{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:25:01Z","timestamp":1770834301605,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.jss.2005.05.018","type":"journal-article","created":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T11:12:52Z","timestamp":1125573172000},"page":"292-297","source":"Crossref","is-referenced-by-count":20,"title":["Pneumonia-Induced Sepsis and Gut Injury: Effects of a Poly-(ADP-Ribose) Polymerase Inhibitor"],"prefix":"10.1016","volume":"129","author":[{"given":"Suzana M.","family":"Lobo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana R. Perez","family":"Orrico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio M.","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geni S.","family":"Cunrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela S.A.","family":"Chibeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligia M.","family":"Contrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia M.","family":"Cury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuel","family":"de Almeida Burdmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia M.","family":"de Oliveira Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Togni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"De Backer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Charles","family":"Preiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Czaba","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2005.05.018_bib1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1086\/647529","article-title":"Nosocomial pneumonia on general medical and surgical wards in a tertiary-care hospital","volume":"18","author":"Greenaway","year":"1997","journal-title":"Infect. Control Hosp. Epidemiol"},{"key":"10.1016\/j.jss.2005.05.018_bib2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00003246-200102000-00015","article-title":"Risk factors for nosocomial pneumonia in critically ill trauma patients","volume":"29","author":"Tejada","year":"2001","journal-title":"Crit. Care Med"},{"key":"10.1016\/j.jss.2005.05.018_bib3","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s00134-003-2008-4","article-title":"A 7-year study of severe hospital-acquired pneumonia requiring ICU admission","volume":"29","author":"Valles","year":"2003","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jss.2005.05.018_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2165\/00151829-200403020-00006","article-title":"Hospital-acquired pneumonia in critically ill patients","volume":"3","author":"Leroy","year":"2004","journal-title":"Treat. Respir. Med"},{"key":"10.1016\/j.jss.2005.05.018_bib5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1378\/chest.127.1.213","article-title":"Multicenter study of hospital-acquired pneumonia in non-ICU patients","volume":"127","author":"Sopena","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.jss.2005.05.018_bib6","doi-asserted-by":"crossref","first-page":"412S","DOI":"10.1378\/chest.119.2_suppl.412S","article-title":"Guidelines and critical pathways for severe hospital-acquired pneumonia","volume":"119","author":"Fiel","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.jss.2005.05.018_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00024382-200115010-00001","article-title":"Post-injury multiple organ failure","volume":"15","author":"Hassoun","year":"2001","journal-title":"Shock"},{"key":"10.1016\/j.jss.2005.05.018_bib8","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1097\/00003246-200007000-00065","article-title":"Increased gut permeability and bacterial translocation in Pseudomonas pneumonia-induced sepsis","volume":"28","author":"Yu","year":"2000","journal-title":"Crit. Care Med"},{"key":"10.1016\/j.jss.2005.05.018_bib9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00024382-200302000-00008","article-title":"Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis","volume":"19","author":"Liaudet","year":"2003","journal-title":"Shock"},{"key":"10.1016\/j.jss.2005.05.018_bib10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1186\/cc1824","article-title":"Bench-to-bedside review","volume":"6","author":"Fink","year":"2002","journal-title":"Crit. Care"},{"key":"10.1016\/j.jss.2005.05.018_bib11","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1042\/bst0250919","article-title":"Role of poly(ADP-ribose) synthetase activation in the suppression of cellular energetics in response to nitric oxide and peroxynitrite","volume":"25","author":"Szabo","year":"1997","journal-title":"Biochem. Soc. Trans"},{"key":"10.1016\/j.jss.2005.05.018_bib12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF01076101","article-title":"Molecular and biochemical features of poly (ADP-ribose) metabolism","volume":"122","author":"Lautier","year":"1993","journal-title":"Mol. Cell Biochem"},{"key":"10.1016\/j.jss.2005.05.018_bib13","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/00003246-200205000-00019","article-title":"Novel phenanthridinone inhibitors of poly (adenosine 5\u2032-diphosphate- ribose) synthetase","volume":"30","author":"Jagtap","year":"2002","journal-title":"Crit. Care Med"},{"key":"10.1016\/j.jss.2005.05.018_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00024382-199807000-00003","article-title":"Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin","volume":"10","author":"Wray","year":"1998","journal-title":"Shock"},{"key":"10.1016\/j.jss.2005.05.018_bib15","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2337\/diabetes.51.2.514","article-title":"The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes","volume":"51","author":"Pacher","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.jss.2005.05.018_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/01.shk.0000048904.46342.22","article-title":"Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia","volume":"19","author":"Ivanyi","year":"2003","journal-title":"Shock"},{"key":"10.1016\/j.jss.2005.05.018_bib17","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1097\/00003246-200205000-00004","article-title":"Protective effect of a novel, potent inhibitor of poly(adenosine 5\u2032-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis","volume":"30","author":"Goldfarb","year":"2002","journal-title":"Crit. Care Med"},{"key":"10.1016\/j.jss.2005.05.018_bib18","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1152\/japplphysiol.00925.2002","article-title":"Gut mucosal damage during endotoxic shock is due to mechanisms other than gut ischemia","volume":"95","author":"Lobo","year":"2003","journal-title":"J. Appl. Physiol"},{"key":"10.1016\/j.jss.2005.05.018_bib19","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/S0006-2952(02)01421-1","article-title":"Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents","volume":"64","author":"Pacher","year":"2002","journal-title":"Biochem. Pharmacol"},{"key":"10.1016\/j.jss.2005.05.018_bib20","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0735-1097(02)02062-4","article-title":"Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure","volume":"40","author":"Pacher","year":"2002","journal-title":"J. Am. Coll. Cardiol"},{"key":"10.1016\/j.jss.2005.05.018_bib21","first-page":"659","article-title":"Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging","volume":"9","author":"Pacher","year":"2002","journal-title":"Int. J. Mol. Med"},{"key":"10.1016\/j.jss.2005.05.018_bib22","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1161\/hh0102.102657","article-title":"Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation","volume":"90","author":"Szabo","year":"2002","journal-title":"Circ. Res"},{"key":"10.1016\/j.jss.2005.05.018_bib23","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/00000542-199709000-00008","article-title":"Monitoring of gastric mucosal PCO2 by gas tonometry","volume":"87","author":"Creteur","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jss.2005.05.018_bib24","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic and metabolic reappraisal","volume":"101","author":"Chiu","year":"1970","journal-title":"Arch. Surg"},{"key":"10.1016\/j.jss.2005.05.018_bib25","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1164\/ajrccm.160.4.9810116","article-title":"Ileal VO(2)-DO(2) alterations induced by endotoxin correlate with severity of mitochondrial injury","volume":"160","author":"Crouser","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.jss.2005.05.018_bib26","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1097\/00003246-200007000-00052","article-title":"Effects of norepinephrine on the distribution of intestinal blood flow and tissue adenosine triphosphate content in endotoxic shock","volume":"28","author":"Revelly","year":"2000","journal-title":"Crit. Care Med"},{"key":"10.1016\/j.jss.2005.05.018_bib27","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00024382-200204000-00008","article-title":"Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice","volume":"17","author":"Soriano","year":"2002","journal-title":"Shock"},{"key":"10.1016\/j.jss.2005.05.018_bib28","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/BF03402192","article-title":"Role of free radicals and poly(ADP-ribose) synthetase in intestinal tight junction permeability","volume":"6","author":"Cuzzocrea","year":"2000","journal-title":"Mol. Med"},{"key":"10.1016\/j.jss.2005.05.018_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00024382-200116020-00013","article-title":"Poly(ADP-ribose) synthetase inhibition reduces bacterial translocation in rats after endotoxin challenge","volume":"16","author":"Taner","year":"2001","journal-title":"Shock"},{"key":"10.1016\/j.jss.2005.05.018_bib30","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.burns.2004.06.007","article-title":"The role of poly (ADP-ribose) synthetase inhibition on the intestinal mucosal barrier after thermal injury","volume":"30","author":"Avlan","year":"2004","journal-title":"Burns"},{"issue":"Suppl 2","key":"10.1016\/j.jss.2005.05.018_bib31","first-page":"S137","article-title":"Effects of a novel poly(ADP-ribose) synthetase inhibitor on serum and luminal gut lactate release in a rabbit model of endotoxic shock","volume":"27","author":"Lobo","year":"2001","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jss.2005.05.018_bib32","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0016-5085(98)70534-7","article-title":"Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells","volume":"114","author":"Kennedy","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2005.05.018_bib33","doi-asserted-by":"crossref","first-page":"10203","DOI":"10.1073\/pnas.170226797","article-title":"Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose) polymerase","volume":"97","author":"Liaudet","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jss.2005.05.018_bib34","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s001340000842","article-title":"Effects of nicotinamide, an inhibitor of PARS activity, on gut and liver O2 exchange and energy metabolism during hyperdynamic porcine endotoxemia","volume":"27","author":"Theisen","year":"2001","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jss.2005.05.018_bib35","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/01.shk.0000108397.56565.4a","article-title":"Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis","volume":"21","author":"Murakami","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.jss.2005.05.018_bib36","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1164\/ajrccm.165.3.2106050","article-title":"Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation","volume":"165","author":"Liaudet","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480405002866?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480405002866?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T02:51:12Z","timestamp":1552963872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480405002866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0022480405002866"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2005.05.018","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}