{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:04:20Z","timestamp":1783109060161,"version":"3.54.6"},"reference-count":129,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jsbmb.2023.106356","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:53:10Z","timestamp":1687913590000},"page":"106356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The role of hormones in the pathogenesis and treatment mechanisms of delirium in ICU: The past, the present, and the future"],"prefix":"10.1016","volume":"233","author":[{"given":"Yuchun","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2023.106356_bib1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41572-020-00223-4","article-title":"Delirium","volume":"6","author":"Wilson","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jsbmb.2023.106356_bib2","first-page":"191","article-title":"Diagnostic and statistical manual of mental disorders (DSM)","volume":"25","author":"Battle","year":"2013","journal-title":"Codas"},{"key":"10.1016\/j.jsbmb.2023.106356_bib3","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1007\/s40520-021-01806-1","article-title":"Delirium in your house: a survey during General Practitioner-programmed home visits","volume":"33","author":"Tremolizzo","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.jsbmb.2023.106356_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/MCC.0000000000000382","article-title":"Limiting sedation for patients with acute respiratory distress syndrome - time to wake up","volume":"23","author":"Shah","year":"2017","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.jsbmb.2023.106356_bib5","first-page":"30","article-title":"Identifying patterns of delirium in hospitalized patients on dexamethasone using a chart abstraction tool","volume":"32","author":"Chang","year":"2018","journal-title":"J. Pain. Palliat. Care Pharm."},{"key":"10.1016\/j.jsbmb.2023.106356_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/J354v21n04_14","article-title":"2nd, Role of corticosteroids in palliative care","volume":"21","author":"Shih","year":"2007","journal-title":"J. Pain. Palliat. Care Pharmacother."},{"key":"10.1016\/j.jsbmb.2023.106356_bib7","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1001\/jama.2020.17023","article-title":"Association between administration of systemic corticosteroids and mortality among critically Ill patients with COVID-19: a meta-analysis","volume":"324","author":"W.H.O.R.E.A.f.C.-T.W. Group","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2023.106356_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/a-1300-2550","article-title":"The role of glucocorticoids in the management of COVID-19","volume":"53","author":"Alexaki","year":"2021","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.jsbmb.2023.106356_bib9","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.4065\/81.10.1361","article-title":"Psychiatric adverse effects of corticosteroids","volume":"81","author":"Warrington","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.jsbmb.2023.106356_bib10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.hlc.2015.09.012","article-title":"Dopamine administration is a risk factor for delirium in patients undergoing coronary artery bypass surgery","volume":"25","author":"Yilmaz","year":"2016","journal-title":"Heart Lung Circ."},{"key":"10.1016\/j.jsbmb.2023.106356_bib11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/iub.1491","article-title":"5-HT(1A) receptor antagonist improves behavior performance of delirium rats through inhibiting PI3K\/Akt\/mTOR activation-induced NLRP3 activity","volume":"68","author":"Qiu","year":"2016","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jsbmb.2023.106356_bib12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.bja.2021.04.033","article-title":"Preoperative inflammatory mediators and postoperative delirium: systematic review and meta-analysis","volume":"127","author":"Noah","year":"2021","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.jsbmb.2023.106356_bib13","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1001\/jama.286.21.2703","article-title":"Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU","volume":"286","author":"Ely","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2023.106356_bib14","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/cc11407","article-title":"The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies","volume":"16","author":"Gusmao-Flores","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.jsbmb.2023.106356_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.749522","article-title":"Preschool confusion assessment method for the intensive care unit-Spanish (psCAM-ICU-S): cross-cultural adaptation and validation in colombia","volume":"9","author":"Pinzon-Casas","year":"2021","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.jsbmb.2023.106356_bib16","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s11011-015-9679-8","article-title":"The confusion assessment method for the intensive care unit in patients with cirrhosis","volume":"30","author":"Orman","year":"2015","journal-title":"Metab. Brain. Dis."},{"key":"10.1016\/j.jsbmb.2023.106356_bib17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/2110-5820-2-49","article-title":"Delirium in the ICU: an overview","volume":"2","author":"Cavallazzi","year":"2012","journal-title":"Ann. Intensive Care"},{"key":"10.1016\/j.jsbmb.2023.106356_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13054-022-03931-3","article-title":"Distribution of delirium motor subtypes in the intensive care unit: a systematic scoping review","volume":"26","author":"la Cour","year":"2022","journal-title":"Crit. Care"},{"key":"10.1016\/j.jsbmb.2023.106356_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jpsychores.2008.05.019","article-title":"Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses","volume":"65","author":"Maclullich","year":"2008","journal-title":"J. Psychosom. Res"},{"key":"10.1016\/j.jsbmb.2023.106356_bib20","doi-asserted-by":"crossref","first-page":"1136386","DOI":"10.1155\/2022\/1136386","article-title":"Correlation analysis of inflammatory markers CRP and IL-6 and postoperative delirium (POD) in elderly patients: a meta-analysis of observational studies","volume":"2022","author":"Huang","year":"2022","journal-title":"J. Environ. Public Health"},{"key":"10.1016\/j.jsbmb.2023.106356_bib21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40560-016-0145-4","article-title":"A clinical perspective of sepsis-associated delirium","volume":"4","author":"Tsuruta","year":"2016","journal-title":"J. Intensive Care"},{"key":"10.1016\/j.jsbmb.2023.106356_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.91229","article-title":"Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice","volume":"2","author":"Feng","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.jsbmb.2023.106356_bib23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1159\/000071472","article-title":"Entry of blood-borne cytokines into the central nervous system: effects on cognitive processes","volume":"10","author":"Banks","year":"2002","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.jsbmb.2023.106356_bib24","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2217\/fnl.10.1","article-title":"Microglia in ischemic brain injury","volume":"5","author":"Weinstein","year":"2010","journal-title":"Future Neurol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib25","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1189\/jlb.1109766","article-title":"Inflammatory mechanisms in ischemic stroke: role of inflammatory cells","volume":"87","author":"Jin","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.686665","article-title":"Predisposing and precipitating risk factors for delirium in elderly patients admitted to a cardiology ward: an observational cohort study in 1,042 patients","volume":"8","author":"Zipser","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.jsbmb.2023.106356_bib27","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0140-6736(09)61158-2","article-title":"Systemic infection and delirium: when cytokines and acetylcholine collide","volume":"375","author":"van Gool","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jsbmb.2023.106356_bib28","article-title":"The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke","volume":"2","author":"Caeiro","year":"2021","journal-title":"Cereb. Circ. Cogn. Behav."},{"key":"10.1016\/j.jsbmb.2023.106356_bib29","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1080\/08820139.2017.1373898","article-title":"Anesthetic immunomodulation of the neuroinflammation in postoperative cognitive dysfunction","volume":"46","author":"Umholtz","year":"2017","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.jsbmb.2023.106356_bib30","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1532-5415.2011.03883.x","article-title":"The cholinergic system and inflammation: common pathways in delirium pathophysiology","volume":"60","author":"Cerejeira","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.jsbmb.2023.106356_bib31","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/cns.13103","article-title":"Abnormal composition of gut microbiota contributes to delirium-like behaviors after abdominal surgery in mice","volume":"25","author":"Zhang","year":"2019","journal-title":"CNS Neurosci. Ther."},{"issue":"86","key":"10.1016\/j.jsbmb.2023.106356_bib32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/prd.12377","article-title":"Microbial transitions from health to disease","volume":"2000","author":"Joseph","year":"2021","journal-title":"Periodontol"},{"key":"10.1016\/j.jsbmb.2023.106356_bib33","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/MCC.0000000000000424","article-title":"Gut microbiota and host defense in critical illness","volume":"23","author":"Jacobs","year":"2017","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.jsbmb.2023.106356_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/nu15030496","article-title":"Protective effect of anthocyanins against neurodegenerative diseases through the microbial-intestinal-brain axis: a critical review","volume":"15","author":"Zhong","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jsbmb.2023.106356_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrgastro.2016.200","article-title":"Gut-brain axis in 2016: Brain-gut-microbiota axis - mood, metabolism and behaviour","volume":"14","author":"Dinan","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12871-018-0642-1","article-title":"Effects of prebiotic galacto-oligosaccharide on postoperative cognitive dysfunction and neuroinflammation through targeting of the gut-brain axis","volume":"18","author":"Yang","year":"2018","journal-title":"BMC Anesth."},{"key":"10.1016\/j.jsbmb.2023.106356_bib37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.biocel.2005.08.020","article-title":"Melatonin","volume":"38","author":"Hardeland","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1385\/ENDO:27:2:201","article-title":"Melatonin, aging, and age-related diseases: perspectives for prevention, intervention, and therapy","volume":"27","author":"Poeggeler","year":"2005","journal-title":"Endocrine"},{"key":"10.1016\/j.jsbmb.2023.106356_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12040959","article-title":"Impaired melatonin secretion, oxidative stress and metabolic syndrome in night shift work","volume":"12","author":"Hohor","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jsbmb.2023.106356_bib40","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00134-022-06656-7","article-title":"Melatonin in ICU delirium: shining light on the hormone of darkness","volume":"48","author":"Burry","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jsbmb.2023.106356_bib41","article-title":"Sleep disturbances and depression are co-morbid conditions: insights from animal models, especially non-human primate model","volume":"12","author":"Li","year":"2021","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.jsbmb.2023.106356_bib42","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/gps.2582","article-title":"Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial","volume":"26","author":"Al-Aama","year":"2011","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jsbmb.2023.106356_bib43","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.genhosppsych.2011.03.013","article-title":"Treatment of delirium with ramelteon: initial experience in three patients","volume":"33","author":"Kimura","year":"2011","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jsbmb.2023.106356_bib44","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00134-005-0061-x","article-title":"Melatonin: possible implications for the postoperative and critically ill patient","volume":"32","author":"Bourne","year":"2006","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jsbmb.2023.106356_bib45","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s00134-022-06638-9","article-title":"Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial","volume":"48","author":"Wibrow","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jsbmb.2023.106356_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/biom11020217","article-title":"Insulin-like growth factor-1 (IGF-1) and its monitoring in medical diagnostic and in sports","volume":"11","author":"Bailes","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jsbmb.2023.106356_bib47","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0165-5728(01)00388-5","article-title":"Tumor necrosis factor(alpha) and insulin-like growth factor-I in the brain: is the whole greater than the sum of its parts?","volume":"119","author":"Venters","year":"2001","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib48","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/advances\/nmaa139","article-title":"Perspective: prospects for nutraceutical support of intestinal barrier function","volume":"12","author":"McCarty","year":"2021","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jsbmb.2023.106356_bib49","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1159\/000527061","article-title":"The role of insulin-like growth factor 1 in delirium: a systematic review and meta-analysis","volume":"51","author":"Adamis","year":"2022","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.jsbmb.2023.106356_bib50","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1210\/endo.135.5.7525251","article-title":"Insulin-like growth factors cross the blood-brain barrier","volume":"135","author":"Reinhardt","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2023.106356_bib51","doi-asserted-by":"crossref","first-page":"M79","DOI":"10.1093\/gerona\/56.2.M79","article-title":"Serum insulin-like growth factor-1 in centenarians: implications of IGF-1 as a rapid turnover protein","volume":"56","author":"Arai","year":"2001","journal-title":"J. Gerontol. A-Biol. Sci. Med. Sci."},{"key":"10.1016\/j.jsbmb.2023.106356_bib52","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/gerona\/63.7.764","article-title":"Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence","volume":"63","author":"Hshieh","year":"2008","journal-title":"J. Gerontol. A-Biol. Sci. Med. Sci."},{"key":"10.1016\/j.jsbmb.2023.106356_bib53","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.jagp.2013.09.005","article-title":"Neuropathogenesis of delirium: review of current etiologic theories and common pathways","volume":"21","author":"Maldonado","year":"2013","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jsbmb.2023.106356_bib54","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.neuro.051508.135535","article-title":"The neuropsychopharmacology of fronto-executive function: monoaminergic modulation","volume":"32","author":"Robbins","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.jsbmb.2023.106356_bib55","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1124\/pharmrev.122.000618","article-title":"Dopamine, Immunity, and Disease","volume":"75","author":"Channer","year":"2023","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jsbmb.2023.106356_bib56","first-page":"132","article-title":"Is there a final common neural pathway in delirium? Focus on acetylcholine and dopamine","volume":"5","author":"Trzepacz","year":"2000","journal-title":"Semin Clin. Neuropsychiatry"},{"key":"10.1016\/j.jsbmb.2023.106356_bib57","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1056\/NEJMe1813382","article-title":"Dopamine antagonists in ICU delirium","volume":"379","author":"Bleck","year":"2018","journal-title":"New Engl. J. Med"},{"key":"10.1016\/j.jsbmb.2023.106356_bib58","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0031-9384(98)00225-X","article-title":"Unilateral block of NMDA receptors in the amygdala prevents predator stress-induced lasting increases in anxiety-like behavior and unconditioned startle--effective hemisphere depends on the behavior","volume":"65","author":"Adamec","year":"1999","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jsbmb.2023.106356_bib59","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.bbrc.2017.03.093","article-title":"Chronic stress-induced dendritic reorganization and abundance of synaptosomal PKA-dependent CP-AMPA receptor in the basolateral amygdala in a mouse model of depression","volume":"486","author":"Yi","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jsbmb.2023.106356_bib60","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1159\/000363762","article-title":"Do stress markers and anesthetic technique predict delirium in the elderly?","volume":"38","author":"Deiner","year":"2014","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.jsbmb.2023.106356_bib61","first-page":"51","article-title":"Noradrenaline and behavior","volume":"59","author":"Prokopova","year":"2010","journal-title":"Cesk Fysiol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib62","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1556\/ABiol.53.2002.1-2.21","article-title":"Nonsynaptic noradrenaline release in neuro-immune responses","volume":"53","author":"Vizi","year":"2002","journal-title":"Acta Biol. Hung."},{"key":"10.1016\/j.jsbmb.2023.106356_bib63","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3389\/fneur.2020.00159","article-title":"Research on the relationship between vestibular migraine with\/without cognitive impairment and brainstem auditory evoked potential","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib64","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mce.2007.05.019","article-title":"Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists","volume":"275","author":"Stahn","year":"2007","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib65","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.vetimm.2008.10.303","article-title":"Genomic and non-genomic effects of dexamethasone on equine peripheral blood neutrophils","volume":"128","author":"Lecoq","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib66","first-page":"269","article-title":"Brain corticosteroid receptor balance in health and disease","volume":"19","author":"De Kloet","year":"1998","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jsbmb.2023.106356_bib67","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1677\/joe.0.1780331","article-title":"Glucocorticoid action and novel mechanisms of steroid resistance: role of glucocorticoid receptor-interacting proteins for glucocorticoid responsiveness","volume":"178","author":"Wikstrom","year":"2003","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib68","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1189\/jlb.71.1.9","article-title":"Molecular mechanisms of glucocorticoid antiproliferative effects: antagonism of transcription factor activity by glucocorticoid receptor","volume":"71","author":"Almawi","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/md19110586","article-title":"Marine-derived compounds for the potential treatment of glucocorticoid resistance in severe asthma","volume":"19","author":"Ghiciuc","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.jsbmb.2023.106356_bib70","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yfrne.2013.09.005","article-title":"Why do we need nongenomic glucocorticoid mechanisms?","volume":"35","author":"Jiang","year":"2014","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib71","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1182\/blood-2006-02-001115","article-title":"Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes","volume":"109","author":"Ehrchen","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jsbmb.2023.106356_bib72","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00774-014-0586-6","article-title":"Guidelines on the management and treatment of glucocorticoid-induced osteoporosis of the Japanese Society for Bone and Mineral Research: 2014 update","volume":"32","author":"Suzuki","year":"2014","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.jsbmb.2023.106356_bib73","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1007\/s00482-012-1214-9","article-title":"[Glucocorticoids and androgens for treatment of tiredness and weakness in palliative care patients: a systematic review]","volume":"26","author":"Thiem","year":"2012","journal-title":"Schmerz"},{"key":"10.1016\/j.jsbmb.2023.106356_bib74","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJMoa2021436","article-title":"Dexamethasone in hospitalized patients with Covid-19","volume":"384","author":"Group","year":"2021","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2023.106356_bib75","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/archdischild-2015-309522","article-title":"Systematic review of the toxicity of short-course oral corticosteroids in children","volume":"101","author":"Aljebab","year":"2016","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.jsbmb.2023.106356_bib76","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1136\/ard.2008.092163","article-title":"Dose-related patterns of glucocorticoid-induced side effects","volume":"68","author":"Huscher","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jsbmb.2023.106356_bib77","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1365-2885.1988.tb00196.x","article-title":"Gizzard ulceration in chicks fed cysteamine alone or in combination with a histamine H2-receptor antagonist","volume":"11","author":"Zavy","year":"1988","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.jsbmb.2023.106356_bib78","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bandc.2007.02.007","article-title":"The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition","volume":"65","author":"Lupien","year":"2007","journal-title":"Brain Cogn."},{"key":"10.1016\/j.jsbmb.2023.106356_bib79","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.yfrne.2007.10.002","article-title":"Corticosteroid hormones in the central stress response: quick-and-slow","volume":"29","author":"de Kloet","year":"2008","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib80","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060637","article-title":"Psychosocial working conditions and cognitive complaints among Swedish employees","volume":"8","author":"Stenfors","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2023.106356_bib81","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2174\/1570159X14666160325115909","article-title":"Environmental enrichment as a positive behavioral intervention across the lifespan","volume":"15","author":"Sampedro-Piquero","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib82","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1073\/pnas.95.6.3204","article-title":"Glucocorticoid receptor and protein\/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress","volume":"95","author":"Xu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jsbmb.2023.106356_bib83","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.psyneuen.2010.03.007","article-title":"The glucocorticoid receptor: pivot of depression and of antidepressant treatment?","volume":"36","author":"Anacker","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jsbmb.2023.106356_bib84","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.phrs.2017.04.015","article-title":"Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus","volume":"121","author":"Yi","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jsbmb.2023.106356_bib85","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55175","article-title":"LTD at amygdalocortical synapses as a novel mechanism for hedonic learning","volume":"9","author":"Haley","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.jsbmb.2023.106356_bib86","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1523\/JNEUROSCI.2842-14.2015","article-title":"Tau phosphorylation at serine 396 residue is required for hippocampal LTD","volume":"35","author":"Regan","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jsbmb.2023.106356_bib87","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fneur.2019.00515","article-title":"The role of BDNF in the neuroimmune axis regulation of mood disorders","volume":"10","author":"Jin","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib88","article-title":"Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice","volume":"19","author":"Li","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jsbmb.2023.106356_bib89","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0092-8674(91)90395-F","article-title":"trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor","volume":"65","author":"Squinto","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jsbmb.2023.106356_bib90","doi-asserted-by":"crossref","first-page":"12419","DOI":"10.1073\/pnas.94.23.12419","article-title":"Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor","volume":"94","author":"Holgado-Madruga","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2023.106356_bib91","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000496392","article-title":"Bridging the gap between brain-derived neurotrophic factor and glucocorticoid effects on brain networks","volume":"109","author":"Jeanneteau","year":"2019","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jsbmb.2023.106356_bib92","doi-asserted-by":"crossref","first-page":"15045","DOI":"10.1074\/jbc.272.24.15045","article-title":"Regulation of phosphoinositide-specific phospholipase C isozymes","volume":"272","author":"Rhee","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2023.106356_bib93","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1073\/pnas.0800888106","article-title":"Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter","volume":"106","author":"Numakawa","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsbmb.2023.106356_bib94","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/ALN.0000000000000329","article-title":"Decreased functional connectivity and disturbed directionality of information flow in the electroencephalography of intensive care unit patients with delirium after cardiac surgery","volume":"121","author":"van Dellen","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jsbmb.2023.106356_bib95","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/971817","article-title":"Quality and timing of stressors differentially impact on brain plasticity and neuroendocrine-immune function in mice","volume":"2013","author":"Capoccia","year":"2013","journal-title":"Neural Plast."},{"key":"10.1016\/j.jsbmb.2023.106356_bib96","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/nn.3266","article-title":"Glucocorticoid receptors recruit the CaMKIIalpha-BDNF-CREB pathways to mediate memory consolidation","volume":"15","author":"Chen","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jsbmb.2023.106356_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2016.08.005","article-title":"Timing and crosstalk of glucocorticoid signaling with cytokines, neurotransmitters and growth factors","volume":"113","author":"Arango-Lievano","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jsbmb.2023.106356_bib98","doi-asserted-by":"crossref","first-page":"20714","DOI":"10.1073\/pnas.1208342109","article-title":"Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding","volume":"109","author":"Gourley","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jsbmb.2023.106356_bib99","doi-asserted-by":"crossref","first-page":"37231","DOI":"10.1038\/srep37231","article-title":"Deletion of neurotrophin signaling through the glucocorticoid receptor pathway causes tau neuropathology","volume":"6","author":"Arango-Lievano","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jsbmb.2023.106356_bib100","doi-asserted-by":"crossref","first-page":"523","DOI":"10.14336\/AD.2017.0717","article-title":"BDNF Polymorphism: A Review of Its Diagnostic and Clinical Relevance in Neurodegenerative Disorders","volume":"9","author":"Shen","year":"2018","journal-title":"Aging Dis."},{"key":"10.1016\/j.jsbmb.2023.106356_bib101","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/bja\/aex103","article-title":"Association of intraoperative changes in brain-derived neurotrophic factor and postoperative delirium in older adults","volume":"119","author":"Wyrobek","year":"2017","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.jsbmb.2023.106356_bib102","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1196\/annals.1314.046","article-title":"Mineralocorticoid and glucocorticoid receptor-mediated effects on serotonergic transmission in health and disease","volume":"1032","author":"Joels","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jsbmb.2023.106356_bib103","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jchemneu.2003.10.002","article-title":"The human raphe nuclei and the serotonergic system","volume":"26","author":"Hornung","year":"2003","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.jsbmb.2023.106356_bib104","doi-asserted-by":"crossref","DOI":"10.1097\/CCE.0000000000000740","article-title":"The association of selective serotonin reuptake inhibitors with delirium in critically Ill adults: a secondary analysis of the bringing to light the risk factors and incidence of neuropsychologic dysfunction in ICU survivors ICU study","volume":"4","author":"Austin","year":"2022","journal-title":"Crit. Care Explor"},{"key":"10.1016\/j.jsbmb.2023.106356_bib105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11940-019-0599-5","article-title":"Delirium management in the ICU","volume":"21","author":"Reznik","year":"2019","journal-title":"Curr. Treat. Options Neurol."},{"key":"10.1016\/j.jsbmb.2023.106356_bib106","doi-asserted-by":"crossref","first-page":"c3704","DOI":"10.1136\/bmj.c3704","article-title":"Development, diagnosis, prevention, and management of delirium: summary of NICE guidance","volume":"341","author":"Young","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.jsbmb.2023.106356_bib107","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1111\/j.1532-5415.2000.tb03885.x","article-title":"The Hospital Elder Life Program: a model of care to prevent cognitive and functional decline in older hospitalized patients. Hospital Elder Life Program","volume":"48","author":"Inouye","year":"2000","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.jsbmb.2023.106356_bib108","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJM199903043400901","article-title":"A multicomponent intervention to prevent delirium in hospitalized older patients","volume":"340","author":"Inouye","year":"1999","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.jsbmb.2023.106356_bib109","article-title":"Needs assessment survey of healthcare providers' perceptions and practices regarding delirium prevention at a university medical center, Front","volume":"3","author":"Alghamdi","year":"2022","journal-title":"Aging"},{"key":"10.1016\/j.jsbmb.2023.106356_bib110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/CCM.0000000000003482","article-title":"Caring for critically Ill patients with the ABCDEF bundle: results of the ICU liberation collaborative in over 15,000 adults","volume":"47","author":"Pun","year":"2019","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jsbmb.2023.106356_bib111","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/CCM.0000000000002149","article-title":"Improving hospital survival and reducing brain dysfunction at seven california community hospitals: implementing PAD guidelines Via the ABCDEF Bundle in 6,064 patients","volume":"45","author":"Barnes-Daly","year":"2017","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jsbmb.2023.106356_bib112","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/CIRCRESAHA.117.311147","article-title":"New insights into the role of mTOR signaling in the cardiovascular system","volume":"122","author":"Sciarretta","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.jsbmb.2023.106356_bib113","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.mehy.2013.06.017","article-title":"Rapamycin and mTOR inhibitors probably have therapeutic effects for post-operative cognitive dysfunction","volume":"81","author":"Yang","year":"2013","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.jsbmb.2023.106356_bib114","article-title":"mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.jsbmb.2023.106356_bib115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/ANA.0000000000000757","article-title":"Neuroanesthesiology update","volume":"33","author":"Pasternak","year":"2021","journal-title":"J. Neurosurg. Anesth."},{"key":"10.1016\/j.jsbmb.2023.106356_bib116","first-page":"CD009377","article-title":"Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation)","volume":"7","author":"Ostinelli","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jsbmb.2023.106356_bib117","doi-asserted-by":"crossref","first-page":"121","DOI":"10.9758\/cpn.2015.13.2.121","article-title":"Review and Experts' Consensus for Long-acting Injectable Antipsychotics in Bipolar Disorder","volume":"13","author":"Chou","year":"2015","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"10.1016\/j.jsbmb.2023.106356_bib118","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF02245249","article-title":"Extrapyramidal side effects of clozapine and haloperidol","volume":"118","author":"Kurz","year":"1995","journal-title":"Psychopharmacol. (Berl. )"},{"key":"10.1016\/j.jsbmb.2023.106356_bib119","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1056\/NEJMoa2211868","article-title":"Haloperidol for the treatment of delirium in ICU patients","volume":"387","author":"Andersen-Ranberg","year":"2022","journal-title":"New Engl. J. Med"},{"key":"10.1016\/j.jsbmb.2023.106356_bib120","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jocn.2004.06.008","article-title":"The role of alpha2-agonists in neurosurgery","volume":"12","author":"Cormack","year":"2005","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.jsbmb.2023.106356_bib121","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20193410","article-title":"Dexmedetomidine with sufentanil in intravenous patient-controlled analgesia for relief from postoperative pain, inflammation and delirium after esophageal cancer surgery","volume":"40","author":"Tang","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jsbmb.2023.106356_bib122","article-title":"Sedation with dexmedetomidine in critically Ill burn patients reduced delirium during weaning from mechanical ventilation","volume":"14","author":"Stangaciu","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.jsbmb.2023.106356_bib123","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00134-022-06656-7","article-title":"Melatonin in ICU delirium: shining light on the hormone of darkness","volume":"48","author":"Burry","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jsbmb.2023.106356_bib124","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.genhosppsych.2022.10.010","article-title":"Pharmacologic treatment of delirium symptoms: a systematic review","volume":"79","author":"Sadlonova","year":"2022","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jsbmb.2023.106356_bib125","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s13643-016-0378-2","article-title":"Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol","volume":"5","author":"Foster","year":"2016","journal-title":"Syst. Rev."},{"key":"10.1016\/j.jsbmb.2023.106356_bib126","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/418595a","article-title":"Obesity: keeping hunger at bay","volume":"418","author":"Schwartz","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jsbmb.2023.106356_bib127","doi-asserted-by":"crossref","first-page":"866","DOI":"10.12659\/MSM.890878","article-title":"Leptin: new hope for the treatment of post-operative cognitive dysfunction?","volume":"20","author":"Hua","year":"2014","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.jsbmb.2023.106356_bib128","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.peptides.2017.05.002","article-title":"Low plasma leptin level at admission predicts delirium in critically ill patients: a prospective cohort study","volume":"93","author":"Li","year":"2017","journal-title":"Peptides"},{"key":"10.1016\/j.jsbmb.2023.106356_bib129","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.peptides.2004.03.018","article-title":"Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo","volume":"25","author":"Wayner","year":"2004","journal-title":"Peptides"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076023001115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076023001115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T08:07:26Z","timestamp":1736410046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076023001115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":129,"alternative-id":["S0960076023001115"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2023.106356","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of hormones in the pathogenesis and treatment mechanisms of delirium in ICU: The past, the present, and the future","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2023.106356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106356"}}