{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:24:00Z","timestamp":1782768240257,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Saudi Pharmaceutical Journal"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jsps.2024.102168","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T17:19:19Z","timestamp":1725470359000},"page":"102168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["The association between uncontrolled hyperglycemia (Type-2 Diabetes) and cardiovascular sequelae in patients with and without insulin"],"prefix":"10.1007","volume":"32","author":[{"given":"Sultan","family":"Alghadeer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah M.","family":"Mubarak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashayr","family":"Alsuwayni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Almurdhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazim","family":"Almalki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metib","family":"Alotaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"issue":"1","key":"10.1016\/j.jsps.2024.102168_b0005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/2230-8229.172225","article-title":"Diabetic retinopathy and the associated risk factors in diabetes type 2 patients in Abha","volume":"23","author":"Ahmed","year":"2016","journal-title":"Saudi Arabia. J Family Community Med."},{"issue":"4","key":"10.1016\/j.jsps.2024.102168_b0010","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2174\/1573399811666150724095130","article-title":"Diabetes Mellitus in Saudi Arabia: A Review of the Recent Literature","volume":"12","author":"Al Dawish","year":"2016","journal-title":"Curr Diabetes Rev."},{"issue":"1","key":"10.1016\/j.jsps.2024.102168_b0020","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2337\/cd17-0119","article-title":"Standards of Medical Care in Diabetes-2018 Abridged for Primary Care Providers","volume":"36","author":"American Diabetes Association","year":"2018","journal-title":"Clin Diabetes."},{"issue":"4","key":"10.1016\/j.jsps.2024.102168_b0025","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4103\/ajm.ajm_53_20","article-title":"Pathophysiology of diabetes: An overview","volume":"10","author":"Banday","year":"2020","journal-title":"Avicenna J Med."},{"key":"10.1016\/j.jsps.2024.102168_b0030","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2337\/diacare.27.7.1535","article-title":"The burden of treatment failure in type 2 diabetes","volume":"27","author":"Brown","year":"2004","journal-title":"Diabetes Care."},{"issue":"3","key":"10.1016\/j.jsps.2024.102168_b0035","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/1479164109338772","article-title":"Review article: Thiazolidinediones and heart failure","volume":"6","author":"Chaggar","year":"2009","journal-title":"Diab Vasc Dis Res."},{"issue":"5","key":"10.1016\/j.jsps.2024.102168_b0040","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/ejhf.1146","article-title":"Treatment with insulin is associated with worse outcome in patients with chronic heart failure and diabetes","volume":"20","author":"Cosmi","year":"2018","journal-title":"Eur J Heart Fail."},{"issue":"2","key":"10.1016\/j.jsps.2024.102168_b0045","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/2047487319878371","article-title":"Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications","volume":"26","author":"Dal Canto","year":"2019","journal-title":"Eur J Prev Cardiol."},{"key":"10.1016\/j.jsps.2024.102168_b0050","doi-asserted-by":"crossref","unstructured":"Davies MJ, Aroda VR, Collins BS, Gabbay RA, Green J, Maruthur NM, Rosas SE, Del Prato S, Mathieu C, Mingrone G, Rossing P, Tankova T, Tsapas A, Buse JB. Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the (ADA) and the (EASD). Diabetes Care. 2022; 45(11):.","DOI":"10.2337\/dci22-0034"},{"key":"10.1016\/j.jsps.2024.102168_b0055","unstructured":"Dean L, McEntyre J. The Genetic Landscape of Diabetes [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004. Chapter 1, Introduction to Diabetes. 2004 Jul 7. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1671\/."},{"key":"10.1016\/j.jsps.2024.102168_b0060","doi-asserted-by":"crossref","unstructured":"Diabetes Control and Complications Trial Research Group; Nathan DM, Genuth S, Lachin J, Cleary P, Crofford O, Davis M, Rand L, Siebert C. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329(14):977-86.","DOI":"10.1056\/NEJM199309303291401"},{"key":"10.1016\/j.jsps.2024.102168_b0065","doi-asserted-by":"crossref","unstructured":"El-Asrar AM, Al-Rubeaan KA, Al-Amro SA, Kangave D, Moharram OA. Risk factors for diabetic retinopathy among Saudi diabetics. Int Ophthalmol. 1998-1999;22(3):155-61.","DOI":"10.1023\/A:1006240928938"},{"issue":"3","key":"10.1016\/j.jsps.2024.102168_b0070","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF00418270","article-title":"Effect of improved metabolic control on loss of kidney function in type 1 (insulin-dependent) diabetic patients: an update of the Steno studies","volume":"34","author":"Feldt-Rasmussen","year":"1991","journal-title":"Diabetologia."},{"issue":"1","key":"10.1016\/j.jsps.2024.102168_b0075","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/01.STR.0000195175.29487.30","article-title":"Hyperglycemia, insulin, and acute ischemic stroke: a mechanistic justification for a trial of insulin infusion therapy","volume":"37","author":"Garg","year":"2006","journal-title":"Stroke."},{"key":"10.1016\/j.jsps.2024.102168_b0080","doi-asserted-by":"crossref","unstructured":"Gyu Chul Oh, You-Jeong Ki, Kyung Woo Park, Kyung-Do Han, Hyo-Soo Kim. Association Between Dipeptidyl Peptidase-4 Inhibitors and Diabetic Retinopathy in Korean Patients With Type 2 Diabetes Mellitus: Nationwide Population-Based Cohort Study, 17 August 2021, PREPRINT (Version 1) available at Research Square [https:\/\/doi.org\/10.21203\/rs.3.rs-666003\/v1].","DOI":"10.21203\/rs.3.rs-666003\/v1"},{"key":"10.1016\/j.jsps.2024.102168_b0085","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.diabres.2007.03.021","article-title":"Treatment satisfaction and quality of life using an early insulinization strategy with insulin glargine compared to an adjusted oral therapy in the management of type 2 diabetes: The Canadian INSIGHT study","volume":"78","author":"Houlden","year":"2007","journal-title":"Diabetes Res Clin Pract."},{"issue":"13","key":"10.1016\/j.jsps.2024.102168_b0090","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.3390\/jcm10132871","article-title":"Association between Add-On Dipeptidyl Peptidase-4 Inhibitor Therapy and Diabetic Retinopathy Progression","volume":"10","author":"Kang","year":"2021","journal-title":"J Clin Med."},{"issue":"4","key":"10.1016\/j.jsps.2024.102168_b0095","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.diabet.2018.03.004","article-title":"Dipeptidyl peptidase-4 inhibitor use and risk of diabetic retinopathy: A population-based study","volume":"44","author":"Kim","year":"2018","journal-title":"Diabetes Metab."},{"issue":"3","key":"10.1016\/j.jsps.2024.102168_b0100","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2337\/dc17-1144","article-title":"The Legacy Effect in Type 2 Diabetes: Impact of Early Glycemic Control on Future Complications (The Diabetes & Aging Study)","volume":"42","author":"Laiteerapong","year":"2019","journal-title":"Diabetes Care."},{"key":"10.1016\/j.jsps.2024.102168_b0105","doi-asserted-by":"crossref","first-page":"29393","DOI":"10.1038\/srep29393","article-title":"Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation","volume":"6","author":"Lee","year":"2016","journal-title":"Sci Rep."},{"key":"10.1016\/j.jsps.2024.102168_b0110","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jdiacomp.2006.02.004","article-title":"Transition to insulin in type 2 diabetes: family physicians' misconception of patients' fears contributes to existing barriers","volume":"21","author":"Nakar","year":"2007","journal-title":"J Diabetes Complications."},{"key":"10.1016\/j.jsps.2024.102168_b0115","doi-asserted-by":"crossref","unstructured":"Nathan DM, Buse JB, Davidson MB, Ferrannini E, HolmanRR, Sherwin R, Zinman B. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009;\u200832:193 \u2013 203.","DOI":"10.2337\/dc08-9025"},{"issue":"2","key":"10.1016\/j.jsps.2024.102168_b0120","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0168-8227(95)01064-K","article-title":"Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study","volume":"28","author":"Ohkubo","year":"1995","journal-title":"Diabetes Res Clin Pract."},{"key":"10.1016\/j.jsps.2024.102168_b0125","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.2337\/diacare.28.10.2543","article-title":"Psychological insulin resistance in patients with type 2 diabetes: the scope of the problem","volume":"28","author":"Polonsky","year":"2005","journal-title":"Diabetes Care."},{"key":"10.1016\/j.jsps.2024.102168_b0130","doi-asserted-by":"crossref","unstructured":"Rodbard HW, Cariou B, Zinman B, Handelsman Y, Philis-Tsimikas A, Skj\u00f8th TV, Rana A, Mathieu C; BEGIN Once Long trial investigators. Comparison of insulin degludec with insulin glargine in insulin-naive subjects with Type 2 diabetes: a 2-year randomized, treat-to-target trial. Diabet Med. 2013;30(11):1298-304.","DOI":"10.1111\/dme.12303"},{"issue":"10","key":"10.1016\/j.jsps.2024.102168_b0135","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.CIR.97.10.996","article-title":"Insulin and risk of cardiovascular disease: a meta-analysis","volume":"97","author":"Ruige","year":"1998","journal-title":"Circulation."},{"issue":"6","key":"10.1016\/j.jsps.2024.102168_b0140","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/00325481.2016.1191955","article-title":"Obviating much of the need for insulin therapy in type 2 diabetes mellitus: A re-assessment of insulin therapy's safety profile","volume":"128","author":"Schwartz","year":"2016","journal-title":"Postgrad Med."},{"issue":"2","key":"10.1016\/j.jsps.2024.102168_b0145","first-page":"B21","article-title":"Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients","volume":"23","author":"Shichiri","year":"2000","journal-title":"Diabetes Care."},{"issue":"2","key":"10.1016\/j.jsps.2024.102168_b0150","doi-asserted-by":"crossref","first-page":"S253","DOI":"10.2337\/dc09-S318","article-title":"Insulin therapy for type 2 diabetes","volume":"32","author":"Swinnen","year":"2009","journal-title":"Diabetes Care."},{"issue":"9626","key":"10.1016\/j.jsps.2024.102168_b0155","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/S0140-6736(08)60762-X","article-title":"Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial","volume":"371","author":"Weng","year":"2008","journal-title":"Lancet."}],"container-title":["Saudi Pharmaceutical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016424002184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1319016424002184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:25:43Z","timestamp":1736184343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1319016424002184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S1319016424002184"],"URL":"https:\/\/doi.org\/10.1016\/j.jsps.2024.102168","relation":{},"ISSN":["1319-0164"],"issn-type":[{"value":"1319-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association between uncontrolled hyperglycemia (Type-2 Diabetes) and cardiovascular sequelae in patients with and without insulin","name":"articletitle","label":"Article Title"},{"value":"Saudi Pharmaceutical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsps.2024.102168","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}],"article-number":"102168"}}