{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:31:47Z","timestamp":1769099507505,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2017CXGC1401"],"award-info":[{"award-number":["2017CXGC1401"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011432","name":"China-Australia Centre for Health Science Research","doi-asserted-by":"publisher","award":["2016GJ07"],"award-info":[{"award-number":["2016GJ07"]}],"id":[{"id":"10.13039\/501100011432","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.jsbmb.2018.09.016","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T12:30:16Z","timestamp":1537619416000},"page":"66-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Synthesis of 1\u03b1,25-dihydroxyvitamin D3 analogues with \u03b1,\u03b1-difluorocycloketone at the CD-ring side chains and their biological properties in ovariectomized rats"],"prefix":"10.1016","volume":"186","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Dong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-jie","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2018.09.016_bib0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1210\/jc.2008-1454","article-title":"Nonclassic actions of vitamin D","volume":"94","author":"Bikle","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0010","series-title":"Vitamin D","year":"2011"},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0015","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nrd3318","article-title":"Vitamin D, disease and therapeutic opportunities","volume":"9","author":"Plum","year":"2010","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11154-011-9198-9","article-title":"Regulation of target gene expression by the vitamin D receptor \u2013 an update on mechanisms","volume":"13","author":"Pike","year":"2012","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.vh.2015.11.001","article-title":"Vitamin D: historical overview","volume":"100","author":"DeLuca","year":"2016","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0030","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.2174\/092986707781058823","article-title":"Mechanism and potential of the growth-inhibitory actions of vitamin D and analogues","volume":"14","author":"Eelen","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0035","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.mam.2008.04.001","article-title":"Vitamin D analogues: therapeutic applications and mechanisms for selectivity","volume":"29","author":"Brown","year":"2008","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0040","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chembiol.2013.12.016","article-title":"Vitamin D metabolism, mechanism of action and clinical applications","volume":"21","author":"Bikle","year":"2014","journal-title":"Chem. Biol."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0045","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/bs.vh.2015.11.002","article-title":"Analogues of 1\u03b1,25-dihydroxyvitamin D3 in clinical use","volume":"100","author":"DeLuca","year":"2016","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0050","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1517\/13543776.13.6.761","article-title":"New vitamin D receptor ligands, Expert Opin","volume":"13","author":"Carlberg","year":"2003","journal-title":"Ther. Pat."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0055","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1517\/13543784.12.5.825","article-title":"An update on the therapeutic potential of vitamin D analogues","volume":"12","author":"Stein","year":"2003","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/med.10023","article-title":"Structure-function relationships of vitamin D including ligand recognition by the vitamin D receptor","volume":"23","author":"Yamada","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0065","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.2174\/0929867311320160003","article-title":"Recent developments of 2-substituted analogs of 1,25(OH)2D3","volume":"20","author":"Zhang","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0070","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/cmdc.201300160","article-title":"Recent developments of 19-nor-1,25-dihydroxyvitamin D3 analogues","volume":"8","author":"Zhang","year":"2013","journal-title":"ChemMedChem"},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0075","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s12016-013-8361-3","article-title":"The implication of vitamin D and autoimmunity: a comprehensive review","volume":"45","author":"Yang","year":"2013","journal-title":"Clinic Rev. Allerg. Immunol."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cell.2018.04.013","article-title":"Vitamin D switches BAF complexes to protect \u03b2 cells","volume":"173","author":"Wei","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0085","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0003-9861(80)90047-8","article-title":"Isolation of a new metabolite of vitamin D produced in vivo, 1\u03b1, 25-dihydroxyvitamin D3-26,23-lactone","volume":"204","author":"Ohnuma","year":"1980","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0090","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.1073\/pnas.77.11.6411","article-title":"Role of kidney tissue in the production of 25-hydroxyvitamin D3-26,23-lactone and 1\u03b1,25-dihydroxyvitamin D3-26,23-lactone","volume":"77","author":"Tanaka","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0095","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0006-291X(85)80217-5","article-title":"The unique action for bone metabolism of 1\u03b1,25-(OH)2D3-26,23-lactone","volume":"127","author":"Kiyoki","year":"1985","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0303-7207(88)90093-7","article-title":"Effects of diastereoisomers of 1,25-dihydroxyvitamin D3-26,23-lactone on alkaline phosphatase and collagen synthesis in osteoblastic cells","volume":"55","author":"Ishizuka","year":"1988","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0105","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0003-9861(85)90482-5","article-title":"The stereochemical configuration of the natural 1\u03b1,25-dihydroxyvitamin D3-26,23-lactone","volume":"242","author":"Ishizuka","year":"1985","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0110","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0022-4731(86)90395-X","article-title":"The difference of biological activity among four diastereoisomers of 1\u03b1,25-dihydroxycholecalciferol-26,23-lactone","volume":"25","author":"Ishizuka","year":"1986","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0115","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jsbmb.2017.07.017","article-title":"Synthetic studies of (23S,25R)-1\u03b1,25-dihydroxyvitamin D3 26,23-lactone (calcitriol lactone) and its derivatives","volume":"177","author":"Akagi","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0120","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1039\/c1ob05142c","article-title":"Synthesis of C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation, especially biological effect on bone by modification at the C-2 position","volume":"9","author":"Saitoh","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0125","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.1021\/acs.jmedchem.5b00258","article-title":"Applications of fluorine in medicinal chemistry","volume":"58","author":"Gillis","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0130","article-title":"Fluorine and fluorinated motifs in the design and application of bioisosteres for drug design","author":"Nicholas Meanwell","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0135","doi-asserted-by":"crossref","first-page":"962","DOI":"10.2174\/138527210791111786","article-title":"Synthesis and biological activity of fluorinated vitamin D","volume":"14","author":"Fujishima","year":"2010","journal-title":"Cur. Org. Chem."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0140","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jsbmb.2017.07.008","article-title":"Recent developments for introducing a hexafluoroisopropanol unit into the vitamin D side chain","volume":"177","author":"Kawagoea","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0145","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1016\/S0040-4039(00)79565-7","article-title":"l\u03b1-Hydroxy-19-nor-vitamin D C-22 aldehyde. A valuable intermediate in the synthesis of side chain modified l\u03b1,25-dihydroxy-19-nor-vitamin D","volume":"33","author":"Perlman","year":"1992","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0150","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/oxfordjournals.jbchem.a022505","article-title":"A general method for rapid purification of soluble versions of glycosylphosphatidylinositol-anchored proteins expressed in insect cells: an application for human tissue-nonspecific alkaline phosphatase","volume":"126","author":"Oda","year":"1999","journal-title":"J. Biochem."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0155","first-page":"327","article-title":"Histological examination on osteoblastic activities in the alveolar bone of transgenic mice with induced ablation of osteocytes","volume":"28","author":"Li","year":"2013","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0160","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1039\/p19780000590","article-title":"Calciferol and its relatives. Part 22. A direct total synthesis of vitamin D2 and vitamin D3","volume":"1","author":"Lythgoe","year":"1978","journal-title":"J. Chem. Soc. Perkin Trans. I"},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0165","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1021\/ja00374a052","article-title":"Stereoselective total synthesis of 1\u03b1,25-dihydroxycholecalciferol","volume":"104","author":"Baggiolini","year":"1982","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0170","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.steroids.2014.07.005","article-title":"Stereoselective reduction of C-20 ketone of vitamin D CD-ring and a new synthetic approach to maxacalcitol","volume":"88","author":"Zhao","year":"2014","journal-title":"Steroids"},{"key":"10.1016\/j.jsbmb.2018.09.016_bib0175","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/jbmr.15","article-title":"A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemia","volume":"25","author":"Sato","year":"2010","journal-title":"J. Bone Miner. Res."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076018304539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076018304539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:01:38Z","timestamp":1760745698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076018304539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":35,"alternative-id":["S0960076018304539"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2018.09.016","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of 1\u03b1,25-dihydroxyvitamin D3 analogues with \u03b1,\u03b1-difluorocycloketone at the CD-ring side chains and their biological properties in ovariectomized rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2018.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}