{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:23:08Z","timestamp":1778610188193,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["3096"],"award-info":[{"award-number":["3096"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jsbmb.2021.105845","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T11:20:49Z","timestamp":1614424849000},"page":"105845","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["N-terminal domain regulates steroid activation of elephant shark glucocorticoid and mineralocorticoid receptors"],"prefix":"10.1016","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2625-4626","authenticated-orcid":false,"given":"Yoshinao","family":"Katsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-882X","authenticated-orcid":false,"given":"Islam M.D.","family":"Shariful","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-8145","authenticated-orcid":false,"given":"Xiaozhi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7882-0223","authenticated-orcid":false,"given":"Wataru","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2079-738X","authenticated-orcid":false,"given":"Hiroshi","family":"Urushitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6184-3616","authenticated-orcid":false,"given":"Satomi","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Hyodo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jsbmb.2021.105845_bib0005","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nri.2017.1","article-title":"Immune regulation by glucocorticoids","volume":"17","author":"Cain","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.jsbmb.2021.105845_bib0010","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1210\/en.2014-1048","article-title":"From receptor balance to rational glucocorticoid therapy","volume":"155","author":"de Kloet","year":"2014","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.jsbmb.2021.105845_bib0015","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tem.2008.07.009","article-title":"Tissue-specific glucocorticoid action: a family affair","volume":"19","author":"Gross","year":"2008","journal-title":"Trends Endocrinol. Metab."},{"issue":"32","key":"10.1016\/j.jsbmb.2021.105845_bib0020","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.1602185113","article-title":"Stress and corticosteroids regulate rat hippocampal mitochondrial DNA gene expression via the glucocorticoid receptor","volume":"113","author":"Hunter","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.jsbmb.2021.105845_bib0025","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nrm.2016.152","article-title":"Glucocorticoid receptor control of transcription: precision and plasticity via allostery","volume":"18","author":"Weikum","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jsbmb.2021.105845_bib0030","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jsbmb.2014.10.020","article-title":"Origin of the response to adrenal and sex steroids: roles of promiscuity and co-evolution of enzymes and steroid receptors","volume":"151","author":"Baker","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"5770","key":"10.1016\/j.jsbmb.2021.105845_bib0035","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1123348","article-title":"Evolution of hormone-receptor complexity by molecular exploitation","volume":"312","author":"Bridgham","year":"2006","journal-title":"Science"},{"issue":"4854","key":"10.1016\/j.jsbmb.2021.105845_bib0040","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.3283939","article-title":"The steroid and thyroid hormone receptor superfamily","volume":"240","author":"Evans","year":"1988","journal-title":"Science"},{"issue":"4812","key":"10.1016\/j.jsbmb.2021.105845_bib0045","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.3037703","article-title":"Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor","volume":"237","author":"Arriza","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.jsbmb.2021.105845_bib0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jsbmb.2013.07.009","article-title":"Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors [published correction appears in J Steroid Biochem Mol Biol. 2014 Jan;139:104]","volume":"137","author":"Baker","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"5","key":"10.1016\/j.jsbmb.2021.105845_bib0055","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1210\/en.2010-1444","article-title":"Mineralocorticoid receptors: evolutionary and pathophysiological considerations","volume":"152","author":"Kassahn","year":"2011","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105845_bib0060","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1152\/physrev.00011.2014","article-title":"Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited","volume":"95","author":"Rossier","year":"2015","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105845_bib0065","doi-asserted-by":"crossref","first-page":"T1","DOI":"10.1530\/JOE-16-0661","article-title":"30 YEARS OF THE MINERALOCORTICOID RECEPTOR: evolution of the mineralocorticoid receptor: sequence, structure and function","volume":"234","author":"Baker","year":"2017","journal-title":"J. Endocrinol."},{"issue":"7482","key":"10.1016\/j.jsbmb.2021.105845_bib0070","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nature12826","article-title":"Elephant shark genome provides unique insights into gnathostome evolution [published correction appears in Nature. 2014 Sep 25;513(7519):574]","volume":"505","author":"Venkatesh","year":"2014","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.jsbmb.2021.105845_bib0075","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0896-6273(88)90136-5","article-title":"The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response","volume":"1","author":"Arriza","year":"1988","journal-title":"Neuron"},{"issue":"1-2","key":"10.1016\/j.jsbmb.2021.105845_bib0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0014-5793(99)01667-1","article-title":"Specific hydroxylations determine selective corticosteroid recognition by human glucocorticoid and mineralocorticoid receptors","volume":"464","author":"Hellal-Levy","year":"1999","journal-title":"FEBS Lett."},{"issue":"537","key":"10.1016\/j.jsbmb.2021.105845_bib0085","doi-asserted-by":"crossref","first-page":"eaao1520","DOI":"10.1126\/scisignal.aao1520","article-title":"Evolution of human, chicken, alligator, frog, and zebrafish mineralocorticoid receptors: allosteric influence on steroid specificity","volume":"11","author":"Katsu","year":"2018","journal-title":"Sci. Signal."},{"issue":"3","key":"10.1016\/j.jsbmb.2021.105845_bib0090","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1210\/endo.135.3.8070376","article-title":"The mineralocorticoid receptor discriminates aldosterone from glucocorticoids independently of the 11 beta-hydroxysteroid dehydrogenase","volume":"135","author":"Lombes","year":"1994","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.jsbmb.2021.105845_bib0095","first-page":"597","article-title":"Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor","volume":"7","author":"Rupprecht","year":"1993","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.jsbmb.2021.105845_bib0100","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0922-4106(93)90072-H","article-title":"Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands","volume":"247","author":"Rupprecht","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jsbmb.2021.105845_bib0105","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jsbmb.2015.07.025","article-title":"Allosteric role of the amino-terminal A\/B domain on corticosteroid transactivation of gar and human glucocorticoid receptors","volume":"154","author":"Oka","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1-2","key":"10.1016\/j.jsbmb.2021.105845_bib0110","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mce.2008.10.001","article-title":"Molecular mechanisms regulating glucocorticoid sensitivity and resistance","volume":"300","author":"Gross","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105845_bib0115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0092-8674(87)90753-7","article-title":"Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor","volume":"49","author":"Hollenberg","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.jsbmb.2021.105845_bib0120","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.32762","article-title":"Proteins acting out of (dis)order","volume":"6","author":"Eliezer","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.jsbmb.2021.105845_bib0125","article-title":"Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor [published correction appears in Elife. 2018 Feb 12;7:]","volume":"6","author":"Li","year":"2017","journal-title":"Elife"},{"issue":"5","key":"10.1016\/j.jsbmb.2021.105845_bib0130","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1073\/pnas.91.5.1619","article-title":"Delineation of a small region within the major transactivation domain of the human glucocorticoid receptor that mediates transactivation of gene expression","volume":"91","author":"Dahlman-Wright","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2021.105845_bib0135","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.steroids.2016.06.005","article-title":"Evolution of corticosteroid specificity for human, chicken, alligator and frog glucocorticoid receptors","volume":"113","author":"Katsu","year":"2016","journal-title":"Steroids"},{"issue":"9","key":"10.1016\/j.jsbmb.2021.105845_bib0140","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1021\/bi048777i","article-title":"Role of activation function domain-1, DNA binding, and coactivator GRIP1 in the expression of partial agonist activity of glucocorticoid receptor-antagonist complexes","volume":"44","author":"Cho","year":"2005","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.jsbmb.2021.105845_bib0145","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1124\/pr.114.008862","article-title":"International Union of Basic and Clinical Pharmacology. XC. Multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands","volume":"66","author":"Christopoulos","year":"2014","journal-title":"Pharmacol. Rev."},{"issue":"53","key":"10.1016\/j.jsbmb.2021.105845_bib0150","doi-asserted-by":"crossref","first-page":"44546","DOI":"10.1074\/jbc.M112.411330","article-title":"Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid receptor is accompanied by conformational reorganizations","volume":"287","author":"Khan","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"4800","key":"10.1016\/j.jsbmb.2021.105845_bib0155","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1126\/science.3563519","article-title":"Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation","volume":"236","author":"Miesfeld","year":"1987","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.jsbmb.2021.105845_bib0160","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1677\/JME-09-0152","article-title":"Mapping of AF1 transactivation domains in duplicated rainbow trout glucocorticoid receptors","volume":"45","author":"Sturm","year":"2010","journal-title":"J. Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.jsbmb.2021.105845_bib0165","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.mce.2011.03.024","article-title":"Folding of the glucocorticoid receptor N-terminal transactivation function: dynamics and regulation","volume":"348","author":"Kumar","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2021.105845_bib0170","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mce.2013.06.007","article-title":"Variable steroid receptor responses: intrinsically disordered AF1 is the key","volume":"376","author":"Simons","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"issue":"June (6)","key":"10.1016\/j.jsbmb.2021.105845_bib0175","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1210\/mend.14.6.0467","article-title":"Characterization of transactivational property and coactivator mediation of rat mineralocorticoid receptor activation function-1 (AF-1)","volume":"14","author":"Fuse","year":"2000","journal-title":"Mol. Endocrinol."},{"issue":"October (10)","key":"10.1016\/j.jsbmb.2021.105845_bib0180","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1210\/me.2010-0005","article-title":"Conformation of the mineralocorticoid receptor N-terminal domain: evidence for induced and stable structure","volume":"24","author":"Fischer","year":"2010","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.jsbmb.2021.105845_bib0185","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.mce.2010.12.033","article-title":"Molecular determinants of hormone sensitivity in rainbow trout glucocorticoid receptors 1 and 2","volume":"333","author":"Sturm","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105845_bib0190","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1530\/JOE-11-0372","article-title":"Mechanisms of ligand specificity of the mineralocorticoid receptor","volume":"213","author":"Fuller","year":"2012","journal-title":"J. Endocrinol."},{"issue":"6","key":"10.1016\/j.jsbmb.2021.105845_bib0195","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s11906-012-0297-0","article-title":"The ubiquitous mineralocorticoid receptor: clinical implications","volume":"14","author":"Hawkins","year":"2012","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.jsbmb.2021.105845_bib0200","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1210\/rp.57.1.339","article-title":"Reproductive functions of progesterone receptors","volume":"57","author":"Conneely","year":"2002","journal-title":"Recent Prog. Horm. Res."},{"issue":"7338","key":"10.1016\/j.jsbmb.2021.105845_bib0205","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/471313a","article-title":"Reproductive biology: progesterone\u2019s gateway into sperm [published correction appears in Nature. 2011 Mar 31;471(7340):589]","volume":"471","author":"Publicover","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jsbmb.2021.105845_bib0210","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2307\/4444260","article-title":"Nothing in biology makes sense except in the light of evolution","volume":"35","author":"Dobzhansky","year":"1973","journal-title":"Am. Biol. Teach."},{"issue":"584","key":"10.1016\/j.jsbmb.2021.105845_bib0215","doi-asserted-by":"crossref","first-page":"eaar2668","DOI":"10.1126\/scisignal.aar2668","article-title":"Transcriptional activation of elephant shark mineralocorticoid receptor by corticosteroids, progesterone, and spironolactone","volume":"12","author":"Katsu","year":"2019","journal-title":"Sci. Signal."},{"issue":"7482","key":"10.1016\/j.jsbmb.2021.105845_bib0220","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nature12826","article-title":"Elephant shark genome provides unique insights into gnathostome evolution [published correction appears in Nature. 2014 Sep 25;513(7519):574]","volume":"505","author":"Venkatesh","year":"2014","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.jsbmb.2021.105845_bib0225","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1093\/molbev\/msn204","article-title":"Evolution of hormone signaling in elasmobranchs by exploitation of promiscuous receptors","volume":"25","author":"Carroll","year":"2008","journal-title":"Mol. Biol. Evol."},{"issue":"2","key":"10.1016\/j.jsbmb.2021.105845_bib0230","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.mce.2012.10.014","article-title":"Molecular cloning and characterization of the corticoid receptors from the American alligator","volume":"365","author":"Oka","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.jsbmb.2021.105845_bib0235","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1210\/en.2009-0766","article-title":"Estrogen-dependent transactivation of amphioxus steroid hormone receptor via both estrogen and androgen response elements","volume":"151","author":"Katsu","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2021.105845_bib0240","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2148-11-14","article-title":"Evolution of ligand specificity in vertebrate corticosteroid receptors","volume":"11","author":"Arterbery","year":"2011","journal-title":"BMC Evol. Biol."},{"issue":"4924","key":"10.1016\/j.jsbmb.2021.105845_bib0245","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.2781282","article-title":"Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor","volume":"245","author":"Baulieu","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.jsbmb.2021.105845_bib0250","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.med.48.1.129","article-title":"RU486 (mifepristone): mechanisms of action and clinical uses","volume":"48","author":"Cadepond","year":"1997","journal-title":"Annu. Rev. Med."},{"issue":"11","key":"10.1016\/j.jsbmb.2021.105845_bib0255","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/molbev\/msq147","article-title":"Evolutionary origin and phylogeny of the modern holocephalans (Chondrichthyes: Chimaeriformes): a mitogenomic perspective","volume":"27","author":"Inoue","year":"2010","journal-title":"Mol. Biol. Evol."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105845_bib0260","doi-asserted-by":"crossref","first-page":"12148","DOI":"10.1038\/s41598-020-69061-4","article-title":"11-Deoxycortisol controls hydromineral balance in the most basal osmoregulating vertebrate, sea lamprey (Petromyzon marinus)","volume":"10","author":"Shaughnessy","year":"2020","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.jsbmb.2021.105845_bib0265","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1073\/pnas.81.12.3879","article-title":"RU 486: a steroid with antiglucocorticosteroid activity that only disinhibits the human pituitary-adrenal system at a specific time of day","volume":"81","author":"Gaillard","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105845_bib0270","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1530\/JME-15-0002","article-title":"Interaction between the trout mineralocorticoid and glucocorticoid receptors in vitro","volume":"55","author":"Kiilerich","year":"2015","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2021.105845_bib0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113976","article-title":"Progesterone: An enigmatic ligand for the mineralocorticoid receptor","volume":"177","author":"Baker","year":"2020","journal-title":"Biochem. Pharmacol."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076021000388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076021000388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:54:12Z","timestamp":1778568852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076021000388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":55,"alternative-id":["S0960076021000388"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2021.105845","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/822718","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-93334\/v1","asserted-by":"object"}]},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-terminal domain regulates steroid activation of elephant shark glucocorticoid and mineralocorticoid receptors","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2021.105845","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105845"}}