{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:20:27Z","timestamp":1763018427287,"version":"build-2065373602"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jsbmb.2021.106041","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T12:25:30Z","timestamp":1638447930000},"page":"106041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Dihydrotestosterone through blockade of TGF-\u03b2\/Smad signaling mediates the anti-fibrosis effect under hypoxia in canine Sertoli cells"],"prefix":"10.1016","volume":"216","author":[{"given":"Longfei","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5790-6645","authenticated-orcid":false,"given":"Zihui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huawei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xihui","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemin","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2021.106041_bib0005","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0195-5616(91)50059-0","article-title":"Canine cryptorchidism","volume":"21","author":"Romagnoli","year":"1991","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0010","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.2460\/ajvr.2001.62.1198","article-title":"Heritability estimations for diseases, coat color, body weight, and height in a birth cohort of Boxers","volume":"62","author":"Nielen","year":"2001","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0015","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jcpa.2007.11.002","article-title":"Canine testicular tumours: a study on 232 dogs","volume":"138","author":"Grieco","year":"2008","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0020","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/tera.1420120107","article-title":"Cryptorchism and related defects in dogs: epidemiologic comparisons with man","volume":"12","author":"Pendergrass","year":"1975","journal-title":"Teratology."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/biolre\/ioy027","article-title":"50 years of spermatogenesis: sertoli cells and their interactions with germ cells","volume":"99","author":"Griswold","year":"2018","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-3-030-36214-0_9","article-title":"Cancer stem cell niche and immune-active tumor microenvironment in testicular germ cell tumors","volume":"1226","author":"Kalavska","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0035","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nrurol.2017.90","article-title":"Risk factors for cryptorchidism","volume":"14","author":"Gurney","year":"2017","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0040","doi-asserted-by":"crossref","first-page":"169","DOI":"10.5301\/uro.5000086","article-title":"Approccio moderno al criptorchidismo: quali evidenze? [Modern management of cryptorchidism: which evidences?]","volume":"81","author":"Caione","year":"2014","journal-title":"Urologia."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0045","doi-asserted-by":"crossref","first-page":"re8","DOI":"10.1126\/scisignal.2005189","article-title":"Signaling mechanisms of the epithelial-mesenchymal transition","volume":"7","author":"Gonzalez","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0050","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-981-13-8871-2_12","article-title":"Myofibroblast in kidney fibrosis: origin, activation, and regulation","volume":"1165","author":"Yuan","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0055","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0060","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.3748\/wjg.v22.i30.6841","article-title":"Cancer-associated fibroblasts in hepatocellular carcinoma","volume":"22","author":"Kubo","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2020.100845","article-title":"Hypoxia, partial EMT and collective migration: emerging culprits in metastasis","volume":"13","author":"Saxena","year":"2020","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0070","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3390\/ijms19051294","article-title":"TGF-\u03b2 and the tissue microenvironment: relevance in fibrosis and Cancer","volume":"19","author":"Caja","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0075","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/dvdy.23892","article-title":"Backdoor pathway for dihydrotestosterone biosynthesis: implications for normal and abnormal human sex development","volume":"242","author":"Fukami","year":"2013","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0080","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0090-4295(03)00045-1","article-title":"The role of dihydrotestosterone in benign prostatic hyperplasia","volume":"61","author":"Carson","year":"2003","journal-title":"Urology."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0085","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1111\/j.1743-6109.2011.02425.x","article-title":"The effects of chronic 5-alpha-reductase inhibitor (dutasteride) treatment on rat erectile function","volume":"8","author":"Pinsky","year":"2011","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0090","first-page":"172","article-title":"Molecular mechanisms of acclimatization to high altitude hypoxia: role of hypoxia mimetic cobalt chloride","volume":"1","author":"Bansal","year":"2009","journal-title":"DRDO Science Spectrum"},{"key":"10.1016\/j.jsbmb.2021.106041_bib0095","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.theriogenology.2017.10.025","article-title":"Melatonin promotes sheep Leydig cell testosterone secretion in a co-culture with Sertoli cells","volume":"106","author":"Deng","year":"2018","journal-title":"Theriogenology."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0100","doi-asserted-by":"crossref","first-page":"15182","DOI":"10.1002\/jcp.28159","article-title":"Dihydrotestosterone synthesis in the sheep corpus luteum and its potential mechanism in luteal regression","volume":"234","author":"Xiao","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0105","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1098\/rstb.2010.0010","article-title":"Tight junctions in the testis: new perspectives","volume":"365","author":"Mruk","year":"2010","journal-title":"Philos. Trans. R. Soc. Lond., B, Biol. Sci."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0110","doi-asserted-by":"crossref","first-page":"906","DOI":"10.2174\/092986709787549262","article-title":"Testicular cell junction: a novel target for male contraception","volume":"16","author":"Lee","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0115","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fendo.2019.00224","article-title":"Molecular mechanisms and signaling pathways involved in sertoli cell proliferation","volume":"10","author":"Meroni","year":"2019","journal-title":"Front. Endocrinol (Lausanne)."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0120","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1262\/jrd.2015-028","article-title":"Malfunction of spermatogenesis in experimental ischemic mice","volume":"61","author":"Yazama","year":"2015","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0125","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3406802","article-title":"Protection of pentoxifylline against testis injury induced by intermittent hypobaric hypoxia","volume":"2016","author":"Yao","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0130","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/j.1464-410X.2007.07406.x","article-title":"Fibrosis correlates with detailed histological analysis of human undescended testes","volume":"101","author":"Suskind","year":"2008","journal-title":"BJU Int."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0135","doi-asserted-by":"crossref","first-page":"16696","DOI":"10.1073\/pnas.0506084102","article-title":"Androgens regulate the permeability of the blood-testis barrier","volume":"102","author":"Meng","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/bies.20513","article-title":"Ectoplasmic specialization: a friend or a foe of spermatogenesis?","volume":"29","author":"Yan","year":"2007","journal-title":"Bioessays."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0145","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/er.2014-1101","article-title":"The mammalian blood-testis barrier: its biology and regulation","volume":"36","author":"Mruk","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0150","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/j.1464-410X.2007.07406.x","article-title":"Fibrosis correlates with detailed histological analysis of human undescended \u202ftestes","volume":"101","author":"Suskind","year":"2008","journal-title":"BJU Int."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0155","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/1096-9926(200101)63:1<42::AID-TERA1007>3.0.CO;2-K","article-title":"Morphologic and histochemical study of blood capillaries in boar testes: effects of abdominal cryptorchidism","volume":"63","author":"Pinart","year":"2001","journal-title":"Teratology."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0160","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1634\/theoncologist.9-90005-10","article-title":"The role of hypoxia-induced factors in tumor progression","volume":"5","author":"Vaupel","year":"2004","journal-title":"Oncologist."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0165","first-page":"172","article-title":"Molecular mechanisms of acclimatization to high altitude hypoxia: role of hypoxia mimetic cobalt chloride","volume":"1","author":"Bansal","year":"2009","journal-title":"DRDO. Science. Spectrum."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0170","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2164\/jandrol.108.007153","article-title":"Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele","volume":"31","author":"Wang","year":"2010","journal-title":"J. Androl."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0175","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000332740","article-title":"Gonadal and sex differentiation abnormalities of dogs and cats","volume":"6","author":"Meyers-Wallen","year":"2012","journal-title":"Sex. Dev."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0180","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.theriogenology.2011.08.030","article-title":"Plasma insulin-like peptide 3 and testosterone concentrations in male dogs: changes with age and effects of cryptorchidism","volume":"77","author":"Pathirana","year":"2012","journal-title":"Theriogenology."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0185","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/biolre\/ioy059","article-title":"Leydig cells: formation, function, and regulation","volume":"99","author":"Zirkin","year":"2018","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0190","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.fertnstert.2013.11.128","article-title":"The effect of 5\u03b1-reductase-2 deficiency on human fertility","volume":"101","author":"Kang","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0195","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1507\/endocrj.EJ19-0111","article-title":"Effects of pre- and post-pubertal dihydrotestosterone treatment on penile length in 5\u03b1-reductase type 2 deficiency","volume":"66","author":"Sasaki","year":"2019","journal-title":"Endocr. J."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0200","doi-asserted-by":"crossref","first-page":"8894","DOI":"10.1038\/srep08894","article-title":"Testosterone regulates the autophagic clearance of androgen binding protein in rat Sertoli cells","volume":"5","author":"Ma","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0205","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1016\/S0021-9258(19)69381-6","article-title":"Androgen-binding protein. Purification from rat epididymis, characterization, and immunocytochemical localization","volume":"256","author":"Feldman","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0210","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1095\/biolreprod56.1.14","article-title":"Expression and distribution of androgen-binding protein\/sex hormone-binding globulin in the female rodent reproductive system","volume":"56","author":"Joseph","year":"1997","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0215","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5603\/FHC.2011.0010","article-title":"DHT deficiency perturbs the integrity of the rat seminiferous epithelium by disrupting tight and adherens junctions","volume":"49","author":"Kolasa","year":"2011","journal-title":"Folia Histochem. Cytobiol."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0220","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12967-020-02249-4","article-title":"Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis","volume":"18","author":"Wang","year":"2020","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0225","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1248\/bpb.29.1246","article-title":"Perifollicular fibrosis: pathogenetic role in androgenetic alopecia","volume":"29","author":"Yoo","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0230","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1152\/ajprenal.00135.2009","article-title":"Dose-dependent effects of dihydrotestosterone in the streptozotocin-induced diabetic rat kidney","volume":"297","author":"Xu","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.154986","article-title":"Hypoxia upregulates Cxcl12 in hepatocytes by a complex mechanism involving hypoxia-inducible factors and transforming growth factor-\u03b2","volume":"127","author":"Strickland","year":"2020","journal-title":"Cytokine."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0240","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1038\/s41467-019-10859-w","article-title":"Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M","volume":"10","author":"Abe","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0245","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1080\/15384101.2019.1670508","article-title":"HIF-1\u03b1 promotes the keloid development through the activation of TGF-\u03b2\/Smad and TLR4\/MyD88\/NF-\u03baB pathways","volume":"18","author":"Lei","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jsbmb.2021.106041_bib0250","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00432-015-1998-y","article-title":"Role of dihydrotestosterone (DHT) on TGF-\u03b21 signaling pathway in epithelial ovarian cancer cells","volume":"142","author":"Kohan-Ivani","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.jsbmb.2021.106041_bib0255","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1038\/onc.2013.374","article-title":"Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer","volume":"33","author":"Mishra","year":"2014","journal-title":"Oncogene."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096007602100234X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096007602100234X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:08:29Z","timestamp":1760746109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096007602100234X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":51,"alternative-id":["S096007602100234X"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2021.106041","relation":{},"ISSN":["0960-0760"],"issn-type":[{"type":"print","value":"0960-0760"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dihydrotestosterone through blockade of TGF-\u03b2\/Smad signaling mediates the anti-fibrosis effect under hypoxia in canine Sertoli cells","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2021.106041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106041"}}