{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:20:48Z","timestamp":1768346448195,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100013615","name":"American Shoulder and Elbow Surgeons","doi-asserted-by":"publisher","award":["NW-2022-01"],"award-info":[{"award-number":["NW-2022-01"]}],"id":[{"id":"10.13039\/100013615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jshoulderelbow.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Shoulder and Elbow Surgery"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jse.2025.06.009","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T16:19:22Z","timestamp":1753805962000},"page":"e337-e343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biocompatibility of the InSpace subacromial balloon spacer: an in vivo murine pouch model cytokine analysis"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0747-1687","authenticated-orcid":false,"given":"Rishi","family":"Chatterji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2054-5803","authenticated-orcid":false,"given":"Noah","family":"Elagamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-7248","authenticated-orcid":false,"given":"Adam","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5885-906X","authenticated-orcid":false,"given":"Therese","family":"Bou-Akl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6847-9618","authenticated-orcid":false,"given":"Michael","family":"Fry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0268-9775","authenticated-orcid":false,"given":"Paula","family":"Pawlitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6405-1454","authenticated-orcid":false,"given":"David C.","family":"Markel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9702-4437","authenticated-orcid":false,"given":"Jason O.","family":"Holcomb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jse.2025.06.009_bib1","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.jse.2023.04.016","article-title":"Outcomes of subacromial balloon spacer implantation for irreparable rotator cuff tears: a systematic review and meta-analysis","volume":"32","author":"Berk","year":"2023","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2025.06.009_bib2","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.jse.2008.04.007","article-title":"Outcome of latissimus dorsi transfer as a salvage procedure for failed rotator cuff repair with loss of elevation","volume":"17","author":"Birmingham","year":"2008","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.jse.2025.06.009_bib3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00264-018-4065-x","article-title":"Comparative cost-effectiveness analysis of the subacromial spacer for irreparable and massive rotator cuff tears","volume":"43","author":"Castagna","year":"2019","journal-title":"Int Orthopaedics (SICOT)"},{"key":"10.1016\/j.jse.2025.06.009_bib4","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1186\/s13018-022-03411-y","article-title":"Superior capsule reconstruction, partial cuff repair, graft interposition, arthroscopic debridement or balloon spacers for large and massive irreparable rotator cuff tears: a systematic review and meta-analysis","volume":"17","author":"Davies","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.jse.2025.06.009_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.asmr.2024.100907","article-title":"The insertion of a subacromial balloon spacer can provide symptom relief and functional improvement at a minimum 5-year follow-up in patients with massive irreparable rotator cuff tears","volume":"6","author":"Fares","year":"2024","journal-title":"Arthrosc Sports Med Rehabil"},{"key":"10.1016\/j.jse.2025.06.009_bib6","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190103","article-title":"Transforming growth factor\u2013\u03b2 in tissue fibrosis","volume":"217","author":"Frangogiannis","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.jse.2025.06.009_bib7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2172-13-31","article-title":"TGF\u03b2 signaling plays a critical role in promoting alternative macrophage activation","volume":"13","author":"Gong","year":"2012","journal-title":"BMC Immunol"},{"key":"10.1016\/j.jse.2025.06.009_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118870","article-title":"In vitro and in vivo degradation behavior and the long-term performance of biodegradable PLCL balloon implants","volume":"574","author":"Haim Zada","year":"2020","journal-title":"Int J Pharm"},{"key":"10.1016\/j.jse.2025.06.009_bib9","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1053\/j.oto.2018.08.008","article-title":"Balloon interspace arthroplasty for irreparable rotator cuff tears","volume":"28","author":"Horneff","year":"2018","journal-title":"Oper Tech Orthop"},{"key":"10.1016\/j.jse.2025.06.009_bib10","doi-asserted-by":"crossref","first-page":"e855","DOI":"10.1016\/j.asmr.2020.06.011","article-title":"Implantable subacromial balloon spacers in patients with massive irreparable rotator cuff tears: a systematic review of clinical, biomechanical, and financial implications","volume":"2","author":"Johns","year":"2020","journal-title":"Arthrosc Sports Med Rehabil"},{"key":"10.1016\/j.jse.2025.06.009_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.otsm.2023.150978","article-title":"Prevalence, natural history, and nonoperative treatment of rotator cuff disease","volume":"31","author":"Kuhn","year":"2023","journal-title":"Oper Tech Sports Med"},{"key":"10.1016\/j.jse.2025.06.009_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125522","article-title":"Poly-l-lactide-co-\u03b5-caprolactone (PLCL) and poly-l-lactic acid (PLLA)\/gelatin electrospun subacromial spacer improves extracellular matrix (ECM) deposition for the potential treatment of irreparable rotator cuff tears","volume":"245","author":"Liu","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jse.2025.06.009_bib13","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.2106\/JBJS.18.00850","article-title":"Biomechanics of biodegradable subacromial balloon spacer for irreparable superior rotator cuff tears: study of a cadaveric model","volume":"101","author":"Lobao","year":"2019","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.jse.2025.06.009_bib14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/CORR.0000000000000391","article-title":"Does suture type influence bacterial retention and biofilm formation after irrigation in a mouse model?","volume":"477","author":"Markel","year":"2019","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jse.2025.06.009_bib15","first-page":"13","article-title":"Characterization of the inflammatory response to four commercial bone graft substitutes using a murine biocompatibility model","volume":"5","author":"Markel","year":"2012","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.jse.2025.06.009_bib16","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/jbm.b.33116","article-title":"Immunological response to bolus versus multiple injections of hylan G-F 20 (Synvisc) in a murine biocompatibility model","volume":"102","author":"Markel","year":"2014","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.jse.2025.06.009_bib17","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/S0140-6736(22)00652-3","article-title":"Subacromial balloon spacer for irreparable rotator cuff tears of the shoulder (START:REACTS): a group-sequential, double-blind, multicentre randomised controlled trial","volume":"399","author":"Metcalfe","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jse.2025.06.009_bib18","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.arth.2016.11.010","article-title":"Decreased bacterial adherence, biofilm formation, and tissue reactivity of barbed monofilament suture in an in vivo contaminated wound model","volume":"32","author":"Morris","year":"2017","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.jse.2025.06.009_bib19","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1177\/0192623315600275","article-title":"Long-term local and systemic safety of poly(L-lactide-co-epsilon-caprolactone) after subcutaneous and intra-articular implantation in rats","volume":"43","author":"Ramot","year":"2015","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.jse.2025.06.009_bib20","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/jbm.b.33095","article-title":"Effect of erythromycin-doped calcium polyphosphate scaffold composite in a mouse pouch infection model: PVA coating sustained EM release","volume":"102","author":"Ren","year":"2014","journal-title":"J Biomed Mater Res"},{"issue":"4S","key":"10.1016\/j.jse.2025.06.009_bib21","first-page":"75","article-title":"A clinical and radiological study of biodegradable subacromial spacer in the treatment of massive irreparable rotator cuff tears","volume":"88","author":"Ricci","year":"2017","journal-title":"Acta Biomed"},{"key":"10.1016\/j.jse.2025.06.009_bib22","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1016\/j.eats.2012.02.002","article-title":"New solution for massive, irreparable rotator cuff tears: the subacromial \u201cbiodegradable spacer.\u201d","volume":"1","author":"Savarese","year":"2012","journal-title":"Arthrosc Tech"},{"key":"10.1016\/j.jse.2025.06.009_bib23","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/path.1711410406","article-title":"Increased inflammatory reactivity in newly formed lining tissue","volume":"141","author":"Sedgwick","year":"1983","journal-title":"J Pathol"},{"key":"10.1016\/j.jse.2025.06.009_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12178-023-09879-3","article-title":"Subacromial balloon spacer for the massive irreparable cuff tear","volume":"17","author":"Sewpaul","year":"2024","journal-title":"Curr Rev Musculoskelet Med"},{"key":"10.1016\/j.jse.2025.06.009_bib25","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.2106\/JBJS.21.00667","article-title":"InSpace implant compared with partial repair for the treatment of full-thickness massive rotator cuff tears: a multicenter, single-blinded, randomized controlled trial","volume":"104","author":"Verma","year":"2022","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.jse.2025.06.009_bib26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0142-9612(01)00134-X","article-title":"Inflammatory responses to orthopaedic biomaterials in the murine air pouch","volume":"23","author":"Wooley","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.jse.2025.06.009_bib27","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jse.2009.04.006","article-title":"Prevalence and risk factors of a rotator cuff tear in the general population","volume":"19","author":"Yamamoto","year":"2010","journal-title":"J Shoulder Elbow Surg"}],"container-title":["Journal of Shoulder and Elbow Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1058274625005543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1058274625005543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:34:03Z","timestamp":1768322043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1058274625005543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1058274625005543"],"URL":"https:\/\/doi.org\/10.1016\/j.jse.2025.06.009","relation":{},"ISSN":["1058-2746"],"issn-type":[{"value":"1058-2746","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biocompatibility of the InSpace subacromial balloon spacer: an in vivo murine pouch model cytokine analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Shoulder and Elbow Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jse.2025.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}