{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:54:03Z","timestamp":1791356043389,"version":"4.3.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jsbmb.2026.107095","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:13:55Z","timestamp":1785482035000},"page":"107095","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Tissue-predominant estrogen metabolic remodeling in adenomyosis revealed by LC-MS\/MS profiling"],"prefix":"10.1016","volume":"265","author":[{"given":"Qing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BoYang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiping","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jsbmb.2026.107095_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bpobgyn.2006.01.010","article-title":"Adenomyosis: the pathophysiology of an oestrogen-dependent disease","volume":"20","author":"Kitawaki","year":"2006","journal-title":"Best. Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"4","key":"10.1016\/j.jsbmb.2026.107095_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20043762","article-title":"Endometrial inflammation and impaired spontaneous decidualization: insights into the pathogenesis of adenomyosis","volume":"20","author":"Kobayashi","year":"2023","journal-title":"Int. J. Environ. Res. Public. Health"},{"issue":"14","key":"10.1016\/j.jsbmb.2026.107095_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12144828","article-title":"Adenomyosis: An Updated Review on Diagnosis and Classification","volume":"12","author":"Moawad","year":"2023","journal-title":"J. Clin. Med."},{"issue":"10","key":"10.1016\/j.jsbmb.2026.107095_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19105840","article-title":"MRI and Adenomyosis: What Can Radiologists Evaluate?","volume":"19","author":"Celli","year":"2022","journal-title":"Int. J. Environ. Res. Public. Health"},{"issue":"6","key":"10.1016\/j.jsbmb.2026.107095_bib5","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/humupd\/dmab017","article-title":"Adenomyosis pathogenesis: insights from next-generation sequencing","volume":"27","author":"Bulun","year":"2021","journal-title":"Hum. Reprod. Update"},{"issue":"15","key":"10.1016\/j.jsbmb.2026.107095_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11154407","article-title":"Functional Implications of Estrogen and Progesterone Receptors Expression in Adenomyosis, Potential Targets for Endocrinological Therapy","volume":"11","author":"Sztachelska","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jsbmb.2026.107095_bib7","first-page":"1369","article-title":"Catechol estrogens stimulate uterine prostaglandin production","volume":"8","author":"Kelly","year":"1980","journal-title":"Adv. Prostaglandin Thromboxane Res."},{"issue":"2","key":"10.1016\/j.jsbmb.2026.107095_bib8","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/toxsci\/kfn096","article-title":"17-Beta estradiol and hydroxyestradiols interact via the NF-kappa B pathway to elevate cyclooxygenase 2 expression and prostaglandin E2 secretion in human bronchial epithelial cells","volume":"104","author":"Ho","year":"2008","journal-title":"Toxicol. Sci."},{"issue":"8","key":"10.1016\/j.jsbmb.2026.107095_bib9","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1210\/en.2003-0192","article-title":"Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms","volume":"144","author":"Lee","year":"2003","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.jsbmb.2026.107095_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1210\/jc.2003-032154","article-title":"Cytochromes 1A1\/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast","volume":"90","author":"Dubey","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.jsbmb.2026.107095_bib11","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1530\/REP-15-0581","article-title":"Increased expression of CYP1A1 and CYP1B1 in ovarian\/peritoneal endometriotic lesions","volume":"151","author":"Piccinato","year":"2016","journal-title":"Reproduction"},{"key":"10.1016\/j.jsbmb.2026.107095_bib12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.aca.2011.10.058","article-title":"Analysis of multiplex endogenous estrogen metabolites in human urine using ultra-fast liquid chromatography-tandem mass spectrometry: a case study for breast cancer","volume":"711","author":"Huang","year":"2012","journal-title":"Anal. Chim. Acta"},{"issue":"Pt A","key":"10.1016\/j.jsbmb.2026.107095_bib13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.steroids.2014.12.005","article-title":"Improved profiling of estrogen metabolites by orbitrap LC\/MS","volume":"99","author":"Li","year":"2015","journal-title":"Steroids"},{"issue":"12","key":"10.1016\/j.jsbmb.2026.107095_bib14","first-page":"4443","article-title":"Progesterone induces calcitonin gene expression in human endometrium within the putative window of implantation","volume":"83","author":"Kumar","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.jsbmb.2026.107095_bib15","first-page":"S240","volume":"63","author":"Hawker","year":"2011","journal-title":"Arthritis Care Res. (Hoboken)"},{"issue":"7","key":"10.1016\/j.jsbmb.2026.107095_bib16","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1365-2702.2005.01121.x","article-title":"Pain: a review of three commonly used pain rating scales","volume":"14","author":"Williamson","year":"2005","journal-title":"J. Clin. Nurs."},{"issue":"4","key":"10.1016\/j.jsbmb.2026.107095_bib17","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s43032-020-00383-4","article-title":"Markers of Local and Systemic Estrogen Metabolism in Endometriosis","volume":"28","author":"Othman","year":"2021","journal-title":"Reprod. Sci."},{"issue":"2","key":"10.1016\/j.jsbmb.2026.107095_bib18","first-page":"158","article-title":"Endogenous estrogen metabolites as biomarkers for endometrial cancer via a novel method of liquid chromatography-mass spectrometry with hollow fiber liquid-phase microextraction","volume":"47","author":"Zhao","year":"2015","journal-title":"Horm. Metab. Res."},{"issue":"7","key":"10.1016\/j.jsbmb.2026.107095_bib19","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1016\/j.fertnstert.2011.02.051","article-title":"Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis","volume":"95","author":"Mehasseb","year":"2011","journal-title":"Fertil. Steril."},{"issue":"11","key":"10.1016\/j.jsbmb.2026.107095_bib20","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1093\/carcin\/bgu190","article-title":"Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway","volume":"35","author":"Smerdov\u00e1","year":"2014","journal-title":"Carcinogenesis"},{"issue":"8","key":"10.1016\/j.jsbmb.2026.107095_bib21","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/sj.bjp.0705369","article-title":"Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: gene resequencing and functional genomics","volume":"139","author":"Adjei","year":"2003","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.jsbmb.2026.107095_bib22","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1124\/mol.105.019240","article-title":"Sulfotransferase (SULT) 1A1 polymorphic variants *1, *2, and *3 are associated with altered enzymatic activity, cellular phenotype, and protein degradation","volume":"69","author":"Nagar","year":"2006","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.jsbmb.2026.107095_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/09168451.2016.1222266","article-title":"Updated perspectives on the cytosolic sulfotransferases (SULTs) and SULT-mediated sulfation","volume":"81","author":"Suiko","year":"2017","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"4","key":"10.1016\/j.jsbmb.2026.107095_bib24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/17425255.2019.1588884","article-title":"Estrogen sulfotransferase in the metabolism of estrogenic drugs and in the pathogenesis of diseases","volume":"15","author":"Barbosa","year":"2019","journal-title":"Expert. Opin. Drug. Metab. Toxicol."},{"issue":"2","key":"10.1016\/j.jsbmb.2026.107095_bib25","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.mce.2011.06.012","article-title":"Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism","volume":"340","author":"Purohit","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2026.107095_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mehy.2016.04.012","article-title":"A stable epoxide as a potential endogenous estrogen metabolite: Possible significance in breast cancer?","volume":"91","author":"Raeside","year":"2016","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.jsbmb.2026.107095_bib27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jsbmb.2016.10.007","article-title":"A stable epoxide of estrone: Evidence for formation of a 'new' estrogen metabolite","volume":"167","author":"Raeside","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2026.107095_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2025.106788","article-title":"Confirmation of a novel, stable estrogen metabolite, as 5a,6a-epoxy-estrone sulfate in stallion blood by LC-MS\/MS","volume":"252","author":"Raeside","year":"2025","journal-title":"J. Steroid Biochem. Mol. Biol."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076026001615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076026001615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:27:57Z","timestamp":1791354477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076026001615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":28,"alternative-id":["S0960076026001615"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2026.107095","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tissue-predominant estrogen metabolic remodeling in adenomyosis revealed by LC-MS\/MS profiling","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2026.107095","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107095"}}