{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:29:41Z","timestamp":1774974581125,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007292","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jshoulderelbow.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Shoulder and Elbow Surgery"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.jse.2020.01.071","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T02:39:14Z","timestamp":1586918354000},"page":"996-1001","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum uric acid level is associated with the incidence of heterotopic ossification following elbow trauma surgery"],"prefix":"10.1016","volume":"29","author":[{"given":"Jinwu","family":"Bai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Hang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deting","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jse.2020.01.071_bib1","doi-asserted-by":"crossref","first-page":"E338","DOI":"10.1073\/pnas.1515397113","article-title":"Inhibition of Hif1alpha prevents both trauma-induced and genetic heterotopic ossification","volume":"113","author":"Agarwal","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jse.2020.01.071_bib2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ocl.2016.08.009","article-title":"Heterotopic ossification in trauma","volume":"48","author":"Barfield","year":"2017","journal-title":"Orthop Clin North Am"},{"key":"10.1016\/j.jse.2020.01.071_bib3","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.jhsa.2012.03.013","article-title":"Risk factors for posttraumatic heterotopic ossification of the elbow: case-control study","volume":"37","author":"Bauer","year":"2012","journal-title":"J Hand Surg"},{"key":"10.1016\/j.jse.2020.01.071_bib4","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.110.234278","article-title":"The regulation of valvular and vascular sclerosis by osteogenic morphogens","volume":"109","author":"Bostrom","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.jse.2020.01.071_bib5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1302\/0301-620X.57B1.36","article-title":"Observations on the induction of bone in soft tissues","volume":"57","author":"Chalmers","year":"1975","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jse.2020.01.071_bib6","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.injury.2006.04.130","article-title":"Epidemiology of adult fractures: a review","volume":"37","author":"Court-Brown","year":"2006","journal-title":"Injury"},{"key":"10.1016\/j.jse.2020.01.071_bib7","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/ATVBAHA.113.302070","article-title":"Inflammatory, metabolic, and genetic mechanisms of vascular calcification","volume":"34","author":"Demer","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jse.2020.01.071_bib8","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1177\/0003319711433198","article-title":"The relationship between severity of calcific aortic stenosis and serum uric acid levels","volume":"63","author":"Demir","year":"2012","journal-title":"Angiology"},{"key":"10.1016\/j.jse.2020.01.071_bib9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/jramc-2014-000277","article-title":"Heterotopic ossification: a systematic review","volume":"161","author":"Edwards","year":"2015","journal-title":"J R Army Med Corps"},{"key":"10.1016\/j.jse.2020.01.071_bib10","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jare.2017.03.003","article-title":"Physiological functions and pathogenic potential of uric acid: A review","volume":"8","author":"El Ridi","year":"2017","journal-title":"J Adv Res"},{"key":"10.1016\/j.jse.2020.01.071_bib11","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.2106\/JBJS.K.01533","article-title":"Heterotopic ossification after surgery for fractures and fracture-dislocations involving the proximal aspect of the radius or ulna","volume":"95","author":"Foruria","year":"2013","journal-title":"J Bone Joint Surgery Am"},{"key":"10.1016\/j.jse.2020.01.071_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00003086-199102000-00003","article-title":"A clinical perspective on common forms of acquired heterotopic ossification","author":"Garland","year":"1991","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2020.01.071_bib13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0749-0712(21)01180-X","article-title":"The classification and treatment of heterotopic ossification about the elbow and forearm","volume":"10","author":"Hastings","year":"1994","journal-title":"Hand Clin"},{"key":"10.1016\/j.jse.2020.01.071_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.otsr.2014.10.021","article-title":"Clinically relevant heterotopic ossification after elbow fracture surgery: a risk factors study","volume":"101","author":"Hong","year":"2015","journal-title":"Orthop Traumatol Surg Res"},{"key":"10.1016\/j.jse.2020.01.071_bib15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/path.4937","article-title":"Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2","volume":"242","year":"2017","journal-title":"J Pathol"},{"key":"10.1016\/j.jse.2020.01.071_bib16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.5435\/00124635-200403000-00007","article-title":"Heterotopic ossification","volume":"12","author":"Kaplan","year":"2004","journal-title":"J Am Acad Orthop Surg"},{"key":"10.1016\/j.jse.2020.01.071_bib17","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.bbrc.2009.12.027","article-title":"Tumor necrosis factor-alpha increases alkaline phosphatase expression in vascular smooth muscle cells via MSX2 induction","volume":"391","author":"Lee","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jse.2020.01.071_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tcm.2014.10.021","article-title":"Vascular calcification: Mechanisms of vascular smooth muscle cell calcification","volume":"25","author":"Leopold","year":"2015","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.jse.2020.01.071_bib19","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/jbt.21707","article-title":"Uric acid promotes osteogenic differentiation and inhibits adipogenic differentiation of human bone mesenchymal stem cells","volume":"29","author":"Li","year":"2015","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1016\/j.jse.2020.01.071_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.biochi.2015.06.025","article-title":"Uric acid as a modulator of glucose and lipid metabolism","volume":"116","author":"Lima","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.jse.2020.01.071_bib21","doi-asserted-by":"crossref","first-page":"e19901","DOI":"10.1371\/journal.pone.0019901","article-title":"Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study","volume":"6","author":"Lyngdoh","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jse.2020.01.071_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jse.2020.01.071_bib23","first-page":"125","article-title":"Heterotopic bone formation: clinical, laboratory, and imaging correlation","volume":"26","author":"Orzel","year":"1985","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jse.2020.01.071_bib24","first-page":"1281","article-title":"Molecular and cellular mechanisms of heterotopic ossification","volume":"29","author":"Ramirez","year":"2014","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.jse.2020.01.071_bib25","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.2106\/JBJS.N.01056","article-title":"Heterotopic ossification: basic-science principles and clinical correlates","volume":"97","author":"Ranganathan","year":"2015","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2020.01.071_bib26","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1007\/s11999-013-3304-0","article-title":"Injury complexity factors predict heterotopic ossification restricting motion after elbow trauma","volume":"472","author":"Wiggers","year":"2014","journal-title":"Clin Orthop Relat Res"}],"container-title":["Journal of Shoulder and Elbow Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1058274620301087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1058274620301087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:46:45Z","timestamp":1761007605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1058274620301087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S1058274620301087"],"URL":"https:\/\/doi.org\/10.1016\/j.jse.2020.01.071","relation":{},"ISSN":["1058-2746"],"issn-type":[{"value":"1058-2746","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum uric acid level is associated with the incidence of heterotopic ossification following elbow trauma surgery","name":"articletitle","label":"Article Title"},{"value":"Journal of Shoulder and Elbow Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jse.2020.01.071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved.","name":"copyright","label":"Copyright"}]}}