{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:10:08Z","timestamp":1793373008922,"version":"4.5.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009392","name":"Prince Sattam bin Abdulaziz University","doi-asserted-by":"publisher","award":["PSAU\/2023\/R\/1444"],"award-info":[{"award-number":["PSAU\/2023\/R\/1444"]}],"id":[{"id":"10.13039\/100009392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jsps.2023.101734","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T15:49:45Z","timestamp":1691423385000},"page":"101734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Formulation optimization, in vitro and in vivo evaluation of niosomal nanocarriers for enhanced topical delivery of cetirizine"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1298-4863","authenticated-orcid":false,"given":"Mohammed F.","family":"Aldawsari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El-Sayed","family":"Khafagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1076-9740","authenticated-orcid":false,"given":"Ehssan H.","family":"Moglad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Selim Abu Lila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10.1016\/j.jsps.2023.101734_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111868","article-title":"Preparation, characterization and evaluation of anti-inflammatory and anti-nociceptive effects of brucine-loaded nanoemulgel","volume":"205","author":"Abdallah","year":"2021","journal-title":"Colloids and Surfaces B: Biointerfaces."},{"key":"10.1016\/j.jsps.2023.101734_b0010","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3390\/gels7040219","article-title":"Quality by Design for Optimizing a Novel Liposomal Jojoba Oil-Based Emulgel to Ameliorate the Anti-Inflammatory Effect of Brucine","volume":"7","author":"Abdallah","year":"2021","journal-title":"Gels."},{"key":"10.1016\/j.jsps.2023.101734_b0015","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1208\/s12249-021-02113-8","article-title":"Brucine-Loaded Ethosomal Gel: Design, Optimization, and Anti-inflammatory Activity","volume":"22","author":"Abdallah","year":"2021","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jsps.2023.101734_b0020","first-page":"508","article-title":"Experimental Design and Optimization of Nano-Transfersomal Gel to Enhance the Hypoglycemic Activity of Silymarin","volume":"14","author":"Abdallah","year":"2022","journal-title":"Journal"},{"key":"10.1016\/j.jsps.2023.101734_b0025","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijpharm.2015.03.020","article-title":"Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: application of Box-Behnken design, in-vitro evaluation and in-vivo skin deposition study","volume":"485","author":"Abdelbary","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0030","first-page":"811","article-title":"Preparation of niosomes as an ocular delivery system for naltrexone hydrochloride: physicochemical characterization","volume":"65","author":"Abdelkader","year":"2010","journal-title":"Pharmazie"},{"issue":"136\u2013141","key":"10.1016\/j.jsps.2023.101734_b0035","first-page":"e135","article-title":"The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis","volume":"77","author":"Adil","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jsps.2023.101734_b0040","first-page":"121","article-title":"Effect of cholesterol content and surfactant HLB on vesicle properties of niosomes","volume":"66","author":"Agarwal","year":"2004","journal-title":"Indian J. Pharm. Sci."},{"key":"10.1016\/j.jsps.2023.101734_b0045","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ijpharm.2012.08.015","article-title":"Preparation and evaluation of antifungal efficacy of griseofulvin loaded deformable membrane vesicles in optimized guinea pig model of Microsporum canis\u2013dermatophytosis","volume":"437","author":"Aggarwal","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0050","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1080\/10717544.2022.2108939","article-title":"Repurposing levocetirizine hydrochloride loaded into cationic ceramide\/phospholipid composite (CCPCs) for management of alopecia: central composite design optimization, in- silico and in-vivo studies","volume":"29","author":"Albash","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jsps.2023.101734_b0055","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.3390\/polym14194184","article-title":"Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation","volume":"14","author":"Aldawsari","year":"2022","journal-title":"Polymers (Basel)."},{"key":"10.1016\/j.jsps.2023.101734_b0060","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ijpharm.2014.06.041","article-title":"Nano-transfersomal ciprofloxacin loaded vesicles for non-invasive trans-tympanic ototopical delivery: in-vitro optimization, ex-vivo permeation studies, and in-vivo assessment","volume":"472","author":"Al-Mahallawi","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0065","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ijpharm.2015.03.033","article-title":"Investigating the potential of employing bilosomes as a novel vesicular carrier for transdermal delivery of tenoxicam","volume":"485","author":"Al-Mahallawi","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2009.04.020","article-title":"Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery","volume":"377","author":"Balakrishnan","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0075","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejpb.2019.08.015","article-title":"Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications","volume":"144","author":"Chen","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jsps.2023.101734_b0080","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/pharmaceutics10020057","article-title":"Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems","volume":"10","author":"Danaei","year":"2018","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.jsps.2023.101734_b0085","doi-asserted-by":"crossref","first-page":"126ra134","DOI":"10.1126\/scitranslmed.3003122","article-title":"Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia","volume":"4","author":"Garza","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jsps.2023.101734_b0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/pharmaceutics11020055","article-title":"Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery","volume":"11","author":"Ge","year":"2019","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.jsps.2023.101734_b0095","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.2147\/DDDT.S264648","article-title":"Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages","volume":"14","author":"Ghasemiyeh","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.jsps.2023.101734_b0100","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1208\/s12249-013-0017-3","article-title":"Development of novel elastic vesicle-based topical formulation of cetirizine dihydrochloride for treatment of atopic dermatitis","volume":"14","author":"Goindi","year":"2013","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jsps.2023.101734_b0105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1517\/17425247.2013.746310","article-title":"Niosomes as a propitious carrier for topical drug delivery","volume":"10","author":"Hamishehkar","year":"2013","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jsps.2023.101734_b0110","doi-asserted-by":"crossref","first-page":"191","DOI":"10.18433\/jpps31456","article-title":"Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study","volume":"24","author":"Hossein Mostafa","year":"2021","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.jsps.2023.101734_b0115","doi-asserted-by":"crossref","first-page":"9693","DOI":"10.1021\/acsnano.8b03800","article-title":"Enhanced Transdermal Drug Delivery by Transfersome-Embedded Oligopeptide Hydrogel for Topical Chemotherapy of Melanoma","volume":"12","author":"Jiang","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.jsps.2023.101734_b0120","article-title":"Comprehensive Screening of Drug Encapsulation and Co-Encapsulation into Niosomes Produced Using a Microfluidic Device","volume":"8","author":"Joshi","year":"2020","journal-title":"Journal"},{"key":"10.1016\/j.jsps.2023.101734_b0125","first-page":"45","article-title":"Liposomes and niosomes : interactions with human skin","volume":"106","author":"Junginger","year":"1991","journal-title":"Cosmetics and toiletries."},{"key":"10.1016\/j.jsps.2023.101734_b0130","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ijpharm.2016.12.018","article-title":"Enhancement of 8-methoxypsoralen topical delivery via nanosized niosomal vesicles: Formulation development, in vitro and in vivo evaluation of skin deposition","volume":"517","author":"Kassem","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0135","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s40265-016-0629-5","article-title":"Androgenetic Alopecia: An Update of Treatment Options","volume":"76","author":"Kelly","year":"2016","journal-title":"Drugs"},{"key":"10.1016\/j.jsps.2023.101734_b0140","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3390\/polym15030677","article-title":"Tailoring of Novel Bile Salt Stabilized Vesicles for Enhanced Transdermal Delivery of Simvastatin: A New Therapeutic Approach against Inflammation","volume":"15","author":"Khafagy","year":"2023","journal-title":"Polymers (Basel)."},{"key":"10.1016\/j.jsps.2023.101734_b0145","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/10717540701603597","article-title":"Caffeine-Loaded Niosomes: Characterization and in Vitro Release Studies","volume":"14","author":"Khazaeli","year":"2007","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jsps.2023.101734_b0150","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3390\/pharmaceutics14040726","article-title":"Niosomal Nanocarriers for Enhanced Dermal Delivery of Epigallocatechin Gallate for Protection against Oxidative Stress of the Skin","volume":"14","author":"Li","year":"2022","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.jsps.2023.101734_b0155","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12020-017-1280-y","article-title":"Androgenetic alopecia: a review","volume":"57","author":"Lolli","year":"2017","journal-title":"Endocrine"},{"key":"10.1016\/j.jsps.2023.101734_b0160","article-title":"Use of response surface methodology in the formulation and optimization of bisoprolol fumarate matrix tablets for sustained drug release","volume":"2012","author":"Malakar","year":"2012","journal-title":"ISRN Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0165","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s13346-012-0083-1","article-title":"Niosomes as a vesicular carrier for topical administration of minoxidil: formulation and in vitro assessment","volume":"3","author":"Mali","year":"2013","journal-title":"Drug Deliv. and Transl. Res."},{"key":"10.1016\/j.jsps.2023.101734_b0170","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jconrel.2014.04.015","article-title":"Nano-niosomes as nanoscale drug delivery systems: an illustrated review","volume":"185","author":"Moghassemi","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jsps.2023.101734_b0175","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1080\/10717544.2021.1958106","article-title":"Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer","volume":"28","author":"Moin","year":"2021","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jsps.2023.101734_b0180","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijpharm.2008.05.031","article-title":"Effect of some formulation parameters on flurbiprofen encapsulation and release rates of niosomes prepared from proniosomes","volume":"361","author":"Mokhtar","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0185","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0378-5173(99)00222-7","article-title":"Encapsulation characteristics of nystatin in liposomes: effects of cholesterol and polyethylene glycol derivatives","volume":"188","author":"Moribe","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0190","first-page":"820","article-title":"Ameliorative Effect of a Neoteric Regimen of Catechin plus Cetirizine on Ovalbumin-Induced Allergic Rhinitis in Rats","volume":"12","author":"Morsy","year":"2022","journal-title":"Life (Basel)."},{"key":"10.1016\/j.jsps.2023.101734_b0195","first-page":"1","article-title":"Effect of Surfactant Type, Cholesterol Content and Various Downsizing Methods on the Particle Size of Niosomes","volume":"17","author":"Nowroozi","year":"2018","journal-title":"Iran J Pharm Res."},{"key":"10.1016\/j.jsps.2023.101734_b0200","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ijpharm.2006.08.002","article-title":"In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin","volume":"328","author":"Pardakhty","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0205","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3797\/scipharm.1202-12","article-title":"Nanostructured Lipid Carriers (NLC)-Based Gel for the Topical Delivery of Aceclofenac: Preparation, Characterization, and In Vivo Evaluation","volume":"80","author":"Patel","year":"2012","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0210","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1773-2247(07)50049-3","article-title":"Elastic positively-charged liposomes for topical administration of acyclovir","volume":"17","author":"Peira","year":"2007","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.jsps.2023.101734_b0215","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.biopha.2017.06.043","article-title":"Formulation and optimization of lacidipine loaded niosomal gel for transdermal delivery: In-vitro characterization and in-vivo activity","volume":"93","author":"Qumbar","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jsps.2023.101734_b0220","doi-asserted-by":"crossref","first-page":"508","DOI":"10.7897\/2277-4343.054103","article-title":"Transdermal permeation enhancement of ibuprofen and its solid dispersions","volume":"5","author":"Rajitha","year":"2014","journal-title":"Int J Res Ayur Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0225","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/09546634.2017.1341610","article-title":"A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia","volume":"29","author":"Rossi","year":"2018","journal-title":"J. Dermatolog. Treat."},{"key":"10.1016\/j.jsps.2023.101734_b0230","doi-asserted-by":"crossref","first-page":"181","DOI":"10.22159\/ijap.2020v12i5.38639","article-title":"Quality by design approach for development and optimization of nitrendipine loaded niosomal gel for accentuated transdermal delivery","volume":"12","author":"Sharma","year":"2020","journal-title":"Int J App Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0235","first-page":"107","article-title":"Niosome as a drug carrier for topical delivery of N-acetyl glucosamine","volume":"5","author":"Shatalebi","year":"2010","journal-title":"Res Pharm Sci."},{"key":"10.1016\/j.jsps.2023.101734_b0240","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.3390\/nano10101954","article-title":"Therapeutic Applications of Biostable Silver Nanoparticles Synthesized Using Peel Extract of Benincasa hispida: Antibacterial and Anticancer Activities","volume":"10","author":"Soliman","year":"2020","journal-title":"Nanomaterials (Basel)."},{"key":"10.1016\/j.jsps.2023.101734_b0245","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.2147\/DDDT.S214907","article-title":"Minoxidil and its use in hair disorders: a review","volume":"13","author":"Suchonwanit","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.jsps.2023.101734_b0250","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.colsurfb.2013.09.055","article-title":"Co-encapsulation of lipophilic antioxidants into niosomal carriers: percutaneous permeation studies for cosmeceutical applications","volume":"114","author":"Tavano","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.jsps.2023.101734_b0255","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0168-3659(97)00100-4","article-title":"Proniosome based transdermal delivery of levonorgestrel for effective contraception","volume":"54","author":"Vora","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jsps.2023.101734_b0260","doi-asserted-by":"crossref","DOI":"10.1063\/1.3079097","article-title":"Dynamics of vesicle formation from lipid droplets: mechanism and controllability","volume":"130","author":"Wang","year":"2009","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jsps.2023.101734_b0265","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijpharm.2014.11.018","article-title":"Evaluation of transdermal salidroside delivery using niosomes via in vitro cellular uptake","volume":"478","author":"Zhang","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jsps.2023.101734_b0270","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.940213","article-title":"Cetirizine for the treatment of allergic diseases in children: A systematic review and meta-analysis","volume":"10","author":"Zhou","year":"2022","journal-title":"Front. Pediatr."}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016423002293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016423002293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:28:36Z","timestamp":1736184516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319016423002293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":54,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S1319016423002293"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2023.101734","relation":{},"ISSN":["1319-0164"],"issn-type":[{"value":"1319-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formulation optimization, in vitro and in vivo evaluation of niosomal nanocarriers for enhanced topical delivery of cetirizine","name":"articletitle","label":"Article Title"},{"value":"Saudi Pharmaceutical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsps.2023.101734","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}],"article-number":"101734"}}