{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:49:04Z","timestamp":1790470144532,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jsbmb.2019.02.011","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T18:09:18Z","timestamp":1555783758000},"page":"105316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["High expression of adrenal P450 aromatase (CYP19A1) in association with ARMC5-primary bilateral macronodular adrenocortical hyperplasia"],"prefix":"10.1016","volume":"191","author":[{"given":"Annabel","family":"Berthon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-6205","authenticated-orcid":false,"given":"Fady","family":"Hannah-Shmouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Gutierrez","family":"Maria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio R.","family":"Faucz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine A.","family":"Stratakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2019.02.011_bib0005","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1056\/NEJMoa1304603","article-title":"ARMC5 mutations in macronodular adrenal hyperplasia with Cushing\u2019s syndrome","volume":"369","author":"Assie","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0010","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1530\/EJE-15-0205","article-title":"The ARMC5 gene shows extensive genetic variance in primary macronodular adrenocortical hyperplasia","volume":"173","author":"Correa","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0015","doi-asserted-by":"crossref","first-page":"E1113","DOI":"10.1210\/jc.2013-4280","article-title":"Macronodular adrenal hyperplasia due to mutations in an armadillo repeat containing 5 (armc5) gene: a clinical and genetic investigation","volume":"99","author":"Faucz","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0020","doi-asserted-by":"crossref","first-page":"E926","DOI":"10.1210\/jc.2014-4204","article-title":"ARMC5 Mutations in a large cohort of primary macronodular adrenal hyperplasia: clinical and functional consequences","volume":"100","author":"Espiard","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0025","doi-asserted-by":"crossref","first-page":"E1784","DOI":"10.1210\/jc.2014-1265","article-title":"ARMC5 Mutations are common in familial bilateral macronodular adrenal hyperplasia","volume":"99","author":"Gagliardi","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0030","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1210\/jc.2002-021362","article-title":"Cushing\u2019s syndrome secondary to adrenocorticotropin-independent macronodular adrenocortical hyperplasia due to activating mutations of GNAS1 gene","volume":"88","author":"Fragoso","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0035","doi-asserted-by":"crossref","first-page":"E687","DOI":"10.1210\/jc.2011-3000","article-title":"Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations","volume":"97","author":"Almeida","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0040","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1210\/jc.2005-2608","article-title":"17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia","volume":"91","author":"Bourdeau","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0045","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1158\/1078-0432.CCR-08-0106","article-title":"Phosphodiesterase 11A (PDE11A) and genetic predisposition to adrenocortical tumors","volume":"14","author":"Libe","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0050","doi-asserted-by":"crossref","first-page":"E2063","DOI":"10.1210\/jc.2012-2275","article-title":"Phosphodiesterase 11A (PDE11A) gene defects in patients with acth-independent macronodular adrenal hyperplasia (AIMAH): functional variants may contribute to genetic susceptibility of bilateral adrenal tumors","volume":"97","author":"Vezzosi","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0055","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.humpath.2014.09.005","article-title":"Germline PRKACA amplification leads to Cushing syndrome caused by 3 adrenocortical pathologic phenotypes","volume":"46","author":"Carney","year":"2015","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0060","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1056\/NEJMoa1310359","article-title":"Constitutive activation of PKA catalytic subunit in adrenal Cushing\u2019s syndrome","volume":"370","author":"Beuschlein","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0065","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.mce.2003.10.052","article-title":"Constitutive activation of the human ACTH receptor resulting from a synergistic interaction between two naturally occurring missense mutations in the MC2R gene","volume":"213","author":"Swords","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0070","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1590\/S0004-27302007000800008","article-title":"Cushing\u2019s syndrome secondary to ACTH-independent macronodular adrenal hyperplasia","volume":"51","author":"Costa","year":"2007","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/JOE-07-0413","article-title":"Expression of vasopressin receptors in ACTH-independent macronodular bilateral adrenal hyperplasia causing Cushing\u2019s syndrome: molecular, immunohistochemical and pharmacological correlates","volume":"196","author":"Louiset","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0080","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tem.2009.12.009","article-title":"The pathophysiology, diagnosis and prognosis of adrenocortical tumors revisited by transcriptome analyses","volume":"21","author":"Assie","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0085","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1056\/NEJM199911183412104","article-title":"Leuprolide acetate therapy in luteinizing hormone--dependent Cushing\u2019s syndrome","volume":"341","author":"Lacroix","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0090","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mce.2006.06.014","article-title":"Human adrenal cortex hyperfunction due to LH\/hCG","volume":"269","author":"Carlson","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0095","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1210\/jc.2004-1256","article-title":"In vivo and in vitro screening for illegitimate receptors in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing\u2019s syndrome: identification of two cases of gonadotropin\/gastric inhibitory polypeptide-dependent hypercortisolism","volume":"90","author":"Bertherat","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0100","first-page":"2336","article-title":"Lysine vasopressin stimulation of cortisol secretion in patients with adrenocorticotropin-independent macronodular adrenal hyperplasia","volume":"80","author":"Horiba","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0105","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1365-2265.2008.03471.x","article-title":"Familial vasopressin-sensitive ACTH-independent macronodular adrenal hyperplasia (VPs-AIMAH): clinical studies of three kindreds","volume":"70","author":"Gagliardi","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.beem.2018.01.003","article-title":"Aberrant G-protein coupled hormone receptor in adrenal diseases","volume":"32","author":"St-Jean","year":"2018","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0115","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.92184","article-title":"Adrenal GIPR expression and chromosome 19q13 microduplications in GIP-dependent Cushing\u2019s syndrome","volume":"2","author":"Lecoq","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0120","first-page":"245","article-title":"ACTH-independent macronodular adrenal hyperplasia, Best practice & research","volume":"23","author":"Lacroix","year":"2009","journal-title":"Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0125","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1055\/s-0043-122074","article-title":"Successful Treatment of Estrogen Excess in Primary Bilateral Macronodular Adrenocortical Hyperplasia with Leuprolide Acetate","volume":"50","author":"Hannah-Shmouni","year":"2018","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0130","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1093\/hmg\/ddx235","article-title":"Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function","volume":"26","author":"Berthon","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jsbmb.2019.02.011_bib0135","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3389\/fendo.2016.00111","article-title":"Alterations of phosphodiesterases in adrenocortical tumors","volume":"7","author":"Hannah-Shmouni","year":"2016","journal-title":"Front. Endocrinol. (Lausanne)"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076018306654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076018306654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:42Z","timestamp":1760745642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076018306654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":27,"alternative-id":["S0960076018306654"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2019.02.011","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High expression of adrenal P450 aromatase (CYP19A1) in association with ARMC5-primary bilateral macronodular adrenocortical hyperplasia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2019.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105316"}}