{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:25:12Z","timestamp":1790141112497,"version":"4.0.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973502"],"award-info":[{"award-number":["81973502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274126"],"award-info":[{"award-number":["82274126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jsbmb.2024.106622","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T23:51:33Z","timestamp":1727221893000},"page":"106622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["KaiXinSan improves learning and memory impairment by regulating cholesterol homeostasis in mice overloaded with 27-OHC"],"prefix":"10.1016","volume":"245","author":[{"given":"Rui","family":"Jing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaochen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2024.106622_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.766587","article-title":"Neurodegenerative Diseases and Cholesterol: Seeing the Field Through the Players","volume":"13","author":"Pfrieger","year":"2021","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.jsbmb.2024.106622_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41514-021-00064-9","article-title":"Abnormal brain cholesterol homeostasis in Alzheimer's disease-a targeted metabolomic and transcriptomic study","volume":"7","author":"Varma","year":"2021","journal-title":"NPJ Aging Mech. Dis."},{"key":"10.1016\/j.jsbmb.2024.106622_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2023.105635","article-title":"Brain cholesterol homeostasis and its association with neurodegenerative diseases","volume":"171","author":"Gao","year":"2023","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jsbmb.2024.106622_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adc9967","article-title":"Assessment of cholesterol homeostasis in the living human brain","volume":"14","author":"Haider","year":"2022","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.jsbmb.2024.106622_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5607\/en23010","article-title":"Impaired cholesterol metabolism, neurons, and neuropsychiatric disorders","volume":"32","author":"Cheon","year":"2023","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib6","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.1007\/s12035-023-03529-y","article-title":"Reexamining the causes and effects of cholesterol deposition in the brains of patients with Alzheimer's disease","volume":"60","author":"Hu","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.619916","article-title":"Increased plasma level of 24S-hydroxycholesterol and polymorphism of CYP46A1 SNP (rs754203) are associated with mild cognitive impairment in patients with type 2 diabetes","volume":"13","author":"Shi","year":"2021","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.jsbmb.2024.106622_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10100384","article-title":"Diverse immunoregulatory roles of oxysterols-the oxidized cholesterol metabolites","volume":"10","author":"Choi","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.jsbmb.2024.106622_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100165","article-title":"Cholesterol metabolism: from lipidomics to immunology","volume":"63","author":"Griffiths","year":"2022","journal-title":"J. Lipid Res"},{"key":"10.1016\/j.jsbmb.2024.106622_bib10","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/s41587-021-00972-x","article-title":"Cholesterol-functionalized DNA\/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS","volume":"39","author":"Nagata","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.tins.2022.01.002","article-title":"Brain cell type-specific cholesterol metabolism and implications for learning and memory","volume":"45","author":"Li","year":"2022","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jsbmb.2024.106622_bib12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41573-021-00139-y","article-title":"Strategies for delivering therapeutics across the blood-brain barrier","volume":"20","author":"Terstappen","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jsbmb.2024.106622_bib13","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.18632\/aging.203880","article-title":"Cholesterol metabolism in aging simultaneously altered in liver and nervous system","volume":"14","author":"Nunes","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jsbmb.2024.106622_bib14","article-title":"Regulation of Th17\/Treg Balance by 27-Hydroxycholesterol and 24S-Hydroxycholesterol Correlates with Learning and Memory Ability in Mice","volume":"23","author":"Wang","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jsbmb.2024.106622_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10050740","article-title":"The controversial role of 24-S-hydroxycholesterol in Alzheimer's disease","volume":"10","author":"Gamba","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.jsbmb.2024.106622_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JAD-150734","article-title":"Cholesterol, 24-hydroxycholesterol, and 27-hydroxycholesterol as surrogate biomarkers in cerebrospinal fluid in mild cognitive impairment and alzheimer's disease: a meta-analysis","volume":"51","author":"Wang","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jsbmb.2024.106622_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12974-020-01873-7","article-title":"27-Hydroxycholesterol contributes to cognitive deficits in APP\/PS1 transgenic mice through microbiota dysbiosis and intestinal barrier dysfunction","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.jsbmb.2024.106622_bib18","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1007\/s12035-020-02232-6","article-title":"Cholesterol metabolism in neurodegenerative diseases: molecular mechanisms and therapeutic targets","volume":"58","author":"Dai","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.690372","article-title":"Cholesterol and Alzheimer's disease; from risk genes to pathological effects","volume":"13","author":"Feringa","year":"2021","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.jsbmb.2024.106622_bib20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s13238-014-0131-3","article-title":"Cholesterol metabolism and homeostasis in the brain","volume":"6","author":"Zhang","year":"2015","journal-title":"Protein Cell"},{"key":"10.1016\/j.jsbmb.2024.106622_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700531","article-title":"Increased levels of 27-hydroxycholesterol induced by dietary cholesterol in brain contribute to learning and memory impairment in rats","volume":"62","author":"Zhang","year":"2018","journal-title":"Mol. Nutr. Food Res"},{"key":"10.1016\/j.jsbmb.2024.106622_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnmol.2019.00014","article-title":"27-hydroxycholesterol contributes to lysosomal membrane permeabilization-mediated pyroptosis in co-cultured SH-SY5Y cells and C6 cells","volume":"12","author":"Chen","year":"2019","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.jsbmb.2024.106622_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuro.2017.02.001","article-title":"27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells","volume":"59","author":"An","year":"2017","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jsbmb.2024.106622_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.696778","article-title":"Cholesterol hydroxylating cytochrome P450 46A1: from mechanisms of action to clinical applications","volume":"13","author":"Pikuleva","year":"2021","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.jsbmb.2024.106622_bib25","doi-asserted-by":"crossref","first-page":"823","DOI":"10.2174\/1567205017666201203123046","article-title":"Association between oxidative stress and altered cholesterol metabolism in Alzheimer's disease patients","volume":"17","author":"Zarrouk","year":"2020","journal-title":"Curr. Alzheimer Res"},{"key":"10.1016\/j.jsbmb.2024.106622_bib26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.arr.2014.09.006","article-title":"Involvement of oxysterols in age-related diseases and ageing processes","volume":"18","author":"Zarrouk","year":"2014","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.jsbmb.2024.106622_bib27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jns.2015.08.1537","article-title":"Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis","volume":"358","author":"Novakova","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jsbmb.2024.106622_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.mam.2009.02.001","article-title":"Oxysterols and neurodegenerative diseases","volume":"30","author":"Bjorkhem","year":"2009","journal-title":"Mol. Asp. Med"},{"key":"10.1016\/j.jsbmb.2024.106622_bib29","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1007\/s12035-021-02626-0","article-title":"Kai-xin-san inhibits Tau pathology and neuronal apoptosis in aged SAMP8 mice","volume":"59","author":"Jiao","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neulet.2009.06.073","article-title":"Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease","volume":"462","author":"Solomon","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jsbmb.2024.106622_bib31","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.chemphyslip.2011.04.002","article-title":"Oxysterols as biomarkers in neurodegenerative diseases","volume":"164","author":"Leoni","year":"2011","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.jsbmb.2024.106622_bib32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/lipd.12041","article-title":"Identification of correlative shifts in indices of brain cholesterol metabolism in the C57BL6\/Mecp2(tm1.1Bird) mouse, a model for rett syndrome","volume":"53","author":"Lutjohann","year":"2018","journal-title":"Lipids"},{"key":"10.1016\/j.jsbmb.2024.106622_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-2275(20)32052-6","article-title":"Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients","volume":"41","author":"Lutjohann","year":"2000","journal-title":"J. Lipid Res"},{"key":"10.1016\/j.jsbmb.2024.106622_bib34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.32607\/20758251-2016-8-1-58-73","article-title":"Brain cholesterol metabolism and its defects: linkage to neurodegenerative diseases and synaptic dysfunction","volume":"8","author":"Petrov","year":"2016","journal-title":"Acta Nat."},{"key":"10.1016\/j.jsbmb.2024.106622_bib35","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.3892\/etm.2016.3773","article-title":"Kai-Xin-San, a traditional Chinese medicine formulation, exerts antidepressive and neuroprotective effects by promoting pCREB upstream pathways","volume":"12","author":"Dong","year":"2016","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.jsbmb.2024.106622_bib36","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1007\/s12035-023-03707-y","article-title":"Classic famous prescription kai-xin-san ameliorates Alzheimer's disease via the wnt\/beta-catenin signaling pathway","volume":"61","author":"Shan","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.626949","article-title":"Chinese Medicine Formula Kai-Xin-San Ameliorates Neuronal Inflammation of CUMS-Induced Depression-like Mice and Reduces the Expressions of Inflammatory Factors via Inhibiting TLR4\/IKK\/NF-kappaB Pathways on BV2 Cells","volume":"12","author":"Qu","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.jsbmb.2024.106622_bib38","doi-asserted-by":"crossref","first-page":"1338024","DOI":"10.3389\/fphar.2024.1338024","article-title":"Constituents, pharmacological activities, pharmacokinetic studies, clinical applications, and safety profile on the classical prescription Kaixinsan","volume":"15","author":"Chen","year":"2024","journal-title":"Front Pharm."},{"key":"10.1016\/j.jsbmb.2024.106622_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104759","article-title":"Polygalae Radix: A review of its traditional uses, phytochemistry, pharmacology, toxicology, and pharmacokinetics","volume":"147","author":"Zhao","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jsbmb.2024.106622_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112615","article-title":"Anti-depressive effects of Kai-Xin-San on lipid metabolism in depressed patients and CUMS rats using metabolomic analysis","volume":"252","author":"Zhou","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib41","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jchromb.2018.06.032","article-title":"High-throughput lipidomics characterize key lipid molecules as potential therapeutic targets of Kaixinsan protects against Alzheimer's disease in APP\/PS1 transgenic mice","volume":"1092","author":"Gao","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jsbmb.2024.106622_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4724","article-title":"High-throughput lipidomics analysis to discover lipid biomarkers and profiles as potential targets for evaluating efficacy of Kai-Xin-San against APP\/PS1 transgenic mice based on UPLC-Q\/TOF-MS","volume":"34","author":"Zhang","year":"2020","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jsbmb.2024.106622_bib43","first-page":"240","article-title":"New insights into effects of Kaixin Powder on depression via lipid metabolism related adiponectin signaling pathway","volume":"15","author":"Yang","year":"2023","journal-title":"Chin. Herb. Med"},{"key":"10.1016\/j.jsbmb.2024.106622_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.561817","article-title":"Behavioral and biochemical effects of KXS on postmyocardial infarction depression","volume":"11","author":"Hu","year":"2020","journal-title":"Front Pharm."},{"key":"10.1016\/j.jsbmb.2024.106622_bib45","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1471-4159.2012.07893.x","article-title":"Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease","volume":"123","author":"Popp","year":"2012","journal-title":"J. Neurochem"},{"key":"10.1016\/j.jsbmb.2024.106622_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101837","article-title":"Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: a major role for lipocalin-2","volume":"39","author":"Staurenghi","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib47","first-page":"102","article-title":"Lipophilic statins in subjects with early mild cognitive impairment: associations with conversion to dementia and decline in posterior cingulate brain metabolism in a long-term prospective longitudinal multi-center study","volume":"62","author":"Padmanabham","year":"2021","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.jsbmb.2024.106622_bib48","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2318-14-36","article-title":"Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature","volume":"14","author":"Lathe","year":"2014","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.jsbmb.2024.106622_bib49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neulet.2012.01.017","article-title":"Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms","volume":"510","author":"Besga","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jsbmb.2024.106622_bib50","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jsbmb.2024.106622_bib51","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/bpa.12698","article-title":"27-hydroxycholesterol promotes Abeta accumulation via altering Abeta metabolism in mild cognitive impairment patients and APP\/PS1 mice","volume":"29","author":"Zhang","year":"2019","journal-title":"Brain Pathol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib52","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbrc.2014.02.010","article-title":"Diverse functions of 24(S)-hydroxycholesterol in the brain","volume":"446","author":"Noguchi","year":"2014","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.jsbmb.2024.106622_bib53","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1142\/S0192415X20500251","article-title":"Traditional chinese medicine for Alzheimer's disease and other cognitive impairment: a review","volume":"48","author":"Pei","year":"2020","journal-title":"Am. J. Chin. Med"},{"key":"10.1016\/j.jsbmb.2024.106622_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.688703","article-title":"Protective effects and mechanism of radix polygalae against neurological diseases as well as effective substance","volume":"12","author":"Jiang","year":"2021","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.jsbmb.2024.106622_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118145","article-title":"Kai-Xin-San ameliorates Alzheimer's disease-related neuropathology and cognitive impairment in APP\/PS1 mice via the mitochondrial autophagy-NLRP3 inflammasome pathway","volume":"329","author":"Shan","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib56","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13020-023-00722-y","article-title":"Kai-Xin-San protects against mitochondrial dysfunction in Alzheimer's disease through SIRT3\/NLRP3 pathway","volume":"18","author":"Su","year":"2023","journal-title":"Chin. Med"},{"key":"10.1016\/j.jsbmb.2024.106622_bib57","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40168-023-01471-8","article-title":"Dimethyl itaconate ameliorates cognitive impairment induced by a high-fat diet via the gut-brain axis in mice","volume":"11","author":"Pan","year":"2023","journal-title":"Microbiome"},{"key":"10.1016\/j.jsbmb.2024.106622_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf8764","article-title":"Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function","volume":"9","author":"Adams","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jsbmb.2024.106622_bib59","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00401-023-02616-7","article-title":"Inflammation and the pathological progression of Alzheimer's disease are associated with low circulating choline levels","volume":"146","author":"Judd","year":"2023","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib60","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/path.2980","article-title":"Mouse intermittent hypoxia mimicking apnoea of prematurity: effects on myelinogenesis and axonal maturation","volume":"226","author":"Cai","year":"2012","journal-title":"J. Pathol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib61","first-page":"238","article-title":"27-Hydroxycholesterol alters synaptic structural and functional plasticity in hippocampal neuronal cultures","volume":"78","author":"Wang","year":"2019","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib62","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41593-020-0588-8","article-title":"Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory","volume":"23","author":"Wang","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jsbmb.2024.106622_bib63","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1177\/1352458519884006","article-title":"Remyelination and ageing: reversing the ravages of time","volume":"25","author":"Neumann","year":"2019","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jsbmb.2024.106622_bib64","first-page":"1269","article-title":"Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice","volume":"41","author":"Li","year":"2016","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.jsbmb.2024.106622_bib65","first-page":"36","article-title":"Effect of Kaixin powder on central neurotransmitter and plasma cortisol in forced swimming mice","volume":"28","author":"Wang","year":"2005","journal-title":"J. Beijing Univ. TCM"},{"key":"10.1016\/j.jsbmb.2024.106622_bib66","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.bbalip.2012.09.007","article-title":"Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis","volume":"1831","author":"Chen","year":"2013","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.jsbmb.2024.106622_bib67","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.bbrc.2017.10.154","article-title":"Scavenger receptor class B type 1 regulates neuroblastoma cell proliferation, migration and invasion","volume":"495","author":"Panchoo","year":"2018","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.jsbmb.2024.106622_bib68","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1097-2765(01)00164-2","article-title":"A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis","volume":"7","author":"Chawla","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jsbmb.2024.106622_bib69","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/JLB.2A0817-341RR","article-title":"Apoptotic cells trigger the ABCA1\/STAT6 pathway leading to PPAR-gamma expression and activation in macrophages","volume":"103","author":"Kim","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.580599","article-title":"27-Hydroxycholesterol promotes the transfer of astrocyte-derived cholesterol to neurons in Co-cultured SH-SY5Y cells and C6 cells","volume":"8","author":"Wang","year":"2020","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-4-1","article-title":"Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells","volume":"4","author":"Prasanthi","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jsbmb.2024.106622_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103019","article-title":"Bile duct ligation elevates 5-HT levels in cerebral cortex of rats partly due to impairment of brain UGT1A6 expression and activity via ammonia accumulation","volume":"69","author":"Yang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12989-024-00562-0","article-title":"ROS\/mtROS promotes TNTs formation via the PI3K\/AKT\/mTOR pathway to protect against mitochondrial damages in glial cells induced by engineered nanomaterials","volume":"21","author":"Lin","year":"2024","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.jsbmb.2024.106622_bib74","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuro.2022.07.008","article-title":"The SH-SY5Y human neuroblastoma cell line, a relevant in vitro cell model for investigating neurotoxicology in human: focus on organic pollutants","volume":"92","author":"Lopez-Suarez","year":"2022","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jsbmb.2024.106622_bib75","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.4103\/1673-5374.358621","article-title":"Neural regeneration research model to be explored: SH-SY5Y human neuroblastoma cells","volume":"18","author":"Hoffmann","year":"2023","journal-title":"Neural Regen. Res"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076024001705?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076024001705?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T22:05:48Z","timestamp":1732831548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076024001705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":75,"alternative-id":["S0960076024001705"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2024.106622","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KaiXinSan improves learning and memory impairment by regulating cholesterol homeostasis in mice overloaded with 27-OHC","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2024.106622","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106622"}}