{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:08:29Z","timestamp":1770512909501,"version":"3.49.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7202147"],"award-info":[{"award-number":["7202147"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jsps.2022.01.009","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T18:45:49Z","timestamp":1642617949000},"page":"265-282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Intranasal hydrogel of armodafinil hydroxypropyl-\u03b2-cyclodextrin inclusion complex for the treatment of post-traumatic stress disorder"],"prefix":"10.1007","volume":"30","author":[{"given":"Ge","family":"Ou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiguang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"6","key":"10.1016\/j.jsps.2022.01.009_b0005","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1515\/revneuro-2015-0015","article-title":"Electric foot shock stress: a useful tool in neuropsychiatric studies","volume":"26","author":"Bali","year":"2015","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.jsps.2022.01.009_b0010","doi-asserted-by":"crossref","unstructured":"Bittencourt, V.C.E., Moreira, A., da Silva, J.G., Gomides, A.F.F., Velloso-Rodrigues, C., Kelmann, R.G., Mendon\u00e7a, L.M., Lula, I.S., Denadai \u00c2, M.L., 2019. Hydrophobic nanoprecipitates formed by benzoylphenylureas and \u03b2-cyclodextrin inclusion compounds: synthesis, characterization and toxicity against aedes aegypti larvae. Heliyon 5(7), e02013.","DOI":"10.1016\/j.heliyon.2019.e02013"},{"issue":"11","key":"10.1016\/j.jsps.2022.01.009_b0015","doi-asserted-by":"crossref","first-page":"e4342","DOI":"10.1002\/bmc.4342","article-title":"Quantitative determination of armodafinil in human plasma by liquid chromatography-electrospray mass spectrometry: Application to a clinical study","volume":"32","author":"Chandasana","year":"2018","journal-title":"Biomed. Chromatogr."},{"issue":"5","key":"10.1016\/j.jsps.2022.01.009_b0020","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1183\/13993003.01509-2015","article-title":"Modafinil\/armodafinil in obstructive sleep apnoea: a systematic review and meta-analysis","volume":"47","author":"Chapman","year":"2016","journal-title":"Eur. Respir. J."},{"issue":"3","key":"10.1016\/j.jsps.2022.01.009_b0025","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.3390\/ijms14036499","article-title":"Preparation of a paeonol-containing temperature-sensitive in situ gel and its preliminary efficacy on allergic rhinitis","volume":"14","author":"Chu","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.jsps.2022.01.009_b0030","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1037\/ccp0000220","article-title":"Do changes in trauma-related beliefs predict PTSD symptom improvement in prolonged exposure and sertraline?","volume":"85","author":"Cooper","year":"2017","journal-title":"J. Consult. Clin. Psychol."},{"issue":"9","key":"10.1016\/j.jsps.2022.01.009_b0035","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2165\/11317740-000000000-00000","article-title":"Comparison of steady-state plasma concentrations of armodafinil and modafinil late in the day following morning administration: post hoc analysis of two randomized, double-blind, placebo-controlled, multiple-dose studies in healthy male subjects","volume":"29","author":"Darwish","year":"2009","journal-title":"Clin. Drug. Investig."},{"issue":"12","key":"10.1016\/j.jsps.2022.01.009_b0040","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nrd1576","article-title":"Cyclodextrin-based pharmaceutics: past, present and future","volume":"3","author":"Davis","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jsps.2022.01.009_b0045","doi-asserted-by":"crossref","first-page":"118734","DOI":"10.1016\/j.ijpharm.2019.118734","article-title":"Novel in situ gelling ophthalmic drug delivery system based on gellan gum and hydroxyethylcellulose: Innovative rheological characterization, in vitro and in vivo evidence of a sustained precorneal retention time","volume":"574","author":"Destruel","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jsps.2022.01.009_b0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.addr.2018.03.007","article-title":"In situ forming injectable hydrogels for drug delivery and wound repair","volume":"127","author":"Dimatteo","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.jsps.2022.01.009_b0055","first-page":"303","article-title":"Effect of salvianolic acid B on nasal absorption in rats in situ","volume":"41","author":"Du","year":"2016","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.jsps.2022.01.009_b0060","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3389\/fpsyt.2019.00650","article-title":"Breakthrough for trauma treatment: safety and efficacy of mdma-assisted psychotherapy compared to paroxetine and sertraline","volume":"10","author":"Feduccia","year":"2019","journal-title":"Front Psychiatry."},{"issue":"6","key":"10.1016\/j.jsps.2022.01.009_b0065","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00213-015-4184-7","article-title":"Effects of oxytocin on methamphetamine-seeking exacerbated by predator odor pre-exposure in rats","volume":"233","author":"Ferland","year":"2016","journal-title":"Psychopharmacology (Berl.)"},{"issue":"1","key":"10.1016\/j.jsps.2022.01.009_b0070","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1021\/cn200100h","article-title":"Knowledge-Based, Central Nervous System (CNS) lead selection and lead optimization for CNS drug discovery","volume":"3","author":"Ghose","year":"2012","journal-title":"ACS Chem. Neurosci."},{"issue":"4","key":"10.1016\/j.jsps.2022.01.009_b0075","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1248\/bpb.b14-00398","article-title":"The effect of cilia and the mucociliary clearance on successful drug delivery","volume":"38","author":"Gizurarson","year":"2015","journal-title":"Biol. Pharm. Bull."},{"issue":"10","key":"10.1016\/j.jsps.2022.01.009_b0080","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/mp.2016.234","article-title":"Reduction of smoking urges with intranasal insulin: a randomized, crossover, placebo-controlled clinical trial","volume":"22","author":"Hamidovic","year":"2017","journal-title":"Mol. Psychiat."},{"key":"10.1016\/j.jsps.2022.01.009_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2016.12.007","article-title":"Prophylactic and therapeutic intranasal administration with an immunomodulator, Hiltonol(\u00ae) (Poly IC:LC), in a lethal SARS-CoV-infected BALB\/c mouse model","volume":"139","author":"Kumaki","year":"2017","journal-title":"Antiviral Res."},{"key":"10.1016\/j.jsps.2022.01.009_b0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neures.2017.04.012","article-title":"Early deprivation increases high-leaning behavior, a novel anxiety-like behavior, in the open field test in rats","volume":"123","author":"Kuniishi","year":"2017","journal-title":"Neurosci. Res."},{"issue":"2","key":"10.1016\/j.jsps.2022.01.009_b0095","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/13651501.2017.1291838","article-title":"Effect and safety of sertraline for treat posttraumatic stress disorder: a multicenter randomised controlled study","volume":"21","author":"Li","year":"2017","journal-title":"Int. J. Psychiat. Clin. Pract."},{"issue":"7","key":"10.1016\/j.jsps.2022.01.009_b0100","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.addr.2011.11.002","article-title":"Intranasal delivery of biologics to the central nervous system","volume":"64","author":"Lochhead","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.jsps.2022.01.009_b0105","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.psyneuen.2004.09.003","article-title":"Long-term behavioural alterations in female rats after a single intense footshock followed by situational reminders","volume":"30","author":"Louvart","year":"2005","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jsps.2022.01.009_b0110","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2147\/IJN.S151474","article-title":"Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer's disease","volume":"13","author":"Meng","year":"2018","journal-title":"Int. J. Nanomed."},{"issue":"2","key":"10.1016\/j.jsps.2022.01.009_b0115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"issue":"11","key":"10.1016\/j.jsps.2022.01.009_b0120","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.3390\/polym11111772","article-title":"Crosslinking kinetics of methylcellulose aqueous solution and its potential as a scaffold for tissue engineering","volume":"11","author":"Niemczyk-Soczynska","year":"2019","journal-title":"Polymers (Basel)"},{"issue":"5","key":"10.1016\/j.jsps.2022.01.009_b0125","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10329-019-00741-0","article-title":"Temperature profile of the nasal cavity in Japanese macaques","volume":"60","author":"Nishimura","year":"2019","journal-title":"Primates"},{"issue":"7","key":"10.1016\/j.jsps.2022.01.009_b0130","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/j.apsb.2021.01.014","article-title":"Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder","volume":"11","author":"Pang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.jsps.2022.01.009_b0135","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.biopsych.2004.11.008","article-title":"A rodent model of sleep disturbances in posttraumatic stress disorder: the role of context after fear conditioning","volume":"57","author":"Pawlyk","year":"2005","journal-title":"Biol. Psychiat."},{"issue":"2","key":"10.1016\/j.jsps.2022.01.009_b0140","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0006-3223(95)00088-7","article-title":"A behavioral animal model of posttraumatic stress disorder featuring repeated exposure to situational reminders","volume":"39","author":"Pynoos","year":"1996","journal-title":"Biol. Psychiat."},{"issue":"2","key":"10.1016\/j.jsps.2022.01.009_b0145","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1001\/jamapsychiatry.2018.3412","article-title":"Efficacy of prolonged exposure therapy, sertraline hydrochloride, and their combination among combat veterans with posttraumatic stress disorder: a randomized clinical trial","volume":"76","author":"Rauch","year":"2019","journal-title":"JAMA Psychiat."},{"issue":"1","key":"10.1016\/j.jsps.2022.01.009_b0150","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1513\/pats.201007-050RN","article-title":"Anatomy and physiology of the upper airway","volume":"8","author":"Sahin-Yilmaz","year":"2011","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.jsps.2022.01.009_b0155","doi-asserted-by":"crossref","first-page":"107402","DOI":"10.1016\/j.pharmthera.2019.107402","article-title":"Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders","volume":"204","author":"Sartori","year":"2019","journal-title":"Pharmacol. Ther."},{"issue":"10","key":"10.1016\/j.jsps.2022.01.009_b0160","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1111\/jcmm.13161","article-title":"Post-traumatic stress disorder and beyond: an overview of rodent stress models","volume":"21","author":"Sch\u00f6ner","year":"2017","journal-title":"J. Cell Mol. Med."},{"issue":"9","key":"10.1016\/j.jsps.2022.01.009_b0165","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1093\/ijnp\/pyy048","article-title":"Suicidal ideation and suicidal behavior as rare adverse events of antidepressant medication: current report from the AMSP multicenter drug safety surveillance project","volume":"21","author":"St\u00fcbner","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"3","key":"10.1016\/j.jsps.2022.01.009_b0170","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jobcr.2019.04.001","article-title":"Development of Moxifloxacin Hydrochloride loaded in-situ gel for the treatment of periodontitis: In-vitro drug release study and antibacterial activity","volume":"9","author":"Swain","year":"2019","journal-title":"J. Oral. Biol. Craniofac. Res."},{"issue":"3","key":"10.1016\/j.jsps.2022.01.009_b0175","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1208\/s12249-017-0918-7","article-title":"Nanolipid gel of an antimycotic drug for treating vulvovaginal candidiasis-development and evaluation","volume":"19","author":"Takalkar","year":"2018","journal-title":"AAPS PharmSciTech."},{"issue":"1","key":"10.1016\/j.jsps.2022.01.009_b0180","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13041-019-0449-0","article-title":"Region- and time-dependent gene regulation in the amygdala and anterior cingulate cortex of a PTSD-like mouse model","volume":"12","author":"Tanaka","year":"2019","journal-title":"Mol. Brain"},{"issue":"3","key":"10.1016\/j.jsps.2022.01.009_b0185","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.neuroscience.2008.01.013","article-title":"Delivery of interferon-beta to the monkey nervous system following intranasal administration","volume":"152","author":"Thorne","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.jsps.2022.01.009_b0190","doi-asserted-by":"crossref","first-page":"112957","DOI":"10.1016\/j.jep.2020.112957","article-title":"Shenzao jiannao oral liquid, an herbal formula, ameliorates cognitive impairments by rescuing neuronal death and triggering endogenous neurogenesis in AD-like mice induced by a combination of A\u03b242 and scopolamine","volume":"259","author":"Xiao","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jsps.2022.01.009_b0195","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.psyneuen.2012.02.007","article-title":"Psychosocial animal model of PTSD produces a long-lasting traumatic memory, an increase in general anxiety and PTSD-like glucocorticoid abnormalities","volume":"37","author":"Zoladz","year":"2012","journal-title":"Psychoneuroendocrinology"}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016422000093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016422000093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:27:41Z","timestamp":1736184461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319016422000093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S1319016422000093"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2022.01.009","relation":{},"ISSN":["1319-0164"],"issn-type":[{"value":"1319-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intranasal hydrogel of armodafinil hydroxypropyl-\u03b2-cyclodextrin inclusion complex for the treatment of post-traumatic stress disorder","name":"articletitle","label":"Article Title"},{"value":"Saudi Pharmaceutical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsps.2022.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}