{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:13:15Z","timestamp":1776114795796,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011821","name":"Kingdom of Saudi Arabia Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011821","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jsps.2023.101869","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T08:46:42Z","timestamp":1699519602000},"page":"101869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardioprotective study of Eriobotrya japonica leaf extracts against carbon tetrachloride induced toxicity in rats"],"prefix":"10.1007","volume":"31","author":[{"given":"Abdelaaty A.","family":"Shahat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riaz","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali S.","family":"Alqahtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer I.","family":"Fantoukh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10.1016\/j.jsps.2023.101869_b0005","doi-asserted-by":"crossref","unstructured":"Ahumada, J., Fuentealba, C., Olaeta, J. A., Undurraga, P., Pedreschi, R., Shetty, K., Ranilla, L. G. (2017). Bioactive compounds of loquat (Eriobotrya japonica Lindl.) cv. Golden Nugget and analysis of in vitro functionality for hyperglycemia management. Ciencia e investigaci\u00f3n agraria: revista latinoamericana de ciencias de la agricultura, 44(3), 272-284.","DOI":"10.7764\/rcia.v44i3.1816"},{"issue":"4","key":"10.1016\/j.jsps.2023.101869_b0010","first-page":"735","article-title":"Intervention of adriamycin induced free radical damage","volume":"28","author":"Balanehru","year":"1992","journal-title":"Biochem. Int."},{"issue":"1","key":"10.1016\/j.jsps.2023.101869_b0015","first-page":"95","article-title":"Pharmacological potential of Eriobotrya japonica-an overview","volume":"1","author":"Baljinder","year":"2010","journal-title":"Int. Res. J. Pharm."},{"issue":"2","key":"10.1016\/j.jsps.2023.101869_b0020","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jep.2010.12.017","article-title":"Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica","volume":"134","author":"Cha","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jsps.2023.101869_b0025","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.3390\/ijms19061638","article-title":"Anti-apoptosis and anti-fibrosis effects of eriobotrya japonica in spontaneously hypertensive rat hearts","volume":"19","author":"Chiang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jsps.2023.101869_b0030","doi-asserted-by":"crossref","unstructured":"Cho, Y. H., Lee, S. Y., Kim, C. M., Kim, N. D., Choe, S., Lee, C.-H., & Shin, J.-H. (2016). Effect of loquat leaf extract on muscle strength, muscle mass, and muscle function in healthy adults: a randomized, double-blinded, and placebo-controlled trial. Evidence-Based Complementary and Alternative Medicine, 2016.","DOI":"10.1155\/2016\/4301621"},{"issue":"12","key":"10.1016\/j.jsps.2023.101869_b0035","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1080\/10942912.2015.1013635","article-title":"Antioxidant activity of loquat (Eriobotrya japonica Lindl.) fruit peel and pulp extracts in stabilization of soybean oil during storage conditions","volume":"18","author":"Delfanian","year":"2015","journal-title":"Int. J. Food Prop."},{"issue":"5","key":"10.1016\/j.jsps.2023.101869_b0040","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3892\/ol.2012.596","article-title":"Kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii Korth. inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway","volume":"3","author":"Diantini","year":"2012","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jsps.2023.101869_b0045","doi-asserted-by":"crossref","unstructured":"Hirota, R., & Suganuma, N. (2009). Preventive Effect of Bronchial Asthma by Administration of Japanese Loquat (Eriobotrya japonica) Seeds Extract in Mice B59. PULMONARY FIBROSIS: ANIMAL MODELS (pp. A3432): American Thoracic Society.","DOI":"10.1164\/ajrccm-conference.2009.179.1_MeetingAbstracts.A3432"},{"key":"10.1016\/j.jsps.2023.101869_b0050","doi-asserted-by":"crossref","unstructured":"Ibrahim, R. M. (2021). A review on active constituents and pharmacological effects of Eriobotrya japonica Lindl.(Loquat). Iraqi Journal of Pharmaceutical Sciences (P-ISSN: 1683-3597, E-ISSN: 2521-3512), 30(1), 41-55.","DOI":"10.31351\/vol30iss1pp41-55"},{"issue":"8","key":"10.1016\/j.jsps.2023.101869_b0055","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1021\/jf011083l","article-title":"Antitumor activity of compounds isolated from leaves of Eriobotrya japonica","volume":"50","author":"Ito","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jsps.2023.101869_b0060","unstructured":"Khurana, P. Benefits to the cardiovascular system in health and in aging. Nutrients https:\/\/doi. org\/10.3390\/nu5103779."},{"issue":"1","key":"10.1016\/j.jsps.2023.101869_b0065","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.foodchem.2006.11.043","article-title":"Effect of loquat (Eriobotrya japonica) extracts on LDL oxidation","volume":"104","author":"Koba","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.jsps.2023.101869_b0070","doi-asserted-by":"crossref","unstructured":"Liu, Y., Zhang, W., Xu, C., & Li, X. (2016). Biological activities of extracts from loquat (Eriobotrya japonica Lindl.): a review. International Journal of Molecular Sciences, 17(12), 1983.","DOI":"10.3390\/ijms17121983"},{"issue":"3","key":"10.1016\/j.jsps.2023.101869_b0075","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1111\/jcmm.14130","article-title":"Ursolic acid prevents doxorubicin-induced cardiac toxicity in mice through eNOS activation and inhibition of eNOS uncoupling","volume":"23","author":"Mu","year":"2019","journal-title":"J. Cell Mol. Med."},{"issue":"17","key":"10.1016\/j.jsps.2023.101869_b0080","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.2174\/1381612823666170329144307","article-title":"The relevance of dietary polyphenols in cardiovascular protection","volume":"23","author":"Murillo","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jsps.2023.101869_b0085","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jep.2017.03.037","article-title":"Aqueous extract from leaf of Artocarpus altilis provides cardio-protection from isoproterenol induced myocardial damage in rats: Negative chronotropic and inotropic effects","volume":"203","author":"Nwokocha","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jsps.2023.101869_b0090","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.foodchem.2018.09.029","article-title":"Phytocompounds modulating Aquaporins: Clinical benefits are anticipated","volume":"274","author":"Portincasa","year":"2019","journal-title":"Food Chem."},{"issue":"6","key":"10.1016\/j.jsps.2023.101869_b0095","first-page":"568","article-title":"Cardioprotective effect of aqueous extract of Chichorium intybus on ischemia-reperfusion injury in isolated rat heart","volume":"5","author":"Sadeghi","year":"2015","journal-title":"Avicenna J. Phytomed."},{"key":"10.1016\/j.jsps.2023.101869_b0100","doi-asserted-by":"crossref","unstructured":"Selvamuthukumaran, M., Prabhakar, P. K., & Ghanghas, N. (2020). Loquat (Chinese Plums): Medicinal and Therapeutic Values and Their Processed Products Asian Berries (pp. 205-220): CRC Press.","DOI":"10.1201\/9780429286476-11"},{"issue":"3","key":"10.1016\/j.jsps.2023.101869_b0105","article-title":"Protection of ischemic and reperfused rat heart by aqueous extract of Urtica dioica","volume":"4","author":"Shackebaei","year":"2017","journal-title":"Int. Cardiovasc. Res. J."},{"issue":"06","key":"10.1016\/j.jsps.2023.101869_b0110","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1055\/s-2002-32547","article-title":"Antiviral and antioxidant activity of flavonoids and proanthocyanidins from Crataegus sinaica","volume":"68","author":"Shahat","year":"2002","journal-title":"Planta Med."},{"key":"10.1016\/j.jsps.2023.101869_b0115","doi-asserted-by":"crossref","unstructured":"Shahat, A. A., Ullah, R., Alqahtani, A. S., Alsaid, M. S., Husseiny, H. A., & Al Meanazel, O. T. (2018). Hepatoprotective effect of Eriobotrya japonica leaf extract and its various fractions against carbon tetra chloride induced hepatotoxicity in rats. Evidence-Based Complementary and Alternative Medicine, 2018.","DOI":"10.1155\/2018\/3782768"},{"key":"10.1016\/j.jsps.2023.101869_b0120","doi-asserted-by":"crossref","unstructured":"Shahat, A.A., Hassanein, H.D., Ullah, R., Alqahtani, A.S., Husseiny, H.A., Kowalczyk, A. and Farrag, A.R.H. (2022). Renoprotective and Cardioprotective Potential of Moricandia sinaica (Boiss.) against Carbon Tetrachloride-Induced Toxicity in Rats.Evidence-Based Complementary and Alternative Medicine,2022.","DOI":"10.1155\/2022\/8545695"},{"issue":"2","key":"10.1016\/j.jsps.2023.101869_b0125","article-title":"Effects and safety profile of commonly used herbal anti-diabetic preparations","volume":"4","author":"Suhani","year":"2018","journal-title":"GSC Biol. Pharma. Sci."},{"issue":"12","key":"10.1016\/j.jsps.2023.101869_b0130","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1021\/acs.jafc.8b06954","article-title":"Ursolic acid isolated from the leaves of loquat (Eriobotrya japonica) inhibited osteoclast differentiation through targeting exportin 5","volume":"67","author":"Tan","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"7","key":"10.1016\/j.jsps.2023.101869_b0135","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/FPC.0b013e32833ffb56","article-title":"Doxorubicin pathways: pharmacodynamics and adverse effects","volume":"21","author":"Thorn","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"issue":"5","key":"10.1016\/j.jsps.2023.101869_b0140","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1365-2141.2005.05759.x","article-title":"Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies","volume":"131","author":"Wouters","year":"2005","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jsps.2023.101869_b0145","unstructured":"Younes, S., & Sassine, Y. (2016). Effect of grafting of sugar apple (A. squamosa) scion on the cherimoya (A. cherimola) rootstock on annona fruit production under the climatic conditions of South Lebanon. Lebanese University. Retrieved from website."},{"key":"10.1016\/j.jsps.2023.101869_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110242","article-title":"UHPLC-QTOF-MS based metabolomics and biological activities of different parts of Eriobotrya japonica","volume":"143","author":"Zhang","year":"2021","journal-title":"Food Res. Int."},{"issue":"1","key":"10.1016\/j.jsps.2023.101869_b0155","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/molecules20010542","article-title":"Phenolic composition from different loquat (Eriobotrya japonica Lindl.) cultivars grown in China and their antioxidant properties","volume":"20","author":"Zhang","year":"2015","journal-title":"Molecules"}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S131901642300364X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S131901642300364X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:29:18Z","timestamp":1736184558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S131901642300364X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S131901642300364X"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2023.101869","relation":{},"ISSN":["1319-0164"],"issn-type":[{"value":"1319-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardioprotective study of Eriobotrya japonica leaf extracts against carbon tetrachloride induced toxicity in rats","name":"articletitle","label":"Article Title"},{"value":"Saudi Pharmaceutical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsps.2023.101869","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}],"article-number":"101869"}}