{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:55:39Z","timestamp":1767833739076,"version":"3.49.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T00:00:00Z","timestamp":1490400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.jsps.2017.03.006","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T07:31:28Z","timestamp":1490427088000},"page":"1022-1031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chemometric evaluation of the efficacy of locally administered chlorhexidine in patients with periodontal disease"],"prefix":"10.1007","volume":"25","author":[{"given":"Liljana","family":"Bogdanovska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Poceva Panovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjana","family":"Popovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneta","family":"Dimitrovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumenka","family":"Petkovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.jsps.2017.03.006_b0005","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11306-011-0331-2","article-title":"Metabonomic analysis of saliva reveals generalized chronic periodontitis signature","volume":"8","author":"Aimetti","year":"2012","journal-title":"Metabolomics"},{"key":"10.1016\/j.jsps.2017.03.006_b0010","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5937\/arhfarm1402069B","article-title":"Development and validation of RP-HPLC assay of chlorhexidine in gingival crevicular fluid","volume":"64","author":"Bogdanovska","year":"2014","journal-title":"Arh. Farm."},{"key":"10.1016\/j.jsps.2017.03.006_b0015","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.chemolab.2004.12.011","article-title":"Performance of some variable selection methods when multicollinearity is present","volume":"78","author":"Chong","year":"2005","journal-title":"Chemometr. Intell. Lab."},{"key":"10.1016\/j.jsps.2017.03.006_b0020","series-title":"Analytical Chemistry","article-title":"PCA: the basic building block of chemometrics","author":"Cordella","year":"2012"},{"key":"10.1016\/j.jsps.2017.03.006_b0025","series-title":"Mashine Learning in Medicine","first-page":"183","article-title":"Hierarchical cluster analysis for unsupervised data","author":"Cleophas","year":"2013"},{"key":"10.1016\/j.jsps.2017.03.006_b0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jpba.2010.07.047","article-title":"Effect of the statin therapy on biochemical laboratory tests \u2013 a chemometric study","volume":"54","author":"Durcekova","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jsps.2017.03.006_b0035","series-title":"Multi- and megavariate data analysis, (part II) advanced applications and method extensions","author":"Eriksson","year":"2006"},{"key":"10.1016\/j.jsps.2017.03.006_b0040","unstructured":"European Medicines Agency, 2011. Guideline on bioanalytical method validation, Committee for medicinal products for human use (CHMP). Available from: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2011\/08\/WC500109686.pdf."},{"key":"10.1016\/j.jsps.2017.03.006_b0045","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1600-0765.2012.01500.x","article-title":"Comparison of CCL28, interleukin-8, interleukin-1\u03b2 and tumor necrosis factor-alpha in subjects with gingivitis, chronic periodontitis and generalized aggressive periodontitis","volume":"48","author":"Ertugrul","year":"2013","journal-title":"J. Periodont. Res."},{"key":"10.1016\/j.jsps.2017.03.006_b0050","doi-asserted-by":"crossref","first-page":"e39677","DOI":"10.1371\/journal.pone.0039677","article-title":"Principal component analysis of the cytokine and chemokine response to human traumatic brain injury","volume":"7","author":"Helmy","year":"2012","journal-title":"Plos One"},{"key":"10.1016\/j.jsps.2017.03.006_b0055","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/1746-6148-9-258","article-title":"Multivariate evaluation of the effectiveness of treatment efficacy of cypermethrin agains sea lice (Lepeophtheirus salmonis) in Athlantic salmon (Salmo salar)","volume":"9","author":"Jimenez","year":"2013","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.jsps.2017.03.006_b0060","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1309\/LMCNUQI8ULCUK2BK","article-title":"Enzymatic profile of gingival crevicular fluid in association with periodontal status","volume":"40","author":"Koss","year":"2009","journal-title":"Lab. Med."},{"key":"10.1016\/j.jsps.2017.03.006_b0065","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.trac.2011.02.007","article-title":"Multivariate methods in metabolomics \u2013 from pre-processing to dimension reduction and statistical analysis","volume":"30","author":"Liland","year":"2011","journal-title":"Trends Analyt. Chem."},{"key":"10.1016\/j.jsps.2017.03.006_b0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2478\/v10296-012-0002-3","article-title":"Chemometrics in medicine and pharmacy","volume":"11","author":"Mocak","year":"2012","journal-title":"Nova Biotechnol. et Chim."},{"key":"10.1016\/j.jsps.2017.03.006_b0075","first-page":"563","article-title":"Assessment of hypertension risk in children by chemometric techniques","volume":"3","author":"Mrazova","year":"2014","journal-title":"Eur. Chem. Bull."},{"key":"10.1016\/j.jsps.2017.03.006_b0080","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1902\/jop.2008.070308","article-title":"Clinical and microbiological effects of subgingial controlled- release delivery of chlorhexidine chip in the treatment of periodontitis: a multicenter study","volume":"79","author":"Paolantonio","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.jsps.2017.03.006_b0085","first-page":"273","article-title":"Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients","volume":"31","author":"Perinneti","year":"2004","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.jsps.2017.03.006_b0090","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1902\/jop.2008.070519","article-title":"Gingival crevicular fluid alkaline phosphatase reflects periodontal healing\/recurrent inflammation phases in chronic periodontitis patients","volume":"79","author":"Perinneti","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.jsps.2017.03.006_b0095","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2125.2009.03600.x","article-title":"Multivariate evaluation of pharamacological responses in early clinical trials \u2013 a study of rIL-21 in the treatment of patients with metastatic melanoma","volume":"69","author":"Rasmussen","year":"2010","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jsps.2017.03.006_b0100","first-page":"608637","article-title":"Fast parameters estimation in medication efficacy assessment model for heart failure treatment","volume":"2012","author":"Ren","year":"2012","journal-title":"Comput. Mat. Methods Med."},{"key":"10.1016\/j.jsps.2017.03.006_b0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11306-009-0191-1","article-title":"Dynamic metabolomic data analysis: a tutorial review","volume":"6","author":"Smilde","year":"2010","journal-title":"Metabolomics"},{"key":"10.1016\/j.jsps.2017.03.006_b0110","unstructured":"Spruill, W., Wade, W., DiPiro, J.T., Bloulin, R.A., Pruemer, J.M., 2014. Introduction to pharmacokinetics and pharmacodynamics. In: Concepts of Clinical Pharmacokinetics. American Society of Health-System Pharmacists\u00ae, Bethseda, Maryland, pp.1\u201320. Available from: http:\/\/www.ashp.org\/doclibrary\/bookstore\/p2418-chapter1.aspx."},{"key":"10.1016\/j.jsps.2017.03.006_b0115","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.1600-051X.2009.01475.x","article-title":"Partial least squares modeling for relations between baseline factors and treatment outcomes in periodontal regeneration","volume":"36","author":"Tu","year":"2009","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.jsps.2017.03.006_b0120","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1021\/ac0713510","article-title":"Visualization of GC\/TOF-MS based metabolomics data for identification of biochemically interesting compounds using OPLS class models","volume":"80","author":"Wiklund","year":"2008","journal-title":"Anal. Chem."}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016417300622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016417300622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:29:34Z","timestamp":1736184574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319016417300622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S1319016417300622"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2017.03.006","relation":{},"ISSN":["1319-0164"],"issn-type":[{"value":"1319-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemometric evaluation of the efficacy of locally administered chlorhexidine in patients with periodontal disease","name":"articletitle","label":"Article Title"},{"value":"Saudi Pharmaceutical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsps.2017.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Production and hosting by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}