{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:50:27Z","timestamp":1783036227052,"version":"3.54.6"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["RGP.2\/121\/43 \/ 1443H"],"award-info":[{"award-number":["RGP.2\/121\/43 \/ 1443H"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023674","name":"Deanship of Scientific Research, King Khalid University","doi-asserted-by":"publisher","award":["IEC\/2022\/14"],"award-info":[{"award-number":["IEC\/2022\/14"]}],"id":[{"id":"10.13039\/501100023674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jsps.2023.03.005","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T02:13:25Z","timestamp":1678414405000},"page":"655-658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of vitamin B6 deficiency on the severity of diabetic peripheral neuropathy \u2013 A cross sectional study"],"prefix":"10.1007","volume":"31","author":[{"given":"Moteb","family":"Khobrani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Kandasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajalakshimi","family":"Vasudevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AbdulAziz","family":"Alhossan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranadheer Chowdary","family":"Puvvada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Devanandan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeshri","family":"Dhurke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manusri","family":"Naredla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10.1016\/j.jsps.2023.03.005_b0005","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4162\/nrp.2011.5.1.34","article-title":"Assessment of vitamin B(6) status in Korean patients with newly diagnosed type 2 diabetes","volume":"5","author":"Ahn","year":"2011","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.jsps.2023.03.005_b0010","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00431-008-0823-x","article-title":"Jr Clinical features and the management of pyridoxine-dependent and pyridoxine-responsive seizures: review of 63 North American cases submitted to a patient registry","volume":"168","author":"Basura","year":"2009","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.jsps.2023.03.005_b0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/bmj.3.5974.13","article-title":"Improvement of oral glucose tolerance in gestational diabetes by pyridoxine","volume":"3","author":"Bennink","year":"1975","journal-title":"Br. Med. J."},{"issue":"4","key":"10.1016\/j.jsps.2023.03.005_b0020","doi-asserted-by":"crossref","first-page":"546","DOI":"10.4103\/2230-8210.183480","article-title":"Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum?","volume":"20","author":"Chawla","year":"2016","journal-title":"Indian J. Endocrinol. Metab."},{"key":"10.1016\/j.jsps.2023.03.005_b0025","doi-asserted-by":"crossref","first-page":"394","DOI":"10.7547\/87507315-74-8-394","article-title":"Effect of pyridoxine (vitamin B6) on diabetic patients with peripheral neuropathy","volume":"74","author":"Cohen","year":"1984","journal-title":"J. Am. Podiatry Assoc."},{"key":"10.1016\/j.jsps.2023.03.005_b0030","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/CIRCULATIONAHA.106.621854","article-title":"Advanced glycation end products: sparking the development of diabetic vascular injury","volume":"114","author":"Goldin","year":"2006","journal-title":"Circulation."},{"key":"10.1016\/j.jsps.2023.03.005_b0035","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4137\/NMI.S40595","article-title":"Concentrations of water-soluble vitamins in blood and urinary excretion in patients with diabetes mellitus","volume":"9","author":"Iwakawa","year":"2016","journal-title":"Nutr. Metab. Insights."},{"key":"10.1016\/j.jsps.2023.03.005_b0040","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1055\/s-0029-1202833","article-title":"Pyridoxine-dependent epilepsy: normal outcome in a patient with late diagnosis after prolonged status epilepticus causing cortical blindness","volume":"39","author":"Kluger","year":"2008","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.jsps.2023.03.005_b0045","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ymgme.2009.04.001","article-title":"Cystathionine gamma-lyase: clinical, metabolic, genetic, and structural studies","volume":"97","author":"Kraus","year":"2009","journal-title":"Mol. Genet. Metab."},{"issue":"6","key":"10.1016\/j.jsps.2023.03.005_b0050","doi-asserted-by":"crossref","first-page":"606","DOI":"10.2337\/diacare.4.6.606","article-title":"The influence of pyridoxine in diabetic peripheral neuropathy","volume":"4","author":"Levin","year":"1981","journal-title":"Diabetes Care."},{"key":"10.1016\/j.jsps.2023.03.005_b0055","doi-asserted-by":"crossref","first-page":"1748065","DOI":"10.1155\/2016\/1748065","article-title":"Vitamin B6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in apoe (-\/-) mice fed with high-fat diet","volume":"2016","author":"Liu","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.jsps.2023.03.005_b0060","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mrgentox.2017.10.005","article-title":"Generation of Advanced Glycation End-Products (AGEs) by glycoxidation mediated by copper and ROS in a human serum albumin (HSA) model peptide: Reaction mechanism and damage in motor neuron cells","volume":"824","author":"Marques","year":"2017","journal-title":"Mutat. Res."},{"issue":"4","key":"10.1016\/j.jsps.2023.03.005_b0065","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2174\/157488411798375967","article-title":"Metabolic correction in the management of diabetic peripheral neuropathy: improving clinical results beyond symptom control","volume":"6","author":"Miranda-Massari","year":"2011","journal-title":"Curr. Clin. Pharmacol."},{"key":"10.1016\/j.jsps.2023.03.005_b0070","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/s00125-016-3863-1","article-title":"Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity","volume":"59","author":"Moreno-Navarrete","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.jsps.2023.03.005_b0075","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.diabres.2014.09.058","article-title":"Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy","volume":"107","author":"Nix","year":"2015","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.jsps.2023.03.005_b0080","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s12035-013-8497-4","article-title":"Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways","volume":"48","author":"Oxenkrug","year":"2013","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.jsps.2023.03.005_b0085","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3390\/cells7070084","article-title":"Vitamin B6 and Its Role in Cell Metabolism and Physiology","volume":"7","author":"Parra","year":"2018","journal-title":"Cells."},{"key":"10.1016\/j.jsps.2023.03.005_b0090","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/nure.12014","article-title":"Mechanistic perspective on the relationship between pyridoxal 5\u2032-phosphate and inflammation","volume":"71","author":"Paul","year":"2013","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.jsps.2023.03.005_b0095","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.3390\/ijms19113342","article-title":"The Pathophysiology of Gestational Diabetes Mellitus","volume":"19","author":"Plows","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jsps.2023.03.005_b0100","doi-asserted-by":"crossref","first-page":"e26747","DOI":"10.1371\/journal.pone.0026747","article-title":"Status of B-vitamins and homocysteine in diabetic retinopathy: Association with vitamin-B12 deficiency and hyperhomocysteinemia","volume":"6","author":"Satyanarayana","year":"2011","journal-title":"PLoS ONE."},{"key":"10.1016\/j.jsps.2023.03.005_b0105","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1620\/tjem.134.331","article-title":"The endocrine pancreas in pyridoxine deficient rats","volume":"134","author":"Toyota","year":"1981","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.jsps.2023.03.005_b0110","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1021\/bi800351a","article-title":"Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase","volume":"47","author":"Zhu","year":"2008","journal-title":"Biochemistry."}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016423000555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016423000555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:30:04Z","timestamp":1736184604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319016423000555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S1319016423000555"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2023.03.005","relation":{},"ISSN":["1319-0164"],"issn-type":[{"value":"1319-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of vitamin B6 deficiency on the severity of diabetic peripheral neuropathy \u2013 A cross sectional study","name":"articletitle","label":"Article Title"},{"value":"Saudi Pharmaceutical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsps.2023.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}]}}