{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:30:53Z","timestamp":1789831853834,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","jshoulderelbow.org","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Shoulder and Elbow Surgery"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.jse.2016.02.037","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T02:28:45Z","timestamp":1461983325000},"page":"1561-1570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Gene expression profiles of changes underlying different-sized human rotator cuff tendon tears"],"prefix":"10.1016","volume":"25","author":[{"given":"Salma","family":"Chaudhury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipti","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osnat","family":"Hakimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jse.2016.02.037_bib0010","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1002\/1529-0131(200112)44:12<2777::AID-ART465>3.0.CO;2-H","article-title":"Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology","volume":"44","author":"Aigner","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jse.2016.02.037_bib0015","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jse.2009.07.010","article-title":"The effect of matrix metalloproteinase inhibition on tendon-to-bone healing in a rotator cuff repair model","volume":"19","author":"Bedi","year":"2010","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.02.037_bib0020","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/00132585-200008010-00009","article-title":"An operative approach to Achilles tendinopathy","volume":"8","author":"Benazzo","year":"2000","journal-title":"Sports Med Arthroscopy Rev"},{"key":"10.1016\/j.jse.2016.02.037_bib0025","doi-asserted-by":"crossref","first-page":"84S","DOI":"10.1016\/j.jse.2004.09.022","article-title":"The molecular pathophysiology of subacromial bursitis in rotator cuff disease","volume":"14","author":"Blaine","year":"2005","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.02.037_bib0030","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/nrd961","article-title":"The use and analysis of microarray data","volume":"1","author":"Butte","year":"2002","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jse.2016.02.037_bib0035","first-page":"132","article-title":"Matrix metalloproteases and their inhibitors are altered in torn rotator cuff tendons, but also in the macroscopically and histologically intact portion of those tendons","volume":"3","author":"Castagna","year":"2013","journal-title":"Muscles Ligaments Tendons J"},{"key":"10.1016\/j.jse.2016.02.037_bib0040","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1302\/0301-620X.93B3.25470","article-title":"Fourier transform infrared spectroscopic analysis of normal and torn rotator-cuff tendons","volume":"93B","author":"Chaudhury","year":"2011","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jse.2016.02.037_bib0045","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/jor.21450","article-title":"Torn human rotator cuff tendons have reduced collagen thermal properties on differential scanning calorimetry","volume":"29","author":"Chaudhury","year":"2011","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jse.2016.02.037_bib0050","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.2106\/JBJS.M.01585","article-title":"Muscle gene expression patterns in human rotator cuff pathology","volume":"96","author":"Choo","year":"2014","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2016.02.037_bib0055","series-title":"The shoulder: rupture of the supraspinatus tendon and other lesions in or about the subacromial bursa","author":"Codman","year":"1934"},{"key":"10.1016\/j.jse.2016.02.037_bib0060","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2106\/JBJS.E.00117","article-title":"Clinical and structural results of open repair of an isolated one-tendon tear of the rotator cuff","volume":"88A","author":"Fuchs","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2016.02.037_bib0065","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s00167-012-2209-x","article-title":"Increased matrix metalloprotease-3 gene expression in ruptured rotator cuff tendons is associated with postoperative tendon retear","volume":"21","author":"Gotoh","year":"2013","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.jse.2016.02.037_bib0070","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.2106\/00004623-200706000-00013","article-title":"Arthroscopic rotator cuff repair with double-row fixation","volume":"89A","author":"Huijsmans","year":"2007","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2016.02.037_bib0075","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0945-053X(01)00128-7","article-title":"Multiple changes in gene expression in chronic human Achilles tendinopathy","volume":"20","author":"Ireland","year":"2001","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jse.2016.02.037_bib0080","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1634\/stemcells.2004-0304","article-title":"Differential gene expression profiling of human umbilical cord blood\u2013derived mesenchymal stem cells by DNA microarray","volume":"23","author":"Jeong","year":"2005","journal-title":"Stem Cells"},{"key":"10.1016\/j.jse.2016.02.037_bib0085","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1177\/0363546503262200","article-title":"Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase mRNA levels are specifically altered in torn rotator cuff tendons","volume":"32","author":"Lo","year":"2004","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jse.2016.02.037_bib0090","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1302\/0301-620X.88B4.16845","article-title":"Pathology of the torn rotator cuff tendon. Reduction in potential for repair as tear size increases","volume":"88","author":"Matthews","year":"2006","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jse.2016.02.037_bib0095","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1302\/0301-620X.89B5.18905","article-title":"In vivo measurement of tissue metabolism in tendons of the rotator cuff: implications for surgical management","volume":"89","author":"Matthews","year":"2007","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jse.2016.02.037_bib0100","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s11999-008-0265-9","article-title":"Heat shock protein and apoptosis in supraspinatus tendinopathy","volume":"466","author":"Millar","year":"2008","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2016.02.037_bib0105","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1302\/0301-620X.91B3.21652","article-title":"Cytokines and apoptosis in supraspinatus tendinopathy","volume":"91","author":"Millar","year":"2009","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jse.2016.02.037_bib0110","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/00003086-199407000-00010","article-title":"Surgical procedure and results of repair of massive tears of the rotator cuff","volume":"304","author":"Nobuhara","year":"1994","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2016.02.037_bib0115","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s00296-004-0509-2","article-title":"Multivariate analysis of biochemical markers in synovial fluid from the shoulder joint for diagnosis of rotator cuff tears","volume":"25","author":"Osawa","year":"2005","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.jse.2016.02.037_bib0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2559.2007.02894.x","article-title":"Expression profiling technology: its contribution to our understanding of breast cancer","volume":"52","author":"Rakha","year":"2008","journal-title":"Histopathology"},{"key":"10.1016\/j.jse.2016.02.037_bib0125","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1006\/bbrc.1998.9734","article-title":"Temporal alterations in mRNA levels for proteinases and inhibitors and their potential regulators in the healing medial collateral ligament","volume":"252","author":"Reno","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jse.2016.02.037_bib0130","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-0838.2005.00456.x","article-title":"Gene expression and matrix turnover in overused and damaged tendons","volume":"15","author":"Riley","year":"2005","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.jse.2016.02.037_bib0135","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1177\/0363546512456519","article-title":"Failed healing of rotator cuff repair correlates with altered collagenase and gelatinase in supraspinatus and subscapularis tendons","volume":"40","author":"Robertson","year":"2012","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jse.2016.02.037_bib0140","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jsams.2014.02.011","article-title":"BMP4 and FGF3 haplotypes increase the risk of tendinopathy in volleyball athletes","volume":"18","author":"Salles","year":"2015","journal-title":"J Sci Med Sport"},{"key":"10.1016\/j.jse.2016.02.037_bib0145","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11999-008-0565-0","article-title":"Expression of atrophy mRNA relates to tendon tear size in supraspinatus muscle","volume":"467","author":"Schmutz","year":"2009","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2016.02.037_bib0150","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2199-7-3","article-title":"The RIN: an RNA integrity number for assigning integrity values to RNA measurements","volume":"7","author":"Schroeder","year":"2006","journal-title":"BMC Mol Biol"},{"key":"10.1016\/j.jse.2016.02.037_bib0155","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/117693510700300022","article-title":"Analysis of gene expression data using BRB-array tools","volume":"3","author":"Simon","year":"2007","journal-title":"Cancer Inform"},{"key":"10.1016\/j.jse.2016.02.037_bib0160","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2106\/JBJS.F.00512","article-title":"Repair integrity and functional outcome after arthroscopic double-row rotator cuff repair\u2014a prospective outcome study","volume":"89A","author":"Sugaya","year":"2007","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2016.02.037_bib0165","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1016\/j.jse.2014.06.052","article-title":"Significant association of full-thickness rotator cuff tears and estrogen-related receptor-beta (ESRRB)","volume":"24","author":"Teerlink","year":"2015","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.02.037_bib0170","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/bjsm.2008.050575","article-title":"Changes in mechanical loading lead to tendon-specific alterations in MMP and TIMP expression: influence of stress deprivation and intermittent cyclic hydrostatic compression on rat supraspinatus and Achilles tendons","volume":"44","author":"Thornton","year":"2008","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.jse.2016.02.037_bib0175","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1182\/blood.V99.5.1745","article-title":"Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells","volume":"99","author":"Zhan","year":"2002","journal-title":"Blood"}],"container-title":["Journal of Shoulder and Elbow Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1058274616001452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1058274616001452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T09:58:17Z","timestamp":1655632697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1058274616001452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1058274616001452"],"URL":"https:\/\/doi.org\/10.1016\/j.jse.2016.02.037","relation":{},"ISSN":["1058-2746"],"issn-type":[{"value":"1058-2746","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene expression profiles of changes underlying different-sized human rotator cuff tendon tears","name":"articletitle","label":"Article Title"},{"value":"Journal of Shoulder and Elbow Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jse.2016.02.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved.","name":"copyright","label":"Copyright"}]}}