHEAS) in healthy males","volume":"69","author":"Chen","year":"2008","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0415","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1365-2265.2012.04332.x","article-title":"Association between plasma 25-OH vitamin D and testosterone levels in men","volume":"77","author":"Nimptsch","year":"2012","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0420","article-title":"Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men","author":"Rafiq","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2016.09.023_bib0425","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/cen.12711","article-title":"Vitamin D supplementation and testosterone concentrations in male human subjects","volume":"31","author":"Heijboer","year":"2015","journal-title":"Clin. Endocrinol. (Oxf.)"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096007601630259X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096007601630259X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:57:20Z","timestamp":1760745440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096007601630259X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":85,"alternative-id":["S096007601630259X"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2016.09.023","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible influence of vitamin D on male reproduction","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2016.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}