{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:57:01Z","timestamp":1788886621342,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","award":["ZNYB2021038"],"award-info":[{"award-number":["ZNYB2021038"]}],"id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["CXPY2020016"],"award-info":[{"award-number":["CXPY2020016"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042021kf0169"],"award-info":[{"award-number":["2042021kf0169"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016359","name":"Zhongnan Hospital of Wuhan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jshoulderelbow.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Shoulder and Elbow Surgery"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jse.2025.01.031","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T19:47:12Z","timestamp":1740080832000},"page":"e913-e923","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Platelet-derived mitochondria attenuate muscle atrophy following rotator cuff tears in a rat model"],"prefix":"10.1016","volume":"34","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-8650","authenticated-orcid":false,"given":"Yulong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jse.2025.01.031_bib1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/CS20201297","article-title":"Platelets: the peripheral donor of mitochondria for diabetes-induced cognitive impairment","volume":"135","author":"Amin","year":"2021","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jse.2025.01.031_bib2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00421-021-04865-4","article-title":"Key concepts in muscle regeneration: muscle \u201ccellular ecology\u201d integrates a gestalt of cellular cross-talk, motility, and activity to remodel structure and restore function","volume":"122","author":"Anderson","year":"2021","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.jse.2025.01.031_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jse.2025.01.031_bib4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1113\/JP283658","article-title":"The myonuclear domain in adult skeletal muscle fibres: past, present and future","volume":"601","author":"Bagley","year":"2023","journal-title":"J Physiol"},{"key":"10.1016\/j.jse.2025.01.031_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.132227","article-title":"Safety and efficacy of platelet-derived mitochondrial transplantation in ischaemic heart disease","volume":"410","author":"Baharvand","year":"2024","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jse.2025.01.031_bib6","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1182\/blood-2014-05-573543","article-title":"Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation","volume":"124","author":"Boudreau","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jse.2025.01.031_bib7","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.24662","article-title":"Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila","volume":"6","author":"Brandt","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.jse.2025.01.031_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/physrev.00019.2003","article-title":"Cellular and molecular regulation of muscle regeneration","volume":"84","author":"Charg\u00e9","year":"2004","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jse.2025.01.031_bib9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/09537104.2021.1961717","article-title":"Platelet-derived respiratory-competent mitochondria transfer to mesenchymal stem cells to promote wound healing via metabolic reprogramming","volume":"33","author":"Chen","year":"2022","journal-title":"Platelets"},{"key":"10.1016\/j.jse.2025.01.031_bib10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s12967-023-04369-z","article-title":"Mitochondrial dysfunction: roles in skeletal muscle atrophy","volume":"21","author":"Chen","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.jse.2025.01.031_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2013.08.032","article-title":"Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency","volume":"155","author":"Cogliati","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jse.2025.01.031_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biochi.2016.12.016","article-title":"The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism","volume":"134","author":"Crichton","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.jse.2025.01.031_bib13","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00402-014-2009-5","article-title":"Fatty degeneration and atrophy of the rotator cuff muscles after arthroscopic repair: does it improve, halt or deteriorate?","volume":"134","author":"Deniz","year":"2014","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.jse.2025.01.031_bib14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2106\/JBJS.16.00645","article-title":"Perivascular stem cells diminish muscle atrophy following massive rotator cuff tears in a small animal model","volume":"99","author":"Eliasberg","year":"2017","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2025.01.031_bib15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature12985","article-title":"Mitochondrial form and function","volume":"505","author":"Friedman","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jse.2025.01.031_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001576","article-title":"Mitochondria transplantation between living cells","volume":"20","author":"G\u00e4belein","year":"2022","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jse.2025.01.031_bib17","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1177\/0363546506297539","article-title":"Fatty infiltration and atrophy of the rotator cuff do not improve after rotator cuff repair and correlate with poor functional outcome","volume":"35","author":"Gladstone","year":"2007","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jse.2025.01.031_bib18","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1177\/03635465221097102","article-title":"Rates of return to manual labor after arthroscopic rotator cuff repair","volume":"50","author":"Green","year":"2022","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jse.2025.01.031_bib19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.abb.2018.11.005","article-title":"Mitochondrial dysfunction induces muscle atrophy during prolonged inactivity: a review of the causes and effects","volume":"662","author":"Hyatt","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jse.2025.01.031_bib20","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.12688\/f1000research.19139.1","article-title":"Mitochondrial dysregulation and muscle disuse atrophy","volume":"8","author":"Ji","year":"2019","journal-title":"F1000Res"},{"key":"10.1016\/j.jse.2025.01.031_bib21","article-title":"Platelet-derived mitochondria transfer facilitates wound-closure by modulating ROS levels in dermal fibroblasts","volume":"34","author":"Kim","year":"2022","journal-title":"Platelets"},{"key":"10.1016\/j.jse.2025.01.031_bib22","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/cvr\/cvaa012","article-title":"Genetic lineage tracing reveals poor angiogenic potential of cardiac endothelial cells","volume":"117","author":"Kocijan","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jse.2025.01.031_bib23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mito.2023.07.003","article-title":"Mitochondrial dysfunction and skeletal muscle atrophy: causes, mechanisms, and treatment strategies","volume":"72","author":"Kubat","year":"2023","journal-title":"Mitochondrion"},{"key":"10.1016\/j.jse.2025.01.031_bib24","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s12178-021-09714-7","article-title":"Treatment options for massive irreparable rotator cuff tears","volume":"14","author":"Kucirek","year":"2021","journal-title":"Curr Rev Musculoskelet Med"},{"key":"10.1016\/j.jse.2025.01.031_bib25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.freeradbiomed.2023.12.037","article-title":"Overexpression of manganese superoxide dismutase mitigates ACL injury-induced muscle atrophy, weakness and oxidative damage","volume":"212","author":"Latham","year":"2024","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jse.2025.01.031_bib26","first-page":"417","article-title":"Skeletal muscle microvasculature: a highly dynamic lifeline","volume":"30","author":"Latroche","year":"2015","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.jse.2025.01.031_bib27","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jse.2019.09.021","article-title":"Beige fibro-adipogenic progenitor transplantation reduces muscle degeneration and improves function in a mouse model of delayed repair of rotator cuff tears","volume":"29","author":"Lee","year":"2020","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2025.01.031_bib28","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1177\/1941738120944256","article-title":"Muscle atrophy after ACL injury: implications for clinical practice","volume":"12","author":"Lepley","year":"2020","journal-title":"Sports Health"},{"key":"10.1016\/j.jse.2025.01.031_bib29","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.cmet.2020.12.006","article-title":"Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming","volume":"33","author":"Levoux","year":"2021","journal-title":"Cell Metab"},{"key":"10.1016\/j.jse.2025.01.031_bib30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41392-020-00440-z","article-title":"Intercellular mitochondrial transfer as a means of tissue revitalization","volume":"6","author":"Liu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jse.2025.01.031_bib31","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1002\/jor.22096","article-title":"Evaluation of Akt\/mTOR activity in muscle atrophy after rotator cuff tears in a rat model","volume":"30","author":"Liu","year":"2012","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jse.2025.01.031_bib32","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.K.00620","article-title":"A mouse model of massive rotator cuff tears","volume":"94","author":"Liu","year":"2012","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jse.2025.01.031_bib33","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1042\/CS20200530","article-title":"Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db\/db mice","volume":"134","author":"Ma","year":"2020","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jse.2025.01.031_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.maturitas.2019.01.016","article-title":"Management of rotator cuff tears in the elderly population","volume":"123","author":"Micallef","year":"2019","journal-title":"Maturitas"},{"key":"10.1016\/j.jse.2025.01.031_bib35","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125334","article-title":"Non-fibro-adipogenic pericytes from human embryonic stem cells attenuate degeneration of the chronically injured mouse muscle","volume":"4","author":"Mosich","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jse.2025.01.031_bib36","doi-asserted-by":"crossref","first-page":"H326","DOI":"10.1152\/ajpheart.00635.2015","article-title":"Advances and challenges in skeletal muscle angiogenesis","volume":"310","author":"Olfert","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jse.2025.01.031_bib37","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jvs.2019.03.079","article-title":"Mitochondrial transplantation ameliorates acute limb ischemia","volume":"71","author":"Orfany","year":"2020","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jse.2025.01.031_bib38","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.arthro.2022.06.022","article-title":"Platelet-rich plasma injection can be a viable alternative to corticosteroid injection for conservative treatment of rotator cuff disease: a meta-analysis of randomized controlled trials","volume":"39","author":"Pang","year":"2023","journal-title":"Arthroscopy"},{"key":"10.1016\/j.jse.2025.01.031_bib39","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.3390\/ijms22126531","article-title":"Anakinra activates superoxide dismutase 2 to mitigate inflammasome activity","volume":"22","author":"Pariano","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jse.2025.01.031_bib40","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1242\/dev.069088","article-title":"Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage","volume":"139","author":"Relaix","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.jse.2025.01.031_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101128","article-title":"Inter and Intracellular mitochondrial trafficking in health and disease","volume":"62","author":"Shanmughapriya","year":"2020","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jse.2025.01.031_bib42","doi-asserted-by":"crossref","DOI":"10.1177\/09636897211024210","article-title":"Platelet mitochondria transplantation rescues hypoxia\/reoxygenation-induced mitochondrial dysfunction and neuronal cell death involving the FUNDC2\/PIP3\/Akt\/FOXO3a axis","volume":"30","author":"Shi","year":"2021","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jse.2025.01.031_bib43","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.semcdb.2017.08.055","article-title":"Mitochondrial cytochrome c oxidase biogenesis: recent developments","volume":"76","author":"Tim\u00f3n-G\u00f3mez","year":"2018","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jse.2025.01.031_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/srep30610","article-title":"The spectrum of mitochondrial ultrastructural defects in mitochondrial myopathy","volume":"6","author":"Vincent","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jse.2025.01.031_bib45","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1097\/CORR.0000000000000335","article-title":"Reversal of fatty infiltration after suprascapular nerve compression release is dependent on UCP1 expression in mice","volume":"476","author":"Wang","year":"2018","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2025.01.031_bib46","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jse.2020.06.006","article-title":"\u03b2(3)-Adrenergic receptor agonist treats rotator cuff fatty infiltration by activating beige fat in mice","volume":"30","author":"Wang","year":"2021","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2025.01.031_bib47","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.7150\/thno.69533","article-title":"AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages","volume":"12","author":"Xia","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.jse.2025.01.031_bib48","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.phrs.2018.12.020","article-title":"Mitochondrial quality orchestrates muscle-adipose dialog to alleviate dietary obesity","volume":"141","author":"Xu","year":"2019","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jse.2025.01.031_bib49","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1002\/sctm.17-0078","article-title":"Platelet-derived mitochondria display embryonic stem cell markers and improve pancreatic islet \u03b2-cell function in humans","volume":"6","author":"Zhao","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jse.2025.01.031_bib50","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1039\/D1TB00720C","article-title":"Superoxide dismutase nanozymes: an emerging star for anti-oxidation","volume":"9","author":"Zhao","year":"2021","journal-title":"J Mater Chem B"}],"container-title":["Journal of Shoulder and Elbow Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1058274625001727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1058274625001727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:56:10Z","timestamp":1765828570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1058274625001727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1058274625001727"],"URL":"https:\/\/doi.org\/10.1016\/j.jse.2025.01.031","relation":{},"ISSN":["1058-2746"],"issn-type":[{"value":"1058-2746","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet-derived mitochondria attenuate muscle atrophy following rotator cuff tears in a rat model","name":"articletitle","label":"Article Title"},{"value":"Journal of Shoulder and Elbow Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jse.2025.01.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}