{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:52:03Z","timestamp":1760784723650,"version":"build-2065373602"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP\/2007\u20132013","617393"],"award-info":[{"award-number":["FP\/2007\u20132013","617393"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jsbmb.2019.105505","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T12:16:36Z","timestamp":1571919396000},"page":"105505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Translating vitamin D transcriptomics to clinical evidence: Analysis of data in asthma and chronic obstructive pulmonary disease, followed by clinical data meta-analysis"],"prefix":"10.1016","volume":"197","author":[{"given":"Niki","family":"Malliaraki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kleanthi","family":"Lakiotaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodanthi","family":"Vamvoukaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Notas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Tsamardinos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilena","family":"Kampa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Castanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2019.105505_bib0005","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1172\/JCI106168","article-title":"\u201cActivation\u201d of vitamin D by the liver","volume":"48","author":"Ponchon","year":"1969","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0010","series-title":"Vitamin D","first-page":"777","article-title":"Extrarenal 1a-hydroxylase.","author":"Hewison","year":"2011"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0015","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/228764a0","article-title":"Unique biosynthesis by kidney of a biological active vitamin D metabolite","volume":"228","author":"Fraser","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fphys.2014.00167","article-title":"Genome-wide (over)view on the actions of vitamin D","volume":"5","author":"Carlberg","year":"2014","journal-title":"Front Physiol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00223-012-9619-0","article-title":"Molecular mechanisms of vitamin D action","volume":"92","author":"Haussler","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mce.2011.05.012","article-title":"Genome-wide principles of gene regulation by the vitamin D receptor and its activating ligand","volume":"347","author":"Pike","year":"2011","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0035","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mce.2017.02.046","article-title":"Structural aspects of Vitamin D endocrinology","volume":"453","author":"Rochel","year":"2017","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0040","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11154-011-9195-z","article-title":"Vitamin D metabolism and signaling in the immune system","volume":"13","author":"White","year":"2012","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0045","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrendo.2013.75-c1","article-title":"Vitamin D and human health: more than just bone","volume":"9","author":"White","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0050","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1210\/me.2004-0116","article-title":"The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitro","volume":"18","author":"Huhtakangas","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0055","doi-asserted-by":"crossref","first-page":"7392","DOI":"10.1073\/pnas.0402207101","article-title":"Ribozyme knockdown functionally links a 1,25(OH)2D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells","volume":"101","author":"Nemere","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0060","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jsbmb.2014.11.002","article-title":"Membrane-mediated actions of 1,25-dihydroxy vitamin D3: a review of the roles of phospholipase A2 activating protein and Ca(2+)\/calmodulin-dependent protein kinase II","volume":"147","author":"Doroudi","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0065","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/nu8030135","article-title":"The non-genomic actions of vitamin D","volume":"8","author":"Hii","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mce.2017.03.011","article-title":"Bioinformatic approaches to interrogating vitamin D receptor signaling","volume":"453","author":"Campbell","year":"2017","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0075","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1210\/jc.2018-01414","article-title":"Controversies in vitamin D: summary statement from an international conference","volume":"104","author":"Giustina","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0080","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bay011","article-title":"BioDataome: a collection of uniformly preprocessed and automatically annotated datasets for data-driven biology","volume":"2018","author":"Lakiotaki","year":"2018","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41540-019-0117-0","article-title":"A data driven approach reveals disease similarity on a molecular level","volume":"5","author":"Lakiotaki","year":"2019","journal-title":"NPJ Sys. Biol. App."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0090","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1183\/09031936.06.00025805","article-title":"Chronic obstructive pulmonary disease: current burden and future projections","volume":"27","author":"Lopez","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0095","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0140-6736(16)31012-1","article-title":"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"G. B. D. Mortality Causes of Death Collaborators","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0100","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.beem.2011.05.002","article-title":"The effect of vitamin D on bone and osteoporosis","volume":"25","author":"Lips","year":"2011","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0105","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkz401","article-title":"WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0110","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrg3868","article-title":"Methods of integrating data to uncover genotype-phenotype interactions","volume":"16","author":"Ritchie","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0115","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"year":"2014","series-title":"R: A Language And Environment For Statistical Computing","author":"R Core Team","key":"10.1016\/j.jsbmb.2019.105505_bib0120"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0125","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ng0506-500","article-title":"GenePattern 2.0","volume":"38","author":"Reich","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0130","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0135","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cct.2015.05.010","article-title":"Advances in the meta-analysis of heterogeneous clinical trials II: the quality effects model","volume":"45","author":"Doi","year":"2015","journal-title":"Contemp. Clin. Trials"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0140","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cct.2015.05.009","article-title":"Advances in the meta-analysis of heterogeneous clinical trials i: the inverse variance heterogeneity model","volume":"45","author":"Doi","year":"2015","journal-title":"Contemp. Clin. Trials"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/imm.12076","article-title":"SMAD regulatory networks construct a balanced immune system","volume":"139","author":"Malhotra","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0150","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/bioinformatics\/bty693","article-title":"PathwayConnector: finding complementary pathways to enhance functional analysis","volume":"35","author":"Minadakis","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0155","doi-asserted-by":"crossref","first-page":"26113","DOI":"10.1103\/PhysRevE.69.026113","article-title":"Finding and evaluating community structure in networks","volume":"69","author":"Newman","year":"2004","journal-title":"Phys. Rev. E. Stat. Nonlin. Soft. Matter. Phys."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0160","series-title":"International Symposium On Computer And Information Sciences","first-page":"284","article-title":"Computing communities in large networks using random walks","author":"Pons","year":"2005"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0165","doi-asserted-by":"crossref","first-page":"66111","DOI":"10.1103\/PhysRevE.70.066111","article-title":"Finding community structure in very large networks","volume":"70","author":"Clauset","year":"2004","journal-title":"Phys. Rev. E. Stat. Nonlin. Soft Matter. Phys"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0170","doi-asserted-by":"crossref","first-page":"36104","DOI":"10.1103\/PhysRevE.74.036104","article-title":"Finding community structure in networks using the eigenvectors of matrices","volume":"74","author":"Newman","year":"2006","journal-title":"Phys. Rev. E. Stat. Nonlin. Soft Matter. Phys."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0175","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1109\/TKDE.2007.190689","article-title":"On modularity clustering","volume":"20","author":"Brandes","year":"2008","journal-title":"IEEE Trans. Knowl. Data Eng."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0180","doi-asserted-by":"crossref","first-page":"16110","DOI":"10.1103\/PhysRevE.74.016110","article-title":"Statistical mechanics of community detection","volume":"74","author":"Reichardt","year":"2006","journal-title":"Phys. Rev. E. Stat. Nonlin. Soft. Matter. Phys."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0185","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/ajcn\/85.3.788","article-title":"Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age","volume":"85","author":"Camargo","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099856","article-title":"Cord blood 25(OH)-vitamin D deficiency and childhood asthma, allergy and eczema: the COPSAC2000 birth cohort study","volume":"9","author":"Chawes","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0195","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/j.1365-2222.2009.03234.x","article-title":"Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children","volume":"39","author":"Erkkola","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0200","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1001\/jama.2015.18589","article-title":"Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years: the VDAART randomized clinical trial","volume":"315","author":"Litonjua","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0205","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/all.12909","article-title":"Vitamin D supplementation during pregnancy and infancy reduces aeroallergen sensitization: a randomized controlled trial","volume":"71","author":"Grant","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186657","article-title":"Prenatal vitamin D supplementation reduces risk of asthma\/recurrent wheeze in early childhood: a combined analysis of two randomized controlled trials","volume":"12","author":"Wolsk","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0215","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1017\/S2040174415001063","article-title":"Vitamin D exposure during pregnancy, but not early childhood, is associated with risk of childhood wheezing","volume":"6","author":"Anderson","year":"2015","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0220","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.jaci.2017.01.013","article-title":"Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: secondary analyses from the vitamin D antenatal asthma reduction trial","volume":"140","author":"Wolsk","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0225","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1001\/jama.2015.18318","article-title":"Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomized clinical trial","volume":"315","author":"Chawes","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0230","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-017013","article-title":"Pregnancy diet and offspring asthma risk over a 10-year period: the lifeways cross generation cohort study, Ireland","volume":"8","author":"Viljoen","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0235","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/ijo.2017.182","article-title":"The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study","volume":"41","author":"Boyle","year":"2017","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0240","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/cea.12311","article-title":"25-hydroxy vitamin D levels are associated with childhood asthma in a population-based study in Peru","volume":"45","author":"Checkley","year":"2015","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0245","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/1471-2393-13-199","article-title":"Vitamin D intake in mid-pregnancy and child allergic disease - a prospective study in 44,825 Danish mother-child pairs","volume":"13","author":"Maslova","year":"2013","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0250","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1515\/jpem-2012-0143","article-title":"Serum 25-hydroxyvitamin D levels do not correlate with asthma severity in a case-controlled study of children and adolescents","volume":"25","author":"Menon","year":"2012","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0255","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1183\/09031936.00102214","article-title":"Maternal vitamin D and E intakes during pregnancy are associated with asthma in children","volume":"45","author":"Allan","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0260","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s12098-013-1310-6","article-title":"Serum 25 hydroxy vitamin D insufficiency associated with bronchial asthma in Lucknow, India","volume":"81","author":"Awasthi","year":"2014","journal-title":"Indian J. Pediatr."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0265","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1164\/rccm.201107-1239OC","article-title":"Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma","volume":"184","author":"Gupta","year":"2011","journal-title":"Am J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0270","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jaci.2016.07.032","article-title":"Vitamin D over the first decade and susceptibility to childhood allergy and asthma","volume":"139","author":"Hollams","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0275","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/pai.12773","article-title":"Vitamin D intake during the first 4 years and onset of asthma by age 5: a nested case-control study","volume":"28","author":"Nwaru","year":"2017","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0280","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.chest.2017.06.021","article-title":"Rapid vs maintenance vitamin D supplementation in deficient children with asthma to prevent exacerbations","volume":"152","author":"Alansari","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0285","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jaci.2010.12.016","article-title":"Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection","volume":"127","author":"Majak","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0290","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/all.12856","article-title":"Improved control of childhood asthma with low-dose, short-term vitamin D supplementation: a randomized, double-blind, placebo-controlled trial","volume":"71","author":"Tachimoto","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0295","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1007\/s12098-013-1268-4","article-title":"Effect of vitamin D supplementation on moderate to severe bronchial asthma","volume":"81","author":"Yadav","year":"2014","journal-title":"Indian J. Pediatr."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0300","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.anai.2014.07.005","article-title":"The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma","volume":"113","author":"Arshi","year":"2014","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0305","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/pai.12547","article-title":"Vitamin D3 for uncontrolled childhood asthma: a pilot study","volume":"27","author":"Kerley","year":"2016","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0310","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/cea.12299","article-title":"The association of serum 25-OH vitamin D with atopy, asthma, and lung function in a prospective study of Danish adults","volume":"45","author":"Thuesen","year":"2015","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0315","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jsbmb.2016.11.004","article-title":"Prevalence, determinants and clinical correlates of vitamin D deficiency in adults with inhaled corticosteroid-treated asthma in London, UK","volume":"175","author":"Jolliffe","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0320","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1196\/annals.1337.013","article-title":"Infant vitamin d supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966","volume":"1037","author":"Hypponen","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0325","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1164\/rccm.200911-1710OC","article-title":"Vitamin D levels, lung function, and steroid response in adult asthma","volume":"181","author":"Sutherland","year":"2010","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0330","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.rmed.2018.01.017","article-title":"Serum 25-hydroxyvitamin D, vitamin D supplement and asthma control: The HUNT study","volume":"136","author":"Brumpton","year":"2018","journal-title":"Respir. Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0335","article-title":"Asthmatic patients with vitamin D deficiency have decreased exacerbations after vitamin replacement","volume":"9","author":"Solidoro","year":"2017","journal-title":"Ntrients"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0340","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1001\/jama.2014.5052","article-title":"Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial","volume":"311","author":"Castro","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0345","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jaci.2014.11.033","article-title":"Vitamin D reduces eosinophilic airway inflammation in nonatopic asthma","volume":"135","author":"de Groot","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0350","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1136\/thoraxjnl-2014-206449","article-title":"Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs)","volume":"70","author":"Martineau","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0355","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.anai.2017.02.014","article-title":"Effect of alfacalcidol on the pulmonary function of adult asthmatic patients: a randomized trial","volume":"118","author":"Ali","year":"2017","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111599","article-title":"25-Hydroxyvitamin D3-deficiency enhances oxidative stress and corticosteroid resistance in severe asthma exacerbation","volume":"9","author":"Lan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0365","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1378\/chest.128.6.3792","article-title":"Relationship between serum 25-hydroxyvitamin d and pulmonary function in the third national health and nutrition examination survey","volume":"128","author":"Black","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0370","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.rmed.2015.03.005","article-title":"Serum magnesium and not vitamin D is associated with better QoL in COPD: a cross-sectional study","volume":"109","author":"Hashim Ali Hussein","year":"2015","journal-title":"Respir. Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0375","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2147\/COPD.S156121","article-title":"The influence of disease severity and lifestyle factors on the peak annual 25(OH)D value of COPD patients","volume":"13","author":"Kentson","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0380","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/eci.12498","article-title":"Vitamin D deficiency and airflow limitation in the Baltimore longitudinal study of ageing","volume":"45","author":"Moberg","year":"2015","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0385","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1017\/S1368980013002590","article-title":"Dietary and supplemental antioxidant and anti-inflammatory nutrient intakes and pulmonary function","volume":"17","author":"Ng","year":"2014","journal-title":"Public Health Nutr.."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0390","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1378\/chest.13-1296","article-title":"No association of 25-hydroxyvitamin D with exacerbations in primary care patients with COPD","volume":"145","author":"Puhan","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0395","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/07853890.2012.671536","article-title":"Vitamin D status is associated with bone mineral density and functional exercise capacity in patients with chronic obstructive pulmonary disease","volume":"45","author":"Romme","year":"2013","journal-title":"Ann. Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0400","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/thx.2009.120659","article-title":"Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene","volume":"65","author":"Janssens","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0405","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jsbmb.2017.01.019","article-title":"Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK","volume":"175","author":"Jolliffe","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0410","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/resp.13239","article-title":"Vitamin D and respiratory health in the Busselton healthy ageing study","volume":"23","author":"Mulrennan","year":"2018","journal-title":"Respirology"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0415","first-page":"97","article-title":"Supplemental vitamin D and physical performance in COPD: a pilot randomized trial","volume":"8","author":"Bjerk","year":"2013","journal-title":"Int. J. Chron. Ostruct. Pulmon. Dis."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0420","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1465-9921-13-84","article-title":"Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial","volume":"13","author":"Hornikx","year":"2012","journal-title":"Respir. Res."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0425","doi-asserted-by":"crossref","first-page":"105","DOI":"10.7326\/0003-4819-156-2-201201170-00004","article-title":"High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial","volume":"156","author":"Lehouck","year":"2012","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0430","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1586\/17476348.2015.1036032","article-title":"Vitamin D and omega-3 polyunsaturated fatty acid supplementation in athletes with exercise-induced bronchoconstriction: a pilot study","volume":"9","author":"Price","year":"2015","journal-title":"Expert Rev. Respir. Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0435","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12890-015-0101-4","article-title":"Prevention of exacerbations in patients with COPD and vitamin D deficiency through vitamin D supplementation (PRECOVID): a study protocol","volume":"15","author":"Rafiq","year":"2015","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0440","doi-asserted-by":"crossref","DOI":"10.3390\/nu9121353","article-title":"Effect of monthly, high-dose, long-term vitamin d on lung function: a randomized controlled trial","volume":"9","author":"Sluyter","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0445","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S2213-2600(14)70255-3","article-title":"Vitamin D 3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial","volume":"3","author":"Martineau","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0450","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5539\/gjhs.v7n4p243","article-title":"Effects of vitamin D intake on fev1 and copd exacerbation: a randomized clinical trial study","volume":"7","author":"Zendedel","year":"2015","journal-title":"Glob. J. Health Sci."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0455","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.2147\/COPD.S132117","article-title":"Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial","volume":"12","author":"Rafiq","year":"2017","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0460","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0465","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/bies.10368","article-title":"The pleiotropic actions of vitamin D","volume":"26","author":"Lin","year":"2004","journal-title":"Bioessays"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0470","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2164-11-26","article-title":"1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1","volume":"11","author":"Kovalenko","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0475","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022798","article-title":"Biologic phenotyping of the human small airway epithelial response to cigarette smoking","volume":"6","author":"Tilley","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0480","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117445","article-title":"Data-driven asthma endotypes defined from blood biomarker and gene expression data","volume":"10","author":"George","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2019.105505_bib0485","doi-asserted-by":"crossref","first-page":"13002","DOI":"10.1038\/srep13002","article-title":"The hormone-bound vitamin D receptor enhances the FBW7-dependent turnover of NF-kappaB subunits","volume":"5","author":"Fekrmandi","year":"2015","journal-title":"Sci. Rep."},{"issue":"Suppl. B","key":"10.1016\/j.jsbmb.2019.105505_bib0490","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.rmed.2005.09.010","article-title":"Systemic effects of COPD","volume":"99","author":"Decramer","year":"2005","journal-title":"Respir. Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0495","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1513\/pats.200504-026SR","article-title":"Systemic effects of chronic obstructive pulmonary disease","volume":"2","author":"Agusti","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0500","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jaci.2007.08.028","article-title":"Is vitamin D deficiency to blame for the asthma epidemic?","volume":"120","author":"Litonjua","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0505","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jaci.2016.11.019","article-title":"Vitamin D status through the first 10 years of life: a vital piece of the puzzle in asthma inception","volume":"139","author":"Litonjua","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0510","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1185\/03007995.2013.821057","article-title":"Could FEV(1) decline have a role in daily clinical practice for asthma monitoring?","volume":"29","author":"Sposato","year":"2013","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0515","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1164\/rccm.200703-456SO","article-title":"Global initiative for chronic obstructive lung, global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"176","author":"Rabe","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0520","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jsbmb.2017.08.009","article-title":"Why vitamin D clinical trials should be based on 25-hydroxyvitamin D concentrations","volume":"177","author":"Grant","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0525","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jsbmb.2017.06.006","article-title":"Limitations of vitamin D supplementation trials: why observational studies will continue to help determine the role of vitamin D in health","volume":"177","author":"Scragg","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0530","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.2147\/COPD.S101382","article-title":"The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis","volume":"11","author":"Zhu","year":"2016","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0535","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S2213-2600(17)30306-5","article-title":"Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data","volume":"5","author":"Jolliffe","year":"2017","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0540","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S2213-8587(17)30357-1","article-title":"Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials","volume":"5","author":"Autier","year":"2017","journal-title":"Lancet Diabe. Endocrinolo."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0545","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.rmed.2018.04.012","article-title":"The relationship between Vitamin D status and exacerbation in COPD patients- a literature review","volume":"139","author":"Ferrari","year":"2018","journal-title":"Respir. Med."},{"key":"10.1016\/j.jsbmb.2019.105505_bib0550","article-title":"Meta-analysis of gene expression microarray datasets in chronic obstructive pulmonary disease","author":"Rogers","year":"2019","journal-title":"bioRxiv"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096007601930398X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096007601930398X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:03:50Z","timestamp":1760745830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096007601930398X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":110,"alternative-id":["S096007601930398X"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2019.105505","relation":{},"ISSN":["0960-0760"],"issn-type":[{"type":"print","value":"0960-0760"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Translating vitamin D transcriptomics to clinical evidence: Analysis of data in asthma and chronic obstructive pulmonary disease, followed by clinical data meta-analysis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2019.105505","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105505"}}