{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:38:51Z","timestamp":1782938331931,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jsbmb.2025.106678","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T02:22:18Z","timestamp":1736907738000},"page":"106678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Association between serum 25-hydroxyvitamin D concentrations and urinary vitamin D metabolite concentrations measured by the NLucVDR assay"],"prefix":"10.1016","volume":"247","author":[{"given":"Takuya","family":"Kushioka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Mano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyu","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Ikushiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7064-8185","authenticated-orcid":false,"given":"Toshiyuki","family":"Sakaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2025.106678_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.annepidem.2007.12.001","article-title":"Vitamin D status: measurement, interpretation, and clinical application","volume":"19","author":"Holick","year":"2009","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.jsbmb.2025.106678_bib2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2025.106678_bib3","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s00198-009-0954-6","article-title":"Global vitamin D status and determinants of hypovitaminosis D","volume":"20","author":"Mithal","year":"2009","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.jsbmb.2025.106678_bib4","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1161\/ATVBAHA.112.248039","article-title":"25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies","volume":"32","author":"Br\u00f8ndum-Jacobsen","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jsbmb.2025.106678_bib5","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/ijc.25439","article-title":"Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma","volume":"128","author":"Gandini","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jsbmb.2025.106678_bib6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s11154-021-09679-5","article-title":"Vitamin D, infections and immunity","volume":"23","author":"Ismailova","year":"2022","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.jsbmb.2025.106678_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1056\/NEJMoa1915176","article-title":"Vitamin D supplements for prevention of tuberculosis infection and disease","volume":"383","author":"Ganmaa","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2025.106678_bib8","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1007\/s00198-013-2372-z","article-title":"Profiles of vitamin D insufficiency and deficiency in Japanese men and women: association with biological, environmental, and nutritional factors and coexisting disorders: the ROAD study","volume":"24","author":"Yoshimura","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.jsbmb.2025.106678_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/589587","article-title":"Vitamin d status in central europe","volume":"2014","author":"Pludowski","year":"2014","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.jsbmb.2025.106678_bib10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3390\/nu6020729","article-title":"Vitamin D deficiency in India: Prevalence, causalities and interventions","volume":"6","author":"Ritu","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.jsbmb.2025.106678_bib11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bone.2014.12.064","article-title":"Impact of demographic, environmental, and lifestyle factors on vitamin D sufficiency in 9084 Japanese adults","volume":"74","author":"Nakamura","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.jsbmb.2025.106678_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00774-016-0805-4","article-title":"Assessment criteria for vitamin D deficiency\/insufficiency in Japan - proposal by an expert panel supported by Research Program of Intractable Diseases, Ministry of Health, Labour and Welfare, Japan, The Japanese Society for Bone and Mineral Research and","volume":"35","author":"Okazaki","year":"2017","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.jsbmb.2025.106678_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2023.106367","article-title":"Analysis of vitamin D metabolites in biological samples using a nanoluc-based vitamin D receptor ligand sensing system: NLucVDR","volume":"233","author":"Kushioka","year":"2023","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2025.106678_bib14","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/jjco\/hyu096","article-title":"The JPHC study: design and some findings on the typical Japanese diet","volume":"44","author":"Tsugane","year":"2014","journal-title":"Jpn. J. Clin. Oncol."},{"key":"10.1016\/j.jsbmb.2025.106678_bib15","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.tjnut.2023.01.036","article-title":"Determination of a Serum 25-Hydroxyvitamin D reference ranges in Japanese adults using fully automated liquid chromatography\u2013tandem mass spectrometry","volume":"153","author":"Miyamoto","year":"2023","journal-title":"J. Nutr."},{"key":"10.1016\/j.jsbmb.2025.106678_bib16","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1210\/jc.2016-1658","article-title":"Use of estrogen-containing contraception is associated with increased concentrations of 25-hydroxy Vitamin D","volume":"101","author":"Harmon","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2025.106678_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/ijc.29002","article-title":"UV exposure inhibits intestinal tumor growth and progression to malignancy in intestine-specific Apc mutant mice kept on low vitamin D diet","volume":"136","author":"Rebel","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jsbmb.2025.106678_bib18","first-page":"3713","article-title":"The dependency of vitamin D status on body mass index, gender, age and season","volume":"29","author":"Lagunova","year":"2009","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jsbmb.2025.106678_bib19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jsbmb.2013.12.004","article-title":"The longitudinal association of vitamin D serum concentrations & adiposity phenotype","volume":"144","author":"Jamal-Allial","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2025.106678_bib20","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.3390\/nu11123034","article-title":"Sex differences of vitamin D status across BMI classes: an observational prospective cohort study","volume":"11","author":"Muscogiuri","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jsbmb.2025.106678_bib21","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/oby.2011.404","article-title":"Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity","volume":"20","author":"Drincic","year":"2012","journal-title":"Obesity"},{"key":"10.1016\/j.jsbmb.2025.106678_bib22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ijo.2011.119","article-title":"The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications","volume":"36","author":"Earthman","year":"2012","journal-title":"Int. J. Obes. (Lond. )"},{"issue":"3","key":"10.1016\/j.jsbmb.2025.106678_bib23","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/ajcn\/72.3.690","article-title":"Decreased bioavailability of vitamin D in obesity","volume":"72","author":"Wortsman","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jsbmb.2025.106678_bib24","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jsbmb.2008.09.006","article-title":"1\u03b1,25-Dihydroxyvitamin D hydroxylase in adipocytes","volume":"112","author":"Li","year":"2008","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2025.106678_bib25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11154-019-09527-7","article-title":"Obesity and overweight decreases the effect of vitamin D supplementation in adults: systematic review and meta-analysis of randomized controlled trials","volume":"21","author":"de Oliveira","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.jsbmb.2025.106678_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1515\/jomb-2017-0002","article-title":"Analysis of changes in parathyroid hormone and 25 (OH) vitamin D levels with respect to age, gender and season: a data mining study","volume":"36","author":"Serdar","year":"2017","journal-title":"J. Med. Biochem."},{"key":"10.1016\/j.jsbmb.2025.106678_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1070808","article-title":"Global and regional prevalence of vitamin D deficiency in population-based studies from 2000 to 2022: a pooled analysis of 7.9 million participants","volume":"10","author":"Cui","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jsbmb.2025.106678_bib28","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jsbmb.2015.08.008","article-title":"Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: the B-PROOF study","volume":"164","author":"Brouwer-Brolsma","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2025.106678_bib29","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/jid.2014.400","article-title":"Determinants of vitamin D status in Caucasian adults: Influence of sun exposure, dietary intake, sociodemographic, lifestyle, anthropometric, and genetic factors","volume":"135","author":"Touvier","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jsbmb.2025.106678_bib30","article-title":"Vitamin D and bone health: epidemiologic studies","volume":"3","author":"Ebeling","year":"2014","journal-title":"Bone Rep."},{"key":"10.1016\/j.jsbmb.2025.106678_bib31","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2215\/CJN.12511213","article-title":"Association of urinary calcium excretion with serum calcium and vitamin D levels","volume":"10","author":"Rathod","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jsbmb.2025.106678_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4538","article-title":"Identification of conjugation positions of urinary glucuronidated vitamin D3 metabolites by LC\/ESI-MS\/MS after conversion to MS\/MS-fragmentable derivatives","volume":"33","author":"Yoshimura","year":"2019","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jsbmb.2025.106678_bib33","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1017\/S0007114511007409","article-title":"Determinants of plasma 25-hydroxyvitamin D and development of prediction models in three US cohorts","volume":"108","author":"Bertrand","year":"2012","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.jsbmb.2025.106678_bib34","article-title":"Development and validation of a vitamin D status prediction model in Danish pregnant women: a study of the Danish National Birth Cohort","volume":"8","author":"Jensen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2025.106678_bib35","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.3945\/ajcn.2009.28908","article-title":"Predictors of serum 25-hydroxyvitamin D concentrations among postmenopausal women: the women\u2019s health initiative calcium plus vitamin D clinical trial","volume":"91","author":"Millen","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jsbmb.2025.106678_bib36","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.3945\/ajcn.2009.28441","article-title":"Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the framingham offspring study","volume":"91","author":"Liu","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jsbmb.2025.106678_bib37","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3945\/ajcn.113.076430","article-title":"Prediction of vitamin D deficiency by simple patient characteristics","volume":"99","author":"Sohl","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jsbmb.2025.106678_bib38","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1007\/s00774-018-0984-2","article-title":"A simple questionnaire for the prediction of vitamin D deficiency in Japanese adults (Vitaimn D Deficiency questionnaire for Japanese: VDDQ-J)","volume":"37","author":"Kuwabara","year":"2019","journal-title":"J. Bone Miner. Metab."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076025000068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076025000068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:35:13Z","timestamp":1774427713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076025000068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":38,"alternative-id":["S0960076025000068"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2025.106678","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between serum 25-hydroxyvitamin D concentrations and urinary vitamin D metabolite concentrations measured by the NLucVDR assay","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2025.106678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106678"}}