{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:29:49Z","timestamp":1781188189635,"version":"3.54.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","jshoulderelbow.org","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Shoulder and Elbow Surgery"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.jse.2015.10.011","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:50:40Z","timestamp":1452819040000},"page":"989-997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology"],"prefix":"10.1016","volume":"25","author":[{"given":"Geoffrey D.","family":"Abrams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9183-8391","authenticated-orcid":false,"given":"Ayala","family":"Luria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Sokolove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jse.2015.10.011_bib0010","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/0363546509347366","article-title":"Doxycycline-mediated inhibition of matrix metalloproteinases improves healing after rotator cuff repair","volume":"38","author":"Bedi","year":"2010","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jse.2015.10.011_bib0015","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1021\/ja208338j","article-title":"Structural basis for matrix metalloproteinase 1-catalyzed collagenolysis","volume":"134","author":"Bertini","year":"2012","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.jse.2015.10.011_bib0020","doi-asserted-by":"crossref","first-page":"84S","DOI":"10.1016\/j.jse.2004.09.022","article-title":"The molecular pathophysiology of subacromial bursitis in rotator cuff disease","volume":"14","author":"Blaine","year":"2005","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2015.10.011_bib0025","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2741\/1817","article-title":"Matrix metalloproteinases: role in arthritis","volume":"11","author":"Burrage","year":"2006","journal-title":"Front Biosci"},{"key":"10.1016\/j.jse.2015.10.011_bib0030","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1007\/s00402-014-2099-0","article-title":"The effect of diclofenac on matrix metalloproteinase levels in the rotator cuff","volume":"134","author":"Cabuk","year":"2014","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.jse.2015.10.011_bib0035","first-page":"132","article-title":"Matrix metalloproteases and their inhibitors are altered in torn rotator cuff tendons, but also in the macroscopically and histologically intact portion of those tendons","volume":"3","author":"Castagna","year":"2013","journal-title":"Muscles Ligaments Tendons J"},{"issue":"Suppl 1","key":"10.1016\/j.jse.2015.10.011_bib0040","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s12306-013-0264-1","article-title":"Metalloproteases and their inhibitors are altered in both torn and intact rotator cuff tendons","volume":"97","author":"Castagna","year":"2013","journal-title":"Musculoskelet Surg"},{"key":"10.1016\/j.jse.2015.10.011_bib0045","first-page":"1359","article-title":"Shoulder joint movement and its relationship to disability in the elderly","volume":"20","author":"Chakravarty","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jse.2015.10.011_bib0050","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0736-0266(02)00016-5","article-title":"Expression and enzymatic activity of MMP-2 during healing process of the acute supraspinatus tendon tear in rabbits","volume":"20","author":"Choi","year":"2002","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jse.2015.10.011_bib0055","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jse.2011.10.020","article-title":"Metalloproteases and rotator cuff disease","volume":"21","author":"Del Buono","year":"2012","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2015.10.011_bib0060","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s002239900327","article-title":"Estimation of total collagen and types I and III collagen in canine rotator cuff tendons","volume":"61","author":"Fan","year":"1997","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jse.2015.10.011_bib0065","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S1058-2746(99)90097-6","article-title":"Fatty degeneration of the muscles of the rotator cuff: assessment by computed tomography versus magnetic resonance imaging","volume":"8","author":"Fuchs","year":"1999","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2015.10.011_bib0070","first-page":"2886","article-title":"Perforation of rotator cuff increases interleukin 1beta production in the synovium of glenohumeral joint in rotator cuff diseases","volume":"27","author":"Gotoh","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jse.2015.10.011_bib0075","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0736-0266(02)00063-3","article-title":"Interleukin-1-induced glenohumeral synovitis and shoulder pain in rotator cuff diseases","volume":"20","author":"Gotoh","year":"2002","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jse.2015.10.011_bib0080","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1177\/0363546510361235","article-title":"Stem cells genetically modified with the developmental gene MT1-MMP improve regeneration of the supraspinatus tendon-to-bone insertion site","volume":"38","author":"Gulotta","year":"2010","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jse.2015.10.011_bib0085","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jse.2012.05.023","article-title":"The association between arterial hypertension and rotator cuff tear: the influence on rotator cuff tear sizes","volume":"22","author":"Gumina","year":"2013","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2015.10.011_bib0090","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11684-014-0347-x","article-title":"Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis","volume":"9","author":"Gupta","year":"2015","journal-title":"Front Med"},{"key":"10.1016\/j.jse.2015.10.011_bib0095","doi-asserted-by":"crossref","first-page":"276457","DOI":"10.1155\/2014\/276457","article-title":"Relationship of MMP-14 and TIMP-3 expression with macrophage activation and human atherosclerotic plaque vulnerability","volume":"2014","author":"Johnson","year":"2014","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jse.2015.10.011_bib0100","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1167\/iovs.06-1445","article-title":"Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork","volume":"48","author":"Kelley","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jse.2015.10.011_bib0105","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.jse.2015.10.011_bib0110","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1078\/0344-0338-5710261","article-title":"Grading of chronic synovitis\u2013a histopathological grading system for molecular and diagnostic pathology","volume":"198","author":"Krenn","year":"2002","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.jse.2015.10.011_bib0115","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1210\/endo.139.3.5818","article-title":"Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption","volume":"139","author":"Kusano","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.jse.2015.10.011_bib0120","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/ajcp\/60.6.817","article-title":"A consideration of substitutes for alum hematoxylin in routine histologic and cytologic diagnostic procedures","volume":"60","author":"Lillie","year":"1973","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jse.2015.10.011_bib0125","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1177\/0363546503262200","article-title":"Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase mRNA levels are specifically altered in torn rotator cuff tendons","volume":"32","author":"Lo","year":"2004","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jse.2015.10.011_bib0130","doi-asserted-by":"crossref","first-page":"12461","DOI":"10.1073\/pnas.1204991109","article-title":"Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1","volume":"109","author":"Manka","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jse.2015.10.011_bib0135","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jvs.2014.09.002","article-title":"Matrix metalloproteinase 10 is associated with disease severity and mortality in patients with peripheral arterial disease","volume":"61","author":"Martinez-Aguilar","year":"2015","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jse.2015.10.011_bib0140","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1302\/0301-620X.91B3.21652","article-title":"Cytokines and apoptosis in supraspinatus tendinopathy","volume":"91","author":"Millar","year":"2009","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jse.2015.10.011_bib0145","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","article-title":"Matrix metalloproteinases","volume":"274","author":"Nagase","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jse.2015.10.011_bib0150","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.11607\/prd.1922","article-title":"Immunohistochemical expression of matrix metalloproteinase 13 in chronic periodontitis","volume":"34","author":"Nagasupriya","year":"2014","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.jse.2015.10.011_bib0155","first-page":"70","article-title":"Impingement lesions","author":"Neer","year":"1983","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2015.10.011_bib0160","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jse.2011.11.014","article-title":"Basic mechanisms of tendon fatigue damage","volume":"21","author":"Neviaser","year":"2012","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2015.10.011_bib0165","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/BLO.0b013e31802fc175","article-title":"Indications for rotator cuff repair: a systematic review","volume":"455","author":"Oh","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2015.10.011_bib0170","doi-asserted-by":"crossref","first-page":"10229","DOI":"10.1074\/jbc.M100099200","article-title":"The extra domain A of fibronectin activates Toll-like receptor 4","volume":"276","author":"Okamura","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jse.2015.10.011_bib0175","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s00296-004-0509-2","article-title":"Multivariate analysis of biochemical markers in synovial fluid from the shoulder joint for diagnosis of rotator cuff tears","volume":"25","author":"Osawa","year":"2005","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.jse.2015.10.011_bib0180","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.arthro.2014.02.006","article-title":"Clinical outcome and repair integrity after rotator cuff repair in patients older than 70 years versus patients younger than 70 years","volume":"30","author":"Rhee","year":"2014","journal-title":"Arthroscopy"},{"key":"10.1016\/j.jse.2015.10.011_bib0185","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1177\/0363546512456519","article-title":"Failed healing of rotator cuff repair correlates with altered collagenase and gelatinase in supraspinatus and subscapularis tendons","volume":"40","author":"Robertson","year":"2012","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jse.2015.10.011_bib0190","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.joca.2013.05.011","article-title":"The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to 2 years post-operatively in patients undergoing partial meniscectomy","volume":"21","author":"Scanzello","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jse.2015.10.011_bib0195","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/art.30137","article-title":"Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms","volume":"63","author":"Scanzello","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jse.2015.10.011_bib0200","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1172\/JCI23755","article-title":"The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages","volume":"115","author":"Schaefer","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jse.2015.10.011_bib0205","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.jse.2011.02.015","article-title":"Full-thickness supraspinatus tears are associated with more synovial inflammation and tissue degeneration than partial-thickness tears","volume":"20","author":"Shindle","year":"2011","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2015.10.011_bib0210","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1186\/ar3555","article-title":"Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4","volume":"14","author":"Sohn","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jse.2015.10.011_bib0215","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/1759720X12467868","article-title":"Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations","volume":"5","author":"Sokolove","year":"2013","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.jse.2015.10.011_bib0220","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0736-0266(02)00141-9","article-title":"IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells","volume":"21","author":"Tsuzaki","year":"2003","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jse.2015.10.011_bib0225","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/ar401","article-title":"Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors","volume":"4","author":"Vincenti","year":"2002","journal-title":"Arthritis Res"},{"key":"10.1016\/j.jse.2015.10.011_bib0230","doi-asserted-by":"crossref","first-page":"1076.e1","DOI":"10.1016\/j.arthro.2005.05.017","article-title":"Proinflammatory cytokines and metalloproteases are expressed in the subacromial bursa in patients with rotator cuff disease","volume":"21","author":"Voloshin","year":"2005","journal-title":"Arthroscopy"},{"key":"10.1016\/j.jse.2015.10.011_bib0235","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/geno.1996.0546","article-title":"Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1","volume":"37","author":"Xie","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.jse.2015.10.011_bib0240","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.2106\/JBJS.E.00835","article-title":"The demographic and morphological features of rotator cuff disease. A comparison of asymptomatic and symptomatic shoulders","volume":"88","author":"Yamaguchi","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2015.10.011_bib0245","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.gene.2005.08.006","article-title":"Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts","volume":"363","author":"Yang","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.jse.2015.10.011_bib0250","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0736-0266(00)00063-2","article-title":"Biochemical markers in the synovial fluid of glenohumeral joints from patients with rotator cuff tear","volume":"19","author":"Yoshihara","year":"2001","journal-title":"J Orthop Res"}],"container-title":["Journal of Shoulder and Elbow Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1058274615005820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1058274615005820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T01:25:42Z","timestamp":1537061142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1058274615005820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S1058274615005820"],"URL":"https:\/\/doi.org\/10.1016\/j.jse.2015.10.011","relation":{},"ISSN":["1058-2746"],"issn-type":[{"value":"1058-2746","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology","name":"articletitle","label":"Article Title"},{"value":"Journal of Shoulder and Elbow Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jse.2015.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of Journal of Shoulder and Elbow Surgery Board of Trustees.","name":"copyright","label":"Copyright"}]}}