{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:55:12Z","timestamp":1790790912509,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jsbmb.2019.105478","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T11:23:30Z","timestamp":1569324210000},"page":"105478","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Vdr expression in osteoclast precursors is not critical in bone homeostasis"],"prefix":"10.1016","volume":"195","author":[{"given":"Lieve","family":"Verlinden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Janssens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Doms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Vanhevel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Carmeliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke","family":"Verstuyf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2019.105478_bib0005","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0010","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jbmr.2081","article-title":"Identification of the vitamin D receptor in osteoblasts and chondrocytes but not osteoclasts in mouse bone","volume":"29","author":"Wang","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0015","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/jbmr.3096","article-title":"VDR in Osteoblast-Lineage cells primarily mediates vitamin d treatment-induced increase in bone mass by suppressing bone resorption","volume":"32","author":"Nakamichi","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0020","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1210\/en.2012-1542","article-title":"Vitamin D receptor in osteoblasts is a negative regulator of bone mass control","volume":"154","author":"Yamamoto","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2019.105478_bib0025","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1172\/JCI45890","article-title":"Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization","volume":"122","author":"Lieben","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0030","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1172\/JCI29463","article-title":"Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts","volume":"116","author":"Masuyama","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0035","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1507\/endocrj.49.483","article-title":"Cell-to-Cell adhesion via intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 pathway is involved in 1alpha,25(OH)2D3, PTH and IL-1alpha-induced osteoclast differentiation and bone resorption","volume":"49","author":"Okada","year":"2002","journal-title":"Endocr. J."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0040","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/S0021-9258(18)54097-7","article-title":"1 alpha,25-dihydroxyvitamin D3 up-regulates expression of the osteoclast integrin alpha v beta 3","volume":"268","author":"Medhora","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0045","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","article-title":"Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL","volume":"95","author":"Yasuda","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0050","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1210\/en.2010-0334","article-title":"Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption","volume":"151","author":"Kogawa","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2019.105478_bib0055","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jsbmb.2017.10.022","article-title":"Absence of vitamin D receptor in mature osteoclasts results in altered osteoclastic activity and bone loss","volume":"177","author":"Starczak","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0060","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1210\/en.2017-00139","article-title":"Impact on experimental colitis of vitamin d receptor deletion in intestinal epithelial or myeloid cells","volume":"158","author":"Leyssens","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2019.105478_bib0065","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1359\/jbmr.2000.15.8.1510","article-title":"Mice lacking the plasminogen activator inhibitor 1 are protected from trabecular bone loss induced by estrogen deficiency","volume":"15","author":"Daci","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0070","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.bone.2013.03.023","article-title":"Nrp2 deficiency leads to trabecular bone loss and is accompanied by enhanced osteoclast and reduced osteoblast numbers","volume":"55","author":"Verlinden","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.jsbmb.2019.105478_bib0075","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0080","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1210\/endo.140.2.6673","article-title":"Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: studies using VDR knockout mice","volume":"140","author":"Takeda","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2019.105478_bib0085","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/bonekey.2013.216","article-title":"Regulation of gene expression by 1,25-dihydroxyvitamin D3 in bone cells: exploiting new approaches and defining new mechanisms","volume":"3","author":"Pike","year":"2014","journal-title":"Bonekey Rep."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0090","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1210\/endo.139.3.5837","article-title":"Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG\/OCIF inhibits osteoclastogenesis in vitro","volume":"139","author":"Yasuda","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2019.105478_bib0095","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/bonekey.2013.229","article-title":"Vitamin D endocrine system and osteoclasts","volume":"3","author":"Takahashi","year":"2014","journal-title":"Bonekey Rep."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0100","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/421746","article-title":"Biology of bone tissue: structure, function, and factors that influence bone cells","volume":"2015","author":"Florencio-Silva","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.jsbmb.2019.105478_bib0105","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076019304534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076019304534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:05:11Z","timestamp":1760745911000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076019304534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":21,"alternative-id":["S0960076019304534"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2019.105478","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vdr expression in osteoclast precursors is not critical in bone homeostasis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2019.105478","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105478"}}