{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:04:45Z","timestamp":1793045085563,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515010611"],"award-info":[{"award-number":["2024A1515010611"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011943"],"award-info":[{"award-number":["2023A1515011943"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["GZC20231058"],"award-info":[{"award-number":["GZC20231058"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sport and Health Science"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jshs.2025.101077","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T14:57:16Z","timestamp":1754751436000},"page":"101077","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Exercise suppresses osteoclastogenesis by increasing the secretion of muscle-derived L-\u03b2-aminoisobutyric acid"],"prefix":"10.1016","volume":"15","author":[{"given":"Zhi-Wei","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Peng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Rong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Biao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Zhou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hai","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di-Zheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Zheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Wen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Xing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Ming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jshs.2025.101077_bib0001","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"The Lancet"},{"key":"10.1016\/j.jshs.2025.101077_bib0002","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1210\/endrev\/bnab028","article-title":"Secondary osteoporosis","volume":"43","author":"Ebeling","year":"2022","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jshs.2025.101077_bib0003","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev.pathmechdis.3.121806.151431","article-title":"The osteoclast: Friend or foe?","volume":"3","author":"Novack","year":"2008","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jshs.2025.101077_bib0004","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5152\/eurjrheum.2016.048","article-title":"An overview and management of osteoporosis","volume":"4","author":"S\u00f6zen","year":"2017","journal-title":"Eur J Rheumatol"},{"key":"10.1016\/j.jshs.2025.101077_bib0005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ecl.2021.03.009","article-title":"Postmenopausal osteoporosis: Latest guidelines","volume":"50","author":"Arceo-Mendoza","year":"2021","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.jshs.2025.101077_bib0006","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1210\/jc.2019-00221","article-title":"Pharmacological management of osteoporosis in postmenopausal women: An Endocrine Society* Clinical Practice Guideline","volume":"104","author":"Eastell","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jshs.2025.101077_bib0007","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/jbmr.2888","article-title":"A crisis in the treatment of osteoporosis","volume":"31","author":"Khosla","year":"2016","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jshs.2025.101077_bib0008","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41574-019-0170-1","article-title":"Combating osteoporosis and obesity with exercise: Leveraging cell mechanosensitivity","volume":"15","author":"Pagnotti","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jshs.2025.101077_bib0009","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrrheum.2009.239","article-title":"Mechanical signals as anabolic agents in bone","volume":"6","author":"Ozcivici","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jshs.2025.101077_bib0010","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1136\/bjsm.2008.052704","article-title":"A meta-analysis of impact exercise on postmenopausal bone loss: The case for mixed loading exercise programmes","volume":"43","author":"Martyn-St James","year":"2009","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.jshs.2025.101077_bib0011","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(02)08827-X","article-title":"Treatment of postmenopausal osteoporosis","volume":"359","author":"Delmas","year":"2002","journal-title":"The Lancet"},{"key":"10.1016\/j.jshs.2025.101077_bib0012","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jshs.2019.04.002","article-title":"Exercise as a prescription for patients with various diseases","volume":"8","author":"Luan","year":"2019","journal-title":"J Sport Health Sci"},{"key":"10.1016\/j.jshs.2025.101077_bib0013","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1001\/jama.1986.03370090069022","article-title":"Long-distance running, bone density, and osteoarthritis","volume":"255","author":"Lane","year":"1986","journal-title":"JAMA"},{"key":"10.1016\/j.jshs.2025.101077_bib0014","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1359\/jbmr.1997.12.2.255","article-title":"High-impact exercise promotes bone gain in well-trained female athletes","volume":"12","author":"Taaffe","year":"1997","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jshs.2025.101077_bib0015","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s00198-008-0590-6","article-title":"The effect of moderate impact exercise on skeletal integrity in master athletes","volume":"19","author":"Velez","year":"2008","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jshs.2025.101077_bib0016","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-020-00128-8","article-title":"Nrf2 epigenetic derepression induced by running exercise protects against osteoporosis","volume":"9","author":"Chen","year":"2021","journal-title":"Bone Res"},{"key":"10.1016\/j.jshs.2025.101077_bib0017","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/j.2040-4603.2013.tb00522.x","article-title":"Muscle as a secretory organ","volume":"3","author":"Pedersen","year":"2013","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jshs.2025.101077_bib0018","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrendo.2012.49","article-title":"Muscles, exercise and obesity: Skeletal muscle as a secretory organ","volume":"8","author":"Pedersen","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jshs.2025.101077_bib0019","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cmet.2013.12.003","article-title":"\u03b2-aminoisobutyric acid induces browning of white fat and hepatic beta-oxidation and is inversely correlated with cardiometabolic risk factors","volume":"19","author":"Roberts","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.jshs.2025.101077_bib0020","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.celrep.2018.01.041","article-title":"\u03b2-aminoisobutyric acid, L-BAIBA, is a muscle-derived osteocyte survival factor","volume":"22","author":"Kitase","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.jshs.2025.101077_bib0021","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/167307a0","article-title":"\u03b2-aminoisobutyric acid (alpha-methyl-beta-alanine): A new amino-acid obtained from human urine","volume":"167","author":"Crumpler","year":"1951","journal-title":"Nature"},{"key":"10.1016\/j.jshs.2025.101077_bib0022","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostrom","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jshs.2025.101077_bib0023","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1007\/s00125-015-3663-z","article-title":"BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-ppar\u03b4-dependent pathway in mice","volume":"58","author":"Jung","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.jshs.2025.101077_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1192458","article-title":"Signaling metabolite \u03b2-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill","volume":"14","author":"Yi","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jshs.2025.101077_bib0025","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00441-022-03608-x","article-title":"Identification of MrgprD expression in mouse enteric neurons","volume":"388","author":"Xu","year":"2022","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jshs.2025.101077_bib0026","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12889-019-6510-1","article-title":"Effect of diet with or without exercise on abdominal fat in postmenopausal women\u2014A randomised trial","volume":"19","author":"van Gemert","year":"2019","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jshs.2025.101077_bib0027","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/s42255-023-00803-0","article-title":"SIRT2 regulates extracellular vesicle-mediated liver-bone communication","volume":"5","author":"Lin","year":"2023","journal-title":"Nat Metab"},{"key":"10.1016\/j.jshs.2025.101077_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102626","article-title":"Foxf1 knockdown promotes BMSC osteogenesis in part by activating the Wnt\/\u03b2-catenin signalling pathway and prevents ovariectomy-induced bone loss","volume":"52","author":"Shen","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jshs.2025.101077_bib0029","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s42003-020-0766-y","article-title":"Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis","volume":"3","author":"Wang","year":"2020","journal-title":"Commun Biol"},{"key":"10.1016\/j.jshs.2025.101077_bib0030","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/jcsm.12560","article-title":"Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles","volume":"11","author":"Shang","year":"2020","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jshs.2025.101077_bib0031","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2147\/JPR.S234334","article-title":"Oxidative stress contributes to hyperalgesia in osteoporotic mice","volume":"13","author":"Tu","year":"2020","journal-title":"J Pain Res"},{"key":"10.1016\/j.jshs.2025.101077_bib0032","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41586-022-04828-5","article-title":"An exercise-inducible metabolite that suppresses feeding and obesity","volume":"606","author":"Li","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jshs.2025.101077_bib0033","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/s41419-021-04441-w","article-title":"Age-related accumulation of advanced oxidation protein products promotes osteoclastogenesis through disruption of redox homeostasis","volume":"12","author":"Zhuang","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jshs.2025.101077_bib0034","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1359\/jbmr.2000.15.8.1477","article-title":"Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts","volume":"15","author":"Takeshita","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jshs.2025.101077_bib0035","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(00)00066-0","article-title":"Pax7 is required for the specification of myogenic satellite cells","volume":"102","author":"Seale","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jshs.2025.101077_bib0036","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1302\/2046-3758.117.BJR-2021-0554.R2","article-title":"Accumulation of advanced oxidation protein products contributes to age-related impairment of gap junction intercellular communication in osteocytes of male mice","volume":"11","author":"Tu","year":"2022","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.jshs.2025.101077_bib0037","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/8756-3282(90)90082-A","article-title":"A band of F-actin containing podosomes is involved in bone resorption by osteoclasts","volume":"11","author":"Kanehisa","year":"1990","journal-title":"Bone"},{"key":"10.1016\/j.jshs.2025.101077_bib0038","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jshs.2025.101077_bib0039","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000731","article-title":"Linking skeletal muscle aging with osteoporosis by lamin A\/C deficiency","volume":"18","author":"Xiong","year":"2020","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jshs.2025.101077_bib0040","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","article-title":"The molecular understanding of osteoclast differentiation","volume":"40","author":"Asagiri","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.jshs.2025.101077_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114397","article-title":"Both enantiomers of \u03b2-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes","volume":"43","author":"Sakamoto","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.jshs.2025.101077_bib0042","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1152\/physrev.00018.2006","article-title":"Amino acid transport across mammalian intestinal and renal epithelia","volume":"88","author":"Br\u00f6er","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jshs.2025.101077_bib0043","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00726-009-0380-2","article-title":"Taurine inhibits osteoclastogenesis through the taurine transporter","volume":"39","author":"Yuan","year":"2010","journal-title":"Amino Acids"},{"key":"10.1016\/j.jshs.2025.101077_bib0044","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.redox.2016.01.006","article-title":"Molecular regulatory mechanisms of osteoclastogenesis through cytoprotective enzymes","volume":"8","author":"Kanzaki","year":"2016","journal-title":"Redox Biol"},{"key":"10.1016\/j.jshs.2025.101077_bib0045","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00198-020-05723-3","article-title":"Feasibility, safety and effectiveness of a pilot 16-week home-based, impact exercise intervention in postmenopausal women with low bone mineral density","volume":"32","author":"Ng","year":"2021","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jshs.2025.101077_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.maturitas.2023.107844","article-title":"The role of estrogen in female skeletal muscle aging: A systematic review","volume":"178","author":"Critchlow","year":"2023","journal-title":"Maturitas"},{"key":"10.1016\/j.jshs.2025.101077_bib0047","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.arr.2015.03.002","article-title":"Muscle and bone, two interconnected tissues","volume":"21","author":"Tagliaferri","year":"2015","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jshs.2025.101077_bib0048","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3390\/nu11030524","article-title":"Beta-aminoisobutyric acid as a novel regulator of carbohydrate and lipid metabolism","volume":"11","author":"Tanianskii","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jshs.2025.101077_bib0049","first-page":"308","article-title":"Advances in bone biology: The osteoclast","volume":"17","author":"Roodman","year":"1996","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jshs.2025.101077_bib0050","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1172\/JCI133572","article-title":"Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts","volume":"130","author":"Chowdhury","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jshs.2025.101077_bib0051","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/jbmr.3932","article-title":"Increased expression of FGF-21 negatively affects bone homeostasis in dystrophin\/utrophin double knockout mice","volume":"35","author":"Li","year":"2020","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jshs.2025.101077_bib0052","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58172","article-title":"Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo","volume":"9","author":"Estell","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.jshs.2025.101077_bib0053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jot.2022.03.003","article-title":"Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35\/NF\u03baB p65 pathway","volume":"35","author":"Shi","year":"2022","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jshs.2025.101077_bib0054","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/jnr.10027","article-title":"Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons","volume":"66","author":"Chen","year":"2001","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jshs.2025.101077_bib0055","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00726-012-1361-4","article-title":"Taurine and inflammatory diseases","volume":"46","author":"Marcinkiewicz","year":"2014","journal-title":"Amino Acids"},{"key":"10.1016\/j.jshs.2025.101077_bib0056","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1001\/archinte.159.22.2647","article-title":"The continuing importance of bile acids in liver and intestinal disease","volume":"159","author":"Hofmann","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jshs.2025.101077_bib0057","doi-asserted-by":"crossref","first-page":"706","DOI":"10.14348\/molcells.2017.0225","article-title":"Current understanding of RANK signaling in osteoclast differentiation and maturation","volume":"40","author":"Park","year":"2017","journal-title":"Mol Cells"},{"key":"10.1016\/j.jshs.2025.101077_bib0058","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13045-018-0621-5","article-title":"NF-\u03baB signaling and its relevance to the treatment of mantle cell lymphoma","volume":"11","author":"Balaji","year":"2018","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.jshs.2025.101077_bib0059","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI108126","article-title":"The role of superoxide anion and hydrogen peroxide in phagocytosis-associated oxidative metabolic reactions","volume":"56","author":"Baehner","year":"1975","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jshs.2025.101077_bib0060","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1038\/sj.emboj.7600476","article-title":"FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK","volume":"23","author":"Essers","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.jshs.2025.101077_bib0061","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.freeradbiomed.2013.08.005","article-title":"Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation","volume":"65","author":"Hyeon","year":"2013","journal-title":"Free Radic Biol Med"}],"container-title":["Journal of Sport and Health Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095254625000584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095254625000584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T20:09:02Z","timestamp":1780258142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095254625000584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":61,"alternative-id":["S2095254625000584"],"URL":"https:\/\/doi.org\/10.1016\/j.jshs.2025.101077","relation":{},"ISSN":["2095-2546"],"issn-type":[{"value":"2095-2546","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise suppresses osteoclastogenesis by increasing the secretion of muscle-derived L-\u03b2-aminoisobutyric acid","name":"articletitle","label":"Article Title"},{"value":"Journal of Sport and Health Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jshs.2025.101077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V. on behalf of Shanghai University of Sport.","name":"copyright","label":"Copyright"}],"article-number":"101077"}}