{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:18:26Z","timestamp":1778523506922,"version":"3.51.4"},"reference-count":62,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","sleep.theclinics.com","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine Clinics"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jsmc.2021.03.002","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T07:39:15Z","timestamp":1618558755000},"page":"335-348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Isolated Form of Rapid Eye Movement Sleep Behavior Disorder"],"prefix":"10.1016","volume":"16","author":[{"given":"Alex","family":"Iranzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina Agudelo","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabela","family":"Novo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsmc.2021.03.002_bib1","series-title":"International classification of sleep disorders","year":"2014"},{"key":"10.1016\/j.jsmc.2021.03.002_bib2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1474-4422(16)00057-0","article-title":"Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions","volume":"15","author":"Iranzo","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.5665\/sleep.5332","article-title":"The clinical phenotype of idiopathic REM sleep behavior disorder at presentation: a study in 203 consecutive patients","volume":"39","author":"Fern\u00e1ndez-Arcos","year":"2016","journal-title":"Sleep"},{"key":"10.1016\/j.jsmc.2021.03.002_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-018-2852-8","article-title":"The REM sleep circuit and how its impairment leads to REM sleep behavior disorder","volume":"73","author":"Iranzo","year":"2018","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jsmc.2021.03.002_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jsmc.2019.04.003","article-title":"Precision medicine in rapid eye movement sleep behavior disorder","volume":"14","author":"H\u00f6gl","year":"2019","journal-title":"Sleep Med Clin"},{"key":"10.1016\/j.jsmc.2021.03.002_bib6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.sleep.2017.07.021","article-title":"Idiopathic REM sleep behavior disorder in the elderly Spanish community: a primary care center study with a two-stage design using video-polysomnography","volume":"40","author":"Pujol","year":"2017","journal-title":"Sleep Med"},{"issue":"2","key":"10.1016\/j.jsmc.2021.03.002_bib7","doi-asserted-by":"crossref","first-page":"zsx197","DOI":"10.1093\/sleep\/zsx197","article-title":"Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population","volume":"41","author":"Haba-Rubio","year":"2018","journal-title":"Sleep"},{"key":"10.1016\/j.jsmc.2021.03.002_bib8","doi-asserted-by":"crossref","first-page":"835","DOI":"10.5665\/sleep.1886","article-title":"Normative EMG values during REM sleep for the diagnosis of REM sleep behavior disorder","volume":"35","author":"Frauscher","year":"2012","journal-title":"Sleep"},{"issue":"4","key":"10.1016\/j.jsmc.2021.03.002_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx025","article-title":"Diagnostic value of isolated mentalis versus mentalis plus upper limb electromyography in idiopathic REM sleep behavior disorder patients eventually developing a neurodegenerative syndrome","volume":"40","author":"Fern\u00e1ndez-Arcos","year":"2017","journal-title":"Sleep"},{"key":"10.1016\/j.jsmc.2021.03.002_bib10","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.5665\/sleep.4076","article-title":"Validation of an integrated software for the detection of rapid eye movement sleep behavior disorder","volume":"37","author":"Frauscher","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.jsmc.2021.03.002_bib11","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.clinph.2019.01.011","article-title":"Detection of REM sleep behaviour disorder by automated polysomnography analysis","volume":"130","author":"Cooray","year":"2019","journal-title":"Clin Neurophysiol"},{"issue":"11","key":"10.1016\/j.jsmc.2021.03.002_bib12","doi-asserted-by":"crossref","first-page":"zsaa100","DOI":"10.1093\/sleep\/zsaa100","article-title":"Automated 3D video analysis of lower limb movements during REM sleep: a new diagnostic tool for isolated REM sleep behavior disorder","volume":"43","author":"Waser","year":"2020","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.jsmc.2021.03.002_bib13","doi-asserted-by":"crossref","first-page":"zsy053","DOI":"10.1093\/sleep\/zsy053","article-title":"Screening for idiopathic REM sleep behavior disorder: usefulness of actigraphy","volume":"41","author":"Stefani","year":"2018","journal-title":"Sleep"},{"key":"10.1016\/j.jsmc.2021.03.002_bib14","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.sleep.2012.09.008","article-title":"Development of scales for assessment of rapid eye movement sleep behavior disorder (RBD)","volume":"14","author":"Lam","year":"2013","journal-title":"Sleep Med"},{"key":"10.1016\/j.jsmc.2021.03.002_bib15","series-title":"Rapid-eye-movement sleep behavior disorder","first-page":"33","article-title":"Clinical aspects of idiopathic RBD","author":"P\u00e9rez-Carbonell","year":"2019"},{"key":"10.1016\/j.jsmc.2021.03.002_bib16","series-title":"Rapid-eye-movement sleep behavior disorder","first-page":"403","article-title":"Brain imaging in RBD","author":"Kogan","year":"2019"},{"key":"10.1016\/j.jsmc.2021.03.002_bib17","series-title":"Rapid-eye-movement sleep behavior disorder","first-page":"491","article-title":"Neuropsychological aspects: cognition in RBD","author":"Gagnon","year":"2019"},{"key":"10.1016\/j.jsmc.2021.03.002_bib18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/ana.25026","article-title":"Dopamine transporter imaging deficit predicts early transition to synucleinopathy in idiopathic rapid eye movement sleep behavior disorder","volume":"82","author":"Iranzo","year":"2017","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.jsmc.2021.03.002_bib19","first-page":"963","article-title":"Significance of hyposmia in isolated REM sleep behavior disorder","volume":"268","author":"Iranzo","year":"2021","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib20","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S1474-4422(11)70152-1","article-title":"Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study","volume":"10","author":"Iranzo","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib21","series-title":"Rapid-eye-movement sleep behavior disorder","first-page":"589","article-title":"Genetics of REM sleep behavior disorder. RBD","author":"Gan-Or","year":"2019"},{"key":"10.1016\/j.jsmc.2021.03.002_bib22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.parkreldis.2018.02.034","article-title":"Glucocerebrosidase gene variants are accumulated in idiopathic REM sleep behavior disorder","volume":"50","author":"G\u00e1mez-Valero","year":"2018","journal-title":"Parkinsonism Relat Disord"},{"issue":"8","key":"10.1016\/j.jsmc.2021.03.002_bib23","doi-asserted-by":"crossref","first-page":"e1008","DOI":"10.1212\/WNL.0000000000010042","article-title":"GBA variants in REM sleep behavior disorder: a multicenter study","volume":"95","author":"Krohn","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.jsmc.2021.03.002_bib24","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1212\/WNL.0000000000002304","article-title":"Absence of LRRK2 mutations in a cohort of patients with idiopathic REM sleep behavior disorder","volume":"86","author":"Fern\u00e1ndez-Santiago","year":"2016","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.jsmc.2021.03.002_bib25","doi-asserted-by":"crossref","first-page":"e0132368","DOI":"10.1371\/journal.pone.0132368","article-title":"Sleep disorders in parkinsonian and Nonparkinsonian LRRK2 mutation Carriers","volume":"10","author":"Pont-Sunyer","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jsmc.2021.03.002_bib26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/ana.20272","article-title":"Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations","volume":"56","author":"Kumru","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib27","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s10072-017-2945-2","article-title":"SNCA 3'UTR genetic variants in patients with Parkinson's disease and REM sleep behavior disorder","volume":"38","author":"Toffoli","year":"2017","journal-title":"Neurol Sci"},{"key":"10.1016\/j.jsmc.2021.03.002_bib28","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/ana.25687","article-title":"Fine-mapping of SNCA in rapid eye movement sleep behavior disorder and overt synucleinopathies","volume":"87","author":"Krohn","year":"2020","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/ana.25629","article-title":"Genetic, structural, and functional evidence link TMEM175 to synucleinopathies","volume":"87","author":"Krohn","year":"2020","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib30","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/ana.24384","article-title":"MicroRNA association with synucleinopathy conversion in rapid eye movement behavior disorder","volume":"77","author":"Fern\u00e1ndez-Santiago","year":"2015","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib31","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/mds.27385","article-title":"Full sequencing and haplotype analysis of MAPT in Parkinson's disease and rapid eye movement sleep behavior disorder","volume":"33","author":"Li","year":"2018","journal-title":"Mov Disord"},{"key":"10.1016\/j.jsmc.2021.03.002_bib32","doi-asserted-by":"crossref","first-page":"142.e5","DOI":"10.1016\/j.neurobiolaging.2020.04.005","article-title":"SMPD1 variants do not have a major role in rapid eye movement sleep behavior disorder","volume":"93","author":"Rudakou","year":"2020","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jsmc.2021.03.002_bib33","doi-asserted-by":"crossref","first-page":"218.e13","DOI":"10.1016\/j.neurobiolaging.2016.10.002","article-title":"The dementia-associated APOE \u03b54 allele is not associated with rapid eye movement sleep behavior disorder","volume":"49","author":"Gan-Or","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jsmc.2021.03.002_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sleep.2018.07.019","article-title":"Circadian rhythms of melatonin and peripheral clock gene expression in idiopathic REM sleep behavior disorder","volume":"52","author":"Weissov\u00e1","year":"2018","journal-title":"Sleep Med"},{"key":"10.1016\/j.jsmc.2021.03.002_bib35","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1212\/WNL.46.2.388","article-title":"Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder","volume":"46","author":"Schenck","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.jsmc.2021.03.002_bib36","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.sleep.2012.10.009","article-title":"Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder: a 16-year update on a previously reported series","volume":"14","author":"Schenck","year":"2013","journal-title":"Sleep Med"},{"key":"10.1016\/j.jsmc.2021.03.002_bib37","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1474-4422(13)70056-5","article-title":"Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behavior disorder: an observational cohort study","volume":"12","author":"Iranzo","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib38","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/brain\/awz014","article-title":"REM sleep behaviour disorder: an early window for prevention in neurodegeneration?","volume":"142","author":"Postuma","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.jsmc.2021.03.002_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.smrv.2018.09.008","article-title":"The risk of neurodegeneration in REM sleep behavior disorder: a systematic review and meta-analysis of longitudinal studies","volume":"43","author":"Galbiati","year":"2019","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.jsmc.2021.03.002_bib40","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1212\/WNL.0000000000004121","article-title":"Characterization of patients with longstanding idiopathic REM sleep behavior disorder","volume":"89","author":"Iranzo","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.jsmc.2021.03.002_bib41","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S1474-4422(09)70238-8","article-title":"Neuropathological assessment of Parkinson\u2019s disease: refining the diagnostic criteria","volume":"8","author":"Dickson","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib42","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1212\/WNL.45.4.709","article-title":"Incidental Lewy body disease in a patient with REM sleep behaviour disorder","volume":"45","author":"Uchiyama","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.jsmc.2021.03.002_bib43","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.sleep.2006.08.017","article-title":"Insights into REM sleep behaviour disorder pathophysiology in brainstem-predominant Lewy body disease","volume":"8","author":"Boeve","year":"2007","journal-title":"Sleep Med"},{"key":"10.1016\/j.jsmc.2021.03.002_bib44","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/mds.25825","article-title":"Neuropathology of prodromal Lewy body disease","volume":"29","author":"Iranzo","year":"2014","journal-title":"Mov Disord"},{"key":"10.1016\/j.jsmc.2021.03.002_bib45","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.sleep.2012.10.015","article-title":"Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder","volume":"14","author":"Boeve","year":"2013","journal-title":"Sleep Med"},{"key":"10.1016\/j.jsmc.2021.03.002_bib46","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1212\/WNL.0000000000002126","article-title":"Enteric nervous system \u03b1-synuclein immunoreactivity in idiopathic REM sleep behavior disorder","volume":"85","author":"Sprenger","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.jsmc.2021.03.002_bib47","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S1474-4422(16)00080-6","article-title":"Assessment of \u03b1-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study","volume":"15","author":"Vilas","year":"2016","journal-title":"Lancet Neurol"},{"issue":"8","key":"10.1016\/j.jsmc.2021.03.002_bib48","article-title":"\u03b1-Synuclein aggregates in labial salivary glands of idiopathic rapid eye movement sleep behavior disorder","volume":"41","author":"Iranzo","year":"2018","journal-title":"Sleep"},{"key":"10.1016\/j.jsmc.2021.03.002_bib49","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.sleep.2018.08.003","article-title":"Alpha-synuclein aggregates in the parotid gland of idiopathic REM sleep behavior disorder","volume":"52","author":"Fern\u00e1ndez-Arcos","year":"2018","journal-title":"Sleep Med"},{"key":"10.1016\/j.jsmc.2021.03.002_bib50","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1212\/WNL.0000000000003989","article-title":"Skin nerve phosphorylated \u03b1-synuclein deposits in idiopathic REM sleep behavior disorder","volume":"88","author":"Antelmi","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.jsmc.2021.03.002_bib51","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00401-017-1684-z","article-title":"Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease","volume":"133","author":"Doppler","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib52","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.parkreldis.2016.06.003","article-title":"Reduced intraepidermal nerve fiber density in patients with REM sleep behavior disorder","volume":"29","author":"Schrempf","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.jsmc.2021.03.002_bib53","first-page":"294","article-title":"Correlates of cerebrospinal fluid levels of oligomeric and total \u03b1-synuclein in premotor, motor and dementia stages of Parkinson's disease","volume":"262","author":"Compta","year":"2015","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib54","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/acn3.338","article-title":"Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies","volume":"3","author":"Fairfoul","year":"2016","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib55","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00401-020-02160-8","article-title":"Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathy","volume":"140","author":"Rossi","year":"2020","journal-title":"Acta Neuropathol"},{"issue":"3","key":"10.1016\/j.jsmc.2021.03.002_bib56","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1474-4422(20)30449-X","article-title":"Cerebrospinal fluid \u03b1-synuclein detection by RT-QuIC in patients with isolated REM sleep behavior disorder","volume":"20","author":"Iranzo","year":"2021","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib57","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00401-009-0538-8","article-title":"Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction","volume":"117","author":"Beach","year":"2009","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib58","article-title":"Alpha-synuclein seeds in olfactory mucosa of patients with isolated rapid-eye-movement sleep behaviour disorder","author":"Stefani","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.jsmc.2021.03.002_bib59","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1212\/WNL.0000000000009107","article-title":"Disease modification and biomarker development in Parkinson disease","volume":"94","author":"Espay","year":"2020","journal-title":"Neuroloy"},{"key":"10.1016\/j.jsmc.2021.03.002_bib60","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/bs.irn.2019.06.014","article-title":"New therapeutic approaches to target\u00a0alpha-synuclein in Parkinson's disease: the role of immunotherapy","volume":"146","author":"Fern\u00e1ndez-Valle","year":"2019","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.jsmc.2021.03.002_bib61","first-page":"85","article-title":"Best practice guide for the treatment of REM sleep behavior disorder (RBD)","volume":"6","author":"Aurora","year":"2010","journal-title":"J\u00a0Clin Sleep M"},{"key":"10.1016\/j.jsmc.2021.03.002_bib62","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.smrv.2016.11.002","article-title":"Idiopathic REM sleep behavior disorder and neurodegenerative risk: to tell or not to tell to the patient? How to minimize the risk?","volume":"36","author":"Arnaldi","year":"2017","journal-title":"Sleep Med Rev"}],"container-title":["Sleep Medicine Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556407X21000163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556407X21000163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:59:27Z","timestamp":1761562767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1556407X21000163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S1556407X21000163"],"URL":"https:\/\/doi.org\/10.1016\/j.jsmc.2021.03.002","relation":{},"ISSN":["1556-407X"],"issn-type":[{"value":"1556-407X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Isolated Form of Rapid Eye Movement Sleep Behavior Disorder","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsmc.2021.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}