{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:28:46Z","timestamp":1789770526301,"version":"4.0.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jsps.2023.06.015","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T21:38:12Z","timestamp":1687383492000},"page":"101682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of cytotoxic and apoptotic effects of the extracts and phenolic compounds of Astragalus globosus Vahl and Astragalus breviflorus DC"],"prefix":"10.1007","volume":"31","author":[{"given":"Benan","family":"Kalayc\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal","family":"\u015eim\u015fek \u00d6zek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferhunde","family":"Aysin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"\u00d6zbek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cavit","family":"Kazaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"\u00d6nal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u00fchal","family":"G\u00fcvenalp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10.1016\/j.jsps.2023.06.015_b0005","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1248\/bpb.23.834","article-title":"Immunostimulatory effects of cycloartane-type triterpene glycosides from Astragalus species","volume":"23","author":"Bedir","year":"2000","journal-title":"Biol. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.jsps.2023.06.015_b0010","doi-asserted-by":"crossref","first-page":"173","DOI":"10.12991\/mpj.2018.54","article-title":"Evaluation of anti-proliferative and cytotoxic effects of chlorogenic acid on breast cancer cell lines by real-time, label-free and high-throughput screening","volume":"22","author":"Bender","year":"2018","journal-title":"Marmara Pharm. J."},{"key":"10.1016\/j.jsps.2023.06.015_b0015","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.biopha.2016.07.029","article-title":"The apoptotic and autophagic properties of two natural occurring prodrugs, hyperoside and hypoxoside, against pancreatic cancer cell lines","volume":"83","author":"Boukes","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.jsps.2023.06.015_b0020","first-page":"471","article-title":"Diosmin reduces cell viability of A431 skin cancer cells through apoptotic induction","volume":"13","author":"Buddhan","year":"2017","journal-title":"J. Cancer Res. Ther."},{"key":"10.1016\/j.jsps.2023.06.015_b0025","series-title":"Flora of Turkey and the East Aegean Islands","author":"Chamberlain","year":"1970"},{"issue":"6","key":"10.1016\/j.jsps.2023.06.015_b0030","first-page":"1301","article-title":"Analysis of cell growth inhibitory effects of catechin through MAPK in human breast cancer cell line T47D","volume":"21","author":"Deguchi","year":"2002","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jsps.2023.06.015_b0035","first-page":"749","article-title":"Investigation of the apoptotic effect of curcumin in human leukemia HL-60 cells by using flow cytometry","volume":"25","author":"Dikmen","year":"2010","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.jsps.2023.06.015_b0040","doi-asserted-by":"crossref","unstructured":"El-Hawiet, A.M., Toaima, S.M., Asaad, A.M., Radwan, M.M., El-Sebakhy, N.A., 2010. Chemical constituents from Astragalus annularis Forssk. and A. trimestris L., Fabaceae. Rev Bras Farmacogn. 20, 860-865. https:\/\/doi.org\/10.1590\/S0102-695X2010005000047","DOI":"10.1590\/S0102-695X2010005000047"},{"key":"10.1016\/j.jsps.2023.06.015_b0045","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.foodchem.2015.08.129","article-title":"NMR-based identification of the phenolic profile of fruits of Lycium barbarum (goji berries). Isolation and structural determination of a novel N-feruloyl tyramine dimer as the most abundant antioxidant polyphenol of goji berries","volume":"194","author":"Forino","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.jsps.2023.06.015_b0050","first-page":"1","article-title":"Cytotoxic and hepatoprotective effects of Bupleurum flavum flavonoids on hepatocellular carcinoma HEP-G2 cells","volume":"11","author":"Gevrenova","year":"2016","journal-title":"J. Pharmaceut. Res. Int."},{"key":"10.1016\/j.jsps.2023.06.015_b0055","doi-asserted-by":"crossref","unstructured":"Gromova A, Lutsky V, Cannon J, Li D, Owen N., 2001. Secondary metabolites of Astragalus danicus Retz. and A. inopinatus Boriss. Russ. Chem. Bull. 50, 1107-1112. https:\/\/doi.org\/1066-5285\/01\/5006-1107.","DOI":"10.1023\/A:1011302309943"},{"key":"10.1016\/j.jsps.2023.06.015_b0060","first-page":"2125","article-title":"Antimicrobial and antioxidant activities of methanol and hexane extract of some endemic Astragalus species","volume":"20","author":"G\u00fcll\u00fcce","year":"2008","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.jsps.2023.06.015_b0065","series-title":"Turkey plant list (Vascular plants)","author":"G\u00fcner","year":"2012"},{"key":"10.1016\/j.jsps.2023.06.015_b0070","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/10826071003608447","article-title":"Separation and purification of flavonoids from black currant leaves by high-speed countercurrent chromatography and preparative HPLC","volume":"33","author":"He","year":"2010","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.jsps.2023.06.015_b0075","first-page":"1847","article-title":"Secondary metabolites from Astragalus lycius and their cytotoxic activities","volume":"11","author":"Horo","year":"2016","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jsps.2023.06.015_b0080","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/14786419.2012.701213","article-title":"Flavonoid constituents and biological screening of Astragalus bombycinus Boiss","volume":"27","author":"Ibrahim","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jsps.2023.06.015_b0085","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.fitote.2009.12.007","article-title":"Effects of cycloartane saponins from hairy roots of Astragalus membranaceus Bge., on human tumor cell targets","volume":"81","author":"Ionkova","year":"2010","journal-title":"Fitoterapia"},{"issue":"6","key":"10.1016\/j.jsps.2023.06.015_b0090","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0944-7113(00)80034-3","article-title":"Induction of cytotoxicity by chlorogenic acid in human oral tumor cell lines","volume":"7","author":"Jiang","year":"2000","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jsps.2023.06.015_b0095","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1016\/j.lfs.2005.02.028","article-title":"A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: isolation and identification from methanol extract of Euonymus alatus","volume":"77","author":"Jin","year":"2005","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.jsps.2023.06.015_b0100","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.tiv.2014.12.005","article-title":"Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line","volume":"29","author":"Lewinska","year":"2015","journal-title":"Toxicol in Vitro"},{"issue":"11","key":"10.1016\/j.jsps.2023.06.015_b0105","doi-asserted-by":"crossref","first-page":"18850","DOI":"10.3390\/molecules191118850","article-title":"A review of recent research progress on the Astragalus genus","volume":"19","author":"Li","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.jsps.2023.06.015_b0110","doi-asserted-by":"crossref","unstructured":"Lysiuk, R., Darmohray, R., 2016. Pharmacology and ethnomedicine of the genus Astragalus. Int. J. Pharmacol. 3, 46-53. https:\/\/doi.org\/10.18052","DOI":"10.18052\/www.scipress.com\/IJPPE.3.46"},{"issue":"21","key":"10.1016\/j.jsps.2023.06.015_b0115","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1021\/jf020121d","article-title":"Antiproliferative activities of citrus flavonoids against six human cancer cell lines","volume":"50","author":"Manthey","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jsps.2023.06.015_b0120","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/plants7020031","article-title":"Separation, identification, and antidiabetic activity of catechin isolated from Arbutus unedo L. plant roots","volume":"7","author":"Mrabti","year":"2018","journal-title":"Plants"},{"key":"10.1016\/j.jsps.2023.06.015_b0125","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10600-013-0654-5","article-title":"Chemical composition of Dracocephalum heterophyllum","volume":"49","author":"Numonov","year":"2013","journal-title":"Chem. Nat. Compd."},{"issue":"4","key":"10.1016\/j.jsps.2023.06.015_b0130","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/03601234.2017.1410385","article-title":"Cytotoxic activity of the bioactive principles from Ficus burtt-davyi","volume":"53","author":"Ogunlaja","year":"2018","journal-title":"J. Environ. Sci. Health B"},{"key":"10.1016\/j.jsps.2023.06.015_b0135","first-page":"451","article-title":"Antimutagenic activities of methanol extracts of some endemic Astragalus species","volume":"21","author":"\u00d6zbek","year":"2009","journal-title":"Asian J. Chem."},{"issue":"1","key":"10.1016\/j.jsps.2023.06.015_b0140","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11010-010-0655-7","article-title":"Inhibitory effect of caffeic acid on cancer cell proliferation by oxidative mechanism in human HT-1080 fibrosarcoma cell line","volume":"349","author":"Rajendra Prasad","year":"2011","journal-title":"Mol. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.jsps.2023.06.015_b0145","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.3390\/ijms19051518","article-title":"Chlorogenic acid improves the regorafenib effects in human hepatocellular carcinoma cells","volume":"19","author":"Refolo","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jsps.2023.06.015_b0150","first-page":"e00221","article-title":"Spectrometric analysis, chemical constituents and cytotoxic evaluation of Astragalus sieberi DC. (Fabaceae)","volume":"7","author":"Salem","year":"2020","journal-title":"Sci. Afr."},{"issue":"2","key":"10.1016\/j.jsps.2023.06.015_b0155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF02974274","article-title":"Cytotoxic constituents from Solanum lyratum","volume":"29","author":"Sun","year":"2006","journal-title":"Arch. Pharm. Res."},{"issue":"6","key":"10.1016\/j.jsps.2023.06.015_b0160","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.3390\/app10062065","article-title":"Anti-cancer activity of catechin against A549 lung carcinoma cells by induction of cyclin kinase inhibitor P21 and suppression of cyclin E1 and P-AKT","volume":"10","author":"Sun","year":"2020","journal-title":"Appl. Sci."},{"issue":"3","key":"10.1016\/j.jsps.2023.06.015_b0165","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"Ca-Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.jsps.2023.06.015_b0170","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1054\/mehy.2000.1406","article-title":"Hydrogen peroxide: a potent cytotoxic agent effective in causing cellular damage and used in the possible treatment for certain tumours","volume":"57","author":"Symons","year":"2001","journal-title":"Med. Hypotheses"},{"issue":"2","key":"10.1016\/j.jsps.2023.06.015_b0175","first-page":"96","article-title":"Sitotoksik kemoterap\u00f6tiklerin yirminci y\u00fczy\u0131ldaki geli\u015fimi","volume":"30","author":"Temel","year":"2015","journal-title":"Turk. Onkol. Derg."},{"issue":"16","key":"10.1016\/j.jsps.2023.06.015_b0180","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.phymed.2008.12.024","article-title":"Antiproliferation and apoptosis of human tumor cell lines by a lectin (AMML) of Astragalus mongholicus","volume":"2009","author":"Yan","year":"2009","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jsps.2023.06.015_b0185","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/cbdv.201100444","article-title":"Secondary metabolites of the genus Astragalus: Structure and biological-activity update","volume":"10","author":"Yang","year":"2013","journal-title":"Chem. Biodivers."},{"issue":"5","key":"10.1016\/j.jsps.2023.06.015_b0190","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.3892\/mmr.2017.7453","article-title":"Effect of hyperoside on the apoptosis of A549 human non-small cell lung cancer cells and the underlying mechanism","volume":"16","author":"Yang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jsps.2023.06.015_b0195","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.ijbiomac.2018.12.268","article-title":"Apoptosis of human gastric carcinoma MGC-803 cells induced by a novel Astragalus membranaceus polysaccharide via intrinsic mitochondrial pathways","volume":"126","author":"Yu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.jsps.2023.06.015_b0200","doi-asserted-by":"crossref","first-page":"16959","DOI":"10.3390\/molecules191016959","article-title":"Antioxidant, 5-lipoxygenase inhibitory and cytotoxic activities of compounds isolated from the Ferula lutea flowers","volume":"19","author":"Znati","year":"2014","journal-title":"Molecules"}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016423001755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016423001755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:28:21Z","timestamp":1736184501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319016423001755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S1319016423001755"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2023.06.015","relation":{},"ISSN":["1319-0164"],"issn-type":[{"value":"1319-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of cytotoxic and apoptotic effects of the extracts and phenolic compounds of Astragalus globosus Vahl and Astragalus breviflorus DC","name":"articletitle","label":"Article Title"},{"value":"Saudi Pharmaceutical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsps.2023.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}],"article-number":"101682"}}