{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:34:54Z","timestamp":1775500494610,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":294,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.jsps.2012.02.004","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T18:27:57Z","timestamp":1330972077000},"page":"345-353","source":"Crossref","is-referenced-by-count":13,"title":["Incidence of Helicobacter pylori infection and their clarithromycin-resistant strains in otitis media with effusion regarding phenotypic and genotypic studies"],"prefix":"10.1007","volume":"20","author":[{"given":"Nahla A.","family":"Melake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada H.","family":"Shaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdy A.","family":"Salama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.jsps.2012.02.004_b0005","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.ijporl.2005.09.026","article-title":"Chronic otitis media with effusion and Helicobacter pylori","volume":"5","author":"Agirdir","year":"2006","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.jsps.2012.02.004_b0010","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1128\/JCM.41.1.486-488.2003","article-title":"Clarithromycin resistance among Helicobacter pylori strains isolated from children: prevalence and study of mechanism of resistance by PCR \u2013 restriction fragment length polymorphism analysis","volume":"41","author":"Alarc\u00f3n","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jsps.2012.02.004_b0015","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1099\/0022-1317-51-4-312","article-title":"Prevalence of Helicobacter pylori at oral and gastrointestinal sites in children: evidence for possible oral-to-oral transmission","volume":"51","author":"Allaker","year":"2002","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.jsps.2012.02.004_b0020","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1097\/00005537-200112000-00018","article-title":"Incidence of reflux in young children undergoing adenoidectomy","volume":"111","author":"Carr","year":"2001","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jsps.2012.02.004_b0025","doi-asserted-by":"crossref","unstructured":"Clinical and Laboratory Standards Institute (CLSI), January 2007. Antimicrobial susceptibility testing standards M100-S17. 27 (1).","DOI":"10.1201\/9781420014495.ch1"},{"key":"10.1016\/j.jsps.2012.02.004_b0030","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1046\/j.1523-5378.2002.00109.x","article-title":"A population-based survey on gastrointestinal tract symptoms and Helicobacter pylori infection in children and adolescents","volume":"7","author":"De Giacomo","year":"2002","journal-title":"Helicobacter"},{"key":"10.1016\/j.jsps.2012.02.004_b0035","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1053\/jinf.2001.0815","article-title":"Do tonsils represent an extragastric reservoir for Helicobacter pylori infection","volume":"42","author":"Di Bonaventura","year":"2001","journal-title":"J. Infect."},{"issue":"2","key":"10.1016\/j.jsps.2012.02.004_b0040","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.otohns.2008.11.023","article-title":"Otitis media with effusion: a possible role for Helicobacter pylori?","volume":"140","author":"Fancy","year":"2009","journal-title":"Otolaryngol. Head Neck Surg."},{"issue":"1","key":"10.1016\/j.jsps.2012.02.004_b0045","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s13312-010-0010-9","article-title":"Efficacy of short course (<4days) of antibiotics for treatment of acute otitis media in children: a systematic review of randomized controlled trials","volume":"47","author":"Gulani","year":"2010","journal-title":"Indian Pediatr."},{"key":"10.1016\/j.jsps.2012.02.004_b0050","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1046\/j.1365-2036.1999.00555.x","article-title":"A systematic review of Helicobacter pylori eradication therapy \u2013 the impact of resistance on eradication rates","volume":"13","author":"Houben","year":"1999","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jsps.2012.02.004_b0055","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1128\/AAC.48.12.4843-4847.2004","article-title":"Distribution of antibiotic MICs for Helicobacter pylori strains over a 16year period in patients from Seoul, South Korea","volume":"48","author":"Kim","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jsps.2012.02.004_b0060","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1128\/JCM.41.10.4573-4577.2003","article-title":"Fast and accurate quantitative detection of Helicobacter pylori and identification of clarithromycin resistance mutations in H. pylori isolates from gastric biopsy specimens by real-time PCR","author":"Lascols","year":"2003","journal-title":"J. Clin. Microbiol."},{"issue":"4","key":"10.1016\/j.jsps.2012.02.004_b0065","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1128\/AAC.49.4.1600-1603.2005","article-title":"Impact of clarithromycin resistance on eradication of Helicobacter pylori in infected adults","volume":"49","author":"Lee","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jsps.2012.02.004_b0070","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1136\/gut.2003.022111","article-title":"H. pylori antibiotic resistance: prevalence, importance, and advances in testing","volume":"53","author":"M\u00e9graud","year":"2004","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.jsps.2012.02.004_b0075","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.otohns.2005.05.050","article-title":"Detection of Helicobacter pylori in the middle ear fluid of patients with otitis media with effusion","volume":"133","author":"Morinaka","year":"2005","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.jsps.2012.02.004_b0080","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1079-2104(05)80304-X","article-title":"Helicobacter pylori in the oral cavity. A critical review of the literature, oral surg. oral med. oral pathol","volume":"79","author":"Nguyen","year":"2000","journal-title":"Oral Radiol. Endod."},{"issue":"5","key":"10.1016\/j.jsps.2012.02.004_b0085","first-page":"526","article-title":"Does Helicobacter pylori have a role in the development of chronic otitis media with effusion? A preliminary study","volume":"38","author":"Ozcan","year":"2009","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.jsps.2012.02.004_b0090","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0889-8553(05)70155-2","article-title":"Accurate diagnosis of Helicobacter pylori. Culture, including transport","volume":"29","author":"Perez-Perez","year":"2000","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"10.1016\/j.jsps.2012.02.004_b0095","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1001\/archotol.126.7.831","article-title":"Gastroesophageal reflux contributing to chronic sinus disease in children: a prospective analysis","volume":"126","author":"Phipps","year":"2000","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.jsps.2012.02.004_b0100","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1001\/archotol.131.3.256","article-title":"Helicobacter pylori in children who are prone to upper respiratory tract infections","volume":"131","author":"Pitkaranta","year":"2005","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.jsps.2012.02.004_b0105","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1177\/000348940211101013","article-title":"Prospective study on the incidence of chronic ear complaints related to gastroesophageal reflux and on the outcome of antireflux therapy","volume":"111","author":"Poelmans","year":"2002","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.jsps.2012.02.004_b0110","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/00005176-200203000-00009","article-title":"Prolonged esophageal pH monitoring in the evaluation of gastroesophageal reflux in children with chronic tubotympanal disorders","volume":"34","author":"Rozmanic","year":"2002","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.jsps.2012.02.004_b0115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3109\/00016489609137714","article-title":"Bacterial behaviour in middle ear effusion material: an in vitro study","volume":"116","author":"Ruhani","year":"1996","journal-title":"Acta Otolaryngol."},{"issue":"6","key":"10.1016\/j.jsps.2012.02.004_b0120","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1093\/jac\/dkf041","article-title":"Resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime","volume":"49","author":"Samra","year":"2002","journal-title":"J. Antimicrob. Chemothe."},{"key":"10.1016\/j.jsps.2012.02.004_b0125","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1046\/j.1365-2273.2001.00513.x","article-title":"Helicobacter pylori and tonsillectomy","volume":"26","author":"Skinner","year":"2001","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"10.1016\/j.jsps.2012.02.004_b0130","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.jpeds.2004.11.037","article-title":"Helicobacter pylori infection: detection, investigation and management","volume":"146","author":"Steven","year":"2005","journal-title":"J. Pediatr."},{"issue":"9","key":"10.1016\/j.jsps.2012.02.004_b0135","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1017\/S0022215107000989","article-title":"A critical evaluation of the evidence on a causal relationship between Helicobacter pylori and otitis media with effusion","volume":"122","author":"Sudhoff","year":"2008","journal-title":"J. Laryngol. Otol."},{"key":"10.1016\/j.jsps.2012.02.004_b0140","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1046\/j.1365-2036.2001.00971.x","article-title":"Impact of Helicobacter pylori resistance to clarithromycin on the efficacy of the omeprazole-amoxicillin-clarithromycin therapy","volume":"15","author":"Tankovic","year":"2001","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"11","key":"10.1016\/j.jsps.2012.02.004_b0145","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1097\/00005537-200211000-00004","article-title":"Is gastric reflux a cause of otitis media with effusion in children?","volume":"112","author":"Tasker","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jsps.2012.02.004_b0150","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0140-6736(02)07665-1","article-title":"Reflux of gastric juice and glue ear in children","volume":"359","author":"Tasker","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jsps.2012.02.004_b0155","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S1590-8658(03)00265-2","article-title":"Primary and secondary antibiotic resistance of Helicobacter pylori strains isolated in central Italy during the years 1998\u20132002","volume":"35","author":"Toracchio","year":"2003","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.jsps.2012.02.004_b0160","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1128\/JCM.39.7.2677-2680.2001","article-title":"Increasing multidrug resistance in Helicobacter pylori strains isolated from children and adults in Mexico","volume":"39","author":"Torres","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jsps.2012.02.004_b0165","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1097\/00005537-200112000-00021","article-title":"Investigation of Helicobacter pylori colonization in adenotonsillectomy specimens by means of the CLO test","volume":"111","author":"Unver","year":"2001","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.jsps.2012.02.004_b0170","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1046\/j.1365-2036.2002.0160s1016.x","article-title":"Review article: diagnosis of Helicobacter pylori infection","volume":"16","author":"Vaira","year":"2002","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jsps.2012.02.004_b0175","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0165-5876(00)00396-7","article-title":"Gastroesophageal reflux, allergy and chronic tubotympanal disorders in children","volume":"55","author":"Velepic","year":"2000","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.jsps.2012.02.004_b0180","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/00005537-200206000-00004","article-title":"Gastroesophageal reflux and eustachian tube dysfunction in an animal model","volume":"112","author":"White","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jsps.2012.02.004_b0185","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ijporl.2003.10.016","article-title":"Are tonsils a reservoir for H. pylori infection in children?","volume":"68","author":"Yilmaz","year":"2004","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"issue":"6","key":"10.1016\/j.jsps.2012.02.004_b0190","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ijporl.2004.12.009","article-title":"Does Helicobacter pylori have role in development of otitis media with effusion?","volume":"69","author":"Yilmaz","year":"2005","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"issue":"5","key":"10.1016\/j.jsps.2012.02.004_b0195","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.otohns.2006.02.002","article-title":"Helicobacter pylori: a possible association with otitis media with effusion","volume":"134","author":"Yilmaz","year":"2006","journal-title":"Otolaryngol. Head Neck Surg."},{"issue":"12","key":"10.1016\/j.jsps.2012.02.004_b0200","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.3844\/ajassp.2009.2050.2053","article-title":"Helicobacter pylori colonization in biopsies of the adenotonsillectomy specimens","volume":"6","author":"Zahedi","year":"2009","journal-title":"Am. J. Appl. Sci."}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016412000114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016412000114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:26:33Z","timestamp":1736184393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319016412000114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S1319016412000114"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2012.02.004","relation":{},"ISSN":["1319-0164"],"issn-type":[{"value":"1319-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}