{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:17:18Z","timestamp":1782947838665,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","jshoulderelbow.org","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Shoulder and Elbow Surgery"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jse.2016.07.017","type":"journal-article","created":{"date-parts":[[2016,10,9]],"date-time":"2016-10-09T04:52:47Z","timestamp":1475988767000},"page":"186-196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Neer Award 2015: Analysis of cytokine profiles in the diagnosis of periprosthetic joint infections of the shoulder"],"prefix":"10.1016","volume":"26","author":[{"given":"Salvatore J.","family":"Frangiamore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Grosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Farias Kovac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Daly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Derwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Iannotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4371-7998","authenticated-orcid":false,"given":"Eric T.","family":"Ricchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jse.2016.07.017_bib0010","author":"Agency for Healthcare Research and Quality"},{"key":"10.1016\/j.jse.2016.07.017_bib0015","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1007\/s11999-013-3070-z","article-title":"Diagnosis of periprosthetic joint infection: the threshold for serological markers","volume":"471","author":"Alijanipour","year":"2013","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2016.07.017_bib0020","series-title":"CLSI document C49-A.","isbn-type":"print","article-title":"Analysis of body fluids in clinical chemistry; approved guideline","author":"McPherson","year":"2007","ISBN":"https:\/\/id.crossref.org\/isbn\/1562386387"},{"key":"10.1016\/j.jse.2016.07.017_bib0025","first-page":"2279","article-title":"Complications of total shoulder arthroplasty","volume":"88","author":"Bohsali","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2016.07.017_bib0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1302\/0301-620X.86B1.14089","article-title":"The management of infection in arthroplasty of the shoulder","volume":"86","author":"Coste","year":"2004","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jse.2016.07.017_bib0035","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.jse.2010.02.009","article-title":"Prevalence and projections of total shoulder and elbow arthroplasty in the United States to 2015","volume":"19","author":"Day","year":"2010","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.07.017_bib0040","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s11999-010-1298-4","article-title":"Synovial fluid biomarkers for periprosthetic infection","volume":"468","author":"Deirmengian","year":"2010","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2016.07.017_bib0045","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s11999-014-3722-7","article-title":"The alpha-defensin test for periprosthetic joint infection outperforms the leukocyte esterase test strip","volume":"473","author":"Deirmengian","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2016.07.017_bib0050","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.2106\/JBJS.M.01316","article-title":"Combined measurement of synovial fluid \u03b1-Defensin and C-reactive protein levels: highly accurate for diagnosing periprosthetic joint infection","volume":"96","author":"Deirmengian","year":"2014","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2016.07.017_bib0055","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1007\/s11999-014-3543-8","article-title":"Diagnosing periprosthetic joint infection: has the era of the biomarker arrived?","volume":"472","author":"Deirmengian","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2016.07.017_bib0060","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s11999-015-4152-x","article-title":"The alpha-defensin test for periprosthetic joint infection responds to a wide spectrum of organisms","volume":"473","author":"Deirmengian","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2016.07.017_bib0065","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/01.blo.0000185756.17401.32","article-title":"The Mark Coventry Award: white blood cell gene expression: a new approach toward the study and diagnosis of infection","volume":"440","author":"Deirmengian","year":"2005","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2016.07.017_bib0070","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jse.2009.07.065","article-title":"Propionibacterium acnes infection after shoulder arthroplasty: a diagnostic challenge","volume":"19","author":"Dodson","year":"2010","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.07.017_bib0075","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jse.2012.07.017","article-title":"Clinical meaning of unexpected positive cultures (UPC) in revision shoulder arthroplasty","volume":"22","author":"Foruria","year":"2013","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.07.017_bib0080","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.2106\/JBJS.N.00881","article-title":"Early versus late culture growth of propionibacterium acnes in revision shoulder arthroplasty","volume":"97","author":"Frangiamore","year":"2015","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2016.07.017_bib0085","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jse.2014.12.021","article-title":"\u03b1-Defensin as a predictor of periprosthetic shoulder infection","volume":"24","author":"Frangiamore","year":"2015","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.07.017_bib0090","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2106\/JBJS.N.00104","article-title":"Synovial fluid interleukin-6 as a predictor of periprosthetic shoulder infection","volume":"97","author":"Frangiamore","year":"2015","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2016.07.017_bib0095","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jse.2010.11.017","article-title":"Complications of unconstrained shoulder prostheses","volume":"20","author":"Gonzalez","year":"2011","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.07.017_bib0100","doi-asserted-by":"crossref","first-page":"442","DOI":"10.2106\/JBJS.M.00258","article-title":"Sensitivity of frozen section histology for identifying Propionibacterium acnes infections in revision shoulder arthroplasty","volume":"96","author":"Grosso","year":"2014","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2016.07.017_bib0105","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jse.2013.12.023","article-title":"Poor utility of serum interleukin-6 levels to predict indolent periprosthetic shoulder infections","volume":"23","author":"Grosso","year":"2014","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.07.017_bib0110","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jse.2011.08.052","article-title":"Reinfection rates after 1-stage revision shoulder arthroplasty for patients with unexpected positive intraoperative cultures","volume":"21","author":"Grosso","year":"2012","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.07.017_bib0115","series-title":"Regression modeling strategies: with applications to linear models, logistic regression, and survival analysis","author":"Harrell","year":"2015"},{"key":"10.1016\/j.jse.2016.07.017_bib0120","series-title":"Reverse shoulder arthroplasty: what, why, and how","author":"Hawkins","year":"2014"},{"issue":"Suppl 6","key":"10.1016\/j.jse.2016.07.017_bib0125","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.arth.2011.03.025","article-title":"Molecular markers for diagnosis of periprosthetic joint infection","volume":"26","author":"Jacovides","year":"2011","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.jse.2016.07.017_bib0130","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jim.2012.08.012","article-title":"Hyaluronidase treatment of synovial fluid to improve assay precision for biomarker research using multiplex immunoassay platforms","volume":"386","author":"Jayadev","year":"2012","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jse.2016.07.017_bib0135","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1007\/s11999-009-0875-x","article-title":"Positive culture rate in revision shoulder arthroplasty","volume":"467","author":"Kelly","year":"2009","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2016.07.017_bib0140","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.2106\/JBJS.J.01994","article-title":"Increasing incidence of shoulder arthroplasty in the United States","volume":"93","author":"Kim","year":"2011","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2016.07.017_bib0145","doi-asserted-by":"crossref","first-page":"R50","DOI":"10.1186\/ar3293","article-title":"The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors","volume":"13","author":"Kokebie","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jse.2016.07.017_bib0150","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1086\/588477","article-title":"Propionibacterium acnes postoperative shoulder arthritis: an emerging clinical entity","volume":"46","author":"Levy","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jse.2016.07.017_bib0155","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jse.2014.05.008","article-title":"Substantial cultures of Propionibacterium can be found in apparently aseptic shoulders revised three years or more after the index arthroplasty","volume":"24","author":"McGoldrick","year":"2015","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.07.017_bib0160","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jse.2014.11.044","article-title":"Periprosthetic shoulder infection in the United States: incidence and economic burden","volume":"24","author":"Padegimas","year":"2015","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.07.017_bib0165","doi-asserted-by":"crossref","first-page":"e9358","DOI":"10.1371\/journal.pone.0009358","article-title":"C-reactive protein, erythrocyte sedimentation rate and orthopedic implant infection","volume":"5","author":"Piper","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jse.2016.07.017_bib0170","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1128\/JCM.01686-08","article-title":"Microbiologic diagnosis of prosthetic shoulder infection by use of implant sonication","volume":"47","author":"Piper","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jse.2016.07.017_bib0175","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.2106\/JBJS.K.00861","article-title":"Prognostic factors for bacterial cultures positive for Propionibacterium acnes and other organisms in a large series of revision shoulder arthroplasties performed for stiffness, pain, or loosening","volume":"94","author":"Pottinger","year":"2012","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2016.07.017_bib0180","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.2106\/JBJS.RVW.M.00055","article-title":"Diagnosis of periprosthetic infection after shoulder arthroplasty: a critical analysis review","volume":"1","author":"Ricchetti","year":"2013","journal-title":"JBJS Rev"},{"key":"10.1016\/j.jse.2016.07.017_bib0185","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.jse.2012.01.006","article-title":"Periprosthetic infections after total shoulder arthroplasty: a 33-year perspective","volume":"21","author":"Singh","year":"2012","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.07.017_bib0190","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jse.2005.10.001","article-title":"Revision shoulder arthroplasty with positive intraoperative cultures: the value of preoperative studies and intraoperative histology","volume":"15","author":"Topolski","year":"2006","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2016.07.017_bib0195","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/01.blo.0000087324.60612.93","article-title":"Molecular and antibiofilm approaches to prosthetic joint infection","volume":"414","author":"Trampuz","year":"2003","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2016.07.017_bib0200","first-page":"166","article-title":"Nationwide trends in total shoulder arthroplasty and hemiarthroplasty for osteoarthritis","volume":"43","author":"Trofa","year":"2014","journal-title":"Am J Orthop"},{"key":"10.1016\/j.jse.2016.07.017_bib0205","doi-asserted-by":"crossref","first-page":"R262","DOI":"10.1186\/ar4107","article-title":"Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model","volume":"14","author":"Tsuchida","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jse.2016.07.017_bib0210","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jinf.2007.02.006","article-title":"Propionibacterium acnes: an agent of prosthetic joint infection and colonization","volume":"55","author":"Zeller","year":"2007","journal-title":"J Infect"}],"container-title":["Journal of Shoulder and Elbow Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1058274616302440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1058274616302440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T07:44:40Z","timestamp":1568447080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1058274616302440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S1058274616302440"],"URL":"https:\/\/doi.org\/10.1016\/j.jse.2016.07.017","relation":{},"ISSN":["1058-2746"],"issn-type":[{"value":"1058-2746","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neer Award 2015: Analysis of cytokine profiles in the diagnosis of periprosthetic joint infections of the shoulder","name":"articletitle","label":"Article Title"},{"value":"Journal of Shoulder and Elbow Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jse.2016.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved.","name":"copyright","label":"Copyright"}]}}