{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:56:00Z","timestamp":1790085360032,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jsbmb.2021.105844","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T13:18:30Z","timestamp":1613049510000},"page":"105844","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["miR-130b-3p is high-expressed in polycystic ovarian syndrome and promotes granulosa cell proliferation by targeting SMAD4"],"prefix":"10.1016","volume":"209","author":[{"given":"Dongqin","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaohui","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijuan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jsbmb.2021.105844_bib0005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.31053\/1853.0605.v70.n1.20282","article-title":"[Polycystic ovary syndrome: physiopathology review]","volume":"70","author":"Fux Otta","year":"2013","journal-title":"Rev. Fac. Cien. Med. Univ. Nac. Cordoba"},{"key":"10.1016\/j.jsbmb.2021.105844_bib0010","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"10","key":"10.1016\/j.jsbmb.2021.105844_bib0015","first-page":"886","article-title":"[Polycystic ovary syndrome]","volume":"61","author":"Vrbikova","year":"2015","journal-title":"Vnitr. Lek."},{"issue":"3","key":"10.1016\/j.jsbmb.2021.105844_bib0020","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1210\/jc.2007-1650","article-title":"Granulosa cell survival and proliferation are altered in polycystic ovary syndrome","volume":"93","author":"Das","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105844_bib0025","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1210\/en.2017-00219","article-title":"Functional characterization of MicroRNA-27a-3p expression in human polycystic ovary syndrome","volume":"159","author":"Wang","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2021.105844_bib0030","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.biochi.2018.10.021","article-title":"Silencing of LncRNA steroid receptor RNA activator attenuates polycystic ovary syndrome in mice","volume":"157","author":"Li","year":"2019","journal-title":"Biochimie"},{"issue":"3","key":"10.1016\/j.jsbmb.2021.105844_bib0035","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.cell.2013.04.003","article-title":"The long and short of microRNA","volume":"153","author":"Yates","year":"2013","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jsbmb.2021.105844_bib0040","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/s41419-020-03018-3","article-title":"TRIM29 inhibits miR-873-5P biogenesis via CYTOR to upregulate fibronectin 1 and promotes invasion of papillary thyroid cancer cells","volume":"11","author":"Wu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"21","key":"10.1016\/j.jsbmb.2021.105844_bib0045","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1039\/D0BM01251C","article-title":"Smurf1-targeting miR-19b-3p-modified BMSCs combined PLLA composite scaffold to enhance osteogenic activity and treat critical-sized bone defects","volume":"8","author":"Xiong","year":"2020","journal-title":"Biomater. Sci."},{"issue":"9","key":"10.1016\/j.jsbmb.2021.105844_bib0050","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/s41419-020-03021-8","article-title":"Oxygen glucose deprivation\/re-oxygenation-induced neuronal cell death is associated with Lnc-D63785 m6A methylation and miR-422a accumulation","volume":"11","author":"Xu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.jsbmb.2021.105844_bib0055","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1002\/ctm2.179","article-title":"A novel miR-82 target PA2G4 and FHL3 checking myocardial ischemia","volume":"10","author":"Kang","year":"2020","journal-title":"Clin. Transl. Med."},{"issue":"5","key":"10.1016\/j.jsbmb.2021.105844_bib0060","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1139\/bcb-2019-0019","article-title":"MiR-204 suppresses cell proliferation and promotes apoptosis in ovarian granulosa cells via targeting TPT1 in polycystic ovary syndrome","volume":"97","author":"Sun","year":"2019","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.jsbmb.2021.105844_bib0065","article-title":"MicroRNA-130b functions as an oncogene and is a predictive marker of poor prognosis in lung adenocarcinoma","author":"Kim","year":"2020","journal-title":"Lab. Invest."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105844_bib0070","doi-asserted-by":"crossref","first-page":"17036","DOI":"10.1038\/s41598-018-35379-3","article-title":"Extracellular microRNAs profile in human follicular fluid and IVF outcomes","volume":"8","author":"Martinez","year":"2018","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.jsbmb.2021.105844_bib0075","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/molehr\/gaaa044","article-title":"miR-130b regulates gap junctional intercellular communication through connexin 43 in granulosa cells from patients with polycystic ovary syndrome","volume":"26","author":"Jiang","year":"2020","journal-title":"Mol. Hum. Reprod."},{"issue":"5","key":"10.1016\/j.jsbmb.2021.105844_bib0080","first-page":"1571","article-title":"MicroRNA431 inhibits the expression of surfactant proteins through the BMP4\/activin\/TGFbeta signaling pathway by targeting SMAD4","volume":"45","author":"Shen","year":"2020","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105844_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JME-19-0159","article-title":"PCOS serum-derived exosomal miR-27a-5p stimulates endometrial cancer cells migration and invasion","volume":"64","author":"Che","year":"2020","journal-title":"J. Mol. Endocrinol."},{"issue":"6","key":"10.1016\/j.jsbmb.2021.105844_bib0090","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2021.105844_bib0095","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mce.2004.10.012","article-title":"Molecular biology and physiological role of the oocyte factor, BMP-15","volume":"234","author":"Moore","year":"2005","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105844_bib0100","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1210\/edrv-5-1-76","article-title":"Hormonal regulation of the differentiation of cultured ovarian granulosa cells","volume":"5","author":"Hsueh","year":"1984","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jsbmb.2021.105844_bib0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0074-7696(08)61524-7","article-title":"Development of follicles in the mammalian ovary","volume":"124","author":"Hirshfield","year":"1991","journal-title":"Int. Rev. Cytol."},{"issue":"2","key":"10.1016\/j.jsbmb.2021.105844_bib0110","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1095\/biolreprod.107.063446","article-title":"Growth differentiation factor 9 (GDF9) stimulates proliferation and inhibits steroidogenesis by bovine theca cells: influence of follicle size on responses to GDF9","volume":"78","author":"Spicer","year":"2008","journal-title":"Biol. Reprod."},{"issue":"8","key":"10.1016\/j.jsbmb.2021.105844_bib0115","doi-asserted-by":"crossref","first-page":"13858","DOI":"10.1002\/jcp.28067","article-title":"Intraovarian injection of miR-224 as a marker of polycystic ovarian syndrome declines oocyte competency and embryo development","volume":"234","author":"Vahdat-Lasemi","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.jsbmb.2021.105844_bib0120","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1210\/me.2009-0432","article-title":"MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4","volume":"24","author":"Yao","year":"2010","journal-title":"Mol. Endocrinol."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105844_bib0125","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"E.A.-S.P.C.W.G. Rotterdam","year":"2004","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.jsbmb.2021.105844_bib0130","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1530\/REP-08-0315","article-title":"IGF1-induced AKT phosphorylation and cell proliferation are suppressed with the increase in PTEN during luteinization in human granulosa cells","volume":"137","author":"Goto","year":"2009","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105844_bib0135","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1210\/endo.142.1.7862","article-title":"Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor","volume":"142","author":"Nishi","year":"2001","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.jsbmb.2021.105844_bib0140","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"10.1016\/j.jsbmb.2021.105844_bib0145","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2010.217","article-title":"Polycystic ovary syndrome: etiology, pathogenesis and diagnosis","volume":"7","author":"Goodarzi","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jsbmb.2021.105844_bib0150","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mce.2015.01.030","article-title":"Characterization of microRNA profile in human cumulus granulosa cells: identification of microRNAs that regulate Notch signaling and are associated with PCOS","volume":"404","author":"Xu","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2021.105844_bib0155","article-title":"CircPSMC3 alleviates the symptoms of PCOS by sponging miR-296-3p and regulating PTEN expression","author":"Liu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"12","key":"10.1016\/j.jsbmb.2021.105844_bib0160","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.7150\/thno.43640","article-title":"Dysregulated Sp1\/miR-130b-3p\/HOXA5 axis contributes to tumor angiogenesis and progression of hepatocellular carcinoma","volume":"10","author":"Liao","year":"2020","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.jsbmb.2021.105844_bib0165","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41419-020-2621-y","article-title":"Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis","volume":"11","author":"Huang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105844_bib0170","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13046-020-01626-7","article-title":"M2 macrophage-derived extracellular vesicles promote gastric cancer progression via a microRNA-130b-3p\/MLL3\/GRHL2 signaling cascade","volume":"39","author":"Zhang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.jsbmb.2021.105844_bib0175","doi-asserted-by":"crossref","first-page":"e3174","DOI":"10.1038\/cddis.2017.516","article-title":"H19 lncRNA regulates keratinocyte differentiation by targeting miR-130b-3p","volume":"8","author":"Li","year":"2017","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.jsbmb.2021.105844_bib0180","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1093\/humrep\/dei068","article-title":"Serum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVF","volume":"20","author":"Onalan","year":"2005","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.jsbmb.2021.105844_bib0185","doi-asserted-by":"crossref","first-page":"E729","DOI":"10.1210\/jc.2014-3827","article-title":"MicroRNA-93 promotes ovarian granulosa cells proliferation through targeting CDKN1A in polycystic ovarian syndrome","volume":"100","author":"Jiang","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.jsbmb.2021.105844_bib0190","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.prp.2019.01.038","article-title":"MiR-222 promotes the progression of polycystic ovary syndrome by targeting p27 Kip1","volume":"215","author":"Huang","year":"2019","journal-title":"Pathol. Res. Pract."},{"issue":"3","key":"10.1016\/j.jsbmb.2021.105844_bib0195","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1002\/jcb.27688","article-title":"MiR-130b increases fibrosis of HMC cells by regulating the TGF-beta1 pathway in diabetic nephropathy","volume":"120","author":"Ma","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.jsbmb.2021.105844_bib0200","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1177\/1933719115597762","article-title":"Levels of regulatory proteins associated with cell proliferation in endometria from untreated patients having polycystic ovarian syndrome with and without endometrial hyperplasia","volume":"23","author":"Bacallao","year":"2016","journal-title":"Reprod. Sci."},{"issue":"3","key":"10.1016\/j.jsbmb.2021.105844_bib0205","doi-asserted-by":"crossref","first-page":"e2697","DOI":"10.1038\/cddis.2017.91","article-title":"BRE modulates granulosa cell death to affect ovarian follicle development and atresia in the mouse","volume":"8","author":"Yeung","year":"2017","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105844_bib0210","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12958-019-0505-8","article-title":"MicroRNA-200b and microRNA-200c are up-regulated in PCOS granulosa cell and inhibit KGN cell proliferation via targeting PTEN","volume":"17","author":"He","year":"2019","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2021.105844_bib0215","doi-asserted-by":"crossref","first-page":"110589","DOI":"10.1016\/j.mce.2019.110589","article-title":"MALAT1 is involved in the pathophysiological process of PCOS by modulating TGFbeta signaling in granulosa cells","volume":"499","author":"Zhang","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"issue":"28","key":"10.1016\/j.jsbmb.2021.105844_bib0220","doi-asserted-by":"crossref","first-page":"44522","DOI":"10.18632\/oncotarget.9936","article-title":"Onco-miR-130 promotes cell proliferation and migration by targeting TGFbetaR2 in gastric cancer","volume":"7","author":"Duan","year":"2016","journal-title":"Oncotarget"},{"issue":"145","key":"10.1016\/j.jsbmb.2021.105844_bib0225","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0037-2017","article-title":"Heritable pulmonary hypertension: from bench to bedside","volume":"26","author":"Girerd","year":"2017","journal-title":"Eur. Respir. Rev."},{"issue":"8","key":"10.1016\/j.jsbmb.2021.105844_bib0230","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082289","article-title":"Factors associated with heritable pulmonary arterial hypertension exert convergent actions on the miR-130\/301-Vascular matrix feedback loop","volume":"19","author":"Bertero","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105844_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7150\/ijbs.6.1","article-title":"Smad4-mediated TGF-beta signaling in tumorigenesis","volume":"6","author":"Yang","year":"2010","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.jsbmb.2021.105844_bib0240","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/cam4.1981","article-title":"miR-130a-3p regulated TGF-beta1-induced epithelial-mesenchymal transition depends on SMAD4 in EC-1 cells","volume":"8","author":"Tian","year":"2019","journal-title":"Cancer Med."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076021000376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076021000376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:07:14Z","timestamp":1760746034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076021000376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":48,"alternative-id":["S0960076021000376"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2021.105844","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-130b-3p is high-expressed in polycystic ovarian syndrome and promotes granulosa cell proliferation by targeting SMAD4","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2021.105844","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105844"}}