{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:22:19Z","timestamp":1793384539569,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jsbmb.2024.106475","type":"journal-article","created":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T02:15:51Z","timestamp":1707617751000},"page":"106475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["MicroRNA-125b regulates vitamin D resistance by targeting CYP24A1 in the progression of gestational diabetes mellitus"],"prefix":"10.1016","volume":"239","author":[{"given":"K.L.","family":"Milan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravichandran","family":"Jayasuriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan","family":"Harithpriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Anuradha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunka Mohanram","family":"Ramkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2024.106475_bib1","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1111\/jdi.13595","article-title":"Increasing trend in the prevalence of gestational diabetes mellitus in Taiwan","volume":"12","author":"Su","year":"2021","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.jsbmb.2024.106475_bib2","unstructured":"IDF Diabetes Atlas, 10th edn. Brussels, Belgium: International Diabetes Federation, 2021."},{"key":"10.1016\/j.jsbmb.2024.106475_bib3","article-title":"Screening for gestational diabetes mellitus: is there a need for early screening for all women in developing countries?","volume":"15","author":"Akinyemi","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.jsbmb.2024.106475_bib4","article-title":"Early gestational diabetes mellitus: diagnostic strategies and clinical implications","volume":"9","author":"Bhattacharya","year":"2021","journal-title":"Med. Sci."},{"key":"10.1016\/j.jsbmb.2024.106475_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fendo.2018.00007","article-title":"Effects of vitamin D deficiency on incidence risk of gestational diabetes mellitus: a systematic review and meta-analysis","volume":"9","author":"Amraei","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jsbmb.2024.106475_bib6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chembiol.2013.12.016","article-title":"Vitamin D metabolism, mechanism of action, and clinical applications","volume":"21","author":"Bikle","year":"2014","journal-title":"Chem. Biol."},{"key":"10.1016\/j.jsbmb.2024.106475_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1194\/jlr.R031534","article-title":"Cytochrome P450-mediated metabolism of vitamin D","volume":"55","author":"Jones","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jsbmb.2024.106475_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3164\/jcbn.19-79","article-title":"Association of increased renal Cyp24a1 gene expression with low plasma 1,25-dihydroxyvitamin D levels in rats with streptozotocin-induced diabetes","volume":"66","author":"Tajiri","year":"2020","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.jsbmb.2024.106475_bib9","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1177\/0300985813502820","article-title":"MicroRNAs: history, biogenesis, and their evolving role in animal development and disease","volume":"51","author":"Bhaskaran","year":"2014","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.jsbmb.2024.106475_bib10","first-page":"161","article-title":"The role of MicroRNAs in human diseases","volume":"2","author":"Ardekani","year":"2010","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"10.1016\/j.jsbmb.2024.106475_bib11","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-018-0587-8","article-title":"The role and mechanisms of action of microRNAs in cancer drug resistance","volume":"11","author":"Si","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.jsbmb.2024.106475_bib12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1615\/CritRevEukaryotGeneExpr.2013007147","article-title":"Vitamin D and microRNAs in bone","volume":"23","author":"Lisse","year":"2013","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.jsbmb.2024.106475_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.778116","article-title":"The Circ-CYP24A1-miR-224-PRLR axis impairs cell proliferation and apoptosis in recurrent miscarriage","volume":"13","author":"Su","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jsbmb.2024.106475_bib14","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/s12864-016-2850-8","article-title":"MicroRNA-mRNA regulatory networking fine-tunes the porcine muscle fiber type, muscular mitochondrial respiratory and metabolic enzyme activities","volume":"17","author":"Liu","year":"2016","journal-title":"BMC Genom."},{"key":"10.1016\/j.jsbmb.2024.106475_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00221-021-06253-y","article-title":"MiR-30b-5p attenuates neuropathic pain by the CYP24A1-Wnt\/beta-catenin signaling in CCI rats","volume":"240","author":"Liao","year":"2022","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.jsbmb.2024.106475_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23095019","article-title":"Micro-RNAs in response to active forms of vitamin D(3) in human leukemia and lymphoma cells","volume":"23","author":"Gleba","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jsbmb.2024.106475_bib17","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1158\/0008-5472.CAN-14-1329","article-title":"Pertsemlidis, Genetic mutation of p53 and suppression of the miR-17 approximately 92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D Signaling","volume":"75","author":"Borkowski","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2024.106475_bib18","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1124\/mol.109.056986","article-title":"Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b","volume":"76","author":"Komagata","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jsbmb.2024.106475_bib19","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrendo.2012.96","article-title":"Gestational diabetes mellitus: risks and management during and after pregnancy","volume":"8","author":"Buchanan","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jsbmb.2024.106475_bib20","first-page":"9083264","article-title":"Early pregnancy screening for women at high-risk of GDM results in reduced neonatal morbidity and similar maternal outcomes to routine","volume":"2020","author":"Clarke","year":"2020","journal-title":"Screen., J. Pregnancy"},{"key":"10.1016\/j.jsbmb.2024.106475_bib21","first-page":"423","article-title":"Prevalence of gestational diabetes diagnosed before 24 weeks of gestation","volume":"30","author":"Kankamon Prasit","year":"2022","journal-title":"Thai J. Obstet. Gynaecol."},{"key":"10.1016\/j.jsbmb.2024.106475_bib22","doi-asserted-by":"crossref","first-page":"4632745","DOI":"10.1155\/2021\/4632745","article-title":"MiRNAs in gestational diabetes mellitus: potential mechanisms and clinical applications","volume":"2021","author":"Liu","year":"2021","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.jsbmb.2024.106475_bib23","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.molmet.2017.06.020","article-title":"MicroRNAs as stress regulators in pancreatic beta cells and diabetes","volume":"6","author":"LaPierre","year":"2017","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jsbmb.2024.106475_bib24","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.bbalip.2016.05.003","article-title":"New emerging tasks for microRNAs in the control of beta-cell activities","volume":"1861","author":"Guay","year":"2016","journal-title":"Biochim. Et. Biophys. Acta"},{"key":"10.1016\/j.jsbmb.2024.106475_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2019.103924","article-title":"Mohanram, miR-23c regulates wound healing by targeting stromal cell-derived factor-1alpha (SDF-1alpha\/CXCL12) among patients with diabetic foot ulcer","volume":"127","author":"Amin","year":"2020","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.jsbmb.2024.106475_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12134551","article-title":"MicroRNA-27b Impairs Nrf2-Mediated Angiogenesis in the Progression of Diabetic Foot Ulcer","volume":"12","author":"Sakshi","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jsbmb.2024.106475_bib27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1095\/biolreprod.113.107805","article-title":"Human placental microRNAs and preeclampsia","volume":"88","author":"Chen","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jsbmb.2024.106475_bib28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.placenta.2016.12.002","article-title":"Review: Bio-compartmentalization of microRNAs in exosomes during gestational diabetes mellitus","volume":"54","author":"Iljas","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.jsbmb.2024.106475_bib29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tem.2016.09.004","article-title":"Maternal metabolism and vascular adaptation in pregnancy: the PPAR link","volume":"28","author":"Ganss","year":"2017","journal-title":"Trends Endocrinol. Metab.: TEM"},{"key":"10.1016\/j.jsbmb.2024.106475_bib30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2217\/dmt.10.24","article-title":"Mechanisms in the adaptation of maternal beta-cells during pregnancy","volume":"1","author":"Ernst","year":"2011","journal-title":"Diabetes Manag."},{"key":"10.1016\/j.jsbmb.2024.106475_bib31","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s12020-019-02062-0","article-title":"Decreased expression of microRNAs targeting type-2 diabetes susceptibility genes in peripheral blood of patients and predisposed individuals","volume":"66","author":"Kokkinopoulou","year":"2019","journal-title":"Endocrine"},{"key":"10.1016\/j.jsbmb.2024.106475_bib32","doi-asserted-by":"crossref","first-page":"32268","DOI":"10.1038\/srep32268","article-title":"Up-regulation of miR-98 and unraveling regulatory mechanisms in gestational diabetes mellitus","volume":"6","author":"Cao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jsbmb.2024.106475_bib33","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/dom.13748","article-title":"Vitamin D status during pregnancy and the risk of gestational diabetes mellitus: a longitudinal study in a multiracial cohort","volume":"21","author":"Xia","year":"2019","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.jsbmb.2024.106475_bib34","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.4103\/jfmpc.jfmpc_900_20","article-title":"Serum Vitamin D levels and gestational diabetes mellitus: analysis of early pregnancy cohort from a teaching hospital of Kashmir Valley","volume":"9","author":"Iqbal","year":"2020","journal-title":"J. Fam. Med. Prim. Care"},{"key":"10.1016\/j.jsbmb.2024.106475_bib35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12986-020-00509-0","article-title":"Sufficience serum vitamin D before 20 weeks of pregnancy reduces the risk of gestational diabetes mellitus","volume":"17","author":"Yue","year":"2020","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.jsbmb.2024.106475_bib36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.15605\/jafes.035.02.04","article-title":"The association between maternal serum vitamin D levels and gestational diabetes mellitus among filipino patients: a cross-sectional study","volume":"35","author":"Cabrera","year":"2020","journal-title":"J. ASEAN Fed. Endocr. Soc."},{"key":"10.1016\/j.jsbmb.2024.106475_bib37","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1210\/jc.2013-1366","article-title":"Placental CYP27B1 and CYP24A1 expression in human placental tissue and their association with maternal and neonatal calcitropic hormones","volume":"99","author":"O'Brien","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2024.106475_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112340","article-title":"Role of placental VDR expression and function in common late pregnancy disorders","volume":"18","author":"Knabl","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jsbmb.2024.106475_bib39","doi-asserted-by":"crossref","first-page":"e561","DOI":"10.1016\/j.ajog.2013.08.015","article-title":"Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta","volume":"209","author":"Cho","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jsbmb.2024.106475_bib40","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1210\/js.2019-00181","article-title":"Calcifediol Decreases Interleukin-6 Secretion by Cultured Human Trophoblasts From GDM Pregnancies","volume":"3","author":"Lacroix","year":"2019","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.jsbmb.2024.106475_bib41","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jsbmb.2024.106475_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051723","article-title":"Regulatory mechanism of MicroRNA expression in cancer","volume":"21","author":"Ali Syeda","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jsbmb.2024.106475_bib43","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-8722-6-6","article-title":"Diverse functions of miR-125 family in different cell contexts","volume":"6","author":"Sun","year":"2013","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jsbmb.2024.106475_bib44","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/nep.12714","article-title":"Loss of miR-125b contributes to upregulation of CYP24 in uraemic rats","volume":"21","author":"Wang","year":"2016","journal-title":"Nephrology"},{"key":"10.1016\/j.jsbmb.2024.106475_bib45","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1038\/s41598-017-06364-z","article-title":"A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines","volume":"7","author":"Rothbauer","year":"2017","journal-title":"Sci. Rep."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076024000232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076024000232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:12:50Z","timestamp":1760746370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076024000232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":45,"alternative-id":["S0960076024000232"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2024.106475","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-125b regulates vitamin D resistance by targeting CYP24A1 in the progression of gestational diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2024.106475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106475"}}