{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T16:10:40Z","timestamp":1774455040154,"version":"3.50.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T00:00:00Z","timestamp":1420588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.jsps.2014.12.001","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T17:14:16Z","timestamp":1420650856000},"page":"487-498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["The possible antianginal effect of allopurinol in vasopressin-induced ischemic model in rats"],"prefix":"10.1007","volume":"23","author":[{"given":"Yahya A.","family":"Al-Zahrani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer E.","family":"Al-Harthi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lateef M.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hani M.","family":"El-Bassossy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif M.","family":"Edris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai A. Alim","family":"A. Sattar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.jsps.2014.12.001_b0005","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S1471-4892(02)00143-1","article-title":"Uric acid and cardiovascular risk","volume":"2","author":"Alderman","year":"2002","journal-title":"Curr. Opin. Pharmacol."},{"issue":"1","key":"10.1016\/j.jsps.2014.12.001_b0010","first-page":"4","article-title":"Role of uric acid in hypertension and in the progression of chronic renal disease","volume":"23","author":"Barberi","year":"2006","journal-title":"G Ital Nefrol."},{"issue":"5 Pt 1","key":"10.1016\/j.jsps.2014.12.001_b9000","doi-asserted-by":"crossref","first-page":"C1424","DOI":"10.1152\/ajpcell.1996.271.5.C1424","article-title":"Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly","volume":"271","author":"Beckman","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jsps.2014.12.001_b0015","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1001\/archinternmed.2009.295","article-title":"The prevalence of weekly angina among patients with chronic stable angina in primary care practices: the Coronary Artery Disease in General Practice (CADENCE) Study","volume":"169","author":"Beltrame","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.jsps.2014.12.001_b0020","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1113\/jphysiol.2003.055913","article-title":"Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications","volume":"555","author":"Berry","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.jsps.2014.12.001_b0025","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0002-9149(91)90838-C","article-title":"Myocardial malondialdehyde and uric acid release after short-lasting coronary occlusions during coronary angioplasty: potential mechanisms for free radical generation","volume":"68","author":"De scheerder","year":"1991","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.jsps.2014.12.001_b0030","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.2337\/diabetes.51.4.1118","article-title":"Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol","volume":"51","author":"Desco","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.jsps.2014.12.001_b0035","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1161\/01.CIR.0000017502.58595.ED","article-title":"Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies","volume":"105","author":"Doehner","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jsps.2014.12.001_b0260","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/sj.jhh.1000740","article-title":"Ten-year incidence of elevated blood pressure and its predictors: the CARDIA study Coronary Artery Risk Development in (Young) Adults","volume":"13","author":"Dyer","year":"1999","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.jsps.2014.12.001_b0045","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/01.RES.85.5.437","article-title":"Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure","volume":"85","author":"Ekelund","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.jsps.2014.12.001_b0055","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1183\/09031936.06.00101005","article-title":"Allopurinol improves endothelial function in sleep apnoea: a randomised controlled study","volume":"27","author":"El Solh","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jsps.2014.12.001_b0050","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1136\/ard.25.Suppl_6.608","article-title":"Enzymatic and metabolic studies with allopurinol","volume":"25","author":"Elion","year":"1966","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jsps.2014.12.001_b0060","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1113\/jphysiol.2005.102566","article-title":"Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing","volume":"571","author":"Eskurza","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.jsps.2014.12.001_b0065","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1001\/jama.300.8.924","article-title":"Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial","volume":"300","author":"Feig","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.jsps.2014.12.001_b0070","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1681\/ASN.2006080865","article-title":"Plasma uric acid level and risk for incident hypertension among men","volume":"18","author":"Forman","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jsps.2014.12.001_b0075","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.jacc.2007.08.002","volume":"50","author":"Fraker","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jsps.2014.12.001_b0080","first-page":"219","article-title":"Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man","volume":"50","author":"Freireich","year":"1966","journal-title":"Cancer Chemother. Rep."},{"key":"10.1016\/j.jsps.2014.12.001_b0085","first-page":"59","article-title":"The role of urate and xanthine oxidase inhibitors in cardiovascular disease","volume":"26","author":"George","year":"2008","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.jsps.2014.12.001_b0090","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1172\/JCI108880","article-title":"Release of platelet constituents by monosodium urate crystals","volume":"60","author":"Ginsberg","year":"1977","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jsps.2014.12.001_b0095","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/S0735-1097(02)02139-3","article-title":"The effect of sildenafil on human vascular function, platelet activation, and myocardial ischemia","volume":"40","author":"Halcox","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jsps.2014.12.001_b0100","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0891-5849(02)00956-5","article-title":"Oxidoreductase: structure and function of xanthine. where are we now?","volume":"33","author":"Harrison","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jsps.2014.12.001_b0105","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1016\/S0021-9258(19)52512-1","article-title":"Studies on the oxidative half-reaction of xanthine oxidase","volume":"256","author":"Hille","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsps.2014.12.001_b0110","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1248\/bpb.28.811","article-title":"Antianginal effects of lercanidipine or methacholine on the vasopressin induced anginal model in rats","volume":"28","author":"Hirata","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jsps.2014.12.001_b0115","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1248\/yakushi.126.1377","article-title":"Effects of benidipine in a rat model for experimental angina","volume":"126","author":"Ikeda","year":"2006","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.jsps.2014.12.001_b0120","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1620\/tjem.211.369","article-title":"Independent association of high serum uric acid concentration with angiographically defined coronary artery disease","volume":"211","author":"Jelic-Ivanovic","year":"2007","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.jsps.2014.12.001_b0125","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1755-5922.2008.00057.x","article-title":"Allopurinol treatment reduces arterial wave reflection in stroke survivors","volume":"26","author":"Khan","year":"2008","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.jsps.2014.12.001_b0130","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0002-9149(97)00893-X","article-title":"Amlodipine versus diltiazem as additional antianginal treatment to atenolol. Centralised European Studies in Angina Research (CESAR) Investigators","volume":"81","author":"Knight","year":"1998","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.jsps.2014.12.001_b0135","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1161\/01.CIR.103.9.1282","article-title":"Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin","volume":"103","author":"Laursen","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jsps.2014.12.001_b0140","doi-asserted-by":"crossref","DOI":"10.1161\/01.HYP.8.6_Pt_2.II61","article-title":"The loss of endothelium-dependent vascular relaxation in hypertension","volume":"8","author":"Lockette","year":"1986","journal-title":"Hypertension"},{"key":"10.1016\/j.jsps.2014.12.001_b0145","doi-asserted-by":"crossref","first-page":"F991","DOI":"10.1152\/ajprenal.00283.2001","article-title":"Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism","volume":"282","author":"Mazzali","year":"2002","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.jsps.2014.12.001_b0155","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1093\/eurheartj\/ehi305","article-title":"Transient reduction in myocardial free oxygen radical levels is involved in the improved cardiac function and structure after long- term allopurinol treatment initiated in established chronic heart failure","volume":"26","author":"Mellin","year":"2005","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jsps.2014.12.001_b0150","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/nbm.1442","article-title":"Non- invasive and quantitative evaluation of peripheral vascular resistances in rats by combined NMR measurements of perfusion and blood pressure using ASL and dynamic angiography","volume":"23","author":"Menard","year":"2010","journal-title":"NMR Biomed."},{"key":"10.1016\/j.jsps.2014.12.001_b0160","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/S0140-6736(10)60391-1","article-title":"Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomized, placebo controlled crossover trial","volume":"375","author":"Noman","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jsps.2014.12.001_b0165","first-page":"280","article-title":"Allopurinol therapy of ischemic heart disease with infarct extension","volume":"8","author":"Parmley","year":"1992","journal-title":"Can. J. Cardiol."},{"issue":"9","key":"10.1016\/j.jsps.2014.12.001_b0170","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jacc.2012.09.066","article-title":"High-dose allopurinol reduces left ventricular mass in patients with ischemic heart disease","volume":"61","author":"Rekhraj","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jsps.2014.12.001_b0175","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.amjcard.2004.09.025","article-title":"Comparative efficacy of ranolazine versus atenolol for chronic angina pectoris","volume":"95","author":"Rousseau","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.jsps.2014.12.001_b0180","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1161\/hh0302.104531","article-title":"Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart","volume":"90","author":"Saavedra","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.jsps.2014.12.001_b0185","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1532-5415.1978.tb02396.x","article-title":"Serum uric acid and the renin-angiotensin system in hypertension","volume":"26","author":"Saito","year":"1978","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.jsps.2014.12.001_b0195","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1248\/bpb.28.811","article-title":"Antianginal effects of lercanidipine on the vasopressin or methacholine induced anginal model in rats","volume":"28","author":"Sasaki","year":"2005","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.jsps.2014.12.001_b0190","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bmc.2010.11.034","article-title":"Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)- 5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives","volume":"19","author":"Sathisha","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jsps.2014.12.001_b0200","first-page":"385","article-title":"The effects of lowering uric acid levels using allopurinol on markers of metabolic syndrome in end-stage renal disease patients: a pilot study","volume":"9","author":"Shelmadine","year":"2009","journal-title":"Anadolu Kardiyol Derg"},{"key":"10.1016\/j.jsps.2014.12.001_b0210","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1136\/heart.87.3.229","article-title":"Effect of allopurinol on mortality and hospitalisations in chronic heart failure: a retrospective cohort study","volume":"87","author":"Struthers","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.jsps.2014.12.001_b0205","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/01.RES.0000148635.73331.c5","article-title":"Chronic treatment with allopurinol boosts survival and cardiac contractility in murine postischemic cardiomyopathy","volume":"95","author":"Stull","year":"2004","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.jsps.2014.12.001_b0215","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1053\/j.ajkd.2006.08.019","article-title":"J-shaped mortality relationship for uric acid in CKD","volume":"48","author":"Suliman","year":"2006","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.jsps.2014.12.001_b0220","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/eurheartj\/ehn571","article-title":"Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4- month, randomized, placebo-controlled trial","volume":"30","author":"Tardif","year":"2009","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jsps.2014.12.001_b0225","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1016\/S0735-1097(02)02563-9","article-title":"The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease","volume":"40","author":"Thadani","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jsps.2014.12.001_b0230","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1464-5491.2004.01239.x","article-title":"Acid levels with peripheral arterial disease in Taiwanese patients with Type 2 diabetes Independent association of uric 46","volume":"21","author":"Tseng","year":"2004","journal-title":"Diabet. Med."},{"key":"10.1016\/j.jsps.2014.12.001_b0235","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jchromb.2006.07.054","article-title":"Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the L-arginine\/nitric oxide area of research","volume":"851","author":"Tsikas","year":"2007","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"4","key":"10.1016\/j.jsps.2014.12.001_b0240","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/MAJ.0b013e31821d9905","article-title":"Oxidative stress in chronic liver disease: relationship between peripheral and hepatic measurements","volume":"342","author":"Vuppalanchi","year":"2011","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.jsps.2014.12.001_b0245","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/00005344-200202000-00010","article-title":"Effect of an orally active Na+\/H+ exchange inhibitor, SMP-300, on experimental angina and myocardial infarction models in rats","volume":"39","author":"Yamamoto","year":"2002","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.jsps.2014.12.001_b0250","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00392-007-0636-3","article-title":"Allopurinol improves endothelial function and reduces oxidant-inflammatory enzyme of myeloperoxidase in metabolic syndrome","volume":"97","author":"Yiginer","year":"2008","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.jsps.2014.12.001_b0255","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1124\/jpet.108.143396","article-title":"Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats","volume":"328","author":"Zhao","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016414001674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016414001674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:28:31Z","timestamp":1736184511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319016414001674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1319016414001674"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2014.12.001","relation":{},"ISSN":["1319-0164"],"issn-type":[{"value":"1319-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The possible antianginal effect of allopurinol in vasopressin-induced ischemic model in rats","name":"articletitle","label":"Article Title"},{"value":"Saudi Pharmaceutical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsps.2014.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}