{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:46:39Z","timestamp":1762145199111,"version":"3.32.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T00:00:00Z","timestamp":1461715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jsps.2016.04.026","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T15:51:07Z","timestamp":1462117867000},"page":"371-378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The standard aqueous stem bark extract of Mangifera indica L. inhibits toxic PLA 2 \u2013 NN-XIb-PLA 2 of Indian cobra venom"],"prefix":"10.1007","volume":"24","author":[{"given":"Bhadrapura Lakkappa","family":"Dhananjaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivalingaiah","family":"Sudarshan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3114-1167","authenticated-orcid":false,"given":"Yashad","family":"Dongol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil S.","family":"More","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.jsps.2016.04.026_b0005","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0041-0101(01)00232-X","article-title":"Ophidian envenomation strategies and the role of purines","volume":"40","author":"Aird","year":"2002","journal-title":"Toxicon"},{"issue":"2","key":"10.1016\/j.jsps.2016.04.026_b0010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/2231-4040.154530","article-title":"Investigation of cream and ointment on antimicrobial activity of Mangifera indica extract","volume":"6","author":"Awad El-Gied","year":"2015","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"10.1016\/j.jsps.2016.04.026_b0015","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0041-0101(89)90098-6","article-title":"Purification and characterization of a myotoxic phospholipase A2 from Indian cobra (Naja naja naja) venom","volume":"27","author":"Bhat","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.jsps.2016.04.026_b0020","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0006-3002(57)90256-1","article-title":"Chromatography of rattle snake venom, a separation of three phosphodiesterases","volume":"24","author":"Boman","year":"1957","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jsps.2016.04.026_b0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0305-0491(00)00237-6","article-title":"Effects of aqueous extract of Casearia sylvestris (Flacourtiaceae) on actions of snake venom and bee venoms and on activity of phospholipase A2","volume":"127","author":"Borges","year":"2000","journal-title":"Comp. Biochem. Physiol. Biochem. Mol. Biol."},{"key":"10.1016\/j.jsps.2016.04.026_b0030","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.1194\/jlr.R800033-JLR200","article-title":"Phospholipase A2 structure\/function, mechanism, and signaling","volume":"59","author":"Burke","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jsps.2016.04.026_b0035","doi-asserted-by":"crossref","first-page":"153045","DOI":"10.1155\/2013\/153045","article-title":"Snake venom PLA2s inhibitors isolated from Brazilian plants: synthetic and natural molecules","volume":"2013","author":"Carvalho","year":"2013","journal-title":"Biomed. Res. Int."},{"year":"1956","series-title":"Glossary of Indian Medicinal Plants","author":"Chopra","key":"10.1016\/j.jsps.2016.04.026_b0040"},{"key":"10.1016\/j.jsps.2016.04.026_b0045","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0378-8741(96)01424-9","article-title":"Screening of medicinal plants used by the Garifuna of eastern Nicaragua for bioactive compounds","volume":"53","author":"Coe","year":"1996","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jsps.2016.04.026_b0050","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/S0021-9258(19)75694-4","article-title":"Inhibition of phospholipase A2 by \u201clipocortins\u201d and calpactins. An effect of binding to substrate phospholipids","volume":"262","author":"Davidson","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsps.2016.04.026_b0055","series-title":"Handbook of Venoms and Toxins of Reptiles","first-page":"155","article-title":"Snake venom nucleases, nucleotidases and phosphomonoesterase","author":"Dhananjaya","year":"2010"},{"issue":"3","key":"10.1016\/j.jsps.2016.04.026_b0060","first-page":"175","article-title":"Anti-venom potential of aqueous extract of stem bark of Mangifera indica L. against Daboia russelii (Russell\u2019s viper) venom","volume":"48","author":"Dhananjaya","year":"2011","journal-title":"Indian J. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.jsps.2016.04.026_b0065","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1590\/0001-3765201620140574","article-title":"The anti-inflammatory activity of standard aqueous stem bark extract of Mangifera indica L. as evident in inhibition of Group IA sPLA2","volume":"88","author":"Dhananjaya","year":"2016","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.jsps.2016.04.026_b0070","series-title":"Handbook of Venoms and Toxins of Reptiles","first-page":"173","article-title":"Snake venom phospholipase A2 enzymes","author":"Doley","year":"2010"},{"key":"10.1016\/j.jsps.2016.04.026_b0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cbi.2015.11.009","article-title":"Antihepatotoxic efficacy of Mangifera indica L. polysaccharides against cyclophosphamide in rats","volume":"244","author":"Fahmy","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jsps.2016.04.026_b0080","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.phymed.2004.12.003","article-title":"Protective effects of a standard extract of Mangifera indica L. (VIMANG) against mouse ear edemas and its inhibition of eicosanoid production in J7774 murine macrophages","volume":"13","author":"Garrido","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jsps.2016.04.026_b0085","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.phrs.2003.12.003","article-title":"In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG)","volume":"50","author":"Garrido","year":"2004","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jsps.2016.04.026_b0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/01480540802432551","article-title":"In vivo acute toxicological studies of an antioxidant extract from Mangifera indica L. (Vimang)","volume":"32","author":"Garrido","year":"2009","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.jsps.2016.04.026_b0095","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/ptr.5177","article-title":"Antihyperalgesic effects of an aqueous steam bark extract of Mangifera indica L.: role of mangiferin isolated from the extract","volume":"28","author":"Garrido-Su\u00e1rez","year":"2014","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jsps.2016.04.026_b0100","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.2174\/156802611797633393","article-title":"Overlooked issues of snakebite management: time for strategic approach","volume":"11","author":"Girish","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.jsps.2016.04.026_b0105","first-page":"40","article-title":"Inhibition of toxic actions of phospholipase A2 isolated & characterized from the Indian Branded Krait (Bungarus fasciatus) venom by synthetic herbal compounds","volume":"136","author":"Gomes","year":"2012","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.jsps.2016.04.026_b0110","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1016\/j.fct.2007.05.029","article-title":"Lack of in vivo embryotoxic and genotoxic activities of orally administered stem bark aqueous extract of Mangifera indica L. (Vimang)","volume":"45","author":"Gonz\u00e1lez","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jsps.2016.04.026_b0115","series-title":"Abstract of 1\u2019st International Congress Pharmacology\u201998","first-page":"45","article-title":"Ethnopharmacologic study of Mangifera indica L. extract (QF-808)","author":"Guevara","year":"1998"},{"issue":"11","key":"10.1016\/j.jsps.2016.04.026_b0120","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1371\/journal.pmed.0050218","article-title":"The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths","volume":"5","author":"Kasturiratne","year":"2008","journal-title":"PLoS Med."},{"key":"10.1016\/j.jsps.2016.04.026_b0125","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/PL00006450","article-title":"Accelerated evolution and molecular surface of venom phospholipase A2 enzymes","volume":"48","author":"Kini","year":"1999","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.jsps.2016.04.026_b0130","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.toxicon.2003.11.002","article-title":"Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes","volume":"42","author":"Kini","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.jsps.2016.04.026_b0135","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1007\/s00018-006-6315-0","article-title":"Snake venom components and their applications in biomedicine","volume":"63","author":"Koh","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.jsps.2016.04.026_b0140","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4155\/ppa-2016-0003","article-title":"Mangiferin: a promising anticancer bioactive","volume":"5","author":"Khurana","year":"2016","journal-title":"Pharm. Pat. Anal."},{"key":"10.1016\/j.jsps.2016.04.026_b0145","doi-asserted-by":"crossref","first-page":"860","DOI":"10.2174\/092986609788923356","article-title":"The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles","volume":"16","author":"Lomonte","year":"2009","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.jsps.2016.04.026_b0150","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsps.2016.04.026_b0155","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0378-8741(01)00326-9","article-title":"Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice","volume":"78","author":"Makare","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jsps.2016.04.026_b0160","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00394-011-0252-x","article-title":"Mangiferin decreases inflammation and oxidative damage in rat brain after stress","volume":"51","author":"M\u00e1rquez","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.jsps.2016.04.026_b0165","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.3748\/wjg.v16.i39.4922","article-title":"Antiinflammatory effects of Mangifera indica L. extract in a model of colitis","volume":"16","author":"M\u00e1rquez","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jsps.2016.04.026_b0170","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11010-010-0561-z","article-title":"Chemical modification of ascorbic acid and evaluation of its lipophilic derivatives as inhibitors of secretory phospholipase A(2) with anti-inflammatory activity","volume":"345","author":"Mohamed","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jsps.2016.04.026_b0175","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11130-012-0304-2","article-title":"Antimutagenic properties of Mangifera indica L. steam bark extract and evaluation of its effects on hepatic CYPA1","volume":"67","author":"Morffi","year":"2012","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.jsps.2016.04.026_b0180","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2174\/156802607780487623","article-title":"PLA2 mediated arachidonate free radicals: PLA2 inhibition and neutralization of free radicals by anti-oxidants\u2014a new role as anti-inflammatory molecule","volume":"7","author":"Nanda","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"issue":"8","key":"10.1016\/j.jsps.2016.04.026_b0185","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2174\/156802607780487678","article-title":"Chemistry and structural evaluation of different phospholipase A2 inhibitors in arachidonic acid pathway mediated inflammation and snake venom toxicity","volume":"7","author":"Narendra Sharath Chandra","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.jsps.2016.04.026_b0190","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1742-4658.2011.08453.x","article-title":"Conserved domains and evolution of secreted phospholipases A(2)","volume":"279","author":"Nevalainen","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.jsps.2016.04.026_b0195","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1021\/jf011064b","article-title":"Isolation and quantitative analysis of phenolic antioxidants, free sugars, and polyols from Mango (Mangifera indica L.) stem bark aqueous decoction used in Cuba as a nutritional supplement","volume":"50","author":"Nunez-Selles","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jsps.2016.04.026_b0200","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1358\/mf.2005.27.8.928308","article-title":"Antiinflammatory, analgesic and hypoglycemic effects of Mangifera indica linn. (Anacardiaceae) stem-bark aqueous extract","volume":"2","author":"Ojewole","year":"2005","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.jsps.2016.04.026_b0205","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/0006-2952(92)90381-R","article-title":"Inhibition of enzymatic activity of phospholipases A2 by minocycline and doxycycline","volume":"44","author":"Pruzanski","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jsps.2016.04.026_b0210","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00436-014-4219-8","article-title":"Efficacy of larvicidal activity of green synthesized titanium dioxide nanoparticles using Mangifera indica extract against blood-feeding parasites","volume":"114","author":"Rajakumar","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jsps.2016.04.026_b0215","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0041-0101(97)00097-4","article-title":"Purification and characterization of three acidic, cytotoxic phospholipase A2 from Indian cobra (Naja naja) venom","volume":"36","author":"Rudrammaji","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.jsps.2016.04.026_b0220","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1006\/phrs.2000.0727","article-title":"Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice","volume":"42","author":"Sanchez","year":"2000","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jsps.2016.04.026_b0225","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4103\/0973-7847.65325","article-title":"Mangifera indica (Mango)","volume":"4","author":"Shah","year":"2010","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.jsps.2016.04.026_b0230","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jpba.2014.12.010","article-title":"Identification of new phytoconstituents and antimicrobial activity in stem bark of Mangifera indica (L.)","volume":"105","author":"Singh","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jsps.2016.04.026_b0235","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jmr.2492","article-title":"Virtual analysis of structurally diverse synthetic analogs as inhibitors of snake venom secretory phospholipase A2","volume":"29","author":"Sivaramakrishnan","year":"2016","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.jsps.2016.04.026_b0240","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2174\/1381612013398275","article-title":"An update of inhibitors of human 14kDa type II s-PLA2 in development","volume":"7","author":"Springer","year":"2001","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jsps.2016.04.026_b0245","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/BF00914317","article-title":"Edema inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid","volume":"12","author":"Vishwanath","year":"1988","journal-title":"Inflammation"},{"key":"10.1016\/j.jsps.2016.04.026_b0250","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0041-0101(87)90286-8","article-title":"Characterization of three edema inducing phospholipase A2 enzymes from habu (Trimeresurus flavovoridis) venom and their interaction with the alkaloid aristolochic acid","volume":"25","author":"Vishwanath","year":"1987","journal-title":"Toxicon"},{"key":"10.1016\/j.jsps.2016.04.026_b0255","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/138955712800493870","article-title":"Perspectives on medicinal properties of mangiferin","volume":"12","author":"Vyas","year":"2012","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.jsps.2016.04.026_b0260","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0140-6736(09)61754-2","article-title":"Snake bite","volume":"375","author":"Warrell","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jsps.2016.04.026_b0265","first-page":"97","article-title":"Fractionation of Sakishima habu (T. elegans) venom and lethal hemorrhagic and edema forming activity of the fractions","volume":"vol. 1","author":"Yamakawa","year":"1976"}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016416300275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016416300275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:29:05Z","timestamp":1736184545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319016416300275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S1319016416300275"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2016.04.026","relation":{},"ISSN":["1319-0164"],"issn-type":[{"type":"print","value":"1319-0164"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The standard aqueous stem bark extract of Mangifera indica L. inhibits toxic PLA2 \u2013 NN-XIb-PLA2 of Indian cobra venom","name":"articletitle","label":"Article Title"},{"value":"Saudi Pharmaceutical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsps.2016.04.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Production and Hosting by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}