{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T09:12:52Z","timestamp":1788685972245,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2019\/002583"],"award-info":[{"award-number":["CRG\/2019\/002583"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["ICMR-ISRM (12\/67\\u20132022)"],"award-info":[{"award-number":["ICMR-ISRM (12\/67\\u20132022)"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jsbmb.2026.107093","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:06:18Z","timestamp":1784934378000},"page":"107093","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["GPR56 regulates the expression of key androgen-target genes via G13-Rho-PKN1 axis and is overexpressed in prostate cancer"],"prefix":"10.1016","volume":"264","author":[{"given":"Versha","family":"Dahiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh","family":"Balyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diksha","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imtaiyaz","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivaram V.S.","family":"Mylavarapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi Datta","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-2584","authenticated-orcid":false,"given":"Gargi","family":"Bagchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jsbmb.2026.107093_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.jsbmb.2026.107093_bib2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/aja.2011.103","article-title":"Use of androgen deprivation therapy in prostate cancer: indications and prevalence","volume":"14","author":"Connolly","year":"2012","journal-title":"Asian J. Androl."},{"issue":"12","key":"10.1016\/j.jsbmb.2026.107093_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014153","article-title":"Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB","volume":"5","author":"Dai","year":"2010","journal-title":"PLoS. One"},{"issue":"12","key":"10.1016\/j.jsbmb.2026.107093_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2022.119357","article-title":"Non-canonical androgen signaling pathways and implications in prostate cancer","volume":"1869","author":"Dahiya","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell. Res."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2026.107093_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0303-7207(02)00364-7","article-title":"Molecular action of androgens","volume":"198","author":"Gobinet","year":"2002","journal-title":"Mol. Cell. Endocrinol."},{"issue":"9","key":"10.1016\/j.jsbmb.2026.107093_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0226056","article-title":"Activation of GPR56, a novel adhesion GPCR, is necessary for nuclear androgen receptor signaling in prostate cells","volume":"15","author":"Singh","year":"2020","journal-title":"PLoS. One"},{"issue":"6","key":"10.1016\/j.jsbmb.2026.107093_bib7","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.neuron.2016.08.022","article-title":"Structural basis for regulation of GPR56\/ADGRG1 by its alternatively spliced extracellular domains","volume":"91","author":"Salzman","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.jsbmb.2026.107093_bib8","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1126\/science.1092780","article-title":"Protein-coupled receptor-dependent development of human frontal cortex","volume":"303","author":"Piao","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jsbmb.2026.107093_bib9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/geno.1998.5644","article-title":"GPR56, a novel secretin-like human G-protein-coupled receptor gene","volume":"55","author":"Liu","year":"1999","journal-title":"Genomics"},{"issue":"5","key":"10.1016\/j.jsbmb.2026.107093_bib10","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.bj.2021.04.012","article-title":"The role of GPR56\/ADGRG1 in health and disease","volume":"44","author":"Singh","year":"2021","journal-title":"Biomed. J."},{"issue":"24","key":"10.1016\/j.jsbmb.2026.107093_bib11","doi-asserted-by":"crossref","first-page":"9023","DOI":"10.1073\/pnas.0602681103","article-title":"GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis","volume":"103","author":"Xu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.jsbmb.2026.107093_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pediatrneurol.2011.02.004","article-title":"A novel GPR56 mutation causes bilateral frontoparietal polymicrogyria","volume":"45","author":"Luo","year":"2011","journal-title":"Pediatr. Neurol."},{"issue":"19","key":"10.1016\/j.jsbmb.2026.107093_bib13","doi-asserted-by":"crossref","first-page":"6194","DOI":"10.1073\/pnas.1421785112","article-title":"Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist","volume":"112","author":"Stoveken","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.jsbmb.2026.107093_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100043","article-title":"Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation","volume":"9","author":"Luo","year":"2014","journal-title":"PLoS. One"},{"issue":"1","key":"10.1016\/j.jsbmb.2026.107093_bib15","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00018-024-05416-8","article-title":"G protein selectivity profile of GPR56\/ADGRG1 and its effect on downstream effectors","volume":"81","author":"Jallouli","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jsbmb.2026.107093_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114168","article-title":"STAT3 signaling in prostate cancer progression and therapy resistance: An oncogenic pathway with diverse functions","volume":"158","author":"Sadrkhanloo","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.jsbmb.2026.107093_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100043","article-title":"Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation","volume":"9","author":"Luo","year":"2014","journal-title":"PLoS. One"},{"issue":"23","key":"10.1016\/j.jsbmb.2026.107093_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/febs.12529","article-title":"GPR56 promotes myoblast fusion through SRE-and NFAT-mediated signaling but is not essential for muscle development in vivo","volume":"280","author":"Wu","year":"2013","journal-title":"FEBS J."},{"issue":"7","key":"10.1016\/j.jsbmb.2026.107093_bib19","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.3390\/cells10071831","article-title":"The RHO family GTPases: mechanisms of regulation and signaling","volume":"10","author":"Mosaddeghzadeh","year":"2021","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.jsbmb.2026.107093_bib20","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1038\/sj.onc.1208395","article-title":"GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion","volume":"24","author":"Shashidhar","year":"2005","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.jsbmb.2026.107093_bib21","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3390\/cancers6020926","article-title":"Transcription factor STAT3 as a novel molecular target for cancer prevention","volume":"6","author":"Xiong","year":"2014","journal-title":"Cancers"},{"key":"10.1016\/j.jsbmb.2026.107093_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2019.104372","article-title":"RNA sequencing data of human prostate cancer cells treated with androgens","volume":"25","author":"Poluri","year":"2019","journal-title":"Data Brief."},{"issue":"1","key":"10.1016\/j.jsbmb.2026.107093_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/ncb1668","article-title":"Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation","volume":"10","author":"Metzger","year":"2008","journal-title":"Nat. Cell. Biol."},{"issue":"21","key":"10.1016\/j.jsbmb.2026.107093_bib24","doi-asserted-by":"crossref","first-page":"14469","DOI":"10.1074\/jbc.M708919200","article-title":"Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12\/13 and Rho pathway","volume":"283","author":"Iguchi","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.jsbmb.2026.107093_bib25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1158\/1541-7786.MCR-19-0594","article-title":"miR-29a Is Repressed by MYC in Pancreatic Cancer and Its Restoration Drives Tumor-Suppressive Effects via Downregulation of LOXL2","volume":"18","author":"Dey","year":"2020","journal-title":"Mol. Cancer Res."},{"issue":"3","key":"10.1016\/j.jsbmb.2026.107093_bib26","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41419-018-0372-9","article-title":"Estradiol signaling mediates gender difference in visceral adiposity via autophagy","volume":"9","author":"Tao","year":"2018","journal-title":"Cell. Death Dis."},{"issue":"8","key":"10.1016\/j.jsbmb.2026.107093_bib27","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1093\/carcin\/bgt126","article-title":"Androgen-responsive serum response factor target genes regulate prostate cancer cell migration","volume":"34","author":"Verone","year":"2013","journal-title":"Carcinogenesis"},{"issue":"13","key":"10.1016\/j.jsbmb.2026.107093_bib28","doi-asserted-by":"crossref","first-page":"8506","DOI":"10.1074\/jbc.274.13.8506","article-title":"Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C\/EBP transcription factors","volume":"274","author":"Montaner","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"22","key":"10.1016\/j.jsbmb.2026.107093_bib29","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1158\/0008-5472.CAN-09-1541","article-title":"Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone","volume":"69","author":"Liu","year":"2009","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.jsbmb.2026.107093_bib30","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/s12935-024-03519-7","article-title":"RhoA-ROCK2 signaling possesses complex pathophysiological functions in cancer progression and shows promising therapeutic potential","volume":"24","author":"Ning","year":"2024","journal-title":"Cancer Cell. Int."},{"issue":"1","key":"10.1016\/j.jsbmb.2026.107093_bib31","first-page":"15","article-title":"Cytoskeleton targeting value in prostate cancer treatment","volume":"2","author":"Martin","year":"2014","journal-title":"Am. J. Clin. Exp. Urol."},{"issue":"5","key":"10.1016\/j.jsbmb.2026.107093_bib32","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/cm.21172","article-title":"The actin cytoskeleton in rapid steroid hormone actions","volume":"71","author":"Stournaras","year":"2014","journal-title":"Cytoskeleton"},{"issue":"50","key":"10.1016\/j.jsbmb.2026.107093_bib33","doi-asserted-by":"crossref","first-page":"19246","DOI":"10.1074\/jbc.RA119.008234","article-title":"GAIN domain\u2013mediated cleavage is required for activation of G protein\u2013coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist","volume":"294","author":"Zhu","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"23","key":"10.1016\/j.jsbmb.2026.107093_bib34","doi-asserted-by":"crossref","first-page":"11428","DOI":"10.1073\/pnas.1902651116","article-title":"Genomic correlates of clinical outcome in advanced prostate cancer","volume":"116","author":"Abida","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.jsbmb.2026.107093_bib35","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.cell.2015.05.001","article-title":"Integrative clinical genomics of advanced prostate cancer","volume":"161","author":"Robinson","year":"2015","journal-title":"Cell"},{"issue":"7843","key":"10.1016\/j.jsbmb.2026.107093_bib36","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41586-020-03083-w","article-title":"Structures of the glucocorticoid-bound adhesion receptor GPR97\u2013Go complex","volume":"589","author":"Ping","year":"2021","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.jsbmb.2026.107093_bib37","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2117004119","article-title":"Progesterone activates GPR126 to promote breast cancer development via the Gi pathway","volume":"119","author":"An","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"11","key":"10.1016\/j.jsbmb.2026.107093_bib38","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1158\/1541-7786.MCR-19-0436","article-title":"GPR56 drives colorectal tumor growth and promotes drug resistance through upregulation of MDR1 expression via a RhoA-mediated mechanism","volume":"17","author":"Zhang","year":"2019","journal-title":"Mol. Cancer Res."},{"issue":"10","key":"10.1016\/j.jsbmb.2026.107093_bib39","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41419-024-07095-6","article-title":"GPR56 facilitates hepatocellular carcinoma metastasis by promoting the TGF-\u03b2 signaling pathway","volume":"15","author":"Luo","year":"2024","journal-title":"Cell. Death & Dis."},{"key":"10.1016\/j.jsbmb.2026.107093_bib40","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fonc.2018.00008","article-title":"The adhesion g-Protein-coupled receptor, gPr56\/aDgrg1, inhibits cell\u2013extracellular Matrix signaling to Prevent Metastatic Melanoma growth","volume":"8","author":"Millar","year":"2018","journal-title":"Front. Oncol."},{"issue":"4","key":"10.1016\/j.jsbmb.2026.107093_bib41","doi-asserted-by":"crossref","first-page":"683","DOI":"10.4049\/jimmunol.2101048","article-title":"G Protein-Coupled Receptor 56 Characterizes CTLs and Reflects the Progression of Lung Cancer Patients","volume":"211","author":"Liu","year":"2023","journal-title":"J. Immunol."},{"key":"10.1016\/j.jsbmb.2026.107093_bib42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11010-007-9621-4","article-title":"Characterization of GPR56 protein and its suppressed expression in human pancreatic cancer cells","volume":"308","author":"Huang","year":"2008","journal-title":"Mol. Cell. Biochem."},{"issue":"10","key":"10.1016\/j.jsbmb.2026.107093_bib43","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41419-024-07095-6","article-title":"GPR56 facilitates hepatocellular carcinoma metastasis by promoting the TGF-\u03b2 signaling pathway","volume":"15","author":"Luo","year":"2024","journal-title":"Cell. Death Dis."},{"issue":"12","key":"10.1016\/j.jsbmb.2026.107093_bib44","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1002\/dvdy.22468","article-title":"GPR56 is essential for testis development and male fertility in mice","volume":"239","author":"Chen","year":"2010","journal-title":"Dev. Dyn."},{"issue":"5","key":"10.1016\/j.jsbmb.2026.107093_bib45","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41588-018-0078-z","article-title":"The long tail of oncogenic drivers in prostate cancer","volume":"50","author":"Armenia","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jsbmb.2026.107093_bib46","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.steroids.2019.01.006","article-title":"Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: a comparative study of their expression","volume":"142","author":"Kalyvianaki","year":"2019","journal-title":"Steroids"},{"issue":"51","key":"10.1016\/j.jsbmb.2026.107093_bib47","doi-asserted-by":"crossref","first-page":"39953","DOI":"10.1074\/jbc.M110.158063","article-title":"GPRC6A mediates the non-genomic effects of steroids","volume":"285","author":"Pi","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.jsbmb.2026.107093_bib48","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/emboj\/cdg023","article-title":"A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer","volume":"22","author":"Metzger","year":"2003","journal-title":"EMBO J."},{"issue":"23","key":"10.1016\/j.jsbmb.2026.107093_bib49","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1038\/s41388-019-0732-7","article-title":"Protein Kinase N1 control of androgen-responsive serum response factor action provides rationale for novel prostate cancer treatment strategy","volume":"38","author":"Venkadakrishnan","year":"2019","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.jsbmb.2026.107093_bib50","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.cell.2025.01.006","article-title":"Identification, structure, and agonist design of an androgen membrane receptor","volume":"188","author":"Yang","year":"2025","journal-title":"Cell"},{"issue":"22","key":"10.1016\/j.jsbmb.2026.107093_bib51","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1074\/jbc.RA119.007420","article-title":"Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor","volume":"294","author":"Dagar","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jsbmb.2026.107093_bib52","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1210\/mend.14.4.0453","article-title":"Divergent and composite gonadotropin-releasing hormone-responsive elements in the rat luteinizing hormone subunit genes","volume":"14","author":"Weck","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2026.107093_bib53","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.7909.1","article-title":"Rho, ROCK and actomyosin contractility in metastasis as drug targets","volume":"5","author":"Rodriguez-Hernandez","year":"2016","journal-title":"F1000Research"},{"key":"10.1016\/j.jsbmb.2026.107093_bib54","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baw100","article-title":"The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins","volume":"2016","author":"Rouillard","year":"2016","journal-title":"Database"},{"issue":"14-16","key":"10.1016\/j.jsbmb.2026.107093_bib55","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1080\/15384101.2023.2229713","article-title":"SRF inhibitors reduce prostate cancer cell proliferation through cell cycle arrest in an isogenic model of castrate-resistant prostate cancer","volume":"22","author":"Azam","year":"2023","journal-title":"Cell. Cycle"},{"issue":"1","key":"10.1016\/j.jsbmb.2026.107093_bib56","doi-asserted-by":"crossref","first-page":"6122","DOI":"10.1038\/ncomms7122","article-title":"The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with G\u03b112\/13 and RhoA","volume":"6","author":"Ackerman","year":"2015","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.jsbmb.2026.107093_bib57","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1093\/nar\/gkt1382","article-title":"Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer","volume":"42","author":"Wu","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.jsbmb.2026.107093_bib58","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00018-024-05416-8","article-title":"G protein selectivity profile of GPR56\/ADGRG1 and its effect on downstream effectors","volume":"81","author":"Jallouli","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jsbmb.2026.107093_bib59","doi-asserted-by":"crossref","unstructured":"Huang K.Y., Ng K.F., Kuan-Yu I., Chang Y.C., Chen H.Y., Chen T.C., Stacey M., Lin H.H. GPR56\/ADGRG1 induces biased Rho-ROCK-MLC and JAK-STAT3 signaling to promote amoeboid-like morphology and IL-6 upregulation in melanoma cells. https:\/\/doi.org\/doi:10.21203\/rs.3.rs-4423390\/v1.","DOI":"10.21203\/rs.3.rs-4423390\/v1"},{"key":"10.1016\/j.jsbmb.2026.107093_bib60","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s12035-012-8343-0","article-title":"GPR56 and the developing cerebral cortex: cells, matrix, and neuronal migration","volume":"47","author":"Singer","year":"2013","journal-title":"Mol. Neurobiol."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076026001597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076026001597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T08:49:08Z","timestamp":1788684548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076026001597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":60,"alternative-id":["S0960076026001597"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2026.107093","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GPR56 regulates the expression of key androgen-target genes via G13-Rho-PKN1 axis and is overexpressed in prostate cancer","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2026.107093","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107093"}}