{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T11:30:36Z","timestamp":1793619036933,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"am","delay-in-days":290,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jsbmb.2025.106730","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T19:41:49Z","timestamp":1742067709000},"page":"106730","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Chronic intake of Dioscorea esculenta suppresses testicular atrophy, enhances the ability of protection from inflammation in type 2 diabetes rats"],"prefix":"10.1016","volume":"250","author":[{"given":"Koki","family":"Tatara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-6420","authenticated-orcid":false,"given":"Koji","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2025.106730_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001356","article-title":"National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys","volume":"9","author":"Mascarenhas","year":"2012","journal-title":"PLOS Med."},{"key":"10.1016\/j.jsbmb.2025.106730_bib2","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1016\/j.fertnstert.2007.10.011","article-title":"Male obesity and alteration in sperm parameters","volume":"90","author":"Hammoud","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jsbmb.2025.106730_bib3","article-title":"Association between obesity and sperm quality","volume":"50","author":"Ramaraju","year":"2018","journal-title":"Androgia"},{"key":"10.1016\/j.jsbmb.2025.106730_bib4","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.2337\/dc07-1110","article-title":"Dehydroepiandrosterone administration counteracts oxidative imbalance and advanced glycation end product formation in type 2 diabetic patients","volume":"30","author":"Brignardello","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jsbmb.2025.106730_bib5","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1001\/jama.295.11.1288","article-title":"Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis","volume":"295","author":"Ding","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.jsbmb.2025.106730_bib6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1530\/jrf.0.0710393","article-title":"Comparative protective actions of gonadotrophins and testosterone against the antispermatogenic action of ethane dimethanesulphonate","volume":"71","author":"Jackson","year":"1984","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.jsbmb.2025.106730_bib7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/humupd\/2.3.246","article-title":"Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy","volume":"2","author":"Lenzi","year":"1996","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jsbmb.2025.106730_bib8","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.jsbmb.2025.106730_bib9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1095\/biolreprod.102.006544","article-title":"Differential splicing of the phospholipid hydroperoxide glutathione peroxidase gene in diploid and haploid male germ cells in the rats","volume":"68","author":"Puglisi","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jsbmb.2025.106730_bib10","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/mrd.20039","article-title":"Phospholipid hydroperoxide glutathione peroxidase: expression pattern during testicular development in mouse and evolutionary conservation in spermatozoa","volume":"67","author":"Nayernia","year":"2004","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jsbmb.2025.106730_bib11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1095\/biolreprod41.1.183","article-title":"Generation of reactive oxygen species, lipid peroxidation, and human sperm function","volume":"41","author":"Aitken","year":"1989","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jsbmb.2025.106730_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0304-4165(95)00109-O","article-title":"Direct evidence for the elevated synthesis and secretion of procathepsin L in the distal caput epididymis of boar","volume":"1245","author":"Okamura","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jsbmb.2025.106730_bib13","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1095\/biolreprod64.2.674","article-title":"Failure of the expression of phospholipid hydroperoxide glutathione peroxidase in the spermatozoa of human infertile males","volume":"64","author":"Imai","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jsbmb.2025.106730_bib14","doi-asserted-by":"crossref","first-page":"32522","DOI":"10.1074\/jbc.M109.016139","article-title":"Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice","volume":"284","author":"Imai","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2025.106730_bib15","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1074\/jbc.M308831200","article-title":"Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells","volume":"279","author":"Collins","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2025.106730_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0012-1606(88)90412-5","article-title":"Germ cell-Sertoli cell interactions: analysis of the biosynthesis and secretion of cyclic protein-2","volume":"130","author":"Wright","year":"1988","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jsbmb.2025.106730_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/btpr.2732","article-title":"Cathepsin L causes proteolytic cleavage of chinese hamster-ovary cell expressed proteins during processing and storage: identification, characterization, and mitigation","volume":"35","author":"Luo","year":"2019","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jsbmb.2025.106730_bib18","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1158\/1055-9965.1392.13.8","article-title":"Diosgenin, a steroid saponin of Trigonella foenum Graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells","volume":"13","author":"Raju","year":"2004","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.jsbmb.2025.106730_bib19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1749-6632.1995.tb17369.x","article-title":"DHEA and peripheral androgen and estrogen formation: intracrinology","volume":"774","author":"Labrie","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jsbmb.2025.106730_bib20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1365-2265.1998.00533.x","article-title":"Reduced serum dehydroepiandrosterone levels in diabetic patients with hyperinsulinaemia","volume":"49","author":"Yamaguchi","year":"1998","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.jsbmb.2025.106730_bib21","first-page":"E274","article-title":"Increased muscular dehydroepiandrosterone levels are associated with improved hype glycemia in obese rats","volume":"301","author":"Sato","year":"2011","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jsbmb.2025.106730_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jsbmb.2019.03.019","article-title":"Aerobic exercise training and dehydroepiandrosterone administration increase testicular sex steroid hormones and enhance reproductive function in high-sucrose-induced obese rats","volume":"190","author":"Tatara","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2025.106730_bib23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1439-0272.1975.tb01233.x","article-title":"The effect of epididymal and testicular fluids on the fertilising capacity of testicular and epididymal spermatozoa","volume":"7","author":"Cooper","year":"1975","journal-title":"Andrologia"},{"key":"10.1016\/j.jsbmb.2025.106730_bib24","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1095\/biolreprod16.2.258","article-title":"Effect of aging on the fertilizing capacity of testicular spermatozoa from the rabbit","volume":"16","author":"Cooper","year":"1977","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jsbmb.2025.106730_bib25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1080\/cmt.4.2.144.150","article-title":"Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women","volume":"4","author":"Komesaroff","year":"2001","journal-title":"Climacteric"},{"key":"10.1016\/j.jsbmb.2025.106730_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1744-859X-6-21","article-title":"Psychoimmunological effects of Dioscorea in ovariectomized rats: role of anxiety level","volume":"6","author":"Ho","year":"2007","journal-title":"Ann. Gen. Psychiatry"},{"key":"10.1016\/j.jsbmb.2025.106730_bib27","doi-asserted-by":"crossref","first-page":"9150","DOI":"10.1021\/jf201640j","article-title":"Osteoprotective effect of monascus-fermented Dioscorea in ovariectomized rat model of postmenopausal osteoporosis","volume":"59","author":"Chiang","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jsbmb.2025.106730_bib28","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1177\/02601060221130889","article-title":"The effect of Dioscorea esculenta powder on prostaglandin E2 and cytochrome c oxidase subunit 2 levels, menstrual pain, and premenstrual syndrome in young women: a randomized double-blind controlled trial","volume":"30","author":"Sato","year":"2024","journal-title":"Nutr. Health"},{"key":"10.1016\/j.jsbmb.2025.106730_bib29","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1096\/fj.201600874R","article-title":"Dioscorea esculenta-induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model","volume":"31","author":"Sato","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.jsbmb.2025.106730_bib30","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/db06-1566","article-title":"Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt\/mammalian target of rapamycin signaling","volume":"56","author":"Fujita","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.jsbmb.2025.106730_bib31","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s11655-015-2139-9","article-title":"Effects of Korean red ginseng on semen parameters in male infertility patients: a randomized placebo-controlled, double-blind clinical study","volume":"22","author":"Park","year":"2016","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jsbmb.2025.106730_bib32","first-page":"585","article-title":"Protective effect of rutin and naringin on sperm quality in streptozotocin (STZ) induced type 1 diabetic rats, Iran","volume":"10","author":"Butchi Akondi","year":"2011","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.jsbmb.2025.106730_bib33","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/14017430510035862","article-title":"The association of total antioxidant capacity with sex hormones","volume":"39","author":"Demirbag","year":"2005","journal-title":"Scand. Cardiovasc. J."},{"key":"10.1016\/j.jsbmb.2025.106730_bib34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/13510002.2016.1215643","article-title":"Hyperglycaemia, oxidative stress and inflammation markers","volume":"22","author":"Butkowski","year":"2017","journal-title":"Redox Rep."},{"key":"10.1016\/j.jsbmb.2025.106730_bib35","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.3390\/cells9071679","article-title":"The ins and Outs of cathepsins: physiological function and role in disease management","volume":"9","author":"Yadati","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jsbmb.2025.106730_bib36","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1095\/biolreprod.102.006726","article-title":"Mice that express enzymatically inactive cathepsin L exhibit abnormal spermatogenesis","volume":"68","author":"Wright","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jsbmb.2025.106730_bib37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1748-1716.2009.02011.x","article-title":"DHEA improves impaired activation of Akt and PKC \u03b6\/\u03bb-GLUT4 pathway in skeletal muscle andimproves hyperglycaemia in streptozotocin-induced diabetes rats","volume":"197","author":"Sato","year":"2009","journal-title":"Acta Physiol."},{"key":"10.1016\/j.jsbmb.2025.106730_bib38","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1249\/00005768-199108000-00012","article-title":"Effects of a 15-d race on plasma steroid levels and leg muscle fitness in runners","volume":"23","author":"Dressendorfer","year":"1991","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.jsbmb.2025.106730_bib39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbadis.2009.09.007","article-title":"Direct antioxidant and protective effect on isolated mitochondria","volume":"1802","author":"Borr\u00e1s","year":"2010","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.jsbmb.2025.106730_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/srep39931","article-title":"Effects of elevated \u03b2-estradiol levels on the functional morphology of the testis-new insights","volume":"7","author":"Leavy","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jsbmb.2025.106730_bib41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s10020-023-00771-x","article-title":"Diabetes-induced male infertility: potential mechanisms and treatment options","volume":"30","author":"Huang","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.jsbmb.2025.106730_bib42","doi-asserted-by":"crossref","first-page":"R665","DOI":"10.1152\/ajpregu.00117.2023","article-title":"Ironing out the details: ferroptosis and its relevance to diabetic cardiomyopathy","volume":"325","author":"Gawargi","year":"2023","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jsbmb.2025.106730_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175787","article-title":"Vitexin ameliorated diabetic nephropathy via suppressing GPX4-mediated ferroptosis","volume":"951","author":"Zhang","year":"2023","journal-title":"Eur. J. Pharmacol."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076025000585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076025000585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:19:12Z","timestamp":1744330752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076025000585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":43,"alternative-id":["S0960076025000585"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2025.106730","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic intake of Dioscorea esculenta suppresses testicular atrophy, enhances the ability of protection from inflammation in type 2 diabetes rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2025.106730","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106730"}}