{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T03:16:55Z","timestamp":1772939815860,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007301","name":"Kunming University of Science and Technology","doi-asserted-by":"publisher","award":["KUST-KH2022029Y"],"award-info":[{"award-number":["KUST-KH2022029Y"]}],"id":[{"id":"10.13039\/501100007301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202401AY070001\\u2013130"],"award-info":[{"award-number":["202401AY070001\\u2013130"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003996","name":"Kunming Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jsbmb.2025.106858","type":"journal-article","created":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T14:25:32Z","timestamp":1757255132000},"page":"106858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["White kidney bean extract improves letrozole-induced polycystic ovary syndrome in rats by regulating the Wnt signaling pathway"],"prefix":"10.1016","volume":"255","author":[{"given":"Jiani","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanping","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2025.106858_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1479164117738442","article-title":"Interrelationship of canonical and non-canonical wnt signalling pathways in chronic metabolic diseases","volume":"15","author":"Ackers","year":"2018","journal-title":"Diab Vasc. Dis. Res"},{"key":"10.1016\/j.jsbmb.2025.106858_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.930832","article-title":"Phaseolus vulgaris extract ameliorates high-fat diet-induced colonic barrier dysfunction and inflammation in mice by regulating peroxisome proliferator-activated receptor expression and butyrate levels","volume":"13","author":"Avagliano","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.jsbmb.2025.106858_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1000261","article-title":"The relationship between the level of vitamin D, leptin and FGF23 in girls and young women with polycystic ovary syndrome","volume":"13","author":"Bia\u0142ka-Kosiec","year":"2022","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jsbmb.2025.106858_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/biom15070923","article-title":"Role of granulosa cell dysfunction in women infertility associated with polycystic ovary syndrome and obesity","volume":"15","author":"Chauvin","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.jsbmb.2025.106858_bib5","doi-asserted-by":"crossref","first-page":"782","DOI":"10.7150\/thno.67167","article-title":"Resveratrol ameliorates polycystic ovary syndrome via transzonal projections within oocyte-granulosa cell communication","volume":"12","author":"Chen","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.jsbmb.2025.106858_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ypmed.2023.107634","article-title":"FABP5 inhibitor SBFI-26 regulates FOXM1 expression and wnt signaling pathway in ovarian granulosa cell of patients with polycystic ovary syndrome","volume":"174","author":"Cheng","year":"2023","journal-title":"Prev. Med"},{"key":"10.1016\/j.jsbmb.2025.106858_bib7","article-title":"Interplay of gut microbiota in polycystic ovarian syndrome: role of gut microbiota, mechanistic pathways and potential treatment strategies","volume":"16","author":"Corrie","year":"2023"},{"key":"10.1016\/j.jsbmb.2025.106858_bib8","article-title":"Protective effects of White kidney bean (Phaseolus vulgaris L.) against Diet-Induced hepatic steatosis in mice are linked to modification of gut microbiota and its metabolites","volume":"15","author":"Feng","year":"2023"},{"key":"10.1016\/j.jsbmb.2025.106858_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/nu9010026","article-title":"Impact of glycosidic bond configuration on short chain fatty acid production from model fermentable carbohydrates by the human gut microbiota","volume":"9","author":"Harris","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jsbmb.2025.106858_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119304","article-title":"Butylated starch alleviates polycystic ovary syndrome by stimulating the secretion of peptide tyrosine-tyrosine and regulating faecal microbiota","volume":"287","author":"He","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jsbmb.2025.106858_bib11","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.1039\/C9FO02554E","article-title":"Lactic acid bacteria alleviate polycystic ovarian syndrome by regulating sex hormone related gut microbiota","volume":"11","author":"He","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.jsbmb.2025.106858_bib12","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1080\/10408398.2022.2105303","article-title":"An update on nutritional profile, phytochemical compounds, health benefits, and potential applications in the food industry of pulses seed coats: a comprehensive review","volume":"63","author":"Hou","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jsbmb.2025.106858_bib13","first-page":"2917","article-title":"Sinapic acid modulates oxidative stress and metabolic disturbances to attenuate ovarian fibrosis in letrozole-induced polycystic ovary syndrome SD rats","volume":"12","author":"Lan","year":"2024"},{"key":"10.1016\/j.jsbmb.2025.106858_bib14","article-title":"The beneficial effects of lacticaseibacillus paracasei subsp. Paracasei DSM 27449 in a Letrozole-Induced polycystic ovary syndrome rat model","volume":"25","author":"Lee","year":"2024"},{"key":"10.1016\/j.jsbmb.2025.106858_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/10942912.2021.1876087","article-title":"Proteinaceous \u03b1-amylase inhibitors: purification, detection methods, types and mechanisms","volume":"24","author":"Li","year":"2021","journal-title":"Int. J. Food Prop."},{"key":"10.1016\/j.jsbmb.2025.106858_bib16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13148-023-01487-9","article-title":"Short-chain fatty acid-butyric acid ameliorates granulosa cells inflammation through regulating METTL3-mediated N6-methyladenosine modification of FOSL2 in polycystic ovarian syndrome","volume":"15","author":"Liu","year":"2023","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.jsbmb.2025.106858_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300784","article-title":"\u03b1-Ketoglutarate improves ovarian reserve function in primary ovarian insufficiency by inhibiting NLRP3-Mediated pyroptosis of granulosa cells","volume":"68","author":"Liu","year":"2024","journal-title":"Mol. Nutr. Food Res"},{"key":"10.1016\/j.jsbmb.2025.106858_bib18","article-title":"Effects of soy isoflavones, resistant starch and antibiotics on polycystic ovary syndrome (PCOS)-Like features in Letrozole-Treated rats","volume":"13","author":"Liyanage","year":"2021"},{"key":"10.1016\/j.jsbmb.2025.106858_bib19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11130-015-0477-6","article-title":"Characterization and comparison of protein and peptide profiles and their biological activities of improved common bean cultivars (Phaseolus vulgaris L.) from Mexico and Brazil","volume":"70","author":"Mojica","year":"2015","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.jsbmb.2025.106858_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/nu12051398","article-title":"It's no has bean: a review of the effects of White kidney bean extract on body composition and metabolic health","volume":"12","author":"Nolan","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jsbmb.2025.106858_bib21","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1096\/fj.13-233247","article-title":"Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antim\u00fcllerian hormone expression during oocyte maturation in the female follicle","volume":"28","author":"Prunskaite-Hyyryl\u00e4inen","year":"2014","journal-title":"Faseb J."},{"key":"10.1016\/j.jsbmb.2025.106858_bib22","first-page":"7372","article-title":"Liraglutide improves hepatic insulin resistance via the canonical wnt signaling pathway","volume":"17","author":"Qin","year":"2018","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.jsbmb.2025.106858_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.01.001","article-title":"Metabolic dysfunction in polycystic ovary syndrome: pathogenic role of androgen excess and potential therapeutic strategies","volume":"35","author":"Sanchez-Garrido","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jsbmb.2025.106858_bib24","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1039\/C9FO01813A","article-title":"Anti-obesity effects of \u03b1-amylase inhibitor enriched-extract from White common beans (Phaseolus vulgaris L.) associated with the modulation of gut microbiota composition in high-fat diet-induced obese rats","volume":"11","author":"Shi","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.jsbmb.2025.106858_bib25","doi-asserted-by":"crossref","DOI":"10.1210\/endrev\/bnaa010","article-title":"Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome","volume":"41","author":"Stener-Victorin","year":"2020","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jsbmb.2025.106858_bib26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7015-8-41","article-title":"Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan","volume":"8","author":"Teede","year":"2010","journal-title":"BMC Med"},{"key":"10.1016\/j.jsbmb.2025.106858_bib27","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.fertnstert.2023.07.025","article-title":"Recommendations from the 2023 international Evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"120","author":"Teede","year":"2023","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jsbmb.2025.106858_bib28","article-title":"Improvement of glycemic control by a functional food mixture containing maltodextrin, White kidney bean extract, mulberry leaf extract, and Niacin-Bound chromium complex in obese diabetic db\/db mice","volume":"12","author":"Tzeng","year":"2022"},{"key":"10.1016\/j.jsbmb.2025.106858_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/foods14122038","article-title":"Evaluation of phaseolus vulgaris extract in a rat model of Cafeteria-Diet-Induced obesity: metabolic and biochemical effects","volume":"14","author":"Uawongwattana","year":"2025","journal-title":"Foods"},{"key":"10.1016\/j.jsbmb.2025.106858_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116522","article-title":"Roxadustat alleviates metabolic traits in letrozole-induced PCOS mice","volume":"229","author":"Virtanen","year":"2024","journal-title":"Biochem Pharm."},{"key":"10.1016\/j.jsbmb.2025.106858_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113090","article-title":"Bromodomain-containing protein 4 activates androgen receptor transcription and promotes ovarian fibrosis in PCOS","volume":"42","author":"Wang","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.jsbmb.2025.106858_bib32","article-title":"Loureirin b reduces insulin resistance and chronic inflammation in a rat model of polycystic ovary syndrome by upregulating GPR120 and activating the LKB1\/AMPK signaling pathway","volume":"25","author":"Wang","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jsbmb.2025.106858_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1191759","article-title":"Signaling pathways and targeted therapeutic strategies for polycystic ovary syndrome","volume":"14","author":"Wang","year":"2023","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jsbmb.2025.106858_bib34","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41419-020-2398-z","article-title":"PCDHGA9 represses epithelial-mesenchymal transition and metastatic potential in gastric cancer cells by reducing \u03b2-catenin transcriptional activity","volume":"11","author":"Weng","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jsbmb.2025.106858_bib35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jgyn.2015.08.013","article-title":"The WNT\/\u03b2-catenin signaling pathway May be involved in granulosa cell apoptosis from patients with PCOS in north China","volume":"46","author":"Wu","year":"2017","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"10.1016\/j.jsbmb.2025.106858_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111141","article-title":"Hyperandrogenism drives ovarian inflammation and pyroptosis: a possible pathogenesis of PCOS follicular dysplasia","volume":"125","author":"Xiang","year":"2023","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.jsbmb.2025.106858_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2025.106838","article-title":"Polycystic ovary syndrome: the role of granulosa cell proliferation and apoptosis in disease development","volume":"254","author":"Yi","year":"2025","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.jsbmb.2025.106858_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1077014","article-title":"1,25-Dihydroxyvitamin d inhibits hepatic diacyglycerol accumulation and ameliorates metabolic dysfunction in polycystic ovary syndrome rat models","volume":"14","author":"Yuan","year":"2023","journal-title":"Front Pharm."},{"key":"10.1016\/j.jsbmb.2025.106858_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13048-025-01663-w","article-title":"Transcriptomic analysis of theca cells in a PCOS rat model: insights into follicular development","volume":"18","author":"Yuanyuan","year":"2025","journal-title":"J. Ovarian Res"},{"key":"10.1016\/j.jsbmb.2025.106858_bib40","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/s12964-024-01939-6","article-title":"A ketogenic diet alleviates the apoptosis of granulosa cells by inhibiting the activation of cGAS-STING signaling pathway in PCOS mice","volume":"22","author":"Zhao","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.jsbmb.2025.106858_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13048-022-01091-0","article-title":"Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment","volume":"16","author":"Zhao","year":"2023","journal-title":"J. Ovarian Res"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076025001864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076025001864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T09:53:24Z","timestamp":1772877204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076025001864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":41,"alternative-id":["S0960076025001864"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2025.106858","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"White kidney bean extract improves letrozole-induced polycystic ovary syndrome in rats by regulating the Wnt signaling pathway","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2025.106858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106858"}}