{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:20:30Z","timestamp":1780489230536,"version":"3.54.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T00:00:00Z","timestamp":1592611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research","doi-asserted-by":"publisher","award":["G: 683-140-1439"],"award-info":[{"award-number":["G: 683-140-1439"]}],"id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.jsps.2020.06.012","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:53:30Z","timestamp":1593478410000},"page":"916-926","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Tetramethylpyrazine ameliorates indomethacin-induced gastric ulcer in rats: Impact on oxidative, inflammatory, and angiogenic machineries"],"prefix":"10.1007","volume":"28","author":[{"given":"Huda M.","family":"AlKreathy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed K.","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1937-9300","authenticated-orcid":false,"given":"Ahmed","family":"Esmat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10.1016\/j.jsps.2020.06.012_b0005","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/796405","article-title":"In vivo models used for evaluation of potential antigastroduodenal ulcer agents","author":"Adinortey","year":"2013","journal-title":"Ulcers"},{"key":"10.1016\/j.jsps.2020.06.012_b0010","first-page":"121","article-title":"[13] Catalase in vitro","volume":"vol. 105","author":"Aebi","year":"1984"},{"issue":"5","key":"10.1016\/j.jsps.2020.06.012_b0015","doi-asserted-by":"crossref","first-page":"G903","DOI":"10.1152\/ajpgi.1992.262.5.G903","article-title":"Indomethacin-induced leukocyte adhesion in mesenteric venules: role of lipoxygenase products","volume":"262","author":"Asako","year":"1992","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"issue":"2","key":"10.1016\/j.jsps.2020.06.012_b0020","article-title":"Pattern use of non-steroidal anti-inflammatory drugs among Saudi community: patients\u2019 perspective","volume":"5","author":"Bahdailah","year":"2019","journal-title":"Pharmacol. Toxicol. Biomed. Rep."},{"key":"10.1016\/j.jsps.2020.06.012_b0025","series-title":"Theory and Practice of Histological Techniques","year":"2008"},{"issue":"5","key":"10.1016\/j.jsps.2020.06.012_b0030","doi-asserted-by":"crossref","first-page":"e64751","DOI":"10.1371\/journal.pone.0064751","article-title":"In vivo antioxidant and antiulcer activity of Parkia speciosa ethanolic leaf extract against ethanol-induced gastric ulcer in rats","volume":"8","author":"Al Batran","year":"2013","journal-title":"PLoS ONE"},{"issue":"8","key":"10.1016\/j.jsps.2020.06.012_b0035","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1073\/pnas.95.8.4140","article-title":"The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand","volume":"95","author":"Bella","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jsps.2020.06.012_b0040","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.jsps.2020.06.012_b0045","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.freeradbiomed.2013.07.027","article-title":"Nonsteroidal anti-inflammatory drug induces proinflammatory damage in gastric mucosa through NF-\u03baB activation and neutrophil infiltration: Anti-inflammatory role of heme oxygenase-1 against nonsteroidal anti-inflammatory drug","volume":"65","author":"Bindu","year":"2013","journal-title":"Free Radical Biol. Med."},{"issue":"2","key":"10.1016\/j.jsps.2020.06.012_b0050","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/1319-3767.48963","article-title":"Glimpse of the epidemiological research on Helicobacter Pylori in Saudi Arabia","volume":"15","author":"BinSaeed","year":"2009","journal-title":"Saudi J. Gastroenterol."},{"issue":"13","key":"10.1016\/j.jsps.2020.06.012_b0055","doi-asserted-by":"crossref","first-page":"10993","DOI":"10.1074\/jbc.M210328200","article-title":"A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical","volume":"278","author":"Biswas","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"16","key":"10.1016\/j.jsps.2020.06.012_b0060","first-page":"1867","article-title":"Anti-ulcer effect of Aloe vera in non-steroidal anti-inflammatory drug induced peptic ulcers in rats","volume":"5","author":"Borra","year":"2011","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"10.1016\/j.jsps.2020.06.012_b0065","first-page":"1","article-title":"Immunohistochemistry","volume":"1","author":"Buchwalow","year":"2010","journal-title":"Basics Methods"},{"issue":"1","key":"10.1016\/j.jsps.2020.06.012_b0070","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12906-017-1739-7","article-title":"Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo","volume":"17","author":"Chen","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"issue":"1","key":"10.1016\/j.jsps.2020.06.012_b0075","first-page":"43","article-title":"Radix Salviae Miltiorrhizae and Rhizoma Ligustici Wallichii in Coronary Heart Disease","volume":"4","author":"Chun-sheng","year":"1978","journal-title":"Chin. Med. J."},{"issue":"1","key":"10.1016\/j.jsps.2020.06.012_b0080","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-230X-9-36","article-title":"Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue","volume":"9","author":"Dursun","year":"2009","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.jsps.2020.06.012_b0085","first-page":"15","article-title":"Vascular endothelial growth factor and the regulation of angiogenesis","volume":"55","author":"Ferrara","year":"2000","journal-title":"Recent Prog. Horm. Res."},{"issue":"4","key":"10.1016\/j.jsps.2020.06.012_b0090","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1053\/j.gastro.2005.12.034","article-title":"Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism","volume":"130","author":"Gaudio","year":"2006","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.jsps.2020.06.012_b0095","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.amjcard.2007.11.054","article-title":"The antiplatelet effect of six non-steroidal anti-inflammatory drugs and their pharmacodynamic interaction with aspirin in healthy volunteers","volume":"101","author":"Gladding","year":"2008","journal-title":"Am. J. Cardiol."},{"issue":"2","key":"10.1016\/j.jsps.2020.06.012_b0100","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","article-title":"Determination of serum proteins by means of the biuret reaction","volume":"177","author":"Gornall","year":"1949","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jsps.2020.06.012_b0105","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/0016-5085(93)90277-J","article-title":"Nonsteroidal anti-inflammatory drugs and peptic ulcer hospitalization rates in New South Wales","volume":"104","author":"Henry","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jsps.2020.06.012_b0110","first-page":"174","article-title":"Observation on ischemic cerebrovascular disease (113 cases) treated by injection of ligustrazine","volume":"20","author":"Jiao","year":"2004","journal-title":"J. Pract. Tradition. Chin. Med."},{"issue":"02","key":"10.1016\/j.jsps.2020.06.012_b0115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1055\/s-2007-969959","article-title":"Tetramethylpyrazine in the treatment of cardiovascular and cerebrovascular diseases","volume":"47","author":"Ke-ji","year":"1983","journal-title":"Planta Med."},{"issue":"1","key":"10.1016\/j.jsps.2020.06.012_b0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0009-8981(78)90081-5","article-title":"Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method","volume":"90","author":"Kei","year":"1978","journal-title":"Clin. Chim. Acta"},{"issue":"3","key":"10.1016\/j.jsps.2020.06.012_b0125","doi-asserted-by":"crossref","first-page":"e59296","DOI":"10.1371\/journal.pone.0059296","article-title":"Acute toxicity and gastroprotection studies with a newly synthesized steroid","volume":"8","author":"Ketuly","year":"2013","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.jsps.2020.06.012_b0130","doi-asserted-by":"crossref","first-page":"400","DOI":"10.4014\/jmb.1012.12019","article-title":"Curative effect of selenium against indomethacin-induced gastric ulcers in rats","volume":"21","author":"Kim","year":"2011","journal-title":"J. Microbiol. Biotechnol."},{"issue":"6","key":"10.1016\/j.jsps.2020.06.012_b0135","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0952-3278(97)90593-7","article-title":"Effects of tepoxalin, a dual inhibitor of cyclooxygenase\/5-lipoxygenase, on events associated with NSAID-induced gastrointestinal inflammation","volume":"56","author":"Kirchner","year":"1997","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"issue":"1\u20132","key":"10.1016\/j.jsps.2020.06.012_b0140","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0014-5793(96)00155-X","article-title":"Antioxidant properties of omeprazole","volume":"382","author":"Lapenna","year":"1996","journal-title":"FEBS Lett."},{"issue":"9","key":"10.1016\/j.jsps.2020.06.012_b0145","first-page":"691","article-title":"Protective Effects of tetramethylpyrazine on cerebrovascular regulations in rats with chronic alcoholic encephalopathy","volume":"28","author":"Li","year":"2015","journal-title":"Biomed. Environ. Sci."},{"issue":"1","key":"10.1016\/j.jsps.2020.06.012_b0150","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.exer.2011.05.001","article-title":"Protective effects and mechanism of tetramethylpyrazine against lens opacification induced by sodium selenite in rats","volume":"93","author":"Li","year":"2011","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.jsps.2020.06.012_b0155","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jep.2009.06.008","article-title":"Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-\u03baB signaling pathways","volume":"125","author":"Li","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jsps.2020.06.012_b0160","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.lfs.2015.08.018","article-title":"Tetramethylpyrazine prevents ethanol-induced hepatocyte injury via activation of nuclear factor erythroid 2-related factor 2","volume":"141","author":"Lu","year":"2015","journal-title":"Life Sci."},{"issue":"7","key":"10.1016\/j.jsps.2020.06.012_b0165","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1007\/s12035-016-0028-7","article-title":"Tetramethylpyrazine ameliorates rotenone-induced Parkinson\u2019s disease in rats: involvement of its anti-inflammatory and anti-apoptotic actions","volume":"54","author":"Michel","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.jsps.2020.06.012_b0170","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.freeradbiomed.2010.04.013","article-title":"Gallic acid prevents nonsteroidal anti-inflammatory drug-induced gastropathy in rat by blocking oxidative stress and apoptosis","volume":"49","author":"Pal","year":"2010","journal-title":"Free Radical Biol. Med."},{"issue":"5\u20136","key":"10.1016\/j.jsps.2020.06.012_b0175","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0006-2952(02)01153-X","article-title":"Oxidative stress, transcription factors and chromatin remodelling in lung inflammation","volume":"64","author":"Rahman","year":"2002","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.jsps.2020.06.012_b0180","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1590\/S0100-879X2002000500003","article-title":"Antioxidant properties of natural compounds used in popular medicine for gastric ulcers","volume":"35","author":"Repetto","year":"2002","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"7","key":"10.1016\/j.jsps.2020.06.012_b0185","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4014\/jmb.1501.01099","article-title":"Association of helicobacter pylori caga gene with gastric cancer and peptic ulcer in Saudi patients","volume":"25","author":"Saber","year":"2015","journal-title":"J. Microbiol. Biotechnol."},{"issue":"3","key":"10.1016\/j.jsps.2020.06.012_b0190","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3390\/molecules14030979","article-title":"Flavonoids with gastroprotective activity","volume":"14","author":"de Lira Mota","year":"2009","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jsps.2020.06.012_b0195","first-page":"11","article-title":"Chronic disease prevalence among elderly Saudi men","volume":"11","author":"Saquib","year":"2017","journal-title":"Int. J. Health Sci."},{"key":"10.1016\/j.jsps.2020.06.012_b0200","doi-asserted-by":"crossref","first-page":"336","DOI":"10.4103\/0253-7613.81501","article-title":"Antiulcer and antioxidant activity of ethanolic extract of Passiflora foetida L","volume":"43","author":"Sathish","year":"2011","journal-title":"Indian J. Pharmacol."},{"issue":"10","key":"10.1016\/j.jsps.2020.06.012_b0205","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1016\/j.fct.2010.07.007","article-title":"Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn)","volume":"48","author":"Shaker","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.jsps.2020.06.012_b0210","first-page":"226","article-title":"Gastroprotective effects of pretreatment with Zizyphus sativa fruits against toxic damage in rats","volume":"68","author":"Shah","year":"1997","journal-title":"Fitoterapia (Milano)"},{"key":"10.1016\/j.jsps.2020.06.012_b0215","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.12659\/MSM.904554","article-title":"Tetramethylpyrazine protects neurons from oxygen-glucose deprivation-induced death","volume":"23","author":"Shao","year":"2017","journal-title":"Med. Sci. Monit.: Int. Med. J. Exp. Clin. Res."},{"issue":"1","key":"10.1016\/j.jsps.2020.06.012_b0220","first-page":"21","article-title":"Gastroprotective effect of aqueous extract of Aegle marmelos unripe fruit in albino rats","volume":"3","author":"Sharmila","year":"2013","journal-title":"Int. J. Med. Pharma. Sci."},{"issue":"1","key":"10.1016\/j.jsps.2020.06.012_b0225","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/1472-6882-13-183","article-title":"Gastroprotective effect of desmosdumotin C isolated from mitrella kentii against ethanol-induced gastric mucosal hemorrhage in rats: possible involvement of glutathione, heat-shock protein-70, sulfhydryl compounds, nitric oxide, and anti-helicobacter pylo","volume":"13","author":"Sidahmed","year":"2013","journal-title":"BMC Complement. Altern. Med."},{"issue":"1","key":"10.1016\/j.jsps.2020.06.012_b0230","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jep.2013.04.007","article-title":"Protective effect of ethyl acetate fraction of acacia ferruginea DC against ethanol-induced gastric ulcer in rats","volume":"148","author":"Sowndhararajan","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jsps.2020.06.012_b0235","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s10753-009-9176-5","article-title":"Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers","volume":"33","author":"Suleyman","year":"2010","journal-title":"Inflammation"},{"key":"10.1016\/j.jsps.2020.06.012_b0240","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2036.2000.014s1033.x","article-title":"Transcription factors and growth factors in ulcer healing","volume":"14","author":"Szabo","year":"2000","journal-title":"Aliment. Pharmacol. Therapeut.: Ulcer Heal. Prostagland."},{"issue":"18","key":"10.1016\/j.jsps.2020.06.012_b0245","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.2174\/1381612824666180629111227","article-title":"Roles of cyclooxygenase, prostaglandin E2 and EP receptors in mucosal protection and ulcer healing in the gastrointestinal tract","volume":"24","author":"Takeuchi","year":"2018","journal-title":"Curr. Pharm. Des."},{"issue":"1\u20136","key":"10.1016\/j.jsps.2020.06.012_b0250","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0928-4257(01)00046-8","article-title":"Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways","volume":"95","author":"Tarnawski","year":"2001","journal-title":"J. Physiol.-Paris"},{"issue":"1","key":"10.1016\/j.jsps.2020.06.012_b0255","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1124\/jpet.105.095166","article-title":"Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats","volume":"317","author":"Utsumi","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"8","key":"10.1016\/j.jsps.2020.06.012_b0260","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1023\/A:1018846628019","article-title":"Effect of tetramethylpyrazine on reserpine-induced gastric lesion in rats","volume":"43","author":"Wan","year":"1998","journal-title":"Dig. Dis. Sci."},{"issue":"7","key":"10.1016\/j.jsps.2020.06.012_b0265","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.freeradbiomed.2011.12.023","article-title":"Molecular mechanism of indomethacin-induced gastropathy","volume":"52","author":"Yadav","year":"2012","journal-title":"Free Radical Biol. Med."},{"issue":"13","key":"10.1016\/j.jsps.2020.06.012_b0270","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.phymed.2011.05.003","article-title":"Protective effect of tetramethylpyrazine isolated from Ligusticum chuanxiong on nephropathy in rats with streptozotocin-induced diabetes","volume":"18","author":"Yang","year":"2011","journal-title":"Phytomedicine"}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016420301328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016420301328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:24:50Z","timestamp":1736184290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319016420301328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S1319016420301328"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2020.06.012","relation":{},"ISSN":["1319-0164"],"issn-type":[{"value":"1319-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tetramethylpyrazine ameliorates indomethacin-induced gastric ulcer in rats: Impact on oxidative, inflammatory, and angiogenic machineries","name":"articletitle","label":"Article Title"},{"value":"Saudi Pharmaceutical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsps.2020.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}