{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:50:42Z","timestamp":1792093842397,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jsbmb.2026.107136","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:52:19Z","timestamp":1791993139000},"page":"107136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Murrayanine\u2019s Anticancer Potential in Breast Cancer: Integrative Computational, In Vitro, and Nanoparticle Delivery Approaches"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9696-8475","authenticated-orcid":false,"given":"Yue","family":"Di","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xincheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanagaraj","family":"Rajalakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stalin","family":"Arulsamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natarajan","family":"Kiruthiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panneerselvam","family":"Theivendren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvaraj","family":"Muthusamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2026.107136_bib1","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.1039\/C9FO01721F","article-title":"Isolation of strawberry anthocyanin-rich fractions and their mechanisms of action against murine breast cancer cell lines","volume":"10","author":"Mazzoni","year":"2019","journal-title":"Food Funct"},{"key":"10.1016\/j.jsbmb.2026.107136_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.109623","article-title":"Effect of polyphenols on HER2-positive breast cancer and related miRNAs: Epigenomic regulation","volume":"137","author":"Zabaleta","year":"2020","journal-title":"Food Res. Int."},{"issue":"10","key":"10.1016\/j.jsbmb.2026.107136_bib3","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1080\/10408398.2020.1763910","article-title":"Targeting epigenetics in cancer: therapeutic potential of flavonoids","volume":"61","author":"Khan","year":"2021","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"10.1016\/j.jsbmb.2026.107136_bib4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.tifs.2020.05.017","article-title":"Dietary polyphenols for managing cancers: What have we ignored?","volume":"101","author":"Wu","year":"2020","journal-title":"Trends Food Sci. Tech."},{"issue":"14","key":"10.1016\/j.jsbmb.2026.107136_bib5","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1111\/febs.16768","article-title":"MAEL facilitates metabolic reprogramming and breast cancer progression by promoting the degradation of citrate synthase and fumarate hydratase via chaperone-mediated autophagy","volume":"290","author":"Zhou","year":"2023","journal-title":"The FEBS journal"},{"issue":"2","key":"10.1016\/j.jsbmb.2026.107136_bib6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1089\/jir.2022.0172","article-title":"Analysis of Immune and Inflammatory Microenvironment Characteristics of Noncancer End-Stage Liver Disease","volume":"43","author":"Wang","year":"2023","journal-title":"Journal of interferon & cytokine research: the official journal of the International Society for Interferon and Cytokine Research"},{"issue":"2","key":"10.1016\/j.jsbmb.2026.107136_bib7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/pharmaceutics18020240","article-title":"Molecularly Tailored Artesunate Nanomedicine with Well-Balanced Nanoassembly and Anticancer Performance","volume":"18","author":"Wu","year":"2026","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jsbmb.2026.107136_bib8","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/10408398.2021.1947772","article-title":"Enhancement of bioavailability and bioactivity of diet-derived flavonoids by application of nanotechnology: a review","volume":"63","author":"Teng","year":"2023","journal-title":"Crit. Rev. Food Sci. Nut."},{"key":"10.1016\/j.jsbmb.2026.107136_bib9","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.indcrop.2018.12.031","article-title":"Subcritical water extraction, identification and antiproliferation ability on HepG2 of polyphenols from lotus seed epicarp","volume":"129","author":"Yan","year":"2019","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jsbmb.2026.107136_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.126881","article-title":"Phenolic compounds from Mediterranean foods as nutraceutical tools for the prevention of cancer: The effect of honey polyphenols on colorectal cancer stem-like cells from spheroids","volume":"325","author":"Cianciosi","year":"2020","journal-title":"Food Chem"},{"key":"10.1016\/j.jsbmb.2026.107136_bib11","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1111\/1750-3841.15111","article-title":"Optimization of ultrasonic-assisted extraction conditions for bioactive components from coffee leaves using the Taguchi design and response surface methodology","volume":"85","author":"Chen","year":"2020","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jsbmb.2026.107136_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.109623","article-title":"Effect of polyphenols on HER2-positive breast cancer and related miRNAs: Epigenomic regulation","volume":"137","author":"Zabaleta","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jsbmb.2026.107136_bib13","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.3390\/nu14245246","article-title":"The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders","volume":"14","author":"Aleksic","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jsbmb.2026.107136_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2026.1780357","article-title":"Strategic applications of heterocyclic compounds in pharmaceutical innovation: a business perspective","volume":"14","author":"Dong","year":"2026","journal-title":"Front. Chem."},{"key":"10.1016\/j.jsbmb.2026.107136_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.156092","article-title":"Exploring alkaloids and flavonoids from natural sources: Emerging natural agents for inhibiting cervical cancer progression through apoptosis induction, anti-inflammatory effects, and oxidative stress reduction","volume":"272","author":"Chen","year":"2025","journal-title":"Path. Res. Prac."},{"key":"10.1016\/j.jsbmb.2026.107136_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.810572","article-title":"A novel inflammation-related lncRNAs prognostic signature identifies LINC00346 in promoting proliferation, migration, and immune infiltration of glioma","volume":"13","author":"Zeng","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.jsbmb.2026.107136_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114347","article-title":"A biocompatible tea polyphenol nanoplatform for efficient cytosolic delivery of protein therapeutics","volume":"388","author":"Wang","year":"2025","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.jsbmb.2026.107136_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/medicines7080047","article-title":"Medicinal herbs used in traditional management of breast cancer: mechanisms of action","volume":"7","author":"McGrowder","year":"2020","journal-title":"Medicines"},{"key":"10.1016\/j.jsbmb.2026.107136_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/cimb47010030","article-title":"Phytochemicals in breast cancer prevention and treatment: a comprehensive review","volume":"47","author":"Wali","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.jsbmb.2026.107136_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.diamond.2026.113469","article-title":"Biogenic Ag\/r-GO nanohybrid triggers apoptosis in MDA-MB-231 breast cancer cells and inhibits S. aureus & K. pneumoniae","volume":"164","author":"Zhang","year":"2026","journal-title":"Diamond Rel. Mater."},{"key":"10.1016\/j.jsbmb.2026.107136_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.15406\/mojboc.2018.02.00055","article-title":"Murrayanine-hydantoin and -thiohydantoin analogs as promising anti-convulsant agents: synthesis, characterization and molecular docking studies","volume":"2","author":"Mahapatra","year":"2018","journal-title":"MOJ Bioorg. Org. Chem."},{"key":"10.1016\/j.jsbmb.2026.107136_bib22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5958\/2231-5691.2018.00002.3","article-title":"Murrayanine-chalcone transformed into novel pyrimidine compounds demonstrated promising anti-inflammatory activity","volume":"8","author":"Mahapatra","year":"2018","journal-title":"Asian J. Pharm. Res."},{"key":"10.1016\/j.jsbmb.2026.107136_bib23","doi-asserted-by":"crossref","DOI":"10.1177\/0271678X261470064","article-title":"Ultrasound enhances glymphatic-associated solute transport via Piezo1-related mechanotransduction in 5xFAD mice","author":"Zhang","year":"2026","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"10.1016\/j.jsbmb.2026.107136_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.78549","article-title":"Hydrogen Selenide Gas Therapy Integrated With NIR-II Multimodal Imaging for Precision Theranostics of Cervical Cancer","author":"Du","year":"2026","journal-title":"Advanced Functional Materials"},{"key":"10.1016\/j.jsbmb.2026.107136_bib25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/bcpt.13032","article-title":"Murrayanine attenuates lipopolysaccharide-induced inflammation and protects mice from sepsis-associated organ failure","volume":"124","author":"Gupta","year":"2019","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.jsbmb.2026.107136_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.127513","article-title":"Polyphenol-rich extract of Zhenjiang aromatic vinegar ameliorates high glucose-induced insulin resistance by regulating JNK-IRS-1 and PI3K\/Akt signaling pathways","volume":"335","author":"Xia","year":"2021","journal-title":"Food Chem"},{"key":"10.1016\/j.jsbmb.2026.107136_bib27","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/j.fshw.2023.03.021","article-title":"Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K\/Akt\/Glut-4 signaling pathways in insulin-resistant HepG2 cells","volume":"12","author":"Miao","year":"2023","journal-title":"Food Sci. Human Wellness"},{"key":"10.1016\/j.jsbmb.2026.107136_bib28","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.3390\/nu14245281","article-title":"Hesperidin Reversed Long-Term N-methyl-N-nitro-N-Nitroguanidine Exposure Induced EMT and Cell Proliferation by Activating Autophagy in Gastric Tissues of Rats","volume":"14","author":"Liang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jsbmb.2026.107136_bib29","doi-asserted-by":"crossref","first-page":"6987","DOI":"10.1039\/C9FO02772F","article-title":"Sturgeon hydrolysates alleviate DSS-induced colon colitis in mice by modulating NF-\u03baB, MAPK, and microbiota composition","volume":"11","author":"Gao","year":"2020","journal-title":"Food Func"},{"key":"10.1016\/j.jsbmb.2026.107136_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2019.103598","article-title":"Zein hydrolysate and its peptides exert anti-inflammatory activity on endothelial cells by preventing TNF-\u03b1-induced NF-\u03baB activation","volume":"64","author":"Liang","year":"2020","journal-title":"J. Func. Foods"},{"key":"10.1016\/j.jsbmb.2026.107136_bib31","article-title":"Immunomodulation of RAW264.7 cells by CP80-1, a polysaccharide of Cordyceps cicadae, via Dectin-1\/Syk\/NF-\u03baB signaling pathway","volume":"34","author":"Wan","year":"2023","journal-title":"Food Agri. Immun."},{"key":"10.1016\/j.jsbmb.2026.107136_bib32","article-title":"Targeted anticancer potential of oxazole derivative against breast cancer: Synthesis, molecular docking, dynamics simulation, and in vitro evaluation on ERBB3 receptor","volume":"121","author":"Xu","year":"2026"},{"key":"10.1016\/j.jsbmb.2026.107136_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.144785","article-title":"Design, synthesis, and evaluation of fused Indolin-2-one derivatives as potent anti-inflammatory and anti-cancer agents targeting the CXCR6 pathway","volume":"1353","author":"Dai","year":"2026","journal-title":"J. Mol. Struc."},{"key":"10.1016\/j.jsbmb.2026.107136_bib34","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.3390\/molecules28155901","article-title":"Phytochemistry and biological activities of Murraya species","volume":"28","author":"Yohanes","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jsbmb.2026.107136_bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.67316\/jintb.v1.i1.9","article-title":"Artificial intelligence-driven novel drug discovery: target identification to translational impact","volume":"1","author":"Mandar","year":"2026","journal-title":"J. Integr. Transl. Biomed."},{"key":"10.1016\/j.jsbmb.2026.107136_bib36","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1175\/WAF-D-22-0070.1","article-title":"A machine learning tutorial for operational meteorology. Part I: traditional machine learning","volume":"37","author":"Chase","year":"2022","journal-title":"Weather Forecast"},{"key":"10.1016\/j.jsbmb.2026.107136_bib37","doi-asserted-by":"crossref","first-page":"48908","DOI":"10.1007\/s11356-022-19249-0","article-title":"silico, in vitro screening of antioxidant and anticancer potentials of bioactive secondary metabolites from an endophytic fungus (Curvularia sp.) from Phyllanthus niruri L","volume":"29","author":"Kalimuthu","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.jsbmb.2026.107136_bib38","article-title":"Graph theoretical analysis, in silico modeling and molecular dynamic studies of (5-((2-chloropyridin-4-yl)oxy)-3-phenyl-1H-pyrazol-1-yl)-2-(4-substituted phenyl)-N,N-dimethylethen-1-amine derivatives for the treatment of breast cancer","author":"Panneerselvam","year":"2022","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.jsbmb.2026.107136_bib39","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.3390\/molecules27123799","article-title":"Aphrodisiac performance of bioactive compounds from Mimosa pudica Linn.: in silico molecular docking and dynamics simulation approach","volume":"27","author":"Palanichamy","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jsbmb.2026.107136_bib40","first-page":"487","article-title":"Graph theoretical network analysis, in silico exploration, and validation of bioactive compounds from Cynodon dactylon as potential neuroprotective agents against \u03b1-synuclein","author":"Rajeshkumar","year":"2022","journal-title":"BioImpacts 12"},{"key":"10.1016\/j.jsbmb.2026.107136_bib41","article-title":"Capsaicin-loaded solid lipid nanoparticles: design, biodistribution, in silico modeling and in vitro cytotoxicity evaluation","volume":"32","author":"Kunjiappan","year":"2020","journal-title":"Nanotechnology"},{"key":"10.1016\/j.jsbmb.2026.107136_bib42","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/ddr.21511","article-title":"Graph theoretical analysis, in silico modeling, prediction of toxicity, metabolism and synthesis of novel 2-(methyl\/phenyl)-3-(4-(5-substituted-1,3,4-oxadiazol-2-yl)phenyl)quinazolin-4(3H)-ones as NMDA receptor inhibitor","volume":"80","author":"Saravanan","year":"2019","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.jsbmb.2026.107136_bib43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.67316\/jintb.v1.i1.11","article-title":"Molecular targeting of PIK3CA by allocryptopine in breast cancer","volume":"1","author":"Kanbarkar","year":"2026","journal-title":"J. Integr. Transl. Biomed."},{"key":"10.1016\/j.jsbmb.2026.107136_bib44","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/cimb47030193","article-title":"Molecular docking and pharmacological in silico evaluation of camptothecin and related ligands as promising HER2-targeted therapies for breast cancer","volume":"47","author":"Millan-Casarrubias","year":"2025","journal-title":"Curr. Issues Mol. Biol."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076026002025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076026002025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:35:31Z","timestamp":1792092931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076026002025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":44,"alternative-id":["S0960076026002025"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2026.107136","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of Murrayanine\u2019s Anticancer Potential in Breast Cancer: Integrative Computational, In Vitro, and Nanoparticle Delivery Approaches","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2026.107136","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107136"}}