{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:32:51Z","timestamp":1787509971259,"version":"build-2736575974"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jsps.2022.06.021","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T12:08:50Z","timestamp":1656331730000},"page":"1293-1300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Epigallocatechin gallate ameliorates tetrahydrochloride-induced liver toxicity in rats via inhibition of TGF\u03b2 \/ p-ERK\/p-Smad1\/2 signaling, antioxidant, anti-inflammatory activity"],"prefix":"10.1007","volume":"30","author":[{"given":"Gomaa","family":"Mostafa-Hedeab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Ewaiss Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taher","family":"F. Halawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0650Farooq","family":"Ahmed Wani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10.1016\/j.jsps.2022.06.021_b0005","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.toxrep.2019.07.011","article-title":"Hepatoprotective effects of silymarin on CCl(4)-induced hepatic damage in broiler chickens model","volume":"6","author":"Baradaran","year":"2019","journal-title":"Toxicol. Rep."},{"issue":"1","key":"10.1016\/j.jsps.2022.06.021_b0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1749-8546-5-13","article-title":"Beneficial effects of green tea: a literature review","volume":"5","author":"Chacko","year":"2010","journal-title":"Chinese Med."},{"issue":"3","key":"10.1016\/j.jsps.2022.06.021_b0015","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/ajcn\/80.3.742","article-title":"Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide\u2013derived prooxidants","volume":"80","author":"Chen","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jsps.2022.06.021_b0020","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cbi.2018.12.006","article-title":"Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-\u03b21\/Smad and NOX4\/ROS pathways","volume":"299","author":"Cheng","year":"2019","journal-title":"Chem.-Biol. Interact."},{"issue":"3","key":"10.1016\/j.jsps.2022.06.021_b0025","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/acs.chemrestox.0c00485","article-title":"Liver injury caused by green tea extract in PD-1\u2013\/\u2013mice: an impaired immune tolerance model for idiosyncratic drug-induced liver injury","volume":"34","author":"Cho","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jsps.2022.06.021_b0030","first-page":"3213","article-title":"In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-\u03b1","volume":"119","author":"Connolly","year":"2009","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jsps.2022.06.021_b0035","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cbi.2014.06.018","article-title":"Protective effects of polyphenols-enriched extract from Huangshan Maofeng green tea against CCl4-induced liver injury in mice","volume":"220","author":"Cui","year":"2014","journal-title":"Chemi.-Biol. Interact."},{"key":"10.1016\/j.jsps.2022.06.021_b0040","first-page":"1986","article-title":"Effect of silybin on the hepatic microsomal drug-metabolising enzyme system in the rat","volume":"24","author":"Down","year":"1974","journal-title":"Arzneimittelforschung."},{"key":"10.1016\/j.jsps.2022.06.021_b0045","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1016\/j.ajpath.2014.04.014","article-title":"Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro","volume":"184","author":"Duan","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jsps.2022.06.021_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-01169-0","article-title":"Dynamic regulation of canonical TGF\u03b2 signalling by endothelial transcription factor ERG protects from liver fibrogenesis","volume":"8","author":"Dufton","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jsps.2022.06.021_b0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196411","article-title":"Amelioration of CCl4 induced liver injury in swiss albino mice by antioxidant rich leaf extract of Croton bonplandianus Baill","volume":"13","author":"Dutta","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.jsps.2022.06.021_b0060","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.tifs.2019.04.001","article-title":"Trends of tea in cardiovascular health and disease: a critical review","volume":"88","author":"Fang","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.jsps.2022.06.021_b0065","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3727\/096368909788237140","article-title":"Suppression of carbon tetrachloride-induced liver fibrosis by transplantation of a clonal mesenchymal stem cell line derived from rat bone marrow","volume":"18","author":"Hardjo","year":"2009","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jsps.2022.06.021_b0070","series-title":"Regulation of NF-\u03baB by TNF family cytokines","author":"Hayden","year":"2014"},{"key":"10.1016\/j.jsps.2022.06.021_b0075","article-title":"The therapeutic effects of stem cell enhancer on changes of some physiological parameters in male albino rats treated with mixture of food additives) food preservative, food coloring agent, and flavor enhancer)","volume":"67","author":"Helal","year":"2017","journal-title":"Egypti. J. Hospit. Med."},{"key":"10.1016\/j.jsps.2022.06.021_b0080","doi-asserted-by":"crossref","unstructured":"Higdon, J. V. and B. Frei, 2003. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions.","DOI":"10.1080\/10408690390826464"},{"key":"10.1016\/j.jsps.2022.06.021_b0085","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1021\/jf010153l","article-title":"Total phenol, catechin, and caffeine contents of teas commonly consumed in the United Kingdom","volume":"50","author":"Khokhar","year":"2002","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.jsps.2022.06.021_b0090","doi-asserted-by":"crossref","first-page":"13180","DOI":"10.1073\/pnas.0605669103","article-title":"Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix","volume":"103","author":"Kim","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jsps.2022.06.021_b0095","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10753-007-9053-z","article-title":"The treatment with antibody of TNF-\u03b1 reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine-and choline-deficient diet","volume":"31","author":"Koca","year":"2008","journal-title":"Inflammation"},{"key":"10.1016\/j.jsps.2022.06.021_b0100","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/39348","article-title":"Opposing BMP and EGF signalling pathways converge on the TGF-\u03b2 family mediator Smad1","volume":"389","author":"Kretzschmar","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jsps.2022.06.021_b0105","doi-asserted-by":"crossref","unstructured":"Kucera, O., V. Mezera, A. Moravcova, et al., 2015. In vitro toxicity of epigallocatechin gallate in rat liver mitochondria and hepatocytes. Oxidative Medicine and Cellular Longevity. 2015,","DOI":"10.1155\/2015\/476180"},{"key":"10.1016\/j.jsps.2022.06.021_b0110","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.fct.2009.10.030","article-title":"Hepatotoxicity of high oral dose (\u2212)-epigallocatechin-3-gallate in mice","volume":"48","author":"Lambert","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jsps.2022.06.021_b0115","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bbrc.2011.05.023","article-title":"The antifibrotic effects of TGF-\u03b21 siRNA on hepatic fibrosis in rats","volume":"409","author":"Lang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jsps.2022.06.021_b0120","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/japtr.JAPTR_116_19","article-title":"Beneficial effects of green coffee and green tea extract combination on metabolic syndrome improvement by affecting AMPK and PPAR-\u03b1 gene expression","volume":"11","author":"Lukitasari","year":"2020","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"10.1016\/j.jsps.2022.06.021_b0125","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cbi.2017.09.015","article-title":"Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2\/ARE\/HO-1, PPAR\u03b3 and TGF-\u03b21\/Smad3 signaling, and amelioration of oxidative stress and inflammation","volume":"277","author":"Mahmoud","year":"2017","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.jsps.2022.06.021_b0130","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cbi.2017.04.012","article-title":"Commiphora molmol resin attenuates diethylnitrosamine\/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2\/ARE\/HO-1 signaling","volume":"270","author":"Mahmoud","year":"2017","journal-title":"Chem.-Biol. Interact."},{"issue":"765\u2013776","key":"10.1016\/j.jsps.2022.06.021_b0135","article-title":"Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice","volume":"143","author":"Meng","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jsps.2022.06.021_b0140","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2131\/fts.6.15","article-title":"Supplementation with lower doses of EGCg reduces liver injury markers of type 2 diabetic rats","volume":"6","author":"Mochizuki","year":"2019","journal-title":"Fund. Toxicol. Sci."},{"key":"10.1016\/j.jsps.2022.06.021_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.145288","article-title":"Chitosan-stabilized selenium nanoparticles alleviate cardio-hepatic damage in type 2 diabetes mellitus model via regulation of caspase, Bax\/Bcl-2, and Fas\/FasL-pathway","volume":"768","author":"Mohamed","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.jsps.2022.06.021_b0150","article-title":"Ameliorating effect of olive leaf extract on cyclosporine-induced nephrotoxicity in rats","volume":"9","author":"Mostafa-Hedeab","year":"2015","journal-title":"Iran. J. Kidney Dis."},{"key":"10.1016\/j.jsps.2022.06.021_b0155","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fphar.2013.00051","article-title":"Epigallocatechin-3-gallate reduces inflammation induced by calcium pyrophosphate crystals in vitro","volume":"4","author":"Oliviero","year":"2013","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jsps.2022.06.021_b0160","doi-asserted-by":"crossref","first-page":"10405","DOI":"10.1074\/jbc.M611742200","article-title":"Transforming growth factor-\u03b2 receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1\/2 pathways","volume":"282","author":"Pannu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsps.2022.06.021_b0165","doi-asserted-by":"crossref","unstructured":"Peng, C., Z.-m. Zhou, J. Li, et al., 2019. CCl4-induced liver injury was ameliorated by Qi-Ge decoction through the antioxidant pathway. Evidence-Based Complementary and Alternative Medicine. 2019,","DOI":"10.1155\/2019\/5941263"},{"key":"10.1016\/j.jsps.2022.06.021_b0170","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jsps.2022.06.021_b0175","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31756","article-title":"TGF-\u03b2 uses a novel mode of receptor activation to phosphorylate SMAD1\/5 and induce epithelial-to-mesenchymal transition","volume":"7","author":"Ramachandran","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.jsps.2022.06.021_b0180","doi-asserted-by":"crossref","first-page":"R71","DOI":"10.1186\/ar2700","article-title":"Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-\u03b1 and matrix metalloproteinase-13 in human chondrocytes","volume":"11","author":"Rasheed","year":"2009","journal-title":"Arthrit. Res. Ther."},{"key":"10.1016\/j.jsps.2022.06.021_b0185","doi-asserted-by":"crossref","unstructured":"Reina, M. and A. Mart\u00ednez, 2016. Is Silybin the Best Free Radical Scavenger Compound in Silymarin? The Journal of Physical Chemistry B. 120, 4568-4578. .","DOI":"10.1021\/acs.jpcb.6b02807"},{"key":"10.1016\/j.jsps.2022.06.021_b0190","doi-asserted-by":"crossref","unstructured":"Reyes-Gordillo, K., R. Shah and P. Muriel, 2017. Oxidative stress and inflammation in hepatic diseases: current and future therapy, Hindawi.","DOI":"10.1155\/2017\/3140673"},{"key":"10.1016\/j.jsps.2022.06.021_b0195","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1078\/0171-9335-00182","article-title":"The bcl, NF\u03baB and p53\/p21WAF1 systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGF-\u03b2 or TNF-\u03b1 on activated hepatic stellate cells","volume":"80","author":"Saile","year":"2001","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.jsps.2022.06.021_b0200","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3892\/ijmm.2013.1503","article-title":"Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: a double-blind placebo-controlled study","volume":"32","author":"Sakata","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jsps.2022.06.021_b0205","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.2174\/092986712803341520","article-title":"Role of oxidative stress and molecular changes in liver fibrosis: a review","volume":"19","author":"S\u00e1nchez-Valle","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jsps.2022.06.021_b0210","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2165\/00002018-200831060-00003","article-title":"Safety of green tea extracts","volume":"31","author":"Sarma","year":"2008","journal-title":"Drug Saf."},{"key":"10.1016\/j.jsps.2022.06.021_b0215","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/hep.28677","article-title":"Prevalence of chronic liver disease and cirrhosis by underlying cause in understudied ethnic groups: the multiethnic cohort","volume":"64","author":"Setiawan","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jsps.2022.06.021_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1139\/cjpp-2016-0090","article-title":"Effects of telmisartan and pioglitazone on high fructose induced metabolic syndrome in rats","volume":"94","author":"Shahataa","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.jsps.2022.06.021_b0225","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.bcp.2011.07.093","article-title":"Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications","volume":"82","author":"Singh","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jsps.2022.06.021_b0230","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1002\/art.10443","article-title":"Epigallocatechin-3-gallate inhibits interleukin-1\u03b2\u2013induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: Suppression of nuclear factor \u03baB activation by degradation of the inhibitor of nuclear factor \u03baB","volume":"46","author":"Singh","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jsps.2022.06.021_b0235","doi-asserted-by":"crossref","first-page":"G631","DOI":"10.1152\/ajpgi.00185.2007","article-title":"Selective inactivation of NF-\u03baB in the liver using NF-\u03baB decoy suppresses CCl4-induced liver injury and fibrosis.","volume":"293","author":"Son","year":"2007","journal-title":"Am. J. Physiol.y-Gastrointes. Liver Physiol."},{"key":"10.1016\/j.jsps.2022.06.021_b0240","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.fct.2018.07.048","article-title":"Anthocyanins isolated from blueberry ameliorates CCl4 induced liver fibrosis by modulation of oxidative stress, inflammation and stellate cell activation in mice","volume":"120","author":"Sun","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jsps.2022.06.021_b0245","first-page":"1","article-title":"ENMD-1068 inhibits liver fibrosis through attenuation of TGF-\u03b21\/Smad2\/3 signaling in mice","volume":"7","author":"Sun","year":"2017","journal-title":"Scientific Rep."},{"key":"10.1016\/j.jsps.2022.06.021_b0250","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.it.2013.01.004","article-title":"Regulation of nuclear factor-\u03baB in autoimmunity","volume":"34","author":"Sun","year":"2013","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jsps.2022.06.021_b0255","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jhep.2015.03.039","article-title":"Mechanisms of liver fibrosis resolution","volume":"63","author":"Tacke","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jsps.2022.06.021_b0260","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biocel.2016.11.007","article-title":"Rev-erb agonist and TGF-\u03b2 similarly affect autophagy but differentially regulate hepatic stellate cell fibrogenic phenotype","volume":"81","author":"Thomes","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jsps.2022.06.021_b0265","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1365-2893.2008.00971.x","article-title":"Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats","volume":"15","author":"Tsai","year":"2008","journal-title":"J. Viral Hepatitis"},{"key":"10.1016\/j.jsps.2022.06.021_b0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-020-02906-7","article-title":"Poncirin attenuates CCL4-induced liver injury through inhibition of oxidative stress and inflammatory cytokines in mice","volume":"20","author":"Ullah","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.jsps.2022.06.021_b0275","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1021\/acs.jafc.8b05179","article-title":"Green tea catechins effectively altered hepatic fibrogenesis in rats by inhibiting ERK and Smad1\/2 phosphorylation","volume":"67","author":"Wang","year":"2018","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.jsps.2022.06.021_b0280","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.jsps.2022.06.021_b0285","first-page":"8339","article-title":"The effect of green tea intake on risk of liver disease: a meta analysis","volume":"8","author":"Yin","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.jsps.2022.06.021_b0290","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.jsps.2022.06.021_b0295","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00395-008-0733-0","article-title":"The role of inflammatory cytokines in endothelial dysfunction","volume":"103","author":"Zhang","year":"2008","journal-title":"Basic Res. Cardiol."}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016422001694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016422001694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T12:27:03Z","timestamp":1736166423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319016422001694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S1319016422001694"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2022.06.021","relation":{},"ISSN":["1319-0164"],"issn-type":[{"value":"1319-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigallocatechin gallate ameliorates tetrahydrochloride-induced liver toxicity in rats via inhibition of TGF\u03b2 \/ p-ERK\/p-Smad1\/2 signaling, antioxidant, anti-inflammatory activity","name":"articletitle","label":"Article Title"},{"value":"Saudi Pharmaceutical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsps.2022.06.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}