{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:40:23Z","timestamp":1777444823965,"version":"3.51.4"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund, Egypt","doi-asserted-by":"crossref","award":["14895"],"award-info":[{"award-number":["14895"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jsps.2019.11.014","type":"journal-article","created":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T02:28:28Z","timestamp":1575685708000},"page":"127-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Time and sex dependency of hemodynamic, renal, and survivability effects of endotoxemia in rats"],"prefix":"10.1007","volume":"28","author":[{"given":"Abdalla M.","family":"Wedn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar M.","family":"El-Gowilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud M.","family":"El-Mas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"Pt B","key":"10.1016\/j.jsps.2019.11.014_b0005","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.biocel.2016.07.032","article-title":"Cardiac dysfunction, mitochondrial architecture, energy production, and inflammatory pathways: Interrelated aspects in endotoxemia and sepsis","volume":"81","author":"Alvarez","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.jsps.2019.11.014_b0010","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4161\/viru.26982","article-title":"Gender differences in sepsis: cardiovascular and immunological aspects","volume":"5","author":"Angele","year":"2014","journal-title":"Virulence"},{"issue":"3","key":"10.1016\/j.jsps.2019.11.014_b0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0272-6386(12)80692-5","article-title":"Sepsis-associated renal vasoconstriction: potential targets for future therapy","volume":"20","author":"Badr","year":"1992","journal-title":"Am. J. Kidney Dis."},{"issue":"1","key":"10.1016\/j.jsps.2019.11.014_b0020","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1681\/ASN.2004060441","article-title":"Maintenance of renal vascular reactivity contributes to acute renal failure during endotoxemic shock","volume":"16","author":"Boffa","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.jsps.2019.11.014_b0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40779-018-0182-5","article-title":"Gender differences in trauma, shock and sepsis","volume":"5","author":"Bosch","year":"2018","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.jsps.2019.11.014_b0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000329243","article-title":"Pathophysiology of sepsis-induced acute kidney injury: the role of global renal blood flow and renal vascular resistance","volume":"174","author":"Bougle","year":"2011","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.jsps.2019.11.014_b0035","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3389\/fimmu.2018.00475","article-title":"The acid-base balance and gender in inflammation: a mini-review","volume":"9","author":"Casimir","year":"2018","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.jsps.2019.11.014_b0040","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/09680519050110050901","article-title":"Reprogramming of circulatory cells in sepsis and SIRS","volume":"11","author":"Cavaillon","year":"2005","journal-title":"J. Endotoxin Res."},{"issue":"6","key":"10.1016\/j.jsps.2019.11.014_b0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100631","article-title":"Gender dimorphism of the cardiac dysfunction in murine sepsis: signalling mechanisms and age-dependency","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jsps.2019.11.014_b0050","article-title":"Inducible nitric oxide synthase: regulation, structure, and inhibition","author":"Cinelli","year":"2019","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jsps.2019.11.014_b0055","doi-asserted-by":"crossref","first-page":"27091","DOI":"10.1038\/srep27091","article-title":"miR-146a is essential for lipopolysaccharide (LPS)-induced cross-tolerance against kidney ischemia\/reperfusion injury in mice","volume":"6","author":"Dai","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jsps.2019.11.014_b0060","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejphar.2018.01.051","article-title":"Gonadal hormone receptors underlie the resistance of female rats to inflammatory and cardiovascular complications of endotoxemia","volume":"823","author":"El-Lakany","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"1\u20133","key":"10.1016\/j.jsps.2019.11.014_b0065","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ejphar.2004.01.025","article-title":"Relative roles of endothelial relaxing factors in cyclosporine-induced impairment of cholinergic and beta-adrenergic renal vasodilations","volume":"487","author":"El-Mas","year":"2004","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.jsps.2019.11.014_b0070","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1152\/japplphysiol.01058.2005","article-title":"Upregulation of vascular inducible nitric oxide synthase mediates the hypotensive effect of ethanol in conscious female rats","volume":"100","author":"El-Mas","year":"2006","journal-title":"J. Appl. Physiol."},{"issue":"2","key":"10.1016\/j.jsps.2019.11.014_b0075","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1124\/jpet.103.051805","article-title":"Effects of in vivo lipopolysaccharide infusion on vasoconstrictor function of rat isolated mesentery, kidney, and aorta","volume":"306","author":"Farmer","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.jsps.2019.11.014_b0080","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4161\/viru.26083","article-title":"Animal models of sepsis","volume":"5","author":"Fink","year":"2014","journal-title":"Virulence"},{"issue":"4","key":"10.1016\/j.jsps.2019.11.014_b0085","first-page":"1329","article-title":"Time- and dose-dependent severity of lung injury in a rat model of sepsis","volume":"56","author":"Fodor","year":"2015","journal-title":"Rom. J. Morphol. Embryol."},{"issue":"8","key":"10.1016\/j.jsps.2019.11.014_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106331","article-title":"Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats","volume":"9","author":"Fu","year":"2014","journal-title":"PLoS ONE"},{"issue":"111","key":"10.1016\/j.jsps.2019.11.014_b0095","doi-asserted-by":"crossref","DOI":"10.3791\/53913","article-title":"Intravenous endotoxin challenge in healthy humans: an experimental platform to investigate and modulate systemic inflammation","author":"Fullerton","year":"2016","journal-title":"J Vis Exp"},{"issue":"3","key":"10.1016\/j.jsps.2019.11.014_b0100","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1111\/j.1476-5381.1995.tb16405.x","article-title":"Cardiac and regional haemodynamics, inducible nitric oxide synthase (NOS) activity, and the effects of NOS inhibitors in conscious, endotoxaemic rats","volume":"116","author":"Gardiner","year":"1995","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.jsps.2019.11.014_b0105","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1111\/j.1476-5381.1996.tb15609.x","article-title":"Influence of aminoguanidine and the endothelin antagonist, SB 209670, on the regional haemodynamic effects of endotoxaemia in conscious rats","volume":"118","author":"Gardiner","year":"1996","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.jsps.2019.11.014_b0110","first-page":"1073","article-title":"Effects of lipopolysaccharide-induced septic shock on rat isolated kidney, possible role of nitric oxide and protein kinase C pathways","volume":"21","author":"Gholamnezhad","year":"2018","journal-title":"Iran J Basic Med Sci."},{"issue":"4","key":"10.1016\/j.jsps.2019.11.014_b0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095079","article-title":"PI3K\/Akt-independent NOS\/HO activation accounts for the facilitatory effect of nicotine on acetylcholine renal vasodilations: modulation by ovarian hormones","volume":"9","author":"Gohar","year":"2014","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.jsps.2019.11.014_b0120","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/SHK.0000000000000226","article-title":"Gender-specific differences in the in situ cardiac function of endotoxemic rats detected by pressure-volume catheter","volume":"42","author":"Goncalves","year":"2014","journal-title":"Shock."},{"key":"10.1016\/j.jsps.2019.11.014_b0125","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.taap.2017.09.007","article-title":"CYP4A\/CYP2C modulation of the interaction of calcium channel blockers with cyclosporine on EDHF-mediated renal vasodilations in rats","volume":"334","author":"Hammoud","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.jsps.2019.11.014_b0130","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11255-017-1735-3","article-title":"LPS ameliorates renal ischemia\/reperfusion injury via Hsp27 up-regulation","volume":"50","author":"He","year":"2018","journal-title":"Int. Urol. Nephrol."},{"issue":"11","key":"10.1016\/j.jsps.2019.11.014_b0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142303","article-title":"Additive renoprotection by pioglitazone and fenofibrate against inflammatory, oxidative and apoptotic manifestations of cisplatin nephrotoxicity: modulation by PPARs","volume":"10","author":"Helmy","year":"2015","journal-title":"PLoS ONE"},{"issue":"17","key":"10.1016\/j.jsps.2019.11.014_b0140","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1111\/bph.13199","article-title":"Endothelin ET(A) receptor\/lipid peroxides\/COX-2\/TGF-\u03b21 signalling underlies aggravated nephrotoxicity caused by cyclosporine plus indomethacin in rats","volume":"172","author":"Helmy","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"17","key":"10.1016\/j.jsps.2019.11.014_b0145","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1111\/bph.13199","article-title":"Endothelin ETA receptor\/lipid peroxides\/COX-2\/TGF-\u03b21 signalling underlies aggravated nephrotoxicity caused by cyclosporine plus indomethacin in rats","volume":"172","author":"Helmy","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jsps.2019.11.014_b0150","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.vetimm.2016.03.016","article-title":"Duration of in vivo endotoxin tolerance in horses","volume":"173","author":"Holcombe","year":"2016","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"3","key":"10.1016\/j.jsps.2019.11.014_b0155","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S1473-3099(13)70001-X","article-title":"Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Lancet Infect. Dis."},{"issue":"2","key":"10.1016\/j.jsps.2019.11.014_b0160","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jss.2007.06.027","article-title":"HO-1 overexpression attenuates endotoxin effects on CAT-2 isozymes expression","volume":"148","author":"Huang","year":"2008","journal-title":"J. Surg. Res."},{"issue":"8","key":"10.1016\/j.jsps.2019.11.014_b0165","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1038\/bjp.2008.205","article-title":"Regional haemodynamic responses to adenosine receptor activation vary across time following lipopolysaccharide treatment in conscious rats","volume":"154","author":"Jolly","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.jsps.2019.11.014_b0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092004","article-title":"LPS-induced delayed preconditioning is mediated by Hsp90 and involves the heat shock response in mouse kidney","volume":"9","author":"Kaucs\u00e1r","year":"2014","journal-title":"PLoS ONE"},{"issue":"1\u20132","key":"10.1016\/j.jsps.2019.11.014_b0175","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11010-014-2177-1","article-title":"3,4,5-Trihydroxycinnamic acid increases heme-oxygenase-1 (HO-1) and decreases macrophage infiltration in LPS-induced septic kidney","volume":"397","author":"Lee","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jsps.2019.11.014_b0180","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cellsig.2016.12.004","article-title":"Lipopolysaccharide and heat stress impair the estradiol biosynthesis in granulosa cells via increase of HSP70 and inhibition of smad3 phosphorylation and nuclear translocation","volume":"30","author":"Li","year":"2017","journal-title":"Cell. Signal."},{"issue":"8","key":"10.1016\/j.jsps.2019.11.014_b0185","doi-asserted-by":"crossref","first-page":"H1105","DOI":"10.1152\/ajpheart.00645.2013","article-title":"Age and sex differences in vascular responsiveness in healthy and trauma patients: contribution of estrogen receptor-mediated Rho kinase and PKC pathways","volume":"306","author":"Li","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.jsps.2019.11.014_b0190","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0008-6363(00)00075-4","article-title":"Male gender predisposes to development of endotoxic shock in the rat","volume":"47","author":"Losonczy","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jsps.2019.11.014_b0195","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40779-016-0099-9","article-title":"Pathophysiology of sepsis-induced myocardial dysfunction","volume":"3","author":"Lv","year":"2016","journal-title":"Mil. Med. Res."},{"issue":"1","key":"10.1016\/j.jsps.2019.11.014_b0200","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1164\/ajrccm\/148.1.164","article-title":"Differential impairment of vascular reactivity of small pulmonary and systemic arteries in hyperdynamic sepsis","volume":"148","author":"Martin","year":"1993","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.jsps.2019.11.014_b0205","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.3389\/fimmu.2018.02210","article-title":"Immunotolerant p50\/NFkappaB signaling and attenuated hepatic IFNbeta expression increases neonatal sensitivity to endotoxemia","volume":"9","author":"McKenna","year":"2018","journal-title":"Front. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.jsps.2019.11.014_b0210","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2119\/2007-00102.Monneret","article-title":"Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony","volume":"14","author":"Monneret","year":"2008","journal-title":"Mol. Med."},{"issue":"5","key":"10.1016\/j.jsps.2019.11.014_b0215","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1186\/s13054-014-0501-5","article-title":"Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy","volume":"18","author":"Morrell","year":"2014","journal-title":"Crit. Care"},{"key":"10.1016\/j.jsps.2019.11.014_b0220","doi-asserted-by":"crossref","unstructured":"Otto, G. P., Sossdorf, M., Claus, R. A., R\u00f6del, J., Menge, K., Reinhart, K., Riedemann, N.C., 2011. The late phase of sepsis is characterized by an increased microbiological burden and death rate. Crit. Care. 15(4), R183-R183. doi: 10.1186\/cc10332.","DOI":"10.1186\/cc10332"},{"issue":"12","key":"10.1016\/j.jsps.2019.11.014_b0225","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1097\/00003246-199912000-00022","article-title":"Vascular hyporesponsiveness of the renal circulation during endotoxemia in anesthetized pigs","volume":"27","author":"Pastor","year":"1999","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.jsps.2019.11.014_b0230","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ebiom.2014.10.003","article-title":"An endotoxin tolerance signature predicts sepsis and organ dysfunction at initial clinical presentation","volume":"1","author":"Pena","year":"2014","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/j.jsps.2019.11.014_b0235","first-page":"918","article-title":"Lipopolysaccharide inhibits acetylcholine- and nitric oxide-mediated vasodilation in vivo","volume":"279","author":"Peters","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.jsps.2019.11.014_b0240","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1046\/j.1523-1755.2000.00109.x","article-title":"Lipopolysaccharide impairs endothelial nitric oxide synthesis in rat renal arteries","volume":"57","author":"Piepot","year":"2000","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.jsps.2019.11.014_b0245","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0022-4804(02)00043-4","article-title":"Endotoxin impairs endothelium-dependent vasodilation more in the coronary and renal arteries than in other arteries of the rat","volume":"110","author":"Piepot","year":"2003","journal-title":"J. Surg. Res."},{"issue":"Suppl 1","key":"10.1016\/j.jsps.2019.11.014_b0250","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/SHK.0b013e318181a343","article-title":"Experimental models of sepsis and their clinical relevance","volume":"30","author":"Poli-de-Figueiredo","year":"2008","journal-title":"Shock"},{"issue":"6","key":"10.1016\/j.jsps.2019.11.014_b0255","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1111\/j.1476-5381.1996.tb15567.x","article-title":"Activation of multiple sites by adenosine analogues in the rat isolated aorta","volume":"118","author":"Prentice","year":"1996","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jsps.2019.11.014_b0260","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0014-2999(02)02304-X","article-title":"Role of endothelial adenosine receptor-mediated vasorelaxation in ethanol-induced hypotension in hypertensive rats","volume":"452","author":"Rekik","year":"2002","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.jsps.2019.11.014_b0265","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0022-2143(99)90168-3","article-title":"Time course of lipopolysaccharide-induced nitric oxide synthase mRNA expression in rat glomeruli","volume":"134","author":"Sade","year":"1999","journal-title":"J. Lab. Clin. Med."},{"issue":"2","key":"10.1016\/j.jsps.2019.11.014_b0270","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/FJC.0000000000000400","article-title":"Modulation by central MAPKs\/PI3K\/sGc of the TNF-alpha\/iNOS-dependent hypotension and compromised cardiac autonomic control in endotoxic rats","volume":"68","author":"Sallam","year":"2016","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.jsps.2019.11.014_b0275","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejphar.2018.07.008","article-title":"Additive counteraction by alpha7 and alpha4beta2-nAChRs of the hypotension and cardiac sympathovagal imbalance evoked by endotoxemia in male rats","volume":"834","author":"Sallam","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jsps.2019.11.014_b0280","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.mehy.2008.03.022","article-title":"Sepsis: time has come to focus on the later stages","volume":"71","author":"Schefold","year":"2008","journal-title":"Med. Hypotheses"},{"issue":"7","key":"10.1016\/j.jsps.2019.11.014_b0285","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"issue":"2","key":"10.1016\/j.jsps.2019.11.014_b0290","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJMra032401","article-title":"Acute renal failure and sepsis","volume":"351","author":"Schrier","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsps.2019.11.014_b0500","doi-asserted-by":"crossref","unstructured":"Schrier, R.W., & Wang, W., 2004b. Acute renal failure and sepsis. New Engl. J. Med. 351(2), 159-169. doi: 10.1056\/NEJMra032401.","DOI":"10.1056\/NEJMra032401"},{"issue":"5","key":"10.1016\/j.jsps.2019.11.014_b0295","first-page":"598","article-title":"Quercetin alleviates lipopolysaccharide-induced acute kidney injury in mice by suppressing TLR4\/NF-kappaB pathway","volume":"39","author":"Tan","year":"2019","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao."},{"issue":"6","key":"10.1016\/j.jsps.2019.11.014_b0300","doi-asserted-by":"crossref","first-page":"H2574","DOI":"10.1152\/ajpheart.00912.2004","article-title":"Involvement of p38-mitogen-activated protein kinase in adenosine receptor-mediated relaxation of coronary artery","volume":"288","author":"Teng","year":"2005","journal-title":"Am J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jsps.2019.11.014_b0305","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.biochi.2018.06.014","article-title":"Experimental human endotoxemia as a model of systemic inflammation","volume":"159","author":"van Lier","year":"2019","journal-title":"Biochimie"},{"issue":"2","key":"10.1016\/j.jsps.2019.11.014_b0310","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1186\/cc8932","article-title":"Renal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP pathway","volume":"14","author":"Vaschetto","year":"2010","journal-title":"Crit. Care"},{"issue":"1","key":"10.1016\/j.jsps.2019.11.014_b0315","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/08830185.2017.1380200","article-title":"Toll-like receptors: Significance, ligands, signaling pathways, and functions in mammals","volume":"37","author":"Vidya","year":"2018","journal-title":"Int. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.jsps.2019.11.014_b0320","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1476-5381.1994.tb13190.x","article-title":"Regional haemodynamic responses to acetylcholine, methoxamine, salbutamol and bradykinin during lipopolysaccharide infusion in conscious rats","volume":"112","author":"Waller","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jsps.2019.11.014_b0325","doi-asserted-by":"crossref","DOI":"10.1097\/SHK.0000000000001384","article-title":"Nicotine improves survivability, hypotension, and impaired adenosinergic renal vasodilations in endotoxic rats: role of alpha7-Nachrs\/HO-1 pathway","author":"Wedn","year":"2019","journal-title":"Shock"},{"key":"10.1016\/j.jsps.2019.11.014_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharep.2019.04.013","article-title":"Nicotine reverses the enhanced renal vasodilator capacity in endotoxic rats: role of \u03b17\/\u03b14\u03b22 nAChRs and HSP70","author":"Wedn","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.jsps.2019.11.014_b0335","unstructured":"Wedn, A. M., El-Gowilly, S. M., & El-Mas, M. M., 2019c. Role of alpha7-nAChRs\/ Heme Oxygenase\/Carbon Monoxide Pathway in Septic AKI. Proceedings of the 3rd Asian Conference on Science, Technology and medicine, page 10. https:\/\/acstm.org\/proceeding_2019.pdf."},{"key":"10.1016\/j.jsps.2019.11.014_b0340","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.12659\/MSM.898177","article-title":"Protective effects of luteolin on lipopolysaccharide-induced acute renal injury in mice","volume":"22","author":"Xin","year":"2016","journal-title":"Med. Sci. Monit."},{"issue":"9","key":"10.1016\/j.jsps.2019.11.014_b0345","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1016\/j.peptides.2006.03.025","article-title":"Time-dependent expression of renal vaso-regulatory molecules in LPS-induced endotoxemia in rat","volume":"27","author":"Yamaguchi","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.jsps.2019.11.014_b0350","doi-asserted-by":"crossref","unstructured":"Zellweger, R., Wichmann, M.W., Ayala, A., Stein, S., DeMaso, C. M., & Chaudry, I. H., 1997. Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males. Crit. Care Med. 25(1), 106-110. doi: 10.1097\/00003246-199701000-00021.","DOI":"10.1097\/00003246-199701000-00021"}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S131901641930163X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S131901641930163X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:23:26Z","timestamp":1736184206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S131901641930163X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S131901641930163X"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2019.11.014","relation":{},"ISSN":["1319-0164"],"issn-type":[{"value":"1319-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Time and sex dependency of hemodynamic, renal, and survivability effects of endotoxemia in rats","name":"articletitle","label":"Article Title"},{"value":"Saudi Pharmaceutical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsps.2019.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}