{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:37:13Z","timestamp":1789263433780,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jsbmb.2023.106305","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T13:35:22Z","timestamp":1680010522000},"page":"106305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Discover boy specific-biomarkers and reveal gender-related metabolic differences in central precocious puberty"],"prefix":"10.1016","volume":"231","author":[{"given":"Jinxia","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiping","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2023.106305_bib1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S2213-8587(15)00380-0","article-title":"Causes, diagnosis, and treatment of central precocious puberty","volume":"4","author":"Latronico","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.jsbmb.2023.106305_bib2","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1210\/jcem.87.6.8668","article-title":"Clinical review 148: Monogenic disorders of puberty","volume":"87","author":"Kalantaridou","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2023.106305_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199019","article-title":"Central precocious puberty in Boston boys: A 10-year single center experience","volume":"13","author":"Topor","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2023.106305_bib4","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4274\/jcrpe.galenos.2021.2021.0033","article-title":"Precocious puberty in boys: a study based on five years of data from a single center in Northern China","volume":"13","author":"Ziqin","year":"2021","journal-title":"J. Clin. Res Pedia Endocrinol."},{"key":"10.1016\/j.jsbmb.2023.106305_bib5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/cen.14462","article-title":"The incidence of brain lesions in central precocious puberty: The main cause for Chinese boys was idiopathic","volume":"95","author":"Wang","year":"2021","journal-title":"Clin. Endocrinol. (Oxf. )"},{"key":"10.1016\/j.jsbmb.2023.106305_bib6","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/jamapediatrics.2019.2306","article-title":"Male Pubertal Timing-Boys Will Be Men, but When?","volume":"173","author":"Curtis","year":"2019","journal-title":"JAMA Pedia"},{"key":"10.1016\/j.jsbmb.2023.106305_bib7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000501336","article-title":"Use of gonadotropin-releasing hormone analogs in children: update by an international consortium","volume":"91","author":"Bangalore Krishna","year":"2019","journal-title":"Horm. Res Paediatr."},{"key":"10.1016\/j.jsbmb.2023.106305_bib8","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1021\/acs.jproteome.0c00879","article-title":"Metabolic interactions and differences between coronary heart disease and diabetes mellitus: a pilot study on biomarker determination and pathogenesis","volume":"20","author":"Liu","year":"2021","journal-title":"J. Proteome Res"},{"key":"10.1016\/j.jsbmb.2023.106305_bib9","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.jsbmb.2023.106305_bib10","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.jsbmb.2023.106305_bib11","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.2047-6310.2013.00176.x","article-title":"Timing of puberty and physical growth in obese children: a longitudinal study in boys and girls","volume":"9","author":"De Leonibus","year":"2014","journal-title":"Pedia Obes."},{"key":"10.1016\/j.jsbmb.2023.106305_bib12","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/10253890.2017.1369523","article-title":"Hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes: sex differences in regulation of stress responsivity","volume":"20","author":"Oyola","year":"2017","journal-title":"Stress"},{"key":"10.1016\/j.jsbmb.2023.106305_bib13","doi-asserted-by":"crossref","DOI":"10.1080\/21565562.2014.996025","article-title":"Endocrine control of spermatogenesis: Role of FSH and LH\/ testosterone","volume":"4","author":"Ramaswamy","year":"2014","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.jsbmb.2023.106305_bib14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fendo.2020.00101","article-title":"DHEAS and human development: an evolutionary perspective","volume":"11","author":"Campbell","year":"2020","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jsbmb.2023.106305_bib15","doi-asserted-by":"crossref","first-page":"10774","DOI":"10.1021\/acs.jafc.1c03077","article-title":"Understanding choline bioavailability and utilization: first step toward personalizing choline nutrition","volume":"69","author":"Goh","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jsbmb.2023.106305_bib16","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/jbmr.195","article-title":"Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification","volume":"26","author":"Yadav","year":"2011","journal-title":"J. Bone Min. Res"},{"key":"10.1016\/j.jsbmb.2023.106305_bib17","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuroscience.2021.08.004","article-title":"N, N-dimethylglycine protects behavioral disturbances and synaptic deficits induced by repeated ketamine exposure in mice","volume":"472","author":"Hsieh","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.jsbmb.2023.106305_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152613","article-title":"N,N-dimethylglycine prevents toluene-induced impairment in recognition memory and synaptic plasticity in mice","volume":"446","author":"Hsieh","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.jsbmb.2023.106305_bib19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.aninu.2018.04.003","article-title":"Role of D-aspartate on biosynthesis, racemization, and potential functions: A mini-review","volume":"4","author":"Li","year":"2018","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.jsbmb.2023.106305_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.crvi.2017.11.002","article-title":"Sex hormone levels in the brain of d-aspartate-treated rats","volume":"341","author":"Di Fiore","year":"2018","journal-title":"C. R. Biol."},{"key":"10.1016\/j.jsbmb.2023.106305_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.689719","article-title":"Human D-aspartate Oxidase: A Key Player in D-aspartate Metabolism","volume":"8","author":"Pollegioni","year":"2021","journal-title":"Front Mol. Biosci."},{"key":"10.1016\/j.jsbmb.2023.106305_bib22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bone.2019.01.020","article-title":"Nutritional supplementation with myo-inositol in growing mice specifically augments mandibular endochondral growth","volume":"121","author":"Yamaguchi","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.jsbmb.2023.106305_bib23","first-page":"30","article-title":"Myo-inositol as a male fertility molecule: speed them up!","volume":"21","author":"Condorelli","year":"2017","journal-title":"Eur. Rev. Med Pharm. Sci."},{"key":"10.1016\/j.jsbmb.2023.106305_bib24","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1038\/npp.2015.57","article-title":"Evaluation of myo-inositol as a potential biomarker for depression in schizophrenia","volume":"40","author":"Chiappelli","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jsbmb.2023.106305_bib25","article-title":"Acetoacetate enhancement of glucose mediated DNA glycation","volume":"25","author":"Bagherzadeh-Yazdi","year":"2021","journal-title":"Biochem Biophys. Rep."},{"key":"10.1016\/j.jsbmb.2023.106305_bib26","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.bbrc.2016.03.109","article-title":"Enhanced and suppressed mineralization by acetoacetate and beta-hydroxybutyrate in osteoblast cultures","volume":"473","author":"Saito","year":"2016","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.jsbmb.2023.106305_bib27","first-page":"991","article-title":"Level of serum creatinine and creatinine clearance rate in obese female","volume":"30","author":"Meherubin","year":"2021","journal-title":"Mymensingh Med J."},{"key":"10.1016\/j.jsbmb.2023.106305_bib28","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1373\/clinchem.2014.232918","article-title":"GlycA: a composite nuclear magnetic resonance biomarker of systemic inflammation","volume":"61","author":"Otvos","year":"2015","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jsbmb.2023.106305_bib29","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.clinbiochem.2015.05.001","article-title":"GlycA, a biomarker of inflammatory glycoproteins, is more closely related to the leptin\/adiponectin ratio than to glucose tolerance status","volume":"48","author":"Dullaart","year":"2015","journal-title":"Clin. Biochem"},{"key":"10.1016\/j.jsbmb.2023.106305_bib30","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.011072","article-title":"Urinary metabolite markers of precocious puberty","volume":"11","author":"Qi","year":"2012","journal-title":"Mol. Cell Proteom."},{"issue":"Suppl 3","key":"10.1016\/j.jsbmb.2023.106305_bib31","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1186\/1752-0509-6-S3-S19","article-title":"Potential metabolic mechanism of girls' central precocious puberty: a network analysis on urine metabonomics data","volume":"6","author":"Yang","year":"2012","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.jsbmb.2023.106305_bib32","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41586-020-2857-9","article-title":"Macrophage-derived glutamine boosts satellite cells and muscle regeneration","volume":"587","author":"Shang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jsbmb.2023.106305_bib33","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.cmet.2019.01.016","article-title":"Glutamine metabolism regulates proliferation and lineage allocation in skeletal stem cells","volume":"29","author":"Yu","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.jsbmb.2023.106305_bib34","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1515\/hsz-2016-0261","article-title":"Is N,N-dimethylglycine N-oxide a choline and betaine metabolite?","volume":"398","author":"Lever","year":"2017","journal-title":"Biol. Chem."},{"key":"10.1016\/j.jsbmb.2023.106305_bib35","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1002\/mnfr.201300142","article-title":"Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach","volume":"57","author":"Pekkinen","year":"2013","journal-title":"Mol. Nutr. Food Res"},{"key":"10.1016\/j.jsbmb.2023.106305_bib36","article-title":"Higher Dietary Choline and Betaine Intakes Are Associated with Better Body Composition in the Adult Population of Newfoundland, Canada","volume":"11","author":"Gao","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2023.106305_bib37","article-title":"L-Methionine protects against oxidative stress and mitochondrial dysfunction in an in vitro model of Parkinson's disease","volume":"10","author":"Catanesi","year":"2021","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.jsbmb.2023.106305_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19040954","article-title":"Branched chain amino acids: beyond nutrition metabolism","volume":"19","author":"Nie","year":"2018","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jsbmb.2023.106305_bib39","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1038\/s41467-020-16568-z","article-title":"Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution","volume":"11","author":"Yap","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jsbmb.2023.106305_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101106","article-title":"Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function","volume":"43","author":"Gheller","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jsbmb.2023.106305_bib41","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1039\/D0FO02156C","article-title":"Isoleucine increases muscle mass through promoting myogenesis and intramyocellular fat deposition","volume":"12","author":"Liu","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.jsbmb.2023.106305_bib42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.6065\/apem.2017.22.1.27","article-title":"Change in body mass index and insulin resistance after 1-year treatment with gonadotropin-releasing hormone agonists in girls with central precocious puberty","volume":"22","author":"Park","year":"2017","journal-title":"Ann. Pedia Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2023.106305_bib43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13633-016-0033-7","article-title":"Body mass index in girls with idiopathic central precocious puberty during and after treatment with GnRH analogues","volume":"2016","author":"Arcari","year":"2016","journal-title":"Int J. Pedia Endocrinol."},{"key":"10.1016\/j.jsbmb.2023.106305_bib44","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1080\/09513590.2020.1770212","article-title":"Reis, Telomere length is not altered in girls with idiopathic central precocious puberty treated with a GnRH analog - leuprolide acetate","volume":"36","author":"Furtado","year":"2020","journal-title":"Gynecol. Endocrinol."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076023000602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076023000602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:11:07Z","timestamp":1760746267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076023000602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":44,"alternative-id":["S0960076023000602"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2023.106305","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discover boy specific-biomarkers and reveal gender-related metabolic differences in central precocious puberty","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2023.106305","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106305"}}