{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:01:48Z","timestamp":1786993308399,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17H06428B1"],"award-info":[{"award-number":["17H06428B1"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["420H00539"],"award-info":[{"award-number":["420H00539"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jsbmb.2025.106747","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T09:24:25Z","timestamp":1743758665000},"page":"106747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Production of 11-ketotestosterone in childhood adrenal tumors with virilization or peripheral precocious puberty: Dominant expression of 11\u03b2-hydroxysteroid dehydrogenase type 2"],"prefix":"10.1016","volume":"251","author":[{"given":"Yasuko","family":"Fujisawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Murai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiyoshi","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Masunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kinjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Tanikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibuki","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2025.106747_bib1","doi-asserted-by":"crossref","first-page":"R98","DOI":"10.1093\/ejendo\/lvad047","article-title":"The clinical and biochemical significance of 11-oxygenated androgens in human health and disease","volume":"188","author":"Storbeck","year":"2023","journal-title":"Eur. J. Endocrinol.."},{"key":"10.1016\/j.jsbmb.2025.106747_bib2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1530\/EJE-15-1181","article-title":"Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency","volume":"174","author":"Turcu","year":"2016","journal-title":"Eur. J. Endocrinol.."},{"key":"10.1016\/j.jsbmb.2025.106747_bib3","first-page":"4589","article-title":"11-Ketotestosterone is the dominant circulating bioactive androgen during normal and premature adrenarche","volume":"103","author":"Rege","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2025.106747_bib4","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1210\/jc.2016-3285","article-title":"11-Oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome","volume":"102","author":"O'Reilly","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2025.106747_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2019.105506","article-title":"The role of adrenal derived androgens in castration resistant prostate cancer","volume":"197","author":"Barnard","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2025.106747_bib6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1530\/EJE-22-0143","article-title":"P.N. Transcriptional comparison of testicular adrenal rest tumors with fetal and adult tissues","volume":"187","author":"Schr\u00f6der","year":"2022","journal-title":"Eur. J. Endocrinol.."},{"key":"10.1016\/j.jsbmb.2025.106747_bib7","doi-asserted-by":"crossref","first-page":"C5","DOI":"10.1530\/EJE-22-0820","article-title":"A commentary on the origins of 11-ketotestosterone","volume":"187","author":"Storbeck","year":"2022","journal-title":"Eur. J. Endocrinol.."},{"key":"10.1016\/j.jsbmb.2025.106747_bib8","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1210\/clinem\/dgae008","article-title":"Update on adrenarche-still a mystery","volume":"109","author":"Augsburger","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2025.106747_bib9","first-page":"2027","article-title":"Childhood adrenocortical tumors","volume":"82","author":"Sandrini","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2025.106747_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00431-003-1230-y","article-title":"Virilising adrenocortical tumours in children","volume":"162","author":"Bonfig","year":"2003","journal-title":"Eur. J. Pedia"},{"key":"10.1016\/j.jsbmb.2025.106747_bib11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jsbmb.2016.02.031","article-title":"Combined steroidogenic characters of fetal adrenal and Leydig cells in childhood adrenocortical carcinoma","volume":"159","author":"Fujisawa","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2025.106747_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.steroids.2010.12.001","article-title":"Effect of castration monotherapy on the levels of adrenal androgens in cancerous prostatic tissues","volume":"76","author":"Arai","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.jsbmb.2025.106747_bib13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.2047-2927.2012.00026.x","article-title":"Development of prostate cancer in a patient with primary hypogonadism: intratumoural steroidogenesis in prostate cancer tissues","volume":"1","author":"Arai","year":"2013","journal-title":"Andrology"},{"key":"10.1016\/j.jsbmb.2025.106747_bib14","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/jb\/mvj086","article-title":"Ultrasensitive DNA chip: gene expression profile analysis without RNA amplification","volume":"139","author":"Nagino","year":"2006","journal-title":"J. Biochem"},{"key":"10.1016\/j.jsbmb.2025.106747_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031397","article-title":"Use of non-amplified RNA samples for microarray analysis of gene expression","volume":"7","author":"Sudo","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jsbmb.2025.106747_bib16","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3390\/ijms21030962","article-title":"Establishment and Characterisation by Expression Microarray of Patient-Derived Xenograft Panel of Human Pancreatic Adenocarcinoma Patients","volume":"21","author":"Roche","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jsbmb.2025.106747_bib17","doi-asserted-by":"crossref","first-page":"11427","DOI":"10.1038\/s41598-017-11331-9","article-title":"Gene expression profiling of calcifications in breast cancer","volume":"7","author":"Shin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jsbmb.2025.106747_bib18","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/00000478-198903000-00004","article-title":"Pathologic features of prognostic significance in adrenocortical carcinoma","volume":"13","author":"Weiss","year":"1989","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.jsbmb.2025.106747_bib19","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1097\/00000478-200307000-00001","article-title":"Adrenal cortical neoplasms in the pediatric population: a clinicopathologic and immunophenotypic analysis of 83 patients","volume":"27","author":"Wieneke","year":"2003","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.jsbmb.2025.106747_bib20","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/01.MP.0000081730.72305.81","article-title":"Adrenocortical adenoma and carcinoma: histopathological and molecular comparative analysis","volume":"16","author":"Stojadinovic","year":"2003","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.jsbmb.2025.106747_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mce.2013.07.006","article-title":"11\u03b2-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer","volume":"377","author":"Storbeck","year":"2013","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.jsbmb.2025.106747_bib22","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1210\/jc.2012-2912","article-title":"Liquid chromatography\u2013tandem mass spectrometry analysis of human adrenal vein 19-carbon steroids before and after ACTH stimulation","volume":"98","author":"Rege","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2025.106747_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1051195","article-title":"Adrenal gland involvement in 11-ketotestosterone production analyzed using LC-MS\/MS","volume":"14","author":"Ikegawa","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.jsbmb.2025.106747_bib24","doi-asserted-by":"crossref","first-page":"e272","DOI":"10.1210\/clinem\/dgab598","article-title":"Production of 11-oxygenated androgens by testicular adrenal rest tumors","volume":"107","author":"Schr\u00f6der","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2025.106747_bib25","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1093\/humrep\/deaa221","article-title":"Foetal virilisation caused by overproduction of non-aromatisable 11-oxygenated C19 steroids in maternal adrenal tumour","volume":"35","author":"Nagasaki","year":"2020","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jsbmb.2025.106747_bib26","doi-asserted-by":"crossref","first-page":"K39","DOI":"10.1530\/EJE-22-0508","article-title":"ACTH-independent production of 11-oxygenated androgens and glucocorticoids in an adrenocortical adenoma","volume":"187","author":"Kitamura","year":"2022","journal-title":"Eur. J. Endocrinol.."},{"key":"10.1016\/j.jsbmb.2025.106747_bib27","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0303-7207(99)00077-5","article-title":"Expression of 11\u03b2-hydroxysteroid dehydrogenase type 2 (11\u03b2HSD-2) in the developing human adrenal gland and human adrenal cortical carcinoma and adenoma","volume":"154","author":"Coulter","year":"1999","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2025.106747_bib28","first-page":"2728","article-title":"Expression of 11\u03b2-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors","volume":"86","author":"Korbonits","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2025.106747_bib29","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1038\/sj.onc.1206293","article-title":"Abnormal expression of 11\u03b2-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation","volume":"22","author":"Rabbitt","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.jsbmb.2025.106747_bib30","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s12253-011-9361-3","article-title":"Expression of 11\u03b2-hydroxysteroid dehydrogenase type 1 in breast cancer and adjacent non-malignant tissue. An immunocytochemical study","volume":"17","author":"Lu","year":"2011","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.jsbmb.2025.106747_bib31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0960-0760(00)00157-6","article-title":"Expression of the 11\u03b2-hydroxysteroid dehydrogenase type II enzyme in breast tumors and modulation of activity and cell growth in PMC42 cells","volume":"76","author":"Koyama","year":"2001","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2025.106747_bib32","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1210\/jc.2001-011335","article-title":"Role of local 11\u03b2-hydroxysteroid dehydrogenase type 2 expression in determining the phenotype of adrenal adenomas","volume":"88","author":"Mune","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2025.106747_bib33","unstructured":"The Human Protein, Atlas. \u3008https:\/\/www.proteinatlas.org\/\u3009, 2024 (accessed 1 October 2024)."},{"key":"10.1016\/j.jsbmb.2025.106747_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2023.106436","article-title":"The glucocorticoid-activating enzyme 11\u03b2-hydroxysteroid dehydrogenase type 1 catalyzes the activation of testosterone","volume":"236","author":"Oestlund","year":"2024","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2025.106747_bib35","first-page":"E243","article-title":"Clinical, Biochemical, and Molecular Characterization of Macronodular Adrenocortical Hyperplasia of the Zona Reticularis: A New Syndrome","volume":"96","author":"Hans","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2025.106747_bib36","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/ejendo\/lvae008","article-title":"Reference intervals for serum 11-oxygenated androgens in children","volume":"190","author":"Adriaansen","year":"2024","journal-title":"Eur. J. Endocrinol.."},{"key":"10.1016\/j.jsbmb.2025.106747_bib37","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1210\/jc.2016-2849","article-title":"Determination of 17OHPreg and DHEAS by LC-MS\/MS: impact of age, sex, pubertal stage, and BMI on the \u03945 steroid pathway","volume":"102","author":"Kulle","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2025.106747_bib38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jsbmb.2005.02.009","article-title":"The identification and simultaneous quantification of 7-hydroxylated metabolites of pregnenolone, dehydroepiandrosterone, 3\u03b2,17\u03b2-androstenediol, and testosterone in human serum using gas chromatography-mass spectrometry","volume":"96","author":"Hill","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076025000755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076025000755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T15:58:50Z","timestamp":1746892730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076025000755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":38,"alternative-id":["S0960076025000755"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2025.106747","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Production of 11-ketotestosterone in childhood adrenal tumors with virilization or peripheral precocious puberty: Dominant expression of 11\u03b2-hydroxysteroid dehydrogenase type 2","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2025.106747","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106747"}}