{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:16:25Z","timestamp":1779135385136,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jsbmb.2021.105965","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T18:07:15Z","timestamp":1633457235000},"page":"105965","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Vitamin D association with the renin angiotensin system in polycystic ovary syndrome"],"prefix":"10.1016","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-3917","authenticated-orcid":false,"given":"Alexandra E.","family":"Butler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abu Saleh Md","family":"Moin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thozhukat","family":"Sathyapalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen L.","family":"Atkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jsbmb.2021.105965_bib0005","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s00125-011-2398-8","article-title":"Reno-protective effects of renin-angiotensin system blockade in type 2 diabetic patients: a systematic review and network meta-analysis","volume":"55","author":"Vejakama","year":"2012","journal-title":"Diabetologia"},{"issue":"2A","key":"10.1016\/j.jsbmb.2021.105965_bib0010","doi-asserted-by":"crossref","first-page":"3A","DOI":"10.1016\/S0002-9149(01)02321-9","article-title":"The role of the renin-angiotensin system in the development of cardiovascular disease","volume":"89","author":"Unger","year":"2002","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"10.1016\/j.jsbmb.2021.105965_bib0015","doi-asserted-by":"crossref","first-page":"H1219","DOI":"10.1152\/ajpheart.00796.2011","article-title":"The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome","volume":"302","author":"Putnam","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105965_bib0020","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1467-789X.2003.00091.x","article-title":"Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related disorders","volume":"4","author":"Goossens","year":"2003","journal-title":"Obes. Rev."},{"key":"10.1016\/j.jsbmb.2021.105965_bib0025","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fendo.2014.00023","article-title":"Tissue Renin-Angiotensin systems: a unifying hypothesis of metabolic disease","volume":"5","author":"Skov","year":"2014","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"6","key":"10.1016\/j.jsbmb.2021.105965_bib0030","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr. Rev."},{"issue":"7","key":"10.1016\/j.jsbmb.2021.105965_bib0035","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/sj.ijo.0801994","article-title":"Obesity and the polycystic ovary syndrome","volume":"26","author":"Gambineri","year":"2002","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"issue":"9","key":"10.1016\/j.jsbmb.2021.105965_bib0040","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.2337\/db11-1360","article-title":"Polycystic ovary syndrome is a risk factor for type 2 diabetes: results from a long-term prospective study","volume":"61","author":"Gambineri","year":"2012","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105965_bib0045","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s12916-020-01697-5","article-title":"Polycystic ovary syndrome (PCOS) and COVID-19: an overlooked female patient population at potentially higher risk during the COVID-19 pandemic","volume":"18","author":"Kyrou","year":"2020","journal-title":"BMC Med."},{"issue":"2","key":"10.1016\/j.jsbmb.2021.105965_bib0050","doi-asserted-by":"crossref","first-page":"100113","DOI":"10.1016\/j.ajogmf.2020.100113","article-title":"Two cases of coronavirus 2019-related cardiomyopathy in pregnancy","volume":"2","author":"Juusela","year":"2020","journal-title":"Am J Obstet Gynecol MFM."},{"key":"10.1016\/j.jsbmb.2021.105965_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.metop.2020.100052","article-title":"Renin-angiotensin system overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?","author":"Moin","year":"2020","journal-title":"Metabolism open."},{"issue":"10","key":"10.1016\/j.jsbmb.2021.105965_bib0060","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1055\/s-2006-948308","article-title":"Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome","volume":"114","author":"Hahn","year":"2006","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"4","key":"10.1016\/j.jsbmb.2021.105965_bib0065","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.clnu.2011.12.010","article-title":"Low levels of 25(OH)D and insulin-resistance: 2 unrelated features or a cause-effect in PCOS?","volume":"31","author":"Muscogiuri","year":"2012","journal-title":"Clin. Nutr."},{"issue":"11","key":"10.1016\/j.jsbmb.2021.105965_bib0070","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1210\/jc.2015-2580","article-title":"Vitamin D supplementation decreases TGF-beta1 bioavailability in PCOS: a randomized placebo-controlled trial","volume":"100","author":"Irani","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2021.105965_bib0075","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7850816","article-title":"Vitamin D supplementation ameliorates metabolic dysfunction in patients with PCOS: a SystematicReview of RCTs and insight into the underlying mechanism","volume":"2020","author":"Guo","year":"2020","journal-title":"Int. J. Endocrinol."},{"issue":"9","key":"10.1016\/j.jsbmb.2021.105965_bib0080","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.19722","article-title":"Association of vitamin D status and other clinical characteristics with COVID-19 test results","volume":"3","author":"Meltzer","year":"2020","journal-title":"JAMA network open"},{"issue":"17","key":"10.1016\/j.jsbmb.2021.105965_bib0085","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1111\/febs.15495","article-title":"Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study","volume":"287","author":"Merzon","year":"2020","journal-title":"FEBS J."},{"issue":"9","key":"10.1016\/j.jsbmb.2021.105965_bib0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0239252","article-title":"SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels","volume":"15","author":"Kaufman","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2021.105965_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2020.105771","article-title":"Vitamin D and survival in COVID-19 patients: a quasi-experimental study","volume":"204","author":"Annweiler","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"11","key":"10.1016\/j.jsbmb.2021.105965_bib0100","doi-asserted-by":"crossref","DOI":"10.3390\/nu12113377","article-title":"Vitamin d supplementation associated to better survival in hospitalized frail elderly COVID-19 patients: the GERIA-COVID quasi-experimental study","volume":"12","author":"Annweiler","year":"2020","journal-title":"Nutrients."},{"key":"10.1016\/j.jsbmb.2021.105965_bib0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117808","article-title":"Lungs as target of COVID-19 infection: protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment","volume":"254","author":"Martin Gimenez","year":"2020","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.jsbmb.2021.105965_bib0110","doi-asserted-by":"crossref","first-page":"e2119","DOI":"10.1002\/rmv.2119","article-title":"A brief review of interplay between vitamin D and angiotensin\u2010converting enzyme 2: implications for a potential treatment for COVID\u201019","volume":"30","author":"Malek Mahdavi","year":"2020","journal-title":"Rev. Med. Virol."},{"issue":"6","key":"10.1016\/j.jsbmb.2021.105965_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0252799","article-title":"Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients","volume":"16","author":"Kragstrup","year":"2021","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105965_bib0120","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105965_bib0125","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1038\/s41598-018-22176-1","article-title":"Salivary and serum androgens with anti-Mullerian hormone measurement for the diagnosis of polycystic ovary syndrome","volume":"8","author":"Sathyapalan","year":"2018","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.jsbmb.2021.105965_bib0130","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/jc.2013-2350","article-title":"Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline","volume":"98","author":"Legro","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.jsbmb.2021.105965_bib0135","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/humupd\/dmp008","article-title":"Metabolic features of the reproductive phenotypes of polycystic ovary syndrome","volume":"15","author":"Moran","year":"2009","journal-title":"Hum. Reprod. Update"},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105965_bib0140","doi-asserted-by":"crossref","DOI":"10.3390\/nu11010188","article-title":"A randomized, controlled trial of vitamin d supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome","volume":"11","author":"Javed","year":"2019","journal-title":"Nutrients."},{"key":"10.1016\/j.jsbmb.2021.105965_bib0145","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jsbmb.2017.01.021","article-title":"Vitamin D supplementation guidelines","volume":"175","author":"Pludowski","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105965_bib0150","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.1038\/s41598-020-61531-z","article-title":"Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects","volume":"10","author":"Kahal","year":"2020","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.jsbmb.2021.105965_bib0155","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.2337\/dc20-1115","article-title":"Renin-angiotensin system overactivation in type 2 diabetes: a risk for SARS-CoV-2 infection?","volume":"43","author":"Moin","year":"2020","journal-title":"Diabetes Care"},{"issue":"10","key":"10.1016\/j.jsbmb.2021.105965_bib0160","doi-asserted-by":"crossref","first-page":"e26332","DOI":"10.1371\/journal.pone.0026332","article-title":"From SOMAmer-based biomarker discovery to diagnostic and clinical applications: a SOMAmer-based, streamlined multiplex proteomic assay","volume":"6","author":"Kraemer","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2021.105965_bib0165","doi-asserted-by":"crossref","first-page":"14357","DOI":"10.1038\/ncomms14357","article-title":"Connecting genetic risk to disease end points through the human blood plasma proteome","volume":"8","author":"Suhre","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105965_bib0170","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.1038\/s41598-020-61531-z","article-title":"Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects","volume":"10","author":"Kahal","year":"2020","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.jsbmb.2021.105965_bib0175","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2021.105965_bib0180","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Benjamini","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jsbmb.2021.105965_bib0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.metop.2020.100052","article-title":"Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?","volume":"7","author":"Moin","year":"2020","journal-title":"Metabolism open."},{"issue":"1","key":"10.1016\/j.jsbmb.2021.105965_bib0190","first-page":"1","article-title":"Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system","volume":"7","author":"Shi","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jsbmb.2021.105965_bib0195","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.3892\/mmr.2017.7546","article-title":"Vitamin D alleviates lipopolysaccharide\u2011induced acute lung injury via regulation of the renin\u2011angiotensin system","volume":"16","author":"Xu","year":"2017","journal-title":"Mol Med Report."},{"issue":"12","key":"10.1016\/j.jsbmb.2021.105965_bib0200","first-page":"1284","article-title":"Effect of vitamin D on ACE2 and vitamin D receptor expression in rats with LPS-induced acute lung injury","volume":"25","author":"Yang","year":"2016","journal-title":"Chinese Journal of Emergency Medicine."},{"issue":"4","key":"10.1016\/j.jsbmb.2021.105965_bib0205","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/jcp.30041","article-title":"ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID-19","volume":"236","author":"Rezaei","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.jsbmb.2021.105965_bib0210","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cardiores.2006.09.006","article-title":"ACE2 of the heart: from angiotensin I to angiotensin (1\u20137)","volume":"73","author":"Keidar","year":"2007","journal-title":"Cardiovasc. Res."},{"issue":"3","key":"10.1016\/j.jsbmb.2021.105965_bib0215","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.coph.2006.03.001","article-title":"Angiotensin-converting enzyme 2 in lung diseases","volume":"6","author":"Kuba","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jsbmb.2021.105965_bib0220","doi-asserted-by":"crossref","first-page":"105770","DOI":"10.1016\/j.jsbmb.2020.105770","article-title":"Coronavirus Disease 2019 (SARS-CoV-2) and polycystic ovarian disease: Is there a higher risk for these women?","volume":"205","author":"Morgante","year":"2021","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.jsbmb.2021.105965_bib0225","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1111\/jdv.17004","article-title":"Clinical symptoms of hyperandrogenic women diagnosed with COVID-19","volume":"35","author":"Cadegiani","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"12","key":"10.1016\/j.jsbmb.2021.105965_bib0230","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1210\/me.2013-1098","article-title":"Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element","volume":"27","author":"Clinckemalie","year":"2013","journal-title":"Mol. Endocrinol."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076021001588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076021001588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:10:45Z","timestamp":1760746245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076021001588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":46,"alternative-id":["S0960076021001588"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2021.105965","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D association with the renin angiotensin system in polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2021.105965","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105965"}}